Professor Stuart Maudsley, PhD - University of Antwerp - Odysseus Professor of Receptor Pharmacology

Professor Stuart Maudsley

PhD

University of Antwerp

Odysseus Professor of Receptor Pharmacology

Antwerp, Please select | Belgium

Main Specialties: Cardiovascular Disease, Endocrinology Diabetes & Metabolism, Geriatric Medicine, Geriatric Psychiatry, Interventional Cardiology, Nephrology, Pharmacology, Preventive Medicine

Additional Specialties: Proteomics

ORCID logohttps://orcid.org/0000-0002-1868-184X


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Professor Stuart Maudsley, PhD - University of Antwerp - Odysseus Professor of Receptor Pharmacology

Professor Stuart Maudsley

PhD

Introduction

Stuart Maudsley has been recognized as a visionary pioneer in science (both physical and biomedical) from childhood where his work was publicized on the national television program ‘The Power Game’ – a U.K. wide engineering Olympiad. Stuart has been subsequently awarded and recognized throughout his career as both an intellectual innovator and as an excellent scientist. Stuart’s primary contribution to science is in the field of receptor systems biology and pharmacotherapeutics design – within this field Stuart is one of the world’s leading young Investigators. Stuart graduated from the University of Leeds with First Class Honors in Pharmacology and was awarded the Pfizer Prize for undergraduate research. For his doctoral work Stuart was one of only 6 recipients (from a University population of 40,000) of the Universities venerated ‘Named Scholarships’, i.e. the Ackroyd, Brotherton and Brown Scholarship. After gaining his Ph.D. in Receptor Pharmacology, he was then awarded a Howard Hughes Medical Institute Fellowship Award to train with Professor Robert Lefkowitz (2012 Nobel Laureate in Chemistry) at Duke University. Following this fellowship Stuart was instantly recruited to be Principal Investigator of the Receptor Biology Section at the Medical Research Council (MRC) - Human Reproductive Sciences Unit at the University of Edinburgh. During his time at the MRC his drug discovery and development abilities was implicit in his recruitment as a scientific advisor to Ardana Bioscience Inc. where he subsequently developed a novel prostate cancer therapeutic. To broaden his already considerable biomedical experience Stuart then accepted the position of Head of the Receptor Pharmacology Unit at the National Institutes of Health (NIH-National Institute on Aging) at the Johns Hopkins University Medical Center. In his time at the NIH Stuart was recognized as a ‘Scientist of Extraordinary Ability’ by the U.S. Government Naturalization services through his award of the highest level of employment recognition, i.e. EB1A visa award. In addition, while at the NIH Stuart was the recipient of multiple NIH ‘On-the-Spot’ Excellence Awards, co-recipient of the 2011 Obesity National Best practice award as well as a recipient of the coveted NIH ‘Bench-to-Bedside’ Translational Research Grant Award (one of the few awards available at the NIH) for his work on neurotrophin receptor functionality in rare disorders. Upon starting a new family, and returning to Europe, Stuart continued his rigorous scientific training with his award of the highly-prized and exclusive Odysseus Program Grant. It is clear from his diverse, intense and excellent track record that he is a unique, groundbreaking and thought-provoking young scientist.

Primary Affiliation: University of Antwerp - Antwerp, Please select , Belgium

Specialties:

Additional Specialties:

Research Interests:


View Professor Stuart Maudsley’s Resume / CV

Education

Jan 2000
Howard Hughes Medical Institute, Duke University Medical Center
HHMI Fellowship
Trained with Prof. Robert J. Lefkowitz, 2012 Nobel Laureate in Chemistry
Sep 1996
University of Leeds, U.K.
Ph.D.
Receptor Pharmacology - Ackroyd, Brotherton and Brown Scholar
Oct 1993
University of Leeds, U.K.
B.Sc. (Hons)
1st Class Honours in Pharmacology - Pfizer Prize in Research

Experience

Sep 2002
Scientific Consultant, Ardana Bioscience and Johnson
Project Leader
Developed novel GnRH-based therapeutic for prostate cancer

Publications

40Publications

702Reads

22Profile Views

GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders.

Front Pharmacol 2018 17;9:1484. Epub 2018 Dec 17.

Department of Biomedical Science, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.3389/fphar.2018.01484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304357PMC
December 2018
64 Reads

G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes.

Int J Mol Sci 2018 Sep 26;19(10). Epub 2018 Sep 26.

Department of Biomedical Sciences, University of Antwerp, 2610 Antwerp, Belgium.

