Yoshikazu Uchida

Yoshikazu Uchida

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Yoshikazu Uchida

Publications by authors named "Yoshikazu Uchida"

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Study of the cartilage matrix production-promoting effect of chicken leg extract and identification of the active ingredient.

Nutr Res Pract 2019 Dec 18;13(6):480-487. Epub 2019 Oct 18.

Pharma Foods International Co., Ltd., 1-49 Goryo-Ohara, Nishikyo-ku, Kyoto 615-8245, Japan.

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http://dx.doi.org/10.4162/nrp.2019.13.6.480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883235PMC
December 2019

PPAR-γ signalling as a key mediator of human hair follicle physiology and pathology.

Exp Dermatol 2019 Nov 26. Epub 2019 Nov 26.

Monasterium Laboratory, Skin and Hair Research Solutions GmbH, Muenster, Germany.

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http://dx.doi.org/10.1111/exd.14062DOI Listing
November 2019

Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope.

J Invest Dermatol 2019 Apr 22;139(4):760-768. Epub 2018 Nov 22.

Dermatology Service, Veterans Affairs Medical Center, San Francisco, California, USA; Department of Dermatology, University of California-San Francisco, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.11.005DOI Listing
April 2019

Both Sphingosine Kinase 1 and 2 Coordinately Regulate Cathelicidin Antimicrobial Peptide Production during Keratinocyte Differentiation.

J Invest Dermatol 2019 02 15;139(2):492-494. Epub 2018 Sep 15.

Department of Dermatology, School of Medicine, University of California, San Francisco, California, USA; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342641PMC
February 2019

Tissue microenvironment initiates an immune response to structural components of Staphylococcus aureus.

Exp Dermatol 2019 Feb;28(2):161-168

Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1111/exd.13864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706075PMC
February 2019

Insights into the role of endoplasmic reticulum stress in skin function and associated diseases.

FEBS J 2019 01;286(2):413-425

Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1111/febs.14739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362265PMC
January 2019

Ginsenoside Rb1 Enhances Keratinocyte Migration by a Sphingosine-1-Phosphate-Dependent Mechanism.

J Med Food 2018 Nov 27;21(11):1129-1136. Epub 2018 Aug 27.

1 Department of Food Science and Nutrition, and Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University , Chuncheon, Korea.

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https://www.liebertpub.com/doi/10.1089/jmf.2018.4246
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http://dx.doi.org/10.1089/jmf.2018.4246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913107PMC
November 2018

Naturally Occurring Hair Growth Peptide: Water-Soluble Chicken Egg Yolk Peptides Stimulate Hair Growth Through Induction of Vascular Endothelial Growth Factor Production.

J Med Food 2018 Jul 27;21(7):701-708. Epub 2018 Mar 27.

4 Department of Regenerative Dermatology, Osaka University Graduate School of Medicine , Osaka, Japan .

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http://dx.doi.org/10.1089/jmf.2017.4101DOI Listing
July 2018

Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines.

Am J Pathol 2018 06 13;188(6):1419-1429. Epub 2018 Mar 13.

Dermatology Service, Veterans Affairs Medical Center, San Francisco, California; Department of Dermatology, University of California, San Francisco, San Francisco, California. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971224PMC
June 2018

Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis.

Biomol Ther (Seoul) 2017 Sep;25(5):511-518

Department of Dermatology, School of Medicine, University of California, San Francisco, and Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.4062/biomolther.2017.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590795PMC
September 2017

[Roles of ceramide and its metabolites in cutaneous tissues].

Authors:
Yoshikazu Uchida

Seikagaku 2017 Apr;89(2):164-75

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April 2017

ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex.

Proc Natl Acad Sci U S A 2016 Mar 22;113(10):E1334-42. Epub 2016 Feb 22.

Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94158; Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, CA 94121;

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http://dx.doi.org/10.1073/pnas.1504555113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791017PMC
March 2016

Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production.

J Dermatol Sci 2015 Sep 19;79(3):229-34. Epub 2015 Jun 19.

Department of Dermatology, School of Medicine, University of California, San Francisco, CA 94158, USA; Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA; Northern California Institute for Research and Education, San Francisco, CA 94121, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2015.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624019PMC
September 2015

UVB induces epidermal 11β-hydroxysteroid dehydrogenase type 1 activity in vivo.

