Publications by authors named "Yue Fan"

162 Publications

[Selection and application in the approach of Bonebridge implantation for bilateral congenital malformation of external and middle ear: selection and application].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Jul;35(7):602-607

Department of Otorhinolaryngology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100730,China.

According to whether auricle reconstruction has been performed before the implantation of Bonebridge, the different surgical plan of combination of ear reconstruction and hearing rehabilitation with Bonebridge were respectively applied for the individuals with congenital outer and middle ear malformation. The study aim to explore the feasibility of personalized comprehensive treatment of congenital outer and middle ear malformation. We developed individualized surgical plans of Bonebridge implantation and auricular reconstruction for 35 patients with bilateral external and middle ear malformation. Six patients underwent Bonebridge implantation on one side, and the post-auricular skin expander implantation on the other sidesimultaneously; seven patients underwent Bonebridge implantation at the same time as the second stage of auricular reconstruction; twenty-two patients had their Bonebridge implantations performed after the reconstruction of the auricles. No intraoperative complications occured in 35 patients. No facial paralysis, vertigo, tinnitus and cerebrospinal fluid leakage was reported. One patient had skin infection after Bonebridge implantation. The Bonebridge was removed and 7 months later and the Bonebridge implantation was re-performed on the same side. No complication occurred after 16 months of follow-up. According to the individual condition of the patients, different surgical plans of Bonebridge implantation and auricular reconstruction can be selected personally, which is beneficial to obtain the ideal aesthetic and hearing outcome.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2021.07.006DOI Listing
July 2021

Cryptoyunnanones A-H, Complex Flavanones from .

J Nat Prod 2021 Jul 20. Epub 2021 Jul 20.

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, People's Republic of China.

Eight new complex flavanones with a novel linkage, cryptoyunnanones A-H (-), together with four known α-pyrones, were isolated from the leaves and twigs of . The structures of - including their absolute configurations were characterized by spectroscopic data analysis and single-crystal X-ray crystallography. Plausible biosynthetic pathways for the formation of compounds - were proposed. Compounds - exhibited cytotoxicity against HCT-116, MDA-MB-231, and PC-3 cancer cells with IC values from 6.4 to 9.1 μM.
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http://dx.doi.org/10.1021/acs.jnatprod.1c00287DOI Listing
July 2021

Poor speech recognition, sound localization and reorganization of brain activity in children with unilateral microtia-atresia.

Brain Imaging Behav 2021 Jul 10. Epub 2021 Jul 10.

Department of Otolaryngology, Peking Union Medical College Hospital, Beijing, 100730, China.

Microtia-atresia is a congenital malformation of the external ear, often affecting one side and being associated with severe-to-profound unilateral conductive hearing loss (UCHL). Although the impact of unilateral hearing loss (UHL) on speech recognition, sound localization and brain plasticity has been intensively investigated, less is known about the subjects with unilateral microtia-atresia (UMA). Considering these UMA subjects have hearing loss from birth, we hypothesize it has a great effect on brain organization. A questionnaire on speech recognition and spatial listening ability was administered to 40 subjects with UMA and 40 age- and sex-matched controls. UMA subjects showed poorer speech recognition in laboratory and poorer spatial listening ability. However, cognitive scores determined by the Montreal Cognitive Assessment (MoCA) and Wechsler Intelligence Scale for Children (WISC-IV) did not differ significantly in these two groups. The impact of hearing loss in UMA on brain functional organization was examined by comparing resting-state fMRIs (rs-fMRI) in 27 subjects with right-sided UMA and 27 matched controls. UMA subjects had increased nodal betweenness in visual networks and DMN but decreases in auditory and attention networks. These results indicate that UCHL in UMA causes significant abnormalities in brain organization. The impact of UCHL on cognition should be further examined with a battery of tests that are more challenging and better focused on the cognitive networks identified.
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http://dx.doi.org/10.1007/s11682-021-00478-9DOI Listing
July 2021

Genome-wide identification and phylogenetic relationships of the gene family of , wild emmer wheat () and bread wheat ().

3 Biotech 2021 Jun 29;11(6):301. Epub 2021 May 29.

College of Agriculture, Guizhou University, Guiyang, 550025 People's Republic of China.

Heat shock protein 70 () plays an important role in plant development. It is closely related to the physiological process of cell development and the response to abiotic and biological stress. However, the classification and evolution of genes in bread wheat, wild emmer wheat and are still unclear. Therefore, this study conducted a comprehensive bioinformatics analysis of gene in three species. Among these three species, 113, 79 and 36 genes were identified. They are divided into six subfamilies. Group vi-1 is different from . It may be the result of early evolutionary segregation. The number of exons in different subfamilies (from 1 to 13) was different, but the distribution patterns of exons / introns in the same subfamily were similar. The results of promoter region analysis showed that the cis-regulatory elements of and wild emmer wheat were different from those of wheat. In addition, CpG island proportion of wild emmer was higher than that of wheat, which may be the molecular basis of heat resistance of wild wheat relative to cultivated wheat. Further comprehensive analysis of chromosome location and repeat events of gene showed that whole-genome duplication and tandem duplication events contributed to the evolution and expansion of gene in wheat. The results of non-synonymous substitution and synonymous substitution analysis showed that genes of three species had undergone purification selection. The expression profile analysis showed that gene was highly expressed in the roots during the vegetative growth period. In addition, TaHsp70 gene was highly expressed under various stress. The identification, classification and evolution of in wheat and its relatives provided a basis for further research on its evolution and its molecular mechanism in response to stress.

Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-021-02639-5.
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http://dx.doi.org/10.1007/s13205-021-02639-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164569PMC
June 2021

Iridoid Constituents of .

J Nat Prod 2021 Jul 24;84(7):1915-1923. Epub 2021 Jun 24.

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, People's Republic of China.

