Publications by authors named "Ying Zhao"

1,616 Publications

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Author Correction: Network pharmacology and molecular docking study on the active ingredients of qidengmingmu capsule for the treatment of diabetic retinopathy.

Sci Rep 2021 Aug 2;11(1):16041. Epub 2021 Aug 2.

Eye School, Chengdu University of Traditional Chinese Medicine, 37 Shi Er Qiao Road, Jinniu District, Chengdu, 610036, China.

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http://dx.doi.org/10.1038/s41598-021-95437-1DOI Listing
August 2021

Scoring System to Evaluate the Performance of ICU Ventilators in the Pandemic of COVID-19: A Lung Model Study.

Front Med (Lausanne) 2021 14;8:663608. Epub 2021 Jul 14.

Critical Care, College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.

Ventilators in the intensive care units (ICU) are life-support devices that help physicians to gain additional time to cure the patients. The aim of the study was to establish a scoring system to evaluate the ventilator performance in the context of COVID-19. The scoring system was established by weighting the ventilator performance on five different aspects: the stability of pressurization, response to leaks alteration, performance of reaction, volume delivery, and accuracy in oxygen delivery. The weighting factors were determined with analytic hierarchy process (AHP). Survey was sent out to 66 clinical and mechanical experts. The scoring system was built based on 54 valid replies. A total of 12 commercially available ICU ventilators providing non-invasive ventilation were evaluated using the novel scoring system. A total of eight ICU ventilators with non-invasive ventilation mode and four dedicated non-invasive ventilators were tested according to the scoring system. Four COVID-19 phenotypes were simulated using the ASL5000 lung simulator, namely (1) increased airway resistance (IR) (10 cm HO/L/s), (2) low compliance (LC) (compliance of 20 ml/cmHO), (3) low compliance plus increased respiratory effort (LCIE) (respiratory rate of 40 and inspiratory effort of 10 cmHO), (4) high compliance (HC) (compliance of 50 ml/cmHO). All of the ventilators were set to three combinations of pressure support and positive end-expiratory pressure levels. The data were collected at baseline and at three customized leak levels. Significant inaccuracies and variations in performance between different non-invasive ventilators were observed, especially in the aspect of leaks alteration, oxygen and volume delivery. Some ventilators have stable performance in different simulated phenotypes whereas the others have over 10% scoring differences. It is feasible to use the proposed scoring system to evaluate the ventilator performance. In the COVID-19 pandemic, clinicians should be aware of possible strengths and weaknesses of ventilators.
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http://dx.doi.org/10.3389/fmed.2021.663608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316635PMC
July 2021

Time Perspective and Bedtime Procrastination: The Role of the Chronotype-Time Perspective Relationship.

Nat Sci Sleep 2021 24;13:1307-1318. Epub 2021 Jul 24.

Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian, Liaoning Province, People's Republic of China.

Introduction: Bedtime procrastination (BP) has a close relationship with one's chronotype, from a biological perspective on time. However, it remains unknown whether there is an association between BP and psychological time. Therefore, the aim of the present study was to evaluate the relationship between time perspective (TP) and BP and the effect of TP on the relationship between BP and chronotype by examining a sample of college students pre- and post-COVID-19 outbreak.

Methods: A total of 628 Chinese students (267 in pre-outbreak and 361 in post-outbreak) validly completed the Chinese version of the Bedtime Procrastination Scale, the Zimbardo Time Perspective Inventory (ZTPI), and the Morningness-Eveningness Questionnaire.

Results: Students with more BP behaviors exhibited greater deviation from a balanced TP, especially after the COVID-19 outbreak. Hierarchical regression analyses revealed that the past-negative and future orientations, as operationalized by the ZTPI, contributed independently to BP behaviors. The structural equation modeling analyses further demonstrated that morningness was significantly related to a more future-oriented TP, which in turn decreased BP in pre- and post-COVID-19 outbreak samples, while morningness was associated with a less past-negative-oriented TP, which in turn decreased BP only in the post-COVID-19 outbreak sample.