Exp Dermatol 2015 May;24(5):370-6

Department of Dermatology, VA Medical Center and University of California San Francisco, 1700 Owens Street, San Francisco, CA, 94158, USA.

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http://dx.doi.org/10.1111/exd.12682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365099PMC
May 2015

An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production.

Mol Cell Biol 2014 Dec 13;34(24):4368-78. Epub 2014 Oct 13.

Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA Department of Veterans Affairs Medical Center, San Francisco, California, USA Northern California Institute for Research and Education, San Francisco, California, USA

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http://mcb.asm.org/content/34/24/4368.full.pdf
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http://mcb.asm.org/cgi/doi/10.1128/MCB.00599-14
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http://dx.doi.org/10.1128/MCB.00599-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248733PMC
December 2014

The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism.

J Nutr Biochem 2014 Jul 27;25(7):734-40. Epub 2014 Mar 27.

Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA; Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA; Northern California Institute for Research and Education, San Francisco, CA 94121, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09552863140005
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http://dx.doi.org/10.1016/j.jnutbio.2014.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441818PMC
July 2014

Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing.

Wound Repair Regen 2013 Sep-Oct;21(5):715-22. Epub 2013 Aug 8.

Department of Dermatology, Veterans Affairs Medical Center, San Francisco, California; Northern California Institute for Research and Education, University of California, San Francisco, California.

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http://dx.doi.org/10.1111/wrr.12083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507432PMC
May 2014

Increased glucocorticoid activation during mouse skin wound healing.

J Endocrinol 2014 Apr 7;221(1):51-61. Epub 2014 Mar 7.

Department of Dermatology, University of California San Francisco, 1700 Owens Street, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1530/JOE-13-0420DOI Listing
April 2014

Ceramide signaling in mammalian epidermis.

Authors:
Yoshikazu Uchida

Biochim Biophys Acta 2014 Mar 19;1841(3):453-62. Epub 2013 Sep 19.

Department of Dermatology, University of California, San Francisco, CA, USA; School of Medicine, University of California, San Francisco, CA, USA; Dermatology Service and Research Unit, Veterans Affairs Medical Center, San Francisco, CA, USA; Northern California Institute for Research and Education, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2013.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943494PMC
March 2014

Formation and functions of the corneocyte lipid envelope (CLE).

Biochim Biophys Acta 2014 Mar 27;1841(3):314-8. Epub 2013 Sep 27.

Dermatology Services, Veterans Affairs Medical Center, San Francisco, CA, USA; Department of Dermatology, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.bbalip.2013.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943821PMC
March 2014

Increased OPG/RANKL ratio in the conditioned medium of soybean-treated osteoblasts suppresses RANKL-induced osteoclast differentiation.

Int J Mol Med 2014 Jan 18;33(1):178-84. Epub 2013 Nov 18.

Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Gyeonggi 446-701, Republic of Korea.

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http://dx.doi.org/10.3892/ijmm.2013.1557DOI Listing
January 2014

Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis.

J Dermatol Sci 2013 Dec 23;72(3):296-303. Epub 2013 Aug 23.

Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA; Veteran Affairs Medical Center, San Francisco, CA, USA; Northern California Institute for Research and Education, San Francisco, CA, USA; Integrative Toxicology and Metabolism, Pôle de Toxicologie Alimentaire, Laboratoire de Pharmacologie et Toxicologie, Institut National de la Recherche Agronomique INRA UR66, Toulouse, France.

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http://dx.doi.org/10.1016/j.jdermsci.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866955PMC
December 2013

Activation of TLR3 in keratinocytes increases expression of genes involved in formation of the epidermis, lipid accumulation, and epidermal organelles.

J Invest Dermatol 2013 Aug 28;133(8):2031-40. Epub 2013 Feb 28.

Division of Dermatology, University of California, San Diego, San Diego, California 92093-0869, USA.

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http://dx.doi.org/10.1038/jid.2013.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686920PMC
August 2013

Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production.

J Invest Dermatol 2013 Aug 14;133(8):1942-9. Epub 2013 Mar 14.

Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/jid.2013.133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753186PMC
August 2013

A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity.