Eleven new iridoids, brachybones A-K (-), were isolated from the twigs of . Their structures including absolute configurations were determined by spectroscopic data analysis and from the electronic circular dichroism (ECD) spectra. All of the compounds - possess one or two acetoxysenecioate substituents. Furthermore, compounds - and feature a Cl atom in the molecule, while compounds - exhibit a cagelike rigid skeleton through an unusual oxo bridge from C-3 to C-8 or C-10. The isolates were evaluated for cytotoxic activity against the HCT-116, A549, and Hela cell lines, and the results showed compounds and to be active against HCT-116 cells.
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http://dx.doi.org/10.1021/acs.jnatprod.1c00042DOI Listing
July 2021

Identification of Tumor Microenvironment-Related Prognostic Biomarkers for Ovarian Serous Cancer 3-Year Mortality Using Targeted Maximum Likelihood Estimation: A TCGA Data Mining Study.

Front Genet 2021 3;12:625145. Epub 2021 Jun 3.

Institute for Medical Dataology, Cheeloo College of Medicine, Shandong University, Jinan, China.

Ovarian serous cancer (OSC) is one of the leading causes of death across the world. The role of the tumor microenvironment (TME) in OSC has received increasing attention. Targeted maximum likelihood estimation (TMLE) is developed under a counterfactual framework to produce effect estimation for both the population level and individual level. In this study, we aim to identify TME-related genes and using the TMLE method to estimate their effects on the 3-year mortality of OSC. In total, 285 OSC patients from the TCGA database constituted the studying population. ESTIMATE algorithm was implemented to evaluate immune and stromal components in TME. Differential analysis between high-score and low-score groups regarding ImmuneScore and StromalScore was performed to select shared differential expressed genes (DEGs). Univariate logistic regression analysis was followed to evaluate associations between DEGs and clinical pathologic factors with 3-year mortality. TMLE analysis was conducted to estimate the average effect (AE), individual effect (IE), and marginal odds ratio (MOR). The validation was performed using three datasets from Gene Expression Omnibus (GEO) database. Additionally, 355 DEGs were selected after differential analysis, and 12 genes from DEGs were significant after univariate logistic regression. Four genes remained significant after TMLE analysis. In specific, ARID3C and FREM2 were negatively correlated with OSC 3-year mortality. CROCC2 and PTF1A were positively correlated with OSC 3-year mortality. Combining of ESTIMATE algorithm and TMLE algorithm, we identified four TME-related genes in OSC. AEs were estimated to provide averaged effects based on the population level, while IEs were estimated to provide individualized effects and may be helpful for precision medicine.
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http://dx.doi.org/10.3389/fgene.2021.625145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211425PMC
June 2021

Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome.

Theranostics 2021 31;11(12):5778-5793. Epub 2021 Mar 31.

Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, 100730, Beijing, China.

Prior chronic treatment with statins has been shown to be associated with more favorable outcomes in patients with acute coronary syndrome (ACS). Specific changes in the gut microbiota and microbial metabolites have been shown to influence the progression of coronary artery disease. However, the critical microbial and metabolomic changes associated with the cardiovascular protective effects of statins in ACS remain elusive. In the present study, we performed 16S rRNA sequencing and serum metabolomic analysis in 36 ACS patients who had received chronic statin treatment, 67 ACS patients who had not, and 30 healthy volunteers. A follow-up study was conducted. Metagenomic functional prediction of important bacterial taxa was achieved using PICRUSt2. : Statins modulated the gut microbiome of ACS patients towards a healthier status, i.e., reducing potentially pathogenic bacteria such as but increasing beneficial bacteria such as , and . Moreover, prior chronic statin therapy was associated with improved outcome in ACS patients. Multi-omics analysis revealed that specific changes in bacterial taxa were associated with disease severity or outcomes either directly or by mediating metabolites such as fatty acids and prenol lipids. Finally, we discovered that important taxa associated with statins were correlated with fatty acid- and isoprenoid-related pathways that were predicted by PICRUSt2. Our study suggests that statin treatment might benefit ACS patients by modulating the composition and function of the gut microbiome, which might result in improved circulating metabolites and reduced metabolic risk. Our findings provide new insights for understanding the heterogenic roles of statins in ACS patients through host gut microbiota metabolic interactions.
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http://dx.doi.org/10.7150/thno.55946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058718PMC
March 2021

Polymeric Microparticles Generated via Confinement-Free Fluid Instability.

Adv Mater 2021 Jun 23;33(22):e2007154. Epub 2021 Apr 23.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, P. R. China.

In-fiber fluid instability can be harnessed to realize scalable microparticles fabrication with tunable sizes and multifunctional characteristics making it competitive in comparison to conventional microparticles fabrication methods. However, since in-fiber fluid instability has to be induced via thermal annealing and the resulting microparticles can only be collected after dissolving the fiber cladding, obtaining contamination-free particles for high-temperature incompatible materials remains great challenge. Herein, confinement-free fluid instability is demonstrated to fabricate polymeric microparticles in a facile manner induced by the ultralow surface energy of the superamphiphobic surface. The polymer solution columns break up into uniform droplets then form spherical particles spontaneously in seconds at ambient temperature. This method can be applied to a variety of polymers spanning an exceptionally wide range of sizes: from 1 mm down to 1 µm. With the aid of microfluidic spinning instrument, a large quantity of microparticles can be obtained, making this method promising for scaling up production. Notably, through simple modification of the feed solution configuration, composite/structured micromaterials can also be produced, including quantum-dots-labeled fluorescent particles, magnetic particles, core-shell particles, microcapsules, and necklace-like microfibers. This method, with general applicability and facile control, is envisioned to have great prospects in the field of polymer microprocessing.
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http://dx.doi.org/10.1002/adma.202007154DOI Listing
June 2021

Gene coexpression network approach to develop an immune prognostic model for pancreatic adenocarcinoma.