Conclusion: This study indicated that TP in students with BP predominantly focused on future orientation and that TP can mediate the relationship between chronotype and BP behaviors. However, the COVID-19 pandemic may disrupt the time flow and change the role of chronotype-TP in BP. These findings explain how individual differences in TP are associated with BP, which may be helpful in designing effective interventions to avoid BP, from the viewpoint of time perspective therapy.
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http://dx.doi.org/10.2147/NSS.S313157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318727PMC
July 2021

Targeting the TLR4/NF-κB pathway in β-amyloid-stimulated microglial cells: A possible mechanism that oxysophoridine exerts anti-oxidative and anti-inflammatory effects in an in vitro model of Alzheimer's disease.

Brain Res Bull 2021 Jul 27;175:150-157. Epub 2021 Jul 27.

Department of Neurology, Lianshui People's Hospital Affiliated to Kangda College of Nanjing Medical University, Lianshui, Jiangsu Province, China. Electronic address:

β-amyloid (Aβ) accumulation is a major neuropathological characteristic of Alzheimer's disease (AD) and serves as an inflammatory stimulus for microglial cells. Oxysophoridine has multiple pharmacological effects, including anti-inflammatory and anti-oxidative activities. In view of this, the current study aimed to investigate the effects of oxysophoridine on Aβ-induced activation of microglial BV-2 cells. Cell Counting Kit-8 assay showed that oxysophoridine concentration-dependently attenuated Aβ-induced viability reduction of BV-2 cells. Aβ stimulation reduced the activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) and elevated malondialdehyde (MDA) content in BV-2 cells, but these effects were attenuated by oxysophoridine. Oxysophoridine abolished Aβ-induced increase of mRNA expression, secretion, and protein expression of tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β) in BV-2 cells. Additionally, western blot suggested that oxysophoridine inhibited Aβ-induced activation of the toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) pathways in BV-2 cells. Inhibition of the TLR4/NF-κB pathway by TAK-242 enhanced the effects of oxysophoridine on Aβ-induced viability reduction, oxidative stress, and inflammation in BV-2 cells. Taken together, oxysophoridine suppressed Aβ-induced oxidative stress and inflammation in BV-2 cells by inhibition of the TLR4/NF-κB pathway.
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http://dx.doi.org/10.1016/j.brainresbull.2021.07.019DOI Listing
July 2021

Clinical Outcomes and Prognostic Factors of Salvage Treatment for Local Lymph Node Recurrence After Radical Resection of Oesophageal Carcinoma.

Cancer Manag Res 2021 23;13:5845-5853. Epub 2021 Jul 23.

Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Su Zhou, 215004, Jiang Su Province, People's Republic of China.

Background: There are no standard therapeutic strategies for local lymph node (LN) recurrence after radical resection of oesophageal squamous cell carcinoma (ESCC), and prognostic risk factors remain controversial. We assessed clinical outcomes and prognostic factors of chemoradiotherapy (CRT) or radiotherapy (RT) for LN recurrence of ESCC after curative resection.

Methods: A total of 117 ESCC patients with LN recurrence after radical resection receiving salvage treatment at our hospital were retrospectively reviewed from 2014 to 2017. Overall survival (OS) was estimated using the Kaplan-Meier method; clinical characteristics were assessed using the Log rank test in the univariate analysis. Multivariate prognostic analysis was performed using the Cox proportional hazard model.

Results: With a median follow-up of 19 months, the 1-, 2- and 3-year OS rates were 75.2%, 40.2% and 27.4%, respectively. The median survival time (MST) was 19.0 months. On univariate analysis for OS, pathological TNM stage, number of LN metastasis, LN maximum (Max) diameter, salvage treatment mode and tumor response were significantly associated with OS (P = 0.0074, P = 0.015, P = 0.0011, P = 0.028, P < 0.000, respectively). On multivariate analysis, tumor response [Response vs No-response hazard ratio (HR), 2.43; 95% confidence interval (CI), 1.53-3.90, P < 0.000] and LN Max diameter (≤28 mm vs >28 mm HR, 2.07; 95% CI, 1.33-3.32, P = 0.012) were independent prognostic factors.