Mol Cell Biol 2013 Feb 10;33(4):752-62. Epub 2012 Dec 10.

Department of Dermatology, School of Medicine, University of California, San Francisco, Veterans Affairs Medical Center, San Francisco, California, USA.

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http://dx.doi.org/10.1128/MCB.01103-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3571353PMC
February 2013

Ceramides stimulate caspase-14 expression in human keratinocytes.

Exp Dermatol 2013 Feb;22(2):113-8

Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA.

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http://dx.doi.org/10.1111/exd.12079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099380PMC
February 2013

Cellular changes that accompany shedding of human corneocytes.

J Invest Dermatol 2012 Oct 28;132(10):2430-2439. Epub 2012 Jun 28.

Department of Veterans Affairs Medical Center and Department of Dermatology, Dermatology Service, University of California, San Francisco, San Francisco, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2012.173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447115PMC
October 2012

SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease.

J Invest Dermatol 2012 Apr 26;132(4):1188-95. Epub 2012 Jan 26.

Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121-1545, USA.

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http://dx.doi.org/10.1038/jid.2011.447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3305850PMC
April 2012

Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway.

J Biol Chem 2011 Sep 8;286(39):34121-30. Epub 2011 Aug 8.

Department of Dermatology, School of Medicine, University of California, San Francisco, California 94143, USA.

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http://dx.doi.org/10.1074/jbc.M111.250431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190812PMC
September 2011

Physicochemical analysis of liposome membranes consisting of model lipids in the stratum corneum.

J Oleo Sci 2011 ;60(4):197-202

Department of Pure and Applied Chemistry, Tokyo University of Science, 2641 Yamazaki, Chiba, Japan.

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http://dx.doi.org/10.5650/jos.60.197DOI Listing
July 2011

The role of fatty acid elongation in epidermal structure and function.

Authors:
Yoshikazu Uchida

Dermatoendocrinol 2011 Apr 1;3(2):65-9. Epub 2011 Apr 1.

Department of Dermatology; School of Medicine; University of California San Francisco; Dermatology Service and Research Unit; Veterans Affairs Medical Center; and Northern California Institute for Research and Education; San Francisco, CA USA.

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http://dx.doi.org/10.4161/derm.3.2.14662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117004PMC
April 2011

A murine model of isolated cardiac steatosis leads to cardiomyopathy.

Hypertension 2011 Feb 10;57(2):216-22. Epub 2011 Jan 10.

Department of Medicine and Diabetes Center, University of California at San Francisco, San Francisco, CA 94143-0540, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.160655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322545PMC
February 2011

Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB.

J Invest Dermatol 2010 Oct 3;130(10):2472-80. Epub 2010 Jun 3.

Department of Dermatology, School of Medicine, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/jid.2010.153DOI Listing
October 2010

Epidermal triglyceride levels are correlated with severity of ichthyosis in Dorfman-Chanarin syndrome.

J Dermatol Sci 2010 Feb 21;57(2):102-7. Epub 2009 Dec 21.

Department of Dermatology, Kochi Medical School, Kochi University, Oko-cho, Nankoku, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S092318110900335
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http://dx.doi.org/10.1016/j.jdermsci.2009.10.016DOI Listing
February 2010

Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

J Invest Dermatol 2009 Jul 29;129(7):1824-35. Epub 2009 Jan 29.

Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1038/jid.2008.444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695850PMC
July 2009

Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes.

J Biol Chem 2009 Jul 8;284(28):18942-52. Epub 2009 May 8.

Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1074/jbc.M109.006973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707228PMC
July 2009

Omega-O-acylceramide, a lipid essential for mammalian survival.

J Dermatol Sci 2008 Aug 10;51(2):77-87. Epub 2008 Mar 10.

Department of Dermatology, School of Medicine, University of California San Francisco, Veterans Affairs on Medical Center, San Francisco, CA 94121, United States.

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http://dx.doi.org/10.1016/j.jdermsci.2008.01.002DOI Listing
August 2008

On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides.

J Dermatol Sci 2008 Jul 8;51(1):37-43. Epub 2008 Apr 8.

Department of Dermatology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.jdermsci.2008.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410086PMC
July 2008

Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation.

J Biol Chem 2008 Jun 14;283(24):16682-92. Epub 2008 Apr 14.