World J Surg Oncol 2021 Apr 12;19(1):112. Epub 2021 Apr 12.

Department of Oncology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: Pancreatic adenocarcinoma (PAAD) is a nonimmunogenic tumor, and very little is known about the relationship between the host immune response and patient survival. We aimed to develop an immune prognostic model (IPM) and analyze its relevance to the tumor immune profiles of patients with PAAD.

Methods: We investigated differentially expressed genes between tumor and normal tissues in the TCGA PAAD cohort. Immune-related genes were screened from highly variably expressed genes with weighted gene correlation network analysis (WGCNA) to construct an IPM. Then, the influence of IPM on the PAAD immune profile was comprehensively analyzed.

Results: A total of 4902 genes highly variably expressed among primary tumors were used to construct a weighted gene coexpression network. One hundred seventy-five hub genes in the immune-related module were used for machine learning. Then, we established an IPM with four core genes (FCGR2B, IL10RA, and HLA-DRA) to evaluate the prognosis. The risk score predicted by IPM was an independent prognostic factor and had a high predictive value for the prognosis of patients with PAAD. Moreover, we found that the patients in the low-risk group had higher cytolytic activity and lower innate anti-PD-1 resistance (IPRES) signatures than patients in the high-risk group.

Conclusions: Unlike the traditional methods that use immune-related genes listed in public databases to screen prognostic genes, we constructed an IPM through WGCNA to predict the prognosis of PAAD patients. In addition, an IPM prediction of low risk indicated enhanced immune activity and a decreased anti-PD-1 therapeutic response.
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http://dx.doi.org/10.1186/s12957-021-02201-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042890PMC
April 2021

[Obstructive sleep apnea in microtia children with maxillofacial dysostosis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;35(4):371-374;379

Children with microtia are often associated with maxillofacial dysostosis, such as Treacher Collins syndrome, Goldenhar syndrome, and Nager syndrome, and they are prone to suffer from obstructive sleep apnea(OSA). Obstruction widely occurred in the upper airway is the main mechanism of OSA in these children, and dysplasia of the pharynx and neurodevelopmental abnormalities may also participate. Early diagnosis requires symptom screening and polysomnography. Imaging techniques and endoscopy can be adopted to fully assess the upper airway status to guide further treatment. According to the child's condition and the main obstruction site, treatment methods include maxillofacial deformity correction, continuous positive pressure ventilation and tracheotomy. OSA in microtia children with maxillofacial dysostosis needs to be identified and treated in time to reduce the adverse effects on the growth and development of children.
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http://dx.doi.org/10.13201/j.issn.2096-7993.2021.04.020DOI Listing
April 2021

VPS33B interacts with NESG1 to suppress cell growth and cisplatin chemoresistance in ovarian cancer.

Cancer Sci 2021 May 31;112(5):1785-1797. Epub 2021 Mar 31.

Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.

The pathogenesis and cisplatin chemoresistance of ovarian cancer (OC) are still unclear. Vacuolar protein sorting-associated 33B (VPS33B) has not been reported in OC to date. In this study, immunohistochemistry was used to detect VPS33B protein expression between OC and ovarian tissues. MTT, EdU, colony formation, cell cycle, in vivo tumorigenesis, western blot, ChIP, EMSA, co-immunoprecipitation (CoIP), qRT-PCR, and microconfocal microscopy were used to explore the function and molecular mechanisms of VPS33B in OC cells. The results of the present study demonstrated that VPS33B protein expression was obviously reduced in OC compared with that in ovarian tissues. Overexpressed VPS33B suppressed cell cycle transition, cell growth, and chemoresistance to cisplatin in vitro and in vivo. Analysis of the mechanism indicated that overexpressed VPS33B regulated the epidermal growth factor receptor (EGFR)/PI3K/AKT/c-Myc/p53/miR-133a-3p feedback loop and reduced the expression of the cell cycle factor CDK4. Nasopharyngeal epithelium-specific protein 1 (NESG1) as a tumor suppressor not only interacted with VPS33B, but was also induced by VPS33B by the attenuation of PI3K/AKT/c-Jun-mediated transcription inhibition. Overexpressed NESG1 further suppressed cell growth by mediating VPS33B-modulated signals in VPS33B-overexpressing OC cells. Finally, NESG1 induced VPS33B expression by reducing the inhibition of PI3K/AKT/c-Jun-mediated transcription. Our study is the first to demonstrate that VPS33B serves as a tumor suppressor, and VPS33B can interact with NESG1 to suppress cell growth and promote cisplatin sensitivity by regulating the EGFR/PI3K/AKT/c-Myc/p53/miR-133a-3p feedback loop in OC cells.
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http://dx.doi.org/10.1111/cas.14864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088924PMC
May 2021

Genome-Wide Differentially Methylated Region Analysis to Reveal Epigenetic Differences of Articular Cartilage in Kashin-Beck Disease and Osteoarthritis.

Front Cell Dev Biol 2021 1;9:636291. Epub 2021 Mar 1.

School of Public Health, Health Science Center of Xi'an Jiaotong University, Xi'an, China.

Kashin-Beck disease (KBD) is a degenerative osteoarticular disorder, and displays the significant differences with osteoarthritis (OA) regarding the etiology and molecular changes in articular cartilage. However, the underlying dysfunctions of molecular mechanisms in KBD and OA remain unclear. Here, we primarily performed the various genome-wide differential methylation analyses to reveal the distinct differentially methylated regions (DMRs) in conjunction with corresponding differentially methylated genes (DMGs), and enriched functional pathways in KBD and OA. We identified a total of 131 DMRs in KBD vs. Control, and 58 DMRs in OA vs. Controls, and the results demonstrate that many interesting DMRs are linked to DMGs, such as and , which are all key genes to regulate cartilage/skeletal physiologic and pathologic process, and are further enriched in skeletal system and limb-associated pathways. Our DMR analysis indicates that KBD-associated DMRs has higher proportion than OA-associated DMRs in gene body regions. KBD-associated DMGs were enriched in wounding and coagulation-related functional pathways that may be stimulated by trace elements. The identified molecular features provide novel clues for understanding the pathogenetic and therapeutic studies of both KBD and OA.
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http://dx.doi.org/10.3389/fcell.2021.636291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957013PMC
March 2021

The Structural Understanding of Transthyretin Misfolding and the Inspired Drug Approaches for the Treatment of Heart Failure Associated With Transthyretin Amyloidosis.