Conclusion: Salvage CRT or RT was safe and effective for treating LN recurrence after radical resection in ESCC. Patients with the small LN Max diameter (≤28 mm) and obtained response after salvage therapy appeared to achieve long-term OS.
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http://dx.doi.org/10.2147/CMAR.S315127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8315777PMC
July 2021

Vascular Adhesion Protein-1 (VAP-1)/Semicarbazide-Sensitive Amine Oxidase (SSAO): A Potential Therapeutic Target for Atherosclerotic Cardiovascular Diseases.

Front Pharmacol 2021 8;12:679707. Epub 2021 Jul 8.

Department of Pathophysiology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.

Vascular adhesion protein-1 (VAP-1) is a semicarbazide-sensitive amine oxidase (SSAO), whose enzymatic activity regulates the adhesion/exudation of leukocytes in/from blood vessels. Due to its abundant expressions in vascular systems and prominent roles in inflammations, increasing attentions have been paid to the roles of VAP-1/SSAO in atherosclerosis, a chronic vascular inflammation that eventually drives clinical cardiovascular events. Clinical studies have demonstrated a potential value of soluble VAP-1 (sVAP-1) for the diagnosis and prognosis of cardiovascular diseases. Recent findings revealed that VAP-1 is expressed in atherosclerotic plaques and treatment with VAP-1 inhibitors alleviates the progression of atherosclerosis. This review will focus on the roles of VAP-1/SSAO in the progression of atherosclerotic lesions and therapeutic potentials of VAP-1 inhibitors for cardiovascular diseases.
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http://dx.doi.org/10.3389/fphar.2021.679707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8312380PMC
July 2021

Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis.

Cell Rep 2021 Jul;36(4):109420

Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71103, USA. Electronic address:

Dysregulated glycine metabolism is emerging as a common denominator in cardiometabolic diseases, but its contribution to atherosclerosis remains unclear. In this study, we demonstrate impaired glycine-oxalate metabolism through alanine-glyoxylate aminotransferase (AGXT) in atherosclerosis. As found in patients with atherosclerosis, the glycine/oxalate ratio is decreased in atherosclerotic mice concomitant with suppression of AGXT. Agxt deletion in apolipoprotein E-deficient (Apoe) mice decreases the glycine/oxalate ratio and increases atherosclerosis with induction of hepatic pro-atherogenic pathways, predominantly cytokine/chemokine signaling and dysregulated redox homeostasis. Consistently, circulating and aortic C-C motif chemokine ligand 5 (CCL5) and superoxide in lesional macrophages are increased. Similar findings are observed following dietary oxalate overload in Apoe mice. In macrophages, oxalate induces mitochondrial dysfunction and superoxide accumulation, leading to increased CCL5. Conversely, AGXT overexpression in Apoe mice increases the glycine/oxalate ratio and decreases aortic superoxide, CCL5, and atherosclerosis. Our findings uncover dysregulated oxalate metabolism via suppressed AGXT as a driver and therapeutic target in atherosclerosis.
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http://dx.doi.org/10.1016/j.celrep.2021.109420DOI Listing
July 2021

Inhibition of cell proliferation and promotion of acinus-like structure formation from goat mammary epithelial cells via Wnt/β-catenin signaling.

In Vitro Cell Dev Biol Anim 2021 Jul 26. Epub 2021 Jul 26.

