Kerman Neuroscience Research Center, Kerman University of Medical Sciences, I.R.Iran
PhD by Research Student n Neurosciences
Kerman, Kerman | Iran (Islamic Republic of)
Main Specialties: Addiction Psychiatry, Adolescent Medicine, Biology, Clinical Neurophysiology, Pain Medicine
Additional Specialties: Addiction Neurobiology, Neurosciences, Medical Physiology
B.Sc. in Biology/ Golestan University, Iran 2005-2010
M.Sc. in Medical Ahvaz Jundishapur University 2010-2013
Physiology of Medical Sciences, Iran
Officer in Health Welfare Office and Clinic 2014-2015
Monitoring of Iranian Army
Counsellor Kanoon Farhangi Amoozesh 2015-2016
Lecturer Pouyandegan Danesh 2015-2017
High Education Center (Chalus)
PhD by Research Neuroscience Research Center 2017-now
Student Kerman University of Medical Sciences
Primary Affiliation: Kerman Neuroscience Research Center, Kerman University of Medical Sciences, I.R.Iran - Kerman, Kerman , Iran (Islamic Republic of)
4PubMed Central Citations
Fadaei-Kenarsary, M., et al. (2017).
Brazilian Archives of Biology and Technology
Relapse is highly prevalent after detoxification and depression. Due to the advantages of venlafaxine compared with other antidepressants, it is expected that venlafaxine administration may reduce relapse after detoxification and depression... .
Fadaei-Kenarsary, M., et al. (2015).
Basic and Clinical Neuroscience
Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking water, 7 days), venlafaxine (80 mg/kg/day, intraperitoneally, 7 days) and their combinations with the spontaneous morphine withdrawal syndrome and pain sensitivity. Methods: Twenty eight young male Sprague-Dawley rats were randomly divided into 4 groups: control, venlafaxine treated, methadone treated and venlafaxine + methadone treated. Morphine sulfate (10 mg/kg/day, subcutaneously, 4 days) was injected to all animals. Then primary withdrawal behaviours and tail flick test were performed. The test was then followed by methadone or its vehicle administration. Second intervention was venlafaxine or its vehicle injection. Then final withdrawal behaviours and tail flick test were performed. Results: Combination of chronic methadone substitution and venlafaxine administration, significantly reduced freezing behaviour of spontaneous morphine withdrawal syndrome (p<0.01, 379±144%). Chronic methadone administration (p<0.05, 35±8% difference with venlafaxine treated group) induced hyperalgesia. A positive correlation (p=0.001, +63%) was observed between the animals final freezing scores and their response latencies to the painful stimulus. Discussion: Combination of chronic methadone and venlafaxine administrations reduces freezing withdrawal behaviour. Further investigations on analgesic interventions are needed to overcome this hyperalgesia.