Front Pharmacol 2021 18;12:628184. Epub 2021 Feb 18.

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Substantial controversies exist in the exploration of the molecular mechanism of heart failure (HF) and pose challenges to the diagnosis of HF and the discovery of specific drugs for the treatment. Recently, cardiac transthyretin (TTR) amyloidosis is becoming recognized as one of major causes of underdiagnosed HF. The investigation and modulation of TTR misfolding and amyloidal aggregation open up a new revenue to reveal the molecular mechanisms of HF and provide new possibilities for the treatment of HF. The aim of this review is to briefly introduce the recent advances in the study of TTR native and misfolding structures, discuss the correlation between the genotype and phenotype of cardiac TTR amyloidosis, and summarize the therapeutic applications of TTR structural stabilizers in the treatment of TTR amyloidosis-associated HF.
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http://dx.doi.org/10.3389/fphar.2021.628184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7930814PMC
February 2021

Charge Density Gradient Propelled Ultrafast Sweeping Removal of Dropwise Condensates.

J Phys Chem B 2021 Feb 11;125(7):1936-1943. Epub 2021 Feb 11.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, China.

Continuous sweeping of dropwise condensates is an effective form of vapor to liquid transition in terms of thermal transport at a solid/liquid interface. However, using conventional approaches, it is difficult to simultaneously achieve small activating size and fast departure of condensed droplets with high efficiency, due to the insufficient driving force compared to adhesion. Here, we propose an unexplored method to stimulate a frequent sweeping removal of dropwise condensates at ultrahigh efficiency on a superhydrophobic substrate, aided by a charge density gradient (CDG). We show that the CDG can be injected inside a superhydrophobic substrate on which the condensate droplet with jump-induced charges starts to sweep at a small size down to the microscale followed by quick snowball-like growing and chase-like propelling. The incorporation of the CDG on a superhydrophobic substrate enables a continuous, fast, frequent, long-range, and gravity-independent droplet removal during condensation, making this strategy a promising solution for diverse applications in water harvesting, antifogging, and anti-icing.
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http://dx.doi.org/10.1021/acs.jpcb.0c10285DOI Listing
February 2021

Effect of dexmedetomidine on perioperative hemodynamics and organ protection in children with congenital heart disease: A randomized controlled trial.

Medicine (Baltimore) 2021 Jan;100(1):e23998

Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

Background: This study aimed to investigate the effects of dexmedetomidine (Dex) on hemodynamics and organ protection in congenital heart disease (CHD) children who underwent open-heart surgery under cryogenic cardiopulmonary bypass.

Methods: Ninety children were randomly allocated to group C (0.9% saline 0.2 μg/kg/hour), group D1 (Dex 0.2 μg/kg/hour), and group D2 (Dex 0.4 μg/kg/hour) (n = 30 per group). All participants received fentanyl, propofol and 1% sevoflurane for anesthesia induction. Hemodynamic data were measured from T0 (before the induction) to T7 (30 minutes after extubation). The difference of arterial internal jugular vein bulbar oxygen difference and cerebral oxygen extraction ratio were calculated according to Fick formula. Enzyme-linked immunosorbent assay was performed to detect the serum myocardial, brain and kidney injury markers. The incidence of acute kidney injury (AKI) was calculated by serum creatinine level. Tracheal extubation time, postoperative pain score and emergence agitation score were also recorded.

Results: Compared with group C, group D1, and D2 exhibited reduction in hemodynamic parameters, myocardial and brain injury indicators, and tracheal extubation time. There were no significant differences in blood urea nitrogen and neutrophil gelatinase-associated lipocalin or incidence of AKI among the 3 groups. Besides, the incidence of tachycardia, nausea, vomiting and moderate agitation, and the FLACC scale in group D1 and D2 were lower than those in group C. Moreover, Dex 0.4 g/kg/hour could further reduce the dosage of fentanyl and dopamine compared with Dex 0.2 g/kg/hour.

Conclusions: Dex anesthesia can effectively maintain hemodynamic stability and diminish organ injuries in CHD children.
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http://dx.doi.org/10.1097/MD.0000000000023998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793469PMC
January 2021

Identification of groundwater contamination sources and hydraulic parameters based on bayesian regularization deep neural network.

Environ Sci Pollut Res Int 2021 Apr 4;28(13):16867-16879. Epub 2021 Jan 4.

Key Laboratory of Groundwater Resources and Environment, Ministry of Education, Jilin University, Changchun, 130021, China.

Simultaneous identification of various features of groundwater contamination sources and hydraulic parameters, such as hydraulic conductivities, can result in high-nonlinear inverse problem, which significantly hinders identification. A surrogate model was proposed to relieve computational burden caused by massive callings to simulation model in identification. However, shallow learning surrogate model may show limited fitting ability to high nonlinear problem. Thus, in this study, a simulation-optimization method based on Bayesian regularization deep neural network (BRDNN) surrogate model was proposed to efficiently solve high-nonlinear inverse problem. This method identified eight variables including locations and release intensities of two pollution sources and hydraulic conductivities of two partitions. Three hidden layers were employed in the BRDNN surrogate model, which profoundly improved the fitting capacity of nonlinear mapping relationship to the simulation model. Furthermore, Bayesian regularization was applied in the training process of neural network to solve overfitting problem. The results indicated that BRDNN was capable of establishing input-output interplay of high nonlinear inverse problem, which substantially reduced computational cost while ensuring a desirable level of accuracy. The utility of simulation-optimization on the basis of BRDNN surrogate model provided stable and reliable inversion results for groundwater contamination sources and hydraulic parameters.
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http://dx.doi.org/10.1007/s11356-020-11614-1DOI Listing
April 2021

construction of sulfated TiO nanoparticles with TiOSO for enhanced photocatalytic hydrogen production.