Key Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Mammary epithelial cells have been suggested to be central to control the expansion and remodeling of mammary gland. Wnt/β-catenin signaling modulates cell fate in animals throughout their life span, and represents indispensable roles in tissue homeostasis, cell renewal, and regeneration in organs. Here, we utilized the small molecule 6-bromoindirubin-3'-oxime (BIO), an activator of Wnt/β-catenin signaling, and investigated whether Wnt/β-catenin signaling regulated the proliferation and acinus-like structure formation of goat mammary epithelial cells (GMECs). We showed that isolated GMECs displayed the typical epithelial cobblestone morphology and expressed specific markers of mammary epithelial cells. BIO inhibited the proliferation of GMECs and decreased the expression of proliferation marker c-myc and cell cycle protein cyclin D1. However, the ability of GMECs to form spheroids was accelerated, and the level of E-cadherin mRNA was upregulated with BIO treatment. E-cadherin showed a bright cytomembrane with DMSO treatment, yet E-cadherin was present in cytomembrane and cytoplasm in GMECs with BIO treatment. Meanwhile, BIO increased the protein level of β-catenin and enhanced the translocation of β-catenin into the nucleus in GMECs. Furthermore, the mRNA level of Axin2 was also upregulated. This study suggested that Wnt/β-catenin signaling may play an important role in the proliferation and the acinus-like formation of GMECs.
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http://dx.doi.org/10.1007/s11626-021-00600-7DOI Listing
July 2021

[Determination of vitamin A, vitamin E isomers and cholesterol in foods by reversed-phase high-performance liquid chromatography].

Wei Sheng Yan Jiu 2021 Jul;50(4):615-619

Center for Disease Control and Prevention of Shaanxi Province, Xi'an 710054, China.

Objective: To establish a method for simultaneous analysis of vitamin A, three vitamin E isomers and cholesterol in meat products by reversed-phase high-performance liquid chromatography. This method is used to determine the contents of the corresponding nutrients in several meat products.

Methods: The sample was pretreated with saponification and liquid-liquid extraction, then separated on Waters Symmetry C_(18) column(4.6 mm×250 mm, 5 μm). The mobile phase consisted of methanol(98%) and water(2%). The analytes were detected by photo-diode array(PDA)detector. 325 nm, 294 nm, and 210 nm were selected as the characteristic absorption wavelengths of vitamin A, vitamin E, and cholesterol, respectively by scanning in the range of 190-350 nm in 3 D mode. Benzo[e]pyrene was internal standard for vitamin A and E. Cholesterol was quantified by external standard curve method.

Results: The concentration of vitamin A, three vitamin E isomers and cholesterol showed good linearity in the range of 0.18-9.00 μg/mL、0.76-5.2 μg/mL and 0.11-5.50 mg/mL, respectively, with the correlation coefficients greater than 0.995.The limits of detections(LODs) were 5、20 and 330 μg/100 g and the limits of quantification(LOQs) for vitamin A, three vitamin E isomers and cholesterol were 15、60 and 990 μg/100 g, respectively. The recoveries at three levels in the matrix were 86.3%-105.6%, and the relative standard deviations(RSDs) were all less than 7.0%(n=6).

Conclusion: The method is sensitive, accurate and suitable for analysis of vitamin A, three vitamin E isomers and cholesterol in meat products.
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http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.04.013DOI Listing
July 2021

Effects of probiotic and synbiotic supplementation on insulin resistance in women with polycystic ovary syndrome: a meta-analysis.

J Int Med Res 2021 Jul;49(7):3000605211031758

Department of TCM Gynaecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.

Objective: This meta-analysis evaluated the effect of probiotics and synbiotics on insulin resistance in patients with polycystic ovary syndrome (PCOS).

Methods: A systematic search was performed to identify all relevant publications listed on the electronic databases (PubMed®, Web of Science, Embase® and China National Knowledge Infrastructure) between inception and 30 October 2020. All statistical analyses were performed on randomized controlled trials (RCTs) using RevMan version 5.3 software provided by the Cochrane Collaboration.