Department of Dermatology, School of Medicine, University of California, Northern California Institute for Research and Education, and Veterans Affairs Medical Center, San Francisco, California 94121, USA.

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http://dx.doi.org/10.1074/jbc.M800799200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2423244PMC
June 2008

Primary peripheral adenoid cystic carcinoma of the lung and literature comparison of features.

Intern Med 2007 1;46(21):1799-803. Epub 2007 Nov 1.

Department of Internal Medicine, Iwamizawa Rosai Hospital, Japan Labour Health and Welfare Organization, Iwamizawa, Japan.

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http://dx.doi.org/10.2169/internalmedicine.46.0331DOI Listing
December 2007

Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation.

J Biol Chem 2007 May 12;282(18):13211-9. Epub 2007 Mar 12.

Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1074/jbc.M611562200DOI Listing
May 2007

Epidermal sphingolipids: metabolism, function, and roles in skin disorders.

FEBS Lett 2006 Oct 1;580(23):5456-66. Epub 2006 Sep 1.

Department of Dermatology, School of Medicine, University of California San Francisco, 94121, USA.

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http://doi.wiley.com/10.1016/j.febslet.2006.08.039
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http://dx.doi.org/10.1016/j.febslet.2006.08.039DOI Listing
October 2006

Serine protease signaling of epidermal permeability barrier homeostasis.

J Invest Dermatol 2006 Sep 11;126(9):2074-86. Epub 2006 May 11.

Department of Dermatology and Medical Services (Metabolism), VA Medical Center, San Francisco, California, USA.

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http://dx.doi.org/10.1038/sj.jid.5700351DOI Listing
September 2006

Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.

J Lipid Res 2006 May 13;47(5):1063-70. Epub 2006 Feb 13.

Department of Toxicology, Dermato-Cosmetology, and Pharmacognosy, Vrije Universiteit Brussels, Belgium.

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http://dx.doi.org/10.1194/jlr.M600001-JLR200DOI Listing
May 2006

Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity.

Arch Dermatol Res 2005 Sep 29;297(3):127-33. Epub 2005 Sep 29.

Department of Environmental Toxicology, University of California, One Shields Avenue, Davis, CA 95616-8588, USA.

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http://dx.doi.org/10.1007/s00403-005-0591-7DOI Listing
September 2005

A homolog of Drosophila grainy head is essential for epidermal integrity in mice.

Science 2005 Apr;308(5720):411-3

Rotary Bone Marrow Research Laboratories, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria, Australia 3050.

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http://dx.doi.org/10.1126/science.1107511DOI Listing
April 2005

Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features.

J Invest Dermatol 2004 Sep;123(3):464-9

Basic Research Laboratory, Kanebo Ltd., 5-chome Kotobuki-cho, Odawara-shi, Kanagawa-ken 250-0002, Japan.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23227.xDOI Listing
September 2004

Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells.

Cancer Res 2004 Sep;64(17):6271-9

Department of Hematology and Oncology, Clinical Sciences for Pathological Organs, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-1476DOI Listing
September 2004

De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes.

J Invest Dermatol 2003 Apr;120(4):662-9

Dermatology Service and Research Unit, Department of Veterans Affairs Medical Center, School of Medicine, University of California, San Francisco, USA.

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http://dx.doi.org/10.1046/j.1523-1747.2003.12098.xDOI Listing
April 2003

Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress.

J Lipid Res 2002 Aug;43(8):1293-302

Dermatology Service, Department of Veterans Affairs Medical Center, San Francisco, CA, USA.

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August 2002

Human epidermal glucosylceramides are major precursors of stratum corneum ceramides.

J Invest Dermatol 2002 Aug;119(2):416-23

Sphingolipid Expression Laboratory, Supra-Biomolecular System Research, RIKEN Frontier Research System, Wako, Japan.

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http://dx.doi.org/10.1046/j.1523-1747.2002.01836.xDOI Listing
August 2002

Basis for the permeability barrier abnormality in lamellar ichthyosis.

Exp Dermatol 2002 Jun;11(3):248-56

Dermatology Service & Research Unit, Department of Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA.

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http://dx.doi.org/10.1034/j.1600-0625.2001.110308.xDOI Listing
June 2002