Nanoscale 2021 Jan;13(2):901-911

Ministry Key Laboratory of Oil and Gas Fine Chemicals, School of Chemical Engineering and Technology, Xinjiang University, Urumqi 830046, China.

Photocatalytic hydrogen production from water is a promising method to obtain clean energy in the future. In this work, the sulfated TiO2 photocatalyst is successfully constructed in situ via a soft-templated method for photocatalytic water splitting to produce hydrogen. The content of sulfate species in TiO2 can be tuned by changing the amount of the surfactant. The photocatalyst with the appropriate content of sulfate ions exhibits an apparent quantum efficiency (AQE) of 3.9% at 365 nm and a high hydrogen production rate of 24.32 mmol h-1 g-1, which is 1.65 times that of commercial TiO2 (P25). The optimized photocatalyst has excellent photocatalytic activity for hydrogen evolution benefitting from the presence of sulfate ions on the surface of TiO2, large surface area and oxygen vacancies, which facilitates the rapid migration of photo-generated electrons to its surface and the improvement of the separation efficiency of photo-generated carriers. This work may inspire the rational design and the development of high-efficiency photocatalysts.
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http://dx.doi.org/10.1039/d0nr06436jDOI Listing
January 2021

Upregulation of tissue long noncoding RNA X inactive specific transcript predicts poor postoperative survival in patients with non-small cell lung cancer.

Medicine (Baltimore) 2020 Dec;99(50):e21789

Department of Cardiothoracic Surgery, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Guangxi, Nanning, China.

X inactive specific transcript (XIST) is a novel long noncoding RNA (lncRNA) which has been reported to be frequently upregulated in various human cancer types and to function as an oncogene. It has been reported that the expression of lncRNA XIST was upregulated in non-small cell lung cancer (NSCLC). In the present study, we aimed to investigate the clinical significance and prognostic value of XIST in patients with NSCLC.A total of 156 pairs of NSCLC and corresponding adjacent normal lung tissue samples were obtained from NSCLC patients who had undergone surgery from July 2014 to March 2019. The Student's t test was used in different treated groups for statistical analysis. The association between XIST expression and clinicopathological features of NSCLC patients was evaluated using the chi-squared test. Survival curves were plotted using Kaplan-Meier method and compared by log-rank test.The expression of XIST was significantly higher in NSCLC samples compared to non-cancerous samples (P < .001). Statistically significant correlations were observed between high tissue XIST expression level and lymph node metastasis (P = .036) and high Tumor Node Metastasis (TNM) stage (P = .002). The log-rank test indicated that patients with increased XIST expression experienced poor overall survival (P = .006). Multivariate Cox regression analysis showed that XIST expression level (hazard ratio = 2.645, 95% confidence interval: 1.672-7.393, P = .029) was an independent factors in predicting the overall survival of NSCLC patients.The present study found that XIST expression level was significantly associated with advanced pathological stage and high TNM stage in NSCLC. Furthermore, upregulation of tissue lncRNA XIST predicts poor postoperative survival in patients with NSCLC.
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http://dx.doi.org/10.1097/MD.0000000000021789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738052PMC
December 2020

The mutational pattern of homologous recombination (HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer.

Cancer Biol Med 2020 11 15;17(4):1002-1013. Epub 2020 Dec 15.

Department of Traditional Chinese Medicine, Ruijin Hospital, Shanghai Jiaotong University, Shanghai 200025, China.

Objective: Currently, there is an urgent need to identify immunotherapeutic biomarkers to increase the benefit of immune checkpoint inhibitors (ICIs) for patients with gastric cancer (GC). Homologous recombination deficiency (HRD) can modify the tumor immune microenvironment by increasing the presence of tumor-infiltrating lymphocytes and therefore might serve as a biomarker of immunotherapeutic response. We aimed to analyze the mutational pattern of HR-associated genes in Chinese patients with GC and its relevance to the tumor immune profile and clinical immunotherapeutic response.

Methods: A panel of 543 cancer-associated genes was used to analyze genomic profiles in a cohort comprising 484 Chinese patients with GC. Correlations between HR gene mutations and tumor immunity or clinical outcomes were identified bioinformatic analysis using 2 GC genomic datasets (TCGA and MSK-IMPACT).

Results: Fifty-one of the 484 (10.54%) patients carried at least one somatic mutation in an HR gene; (16/484, 3.31%) was among the most frequently mutated HR genes in the Chinese cohort. Mutations in HR genes were associated with elevated tumor mutational burden, enhanced immune activity, and microsatellite instability status. In the MSK-IMPACT cohort comprising 49 patients with stomach adenocarcinoma or gastroesophageal junction adenocarcinoma treated with ICIs, patients with HR-mut GC ( = 12) had significantly better overall survival than those with HR-wt GC ( = 37) (log-rank test, < 0.05).

Conclusions: Our data suggest that detection of somatic mutations in HR genes might aid in identifying patients who might benefit from immune checkpoint blockade therapy.
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http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721103PMC
November 2020

SNORA72 Activates the Notch1/c-Myc Pathway to Promote Stemness Transformation of Ovarian Cancer Cells.

Front Cell Dev Biol 2020 3;8:583087. Epub 2020 Nov 3.