Results: A total of 486 patients from seven RCTs were included in the meta-analysis. Probiotic and synbiotic supplementation appeared to improve levels of homeostatic model assessment of insulin resistance (mean difference = -0.37; 95% confidence interval -0.69, -0.05) and serum insulin (standardized mean difference = -0.66; 95% confidence interval -1.19, -0.12). The results failed to show any influence of probiotic and synbiotic supplementation on body mass index, waist circumference, hip circumference and fasting blood sugar.

Conclusions: Probiotics and synbiotics appear to have a partially beneficial effect on indices of insulin resistance in patients with PCOS.
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http://dx.doi.org/10.1177/03000605211031758DOI Listing
July 2021

Atomic perspective revealing for combustion evolution of nitromethane/nano-aluminum hydride composite.

J Mol Graph Model 2021 Jul 16;108:107987. Epub 2021 Jul 16.

Key Laboratory of Soft Chemistry and Functional Materials of MOE, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China. Electronic address:

Adding aluminum hydride (AlH) into energetic materials (EMs) can improve their combustion and energy performance effectively. However, the potential mechanism of AlH on EMs is still unclear. Based on the ReaxFF-lg method, the thermal decomposition of nitromethane/nano-aluminum hydride (NM/nano-AlH) composites were studied. The addition of AlH reduces the energy barrier and increases the energy release during the decomposition of NM, accelerates the decomposition of NM. The main way of AlH oxidation involves the capture of O atoms from NM. The results show that AlH content and passivated layer affect the oxidation and hydrogen release of AlH. The explosion of small particle size AlH leads to rapid oxidation and hydrogen release. The oxidation of large particle size AlH is dominated by the inward and outward diffusion of O and Al atoms. The products of NM/nano-AlH composites are HO, CO, N gases, and Al clusters. This work is expected to guide the application of AlH in EMs.
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http://dx.doi.org/10.1016/j.jmgm.2021.107987DOI Listing
July 2021

Association between valproate treatment for acute phase schizophrenia and risk of new onset hypothyroidism.

Schizophr Res 2021 Jul 20;235:12-16. Epub 2021 Jul 20.

School of Public Health, Xinxiang Medical University, Xinxiang 453003, China; Henan International Joint Laboratory of non-Invasive Neuro-modulation, Xinxiang Medical University, Xinxiang 453003, China. Electronic address:

Aim: To assess the association between acute phase treatment by valproate as an adjunctive drug and risk of new onset hypothyroidism in a large cohort of patients affected by schizophrenia.

Methods: We conducted a retrospective cohort study in a psychiatric hospital in China between January 2016 and December 2018. We obtained approval from the Ethics Committee of the study hospital prior to the commencement of the study. Patients who were diagnosed with schizophrenia and admitted to the study hospital during the study period with thyroid function tests at admission and during hospitalization were included. Patients with abnormal thyroid function at admission were excluded. Hypothyroidism, defined as TSH>4.2 mU/L or on L-thyroxine treatment, was the primary outcome. The primary exposure was adjunctive valproate plus atypical antipsychotics (AAPD), the secondary exposure was lithium plus AAPD and the comparison group was AAPD only. Adjusted relative risk (RR) and 95% confidence interval (CI) were estimated by log-binomial model to assess the independent association between valproate treatment and risk of hypothyroidism.

Results: A total of 1622 eligible patients were included the final analysis. Rate of new onset hypothyroidism was 10.7% and 20.9% in AAPD only and valproate plus AAPD groups, respectively. Adjusted RR (95% CI) for valproate plus AAPD was 1.85 (1.44-2.38), with AAPD only group as reference. Similarly, adjusted RR (95% CI) for lithium plus AAPD was 1.93 (1.32-2.69).

Conclusion: Similar with lithium, valproate as adjunctive drug is associated with increased risk of new onset hypothyroidism during acute phase treatment for schizophrenia.
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http://dx.doi.org/10.1016/j.schres.2021.07.011DOI Listing
July 2021

Research capacity of global health institutions in China: a gap analysis focusing on their collaboration with other low-income and middle-income countries.