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http://www.mdpi.com/1422-0067/19/10/2919
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http://dx.doi.org/10.3390/ijms19102919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213947PMC
September 2018
12 Reads
2.862 Impact Factor

Intelligent and effective informatic deconvolution of "Big Data" and its future impact on the quantitative nature of neurodegenerative disease therapy.

Alzheimers Dement 2018 Jul 15;14(7):961-975. Epub 2018 Mar 15.

In Silico Biosciences, Inc., Berwyn, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.01.014DOI Listing
July 2018
17 Reads
12.407 Impact Factor

GIT2-A keystone in ageing and age-related disease.

Ageing Res Rev 2018 May 13;43:46-63. Epub 2018 Feb 13.

Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Translational Neurobiology Group, Center of Molecular Neurology, VIB, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2018.02.002DOI Listing
May 2018
3 Reads
4.940 Impact Factor

Translating in vitro ligand bias into in vivo efficacy.

Cell Signal 2018 01 7;41:46-55. Epub 2017 May 7.

Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.cellsig.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675828PMC
January 2018
50 Reads
4.315 Impact Factor

Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung.

Am J Physiol Heart Circ Physiol 2017 Nov 19;313(5):H934-H945. Epub 2017 Aug 19.

Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium;

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http://dx.doi.org/10.1152/ajpheart.00206.2017DOI Listing
November 2017
42 Reads
3.838 Impact Factor

Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases.

Vitam Horm 2017 29;104:263-311. Epub 2016 Nov 29.

Translational Neurobiology Group, University of Antwerp, Antwerpen, Belgium; Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore MD United States. Electronic address:

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http://dx.doi.org/10.1016/bs.vh.2016.10.006DOI Listing
November 2017
1 Read
2.039 Impact Factor

Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2.

Cell Rep 2016 05 21;15(5):926-934. Epub 2016 Apr 21.

Laboratory of Genetics, National Institute on Aging-Intramural Research Program, NIH, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856555PMC
May 2016
14 Reads
7.207 Impact Factor

GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.

Front Endocrinol (Lausanne) 2015 18;6:191. Epub 2016 Jan 18.

Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Translational Neurobiology Group, VIB Department of Molecular Genetics, University of Antwerp, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.3389/fendo.2015.00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716144PMC
February 2016
16 Reads

Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder.

Front Physiol 2015 24;6:324. Epub 2015 Nov 24.

Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health Baltimore, MD, USA ; Translational Neurobiology Group, VIB Department of Molecular Genetics, University of Antwerp Antwerp, Belgium ; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp Antwerpen, Belgium.

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http://dx.doi.org/10.3389/fphys.2015.00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656818PMC
December 2015
20 Reads

Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus.

Cell Rep 2015 Nov 29;13(6):1073-1080. Epub 2015 Oct 29.

Unit on Metabolism and Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD 20892, USA; Section on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD 20892, USA; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, TN 38103, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01107-9.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501107
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http://dx.doi.org/10.1016/j.celrep.2015.09.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644471PMC
November 2015
53 Reads
7.207 Impact Factor

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

Mol Pharmacol 2015 Sep 1;88(3):579-88. Epub 2015 Jul 1.

Departments of Medicine and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina (L.M.L.); Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M.L.); Translational Neurobiology Group, VIB Department of Molecular Genetics, Laboratory of Neurogenetics-Institute Born-Bunge, University of Antwerp, Belgium (S.M.); and Department of Molecular Therapeutics and Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida (L.M.B.).

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http://dx.doi.org/10.1124/mol.115.099630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551052PMC
September 2015
25 Reads
4.128 Impact Factor

Delineation of a conserved arrestin-biased signaling repertoire in vivo.

Mol Pharmacol 2015 Apr 30;87(4):706-17. Epub 2015 Jan 30.

National Institutes of Health, National Institute on Aging, Baltimore, Maryland (S.M., B.M., S.P., K.G.B., W.H.W., Y.Z., E.L.); Department of Medicine, Duke University Medical Center, Durham, North Carolina (D.G.-P.); National Institutes of Health, Center for Information Technology, Bethesda, Maryland (H.C., C.J.); Department of Medicine and Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina (L.M.L.); and Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M.L.).

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http://molpharm.aspetjournals.org/content/87/4/706.full.pdf
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.114.09
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http://dx.doi.org/10.1124/mol.114.095224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366796PMC
April 2015
9 Reads
4.128 Impact Factor

Nuclear GIT2 is an ATM substrate and promotes DNA repair.

Mol Cell Biol 2015 Apr 20;35(7):1081-96. Epub 2015 Jan 20.