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China.

Cancer stem cells (CSCs) are responsible for the migration and recurrence of cancer progression. Small nucleolar RNAs (snoRNAs) play important roles in tumor development. However, how snoRNAs contribute to the regulation of the stemness of ovarian CSCs (OCSCs) remains unclear. In the present study, we found that SNORA72 was significantly upregulated in OVCAR-3 spheroids (OS) and CAOV-3 spheroids (CS) with the OCSC characteristics attained by serum-free culture in a suspension of OVCAR-3 (OV) and CAOV-3 (CA) cells. The overexpression of SNORA72 increased self-renewal abilities and migration abilities in OV and CA cells and upregulated the expressions of the stemness markers Nanog, Oct4, and CD133. In addition, the ectopic expression of SNORA72 can elevate the messenger RNA (mRNA) and protein expression levels of Notch1 and c-Myc in parental cells. The opposite results were observed in SNORA72-silenced OCSCs. Moreover, we found that Notch1 knockdown inversed the migration abilities and self-renewal abilities raised by overexpressing SNORA72. In summary, stemness transformation of ovarian cancer cells can be activated by SNORA72 through the Notch1/c-Myc pathway. This study introduces a novel therapeutic strategy for improving the treatment efficiency of ovarian cancer.
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http://dx.doi.org/10.3389/fcell.2020.583087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669759PMC
November 2020

Cytotoxic α-pyrone derivatives from .

Nat Prod Res 2020 Nov 19:1-7. Epub 2020 Nov 19.

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, P.R. China.

Five new α-pyrone derivatives, cryptoyunnanes A - E (-), together with four known analogues, were isolated from the leaves and twigs of . Their structures including absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. Compounds and showed significant cytotoxicity against A549, HCT-116, MDA-MB-231, PC-3 and HeLa with IC values from 2.25 to 8.97 M. Compounds , and also displayed good cytotoxicity against HCT-116, MDA-MB-231 and PC-3 with IC values from 1.26 to 8.32 M. This is the first time to report the isolation and bioactivity evaluation of chemical constituents from .
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http://dx.doi.org/10.1080/14786419.2020.1849205DOI Listing
November 2020

Surface-Charge-Assisted Microdroplet Generation on a Superhydrophobic Surface.

Langmuir 2020 Dec 10;36(47):14352-14360. Epub 2020 Nov 10.

Yangtze Delta Region Institute of University of Electronic Science and Technology of China, Huzhou 313000, P. R. China.

The ability to generate and manipulate droplets down to microscales has attracted great attention in a variety of applications, such as in printing, microreactors, and biological assays. However, the production of microdroplets is often limited by special equipment or the size of needles. Here, an unexplored and facile approach is demonstrated; microdroplets can be generated and trapped yet not pinned on a micro-nano-structured superhydrophobic surface by controllable surface charge during drop impact. Tiny droplets with a size at a scale of tens of microns to millimeters are generated by simply changing the impacting velocity, the size of the impact drop, or impact frequency. Theoretical analysis suggests the generation of the microdroplet as a result of the surface-charge-regulated adhesion, competing with liquid dynamic and interfacial energy. The distribution of surface charge which determines the size and the location of the microdroplet is at the top of the micro-nano-structured surface and dependent on the pressure field applied on the surface during the drop impact. The mobility of the resulting microdroplet that can be easily manipulated without liquid retention is also shown, by taking advantage of the shielding property of the surface charge. This facile yet effective method provides a promising candidate for the realization of tiny droplet-generating and -manipulating applications.
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http://dx.doi.org/10.1021/acs.langmuir.0c02707DOI Listing
December 2020

Long-term evaluation of development in patients with bilateral microtia using softband bone conducted hearing devices.

Int J Pediatr Otorhinolaryngol 2020 Nov 8;138:110367. Epub 2020 Sep 8.

Department of Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Beijing, China. Electronic address:

Objective: The ability of early intervention with softband bone conducted hearing device (BCHD) to ensure normal development of speech, language and psychosocial situations remains undetermined. We aimed to evaluate auditory and speech development, as well as psychosocial situations of children with bilateral microtia fitted with a softband BCHD for 3-5 years.

Methods: The study included 53 patients with bilateral microtia and 53 sex- and age-matched children with normal hearing. Auditory development was evaluated using the Meaningful Auditory Integration Scale (MAIS) and Categories of Auditory Performance (CAP). Speech Intelligibility Rating (SIR) and Meaningful Use of Speech Scale (MUSS) were used to assess speech development. The psychometric properties of these patients were evaluated using Achenbach's Child Behavior Checklist (CBCL), and subjective benefits were measured using the Glasgow Children's Benefit Inventory (GCBI) questionnaire.

Results: The average unaided and aided hearing thresholds measured using VRA were 73.8 ± 5.1 dB HL and 30.5 ± 6.0 dB HL, respectively. The total MAIS scores of the patients were 89.6 ± 9.6% and 93.0 ± 8.8% of normal hearing children at the last follow-up. The CAP scores of the two groups were 6.5 ± 1.3 and 6.9 ± 0.3, respectively. The mean MUSS score of the patients and the control group were 31.9 ± 7.0 and 34.3 ± 6.0, respectively. The mean SIR score of the two groups were 4.6 ± 0.7 and 4.8 ± 0.4. CBCL found that only two patients could be considered problematic psychosocially. The average benefit score on the GCBI was 32.9 ± 29.3.

Conclusions: Softband BCHD significantly improved auditory development in patients with bilateral microtia, with speech development reaching the level of normal hearing peers. No significant behavioral problems were found in the patients, with subjective evaluations showing that softband BCHD improved patient quality of life.
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http://dx.doi.org/10.1016/j.ijporl.2020.110367DOI Listing
November 2020

Comprehensive Analysis of Immunoinhibitors Identifies LGALS9 and TGFBR1 as Potential Prognostic Biomarkers for Pancreatic Cancer.