BMJ Glob Health 2021 07;6(7)

Department of Global Health, School of Public Health, Peking University, Beijing, China.

Introduction: This paper presented qualitative and quantitative data collected on the research capacity of global health institutions in China and aimed to provide a landscaping review of the development of global health as a new discipline in the largest emerging economy of the world.

Methods: Mixed methods were used and they included a bibliometric analysis, a standardised survey and indepth interviews with top officials of 11 selected global health research and educational institutions in mainland China.

Results: The bibliometric analysis revealed that each institution had its own focus areas, some with a balanced focus among chronic illness, infectious disease and health systems, while others only focused on one of these areas. Interviews of key staff from each institution showed common themes: recognition that the current research capacity in global health is relatively weak, optimism towards the future, as well as an emphasis on mutual beneficial networking with other countries. Specific obstacles raised and the solutions applied by each institution were listed and discussed.

Conclusion: Global health institutions in China are going through a transition from learning and following established protocols to taking a more leading role in setting up China's own footprint in this area. Gaps still remain, both in comparison with international institutions, as well as between the leading Chinese institutions and those that have just started. More investment needs to be made, from both public and private domains, to improve the overall capacity as well as the mutual learning and communication within the academic community in China.
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http://dx.doi.org/10.1136/bmjgh-2021-005607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8286742PMC
July 2021

Relationship Between Vocabulary Knowledge and Reading Comprehension in Deaf and Hard of Hearing Students.

J Deaf Stud Deaf Educ 2021 Jul 16. Epub 2021 Jul 16.

Faculty of Psychology, Research Center of Children's Reading and Learning, Beijing Key Laboratory of Applied Experimental Psychology, Beijing Normal University, Beijing, China.

Deaf and hard of hearing (DHH) students face great challenges in becoming proficient readers. Vocabulary knowledge is consistently considered to be an important factor affecting DHH students' reading ability. However, the mechanism that underlies the relationship between vocabulary knowledge and reading comprehension in DHH students remains unclear. Thus, the aim of this study was to determine the roles of word segmentation and reading fluency in the contribution of vocabulary knowledge to Chinese DHH students' reading comprehension. A battery of tasks were administered to 116 Chinese DHH students from Grades 4 to 6 (mean age = 14.66 years). The results showed that vocabulary knowledge contributed to reading comprehension significantly in Chinese DHH students, and word segmentation and reading fluency played mediating roles in this relationship. Besides, the chain mediation effect of word segmentation and reading fluency was also significant. Revealing these mechanisms, which underlie the relationship between vocabulary knowledge and reading comprehension, is helpful to tailor remediation for DHH students.
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http://dx.doi.org/10.1093/deafed/enab023DOI Listing
July 2021

A case-control study on the association of intestinal flora with ulcerative colitis.

AMB Express 2021 Jul 15;11(1):106. Epub 2021 Jul 15.

Department of Gastroenterology, The First Affiliated Hospital, Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin, 150001, Heilongjiang, China.

The association between intestinal flora and ulcerative colitis (UC) was studied in order to provide a basis and method for clinical treatment. Fresh fecal samples were collected from 30 active UC patients and 10 healthy controls. The intestinal flora DNA from each sample was extracted and 16S rRNA gene sequencing was carried out using HiSeq platform to identify the intestinal flora in fecal samples. The richness and diversity of intestinal flora in UC patients were significantly lower than those in healthy control group (P < 0.05). Significant differences were observed between the intestinal flora-species of UC patients and healthy controls. Synergistetes (P < 0.01) and Firmicutes (P < 0.05), along with probiotics Veillonella (P < 0.01), Ruminococcus and Coprococcus (P < 0.05) in the UC patients were lower than that in the healthy controls significantly. Furthermore, compared with the control group, Tenericutes (P < 0.01) and intestinal pathogenic bacteria, including Bacteroides (P < 0.01), Escherichia and Sutterella (P < 0.05) were significantly increased. The incidence of UC is significantly associated with the changes in intestinal flora. Changes in intestinal flora may lead to a decrease in the diversity of intestinal flora or to the enrichment of a particular intestinal flora.
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http://dx.doi.org/10.1186/s13568-021-01267-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282830PMC
July 2021

The Differential Diagnosis of Double Aortic Arch and Right Aortic Arch with Mirror-Image Branches in the Fetus: A Potential Novel Method.