Receptor Pharmacology Unit, National Institute on Aging, Baltimore, Maryland, USA VIB Department of Molecular Genetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium

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http://dx.doi.org/10.1128/MCB.01432-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355538PMC
April 2015
13 Reads
4.777 Impact Factor

Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.

J Biol Chem 2015 Jan 11;290(5):2728-43. Epub 2014 Dec 11.

Receptor Pharmacology Unit, the VIB Department of Molecular Genetics, Institute Born-Bunge Laboratory of Neurogenetics, University of Antwerp, 2000 Antwerp, Belgium

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http://dx.doi.org/10.1074/jbc.M114.588608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317004PMC
January 2015
5 Reads
4.573 Impact Factor

What is the role of metabolic hormones in taste buds of the tongue.

Front Horm Res 2014 7;42:134-46. Epub 2014 Apr 7.

Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Md., USA.

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http://dx.doi.org/10.1159/000358322DOI Listing
December 2014
34 Reads
3.304 Impact Factor

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.

J Exp Med 2014 Nov 3;211(12):2373-83. Epub 2014 Nov 3.

Department of Dermatology, Department of Pathology and Laboratory Medicine, Department of Radiation Oncology, and Department of Dermatology and Internal Medicine, University of California, Davis, Sacramento, CA 95817

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http://dx.doi.org/10.1084/jem.20140116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235633PMC
November 2014
15 Reads
12.515 Impact Factor

The effects of aging on the BTBR mouse model of autism spectrum disorder.

Front Aging Neurosci 2014 1;6:225. Epub 2014 Sep 1.

Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging Baltimore, MD, USA ; VIB-Department of Molecular Genetics, University of Antwerp Antwerp, Belgium.

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http://dx.doi.org/10.3389/fnagi.2014.00225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150363PMC
September 2014
5 Reads
2.843 Impact Factor

Systems-Level G Protein-Coupled Receptor Therapy Across a Neurodegenerative Continuum by the GLP-1 Receptor System.

Front Endocrinol (Lausanne) 2014 1;5:142. Epub 2014 Sep 1.

Translational Neurobiology Group, VIB Department of Molecular Genetics, University of Antwerp , Antwerp , Belgium.

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http://dx.doi.org/10.3389/fendo.2014.00142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150252PMC
September 2014
2 Reads

Higher TNF-α, IGF-1, and Leptin Levels are Found in Tasters than Non-Tasters.

Front Endocrinol (Lausanne) 2014 29;5:125. Epub 2014 Jul 29.

Metabolism Unit, National Institute on Aging, National Institutes of Health , Baltimore, MD , USA.

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http://dx.doi.org/10.3389/fendo.2014.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114300PMC
August 2014
2 Reads

Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.

PLoS One 2013 7;8(8):e70257. Epub 2013 Aug 7.

Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070257PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737213PMC
August 2014
12 Reads
3.234 Impact Factor

Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients.

Front Physiol 2014 23;5:231. Epub 2014 Jun 23.

Metabolism Unit, National Institute on Aging, National Institutes of Health Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fphys.2014.00231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066441PMC
July 2014
9 Reads

Altered lipid and salt taste responsivity in ghrelin and GOAT null mice.

PLoS One 2013 4;8(10):e76553. Epub 2013 Oct 4.

Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790684PMC
May 2014
6 Reads
3.234 Impact Factor

Longitudinal analysis of calorie restriction on rat taste bud morphology and expression of sweet taste modulators.

J Gerontol A Biol Sci Med Sci 2014 May 28;69(5):532-44. Epub 2013 Sep 28.

*These authors contributed equally to this work.

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http://dx.doi.org/10.1093/gerona/glt129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991138PMC
May 2014
24 Reads
5.416 Impact Factor

Pharmacophore model of the quercetin binding site of the SIRT6 protein.

J Mol Graph Model 2014 Apr 20;49:38-46. Epub 2014 Jan 20.

Laboratory of Clinical Investigation, Intramural Research Program, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2014.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980043PMC
April 2014
1.722 Impact Factor

Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.

Brain Behav Immun 2014 Feb 18;36:90-100. Epub 2013 Oct 18.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA; School of Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.bbi.2013.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947180PMC
February 2014
18 Reads
5.889 Impact Factor

Plurigon: three dimensional visualization and classification of high-dimensionality data.

Front Physiol 2013 22;4:190. Epub 2013 Jul 22.

Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health Baltimore, MD, USA.

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http://dx.doi.org/10.3389/fphys.2013.00190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717481PMC
July 2013
7 Reads

The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases.

Am J Alzheimers Dis (Columbia) 2013 ;1(1)

Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224.

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http://dx.doi.org/10.7726/ajad.2013.1003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817016PMC
January 2013