Comput Math Methods Med 2020 30;2020:6138039. Epub 2020 Sep 30.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Pancreatic cancer (PC) is one of the most deadly cancers worldwide. To uncover the unknown novel biomarker used to indicate early diagnosis and prognosis in the molecular therapeutic field of PC is extremely of importance. Accumulative evidences indicated that aberrant expression or activation of immunoinhibitors is a common phenomenon in malignances, and significant associations have been noted between immunoinhibitors and tumorigenesis or progression in a wide range of cancers. However, the expression patterns and exact roles of immunoinhibitors contributing to tumorigenesis and progression of pancreatic cancer (PC) have not yet been elucidated clearly. In this study, we investigated the distinct expression and prognostic value of immunoinhibitors in patients with PC by analyzing a series of databases, including TISIDB, GEPIA, cBioPortal, and Kaplan-Meier plotter database. The mRNA expression levels of IDO1, CSF1R, VTCN1, KDR, LGALS9, TGFBR1, TGFB1, IL10RB, and PVRL2 were found to be significantly upregulated in patients with PC. Aberrant expression of TGFBR1, VTCN1, and LGALS9 was found to be associated with the worse outcomes of patients with PC. Bioinformatics analysis demonstrated that LGALS9 was involved in regulating the type I interferon signaling pathway, interferon-gamma-mediated signaling pathway, RIG-I-like receptor signaling pathway, NF-kappa B signaling pathway, cytosolic DNA-sensing pathway, and TNF signaling pathway. And TGFB1 was related to mesoderm formation, cell matrix adhesion, TGF-beta signaling pathway, and Hippo signaling pathway. These results suggested that LGALS9 and TGFBR1 might serve as potential prognostic biomarkers and targets for PC.
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http://dx.doi.org/10.1155/2020/6138039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545442PMC
July 2021

Study of torsional strain effect on dynamic behavior of carbon nanotube thermal actuator.

J Mol Model 2020 Aug 22;26(9):247. Epub 2020 Aug 22.

Department of Engineering Mechanics, School of Civil Engineering, Guangzhou University, Guangzhou, Guangdong Province, 510640, People's Republic of China.

In this paper, a regulation method through torsional strain effect is proposed for carbon nanotube linear thermal actuators. The effects of torsional strain effect on the linear driven performance of linear actuators are systematically studied by molecular dynamics method, and the effect mechanism is revealed as well. It was found that the torsional strain affects the thermal driving force and the friction effect by changing the spacing between the carbon tubes and lattice vibration modes, then further affects the linear driving characteristics. The influence mechanism of torsional strain on the driving characteristics is analyzed and the valuable conclusions for nanoscale strain engineering application are obtained. The work of this paper provides a new idea for performance regulation for nano-driving by using strain effect, and has important guiding significance for nanoscale strain engineering.
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http://dx.doi.org/10.1007/s00894-020-04511-4DOI Listing
August 2020

Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Confirm Its Functional Food Property.

J Agric Food Chem 2020 Aug 7;68(33):8825-8835. Epub 2020 Aug 7.

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, and Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R. China.

In the aim to evaluate the functional food property of , seven new lignans and neolignans, bejolghotins A-G (- and -), along with 14 known ones (- and -), were isolated and their structures including absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. All of the isolates were tested for antioxidant and human cancer cell proliferation inhibitory activities. Twenty compounds showed comparable antioxidant activity to the positive controls, and three significantly inhibited the growth of three cancer cell lines HCT-116, A549, and MDA-MB-231 with IC values of 0.78-2.93 μM, which confirmed its health benefits.
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http://dx.doi.org/10.1021/acs.jafc.0c02885DOI Listing
August 2020

Efficient and effective control of confounding in eQTL mapping studies through joint differential expression and Mendelian randomization analyses.

Bioinformatics 2021 04;37(3):296-302

Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.

Motivation: Identifying cis-acting genetic variants associated with gene expression levels-an analysis commonly referred to as expression quantitative trait loci (eQTLs) mapping-is an important first step toward understanding the genetic determinant of gene expression variation. Successful eQTL mapping requires effective control of confounding factors. A common method for confounding effects control in eQTL mapping studies is the probabilistic estimation of expression residual (PEER) analysis. PEER analysis extracts PEER factors to serve as surrogates for confounding factors, which is further included in the subsequent eQTL mapping analysis. However, it is computationally challenging to determine the optimal number of PEER factors used for eQTL mapping. In particular, the standard approach to determine the optimal number of PEER factors examines one number at a time and chooses a number that optimizes eQTLs discovery. Unfortunately, this standard approach involves multiple repetitive eQTL mapping procedures that are computationally expensive, restricting its use in large-scale eQTL mapping studies that being collected today.

Results: Here, we present a simple and computationally scalable alternative, Effect size Correlation for COnfounding determination (ECCO), to determine the optimal number of PEER factors used for eQTL mapping studies. Instead of performing repetitive eQTL mapping, ECCO jointly applies differential expression analysis and Mendelian randomization analysis, leading to substantial computational savings. In simulations and real data applications, we show that ECCO identifies a similar number of PEER factors required for eQTL mapping analysis as the standard approach but is two orders of magnitude faster. The computational scalability of ECCO allows for optimized eQTL discovery across 48 GTEx tissues for the first time, yielding an overall 5.89% power gain on the number of eQTL harboring genes (eGenes) discovered as compared to the previous GTEx recommendation that does not attempt to determine tissue-specific optimal number of PEER factors.

Availabilityand Implementation: Our method is implemented in the ECCO software, which, along with its GTEx mapping results, is freely available at www.xzlab.org/software.html. All R scripts used in this study are also available at this site.