Pediatr Cardiol 2021 Aug 13;42(6):1405-1409. Epub 2021 Jul 13.

Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University; Beijing Key Laboratory of Maternal-Fetus Medicine in Fetal Heart Disease (BZ0308), No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, People's Republic of China.

The objective of this study was to explore a new method for the differential diagnosis between fetal double aortic arch (DAA) and right aortic arch with mirror-image branches (RAA-MB). Clinical data and prenatal echocardiographic features of the DAA (n = 22) and RAA-MB (n = 65) confirmed by postnatal or autopsy findings were analyzed retrospectively. The angles between the two aortic arches in the DAA group and between the right aortic arch and the mirror branch were measured. The differences between the two groups and differential diagnosis value of the angles were compared and analyzed based on the receiver operating characteristic curve. The proportion of left-sided ductal arteriosus (100%) was higher in the DAA group than that (32.3%) in the RAA-MB group, (P < 0.05). The proportion of conotruncal anomalies is higher in the RAA-MB group (64.6%) than in the DAA group (18.2%) (P < 0.05). There was a significant difference in the angles between the groups (DAA: 50.3° ± 8.3° vs. RAA-MB: 82.9° ± 13.8°) (P < 0.01). When the cutoff value was 62.8°, the sensitivity and specificity of the differential diagnosis were 95.5% and 96.9%, respectively. Distinguishing the angle measurement between DAA and RAA-MB is helpful in prenatal prognosis. We recommend a cutoff value of 62.8°.
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http://dx.doi.org/10.1007/s00246-021-02625-xDOI Listing
August 2021

Manipulated Crystallization and Passivated Defects for Efficient Perovskite Solar Cells via Addition of Ammonium Iodide.

ACS Appl Mater Interfaces 2021 Jul 13;13(29):34053-34063. Epub 2021 Jul 13.

Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin, Engineering Research Center of Thin Film Optoelectronics Technology, Ministry of Education, Institute of Photoelectronic Thin Film Devices and Technology of Nankai University, Solar Energy Research Center of Nankai University, #38 Tongyan Road, Jinnan District, Tianjin 300350, China.

Organic-inorganic metal halide perovskite materials have been widely studied as the light absorber for efficient photovoltaics. However, perovskite layers with defective nature are typically prepared with an uncontrollable crystallization process, intrinsically limiting further advance in device performance, and thus require delicate manipulation of crystallization processes and defect density. Here, we demonstrate an ammonium-assisted crystallization of perovskite absorbers during a two-step deposition to fabricate efficient solar cells. Addition of ammonium iodide (NHI) is devised to manipulate the nucleation and crystal growth of perovskite, wherein the formation and transition of intermediate [NH]•[PbI] enables high-quality perovskite layers with an enlarged grain and reduced defect density. As a result, the perovskite solar cells (PSCs) achieve an average efficiency of 21.36% with a champion efficiency of 22.15% and improved environmental stability over 30 days in ambient conditions with varied relative humidity. These results with addition of NHI provide an available and ingenious way to construct high-quality perovskite layers for efficient solar cells and will advance the commercial application of perovskite-based photovoltaics.
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http://dx.doi.org/10.1021/acsami.1c05903DOI Listing
July 2021

Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes.

Cell Mol Immunol 2021 Aug 12;18(8):1871-1882. Epub 2021 Jul 12.

Key Laboratory for Experimental Teratology, Ministry of Education, School of Basic Medical Sciences, Cheeloo Medical College, Shandong University, Jinan, Shandong, China.