Supplementary Information: Supplementary data are available at Bioinformatics online.
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http://dx.doi.org/10.1093/bioinformatics/btaa715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058772PMC
April 2021

Resveratrol-primed exosomes strongly promote the recovery of motor function in SCI rats by activating autophagy and inhibiting apoptosis via the PI3K signaling pathway.

Neurosci Lett 2020 09 16;736:135262. Epub 2020 Jul 16.

School of Basic Medicine, China Medical University, Liaoning, China.

Spinal cord injury (SCI) is a traumatic condition of the central nervous system (CNS) that can cause paralysis of the limbs. The molecular mechanisms of neural repair following SCI remain unclear and no effective treatment for SCI currently exists, since drugs have difficulty crossing the blood-brain barrier (BBB). The present study aimed to investigate whether exosomes could be used as specific carriers of resveratrol for induction of neuronal autophagy both in vitro and in vivo for the treatment of SCI. The results indicate that exosomes are able to enhance the solubility of resveratrol and enhance penetration of the drug through the BBB, thereby increasing its concentration in the CNS. Exosomes derived from resveratrol-treated primary microglia (Exo + Res) assisted the rehabilitation of paralyzed limbs in rats. Restoration of neural function following SCI was mediated through increased induction of autophagy and inhibition of apoptosis of neurons both in vitro and in vivo via activation of the PI3K signaling pathway. The mechanism of action of Exo + Res may be associated with the PI3K inhibitor 3-methyladenine (3-MA) in primary spinal neurons. The results suggest that Exo + Res are highly effective at crossing the BBB with good stability, suggesting they have potential for enhancing targeted drug delivery and the recovery of neuronal function in SCI therapy, likely associated with the induction of autophagy and inhibition of apoptosis via the PI3K signaling pathway.
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http://dx.doi.org/10.1016/j.neulet.2020.135262DOI Listing
September 2020

upregulation suppresses autophagy and accelerates malignant phenotype in nasopharyngeal carcinoma.

Autophagy 2020 Jul 5:1-17. Epub 2020 Jul 5.

Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

Dysregulated microRNAs (miRNAs) are involved in carcinoma progression, metastasis, and poor prognosis. We demonstrated that in nasopharyngeal carcinoma (NPC), transactivated promotes a malignant phenotype by functioning as a macroautophagy/autophagy suppressor by targeting (BTG anti-proliferation factor 3) and activating autophagy-regulating MAPK signaling. expression was markedly increased in NPC cases based on quantitative real-time PCR, miRNA microarray, and TCGA database analysis findings. Moreover, was correlated with advanced stage, recurrence, and poor clinical outcomes in NPC patients. In addition to three-dimensional cell culture assays, zebrafish and BALB/c mouse tumor models revealed that overexpressed targeted and accelerated the NPC malignant phenotype by inhibiting autophagy. BTG3 promoted autophagy, and its expression was correlated with poor prognosis in NPC. Attenuation of autophagy, mediated by the -BTG3 axis, occurred because of MAPK pathway activation. overexpression in NPC was due to increased transactivation by EGR1 and SOX9. Our findings may lead to novel insights into the pathogenesis of NPC.

Abbreviations: ACTB: actin beta; ATG: autophagy-related; ATG5: autophagy related 5; BLI: bioluminescence; BTG3: BTG anti-proliferation factor 3; CASP3: caspase 3; ChIP: chromatin immunoprecipitation; CQ: chloroquine; Ct: threshold cycle; DAPI: 4',6-diamidino-2-phenylindole; DiL: 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate; EBSS: Earle's balanced salt solution; EGR1: early growth response 1; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GEO: Gene Expression Omnibus; GFP: green fluorescent protein; IF: immunofluorescence; IHC: immunohistochemistry; ISH: hybridization; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MIR106A-5p: microRNA 106a-5p; miRNAs: microRNAs; MKI67: marker of proliferation ki-67; mRNA: messenger RNA; MTOR: mechanistic target of rapamycin kinase; NPC: nasopharyngeal carcinoma; qRT-PCR: quantitative real-time PCR; siRNA: small interfering RNA; SOX9: SRY-box transcription factor 9; SQSTM1: sequestosome 1; TCGA: The Cancer Genome Atlas; WB: western blot.
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http://dx.doi.org/10.1080/15548627.2020.1781368DOI Listing
July 2020

Association of Waist-to-Height Ratio, Metabolic Syndrome, and Carotid Atherosclerosis in Individuals with a High Risk of Stroke: A Cross-Sectional Study of 9605 Study Participants.

Metab Syndr Relat Disord 2020 10 24;18(8):381-388. Epub 2020 Jun 24.

Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

To determine the association of waist-to-height ratio (WHtR), metabolic syndrome (MetS), and carotid atherosclerosis (CAS) in individuals with a high risk of stroke. We performed a cross-sectional analysis of 9605 study responders from eight urban area communities in Northern China. Height, weight, waist circumference, blood pressure (BP), and blood lipid were measured. Information of population characteristics, smoking status, alcohol consumption, physical activity, and diet were determined by validated questionnaire. A total of 9605 study responders were included in this study. The average age was 60 ± 9 years with 5911 (61.5%) patients being females. The prevalence of MetS and CAS was 26.2% and 75.1%, respectively. WHtR was significantly associated with CAS using our final adjusted model [odds ratio (OR): 1.233, 95% confidence interval (CI): 1.096-1.378]. The association of CAS with hypertension and hyperglycemia were statistically significant among factors that constitute MetS. Additional risk factors affecting the development of CAS included age, previous stroke, and smoking history ( < 0.05). WHtR was determined to perform better compared with other traditional indicators for correlating CAS. We believe that WHtR is a better indicator for the early identification of CAS in individuals with a high risk of stroke. This will facilitate the early detection and intervention of CAS.
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http://dx.doi.org/10.1089/met.2020.0003DOI Listing
October 2020
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