HBV is considered as a "stealth" virus that does not invoke interferon (IFN) responses; however, the mechanisms by which HBV bypasses innate immune recognition are poorly understood. In this study, we identified adenosine deaminases acting on RNA 1 (ADAR1), which is a key factor in HBV evasion from IFN responses in hepatocytes. Mechanically, ADAR1 interacted with HBV RNAs and deaminated adenosine (A) to generate inosine (I), which disrupted host immune recognition and thus promoted HBV replication. Loss of ADAR1 or its deficient deaminase activity promoted IFN responses and inhibited HBV replication in hepatocytes, and blocking the IFN signaling pathways released the inhibition of HBV replication caused by ADAR1 deficiency. Notably, the HBV X protein (HBx) transcriptionally promoted ADAR1 expression to increase the threshold required to trigger intrinsic immune activation, which in turn enhanced HBV escape from immune recognition, leading to persistent infection. Supplementation with 8-azaadenosine, an ADAR1 inhibitor, efficiently enhanced liver immune activation to promote HBV clearance in vivo and in vitro. Taken together, our results delineate a molecular mechanism by which HBx promotes ADAR1-derived HBV immune escape and suggest a targeted therapeutic intervention for HBV infection.
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http://dx.doi.org/10.1038/s41423-021-00729-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322072PMC
August 2021

Hepatic fat quantification of magnetic resonance imaging whole-liver segmentation for assessing the severity of nonalcoholic fatty liver disease: comparison with a region of interest sampling method.

Quant Imaging Med Surg 2021 Jul;11(7):2933-2942

Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.

Background: Accurate and early assessment of the hepatic fat content is crucial for patients with nonalcoholic fatty liver disease (NAFLD). For years, magnetic resonance imaging (MRI) has been considered the optimal noninvasive method for the assessment of fat accumulation. To avoid time-consuming manual placement of multiple regions of interest (ROI), the use of whole-liver segmentation has been proposed to measure liver fat, mainly for heterogeneous fat deposition. However, it remains uncertain whether the hepatic mean fat fraction (FF) obtained by whole-liver segmentation with the inclusion of intrahepatic vasculature is consistent with the traditional ROI sampling method. In this study, we assessed the accuracy of hepatic mean FF obtained by whole-liver segmentation in patients of NAFLD with different severities using the ROI sampling method as a reference standard.

Methods: Hepatic FFs were measured by whole-liver segmentation and the ROI sampling method (reference standard) using MRI scanning with the iterative decomposition of water and fat with echo an asymmetry at least-square estimation-iron quantification (IDEAL-IQ) sequence. SPSS version 25.0 software was used to analyze the correlation and consistency of data between the two methods.

Results: There was a strong correlation in hepatic FF between whole-liver segmentation and the ROI sampling method in healthy, mild, and moderate steatosis patients (r = 0.943, 0.990, and 0.961, respectively). Bland-Altman analysis showed a small bias of +0.50±0.27 and +0.05±0.30, which indicated a small overestimation when using whole-liver segmentation in healthy subjects and mild NAFLD patients. The 95% limits of agreement ranged from +1.02 to -0.03, and from +0.65 to -0.55, respectively. However, a small bias of -0.96±0.77 was also evident, which indicated a small underestimation when using whole-liver segmentation in moderate NAFLD patients. The 95% limits of agreement ranged from +0.56 to -2.48.

Conclusions: Due to inclusion of the intrahepatic vasculature, whole-liver segmentation has some effects on hepatic FF assessment in patients with different NAFLD severities; yet, it does not significantly affect the assessment of whole-liver FF in MRI FF maps.
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http://dx.doi.org/10.21037/qims-20-989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8250014PMC
July 2021

Nrf2 Participates in M2 Polarization by to Alleviate TNBS-Induced Colitis in Mice.

Front Immunol 2021 23;12:698494. Epub 2021 Jun 23.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

induced alternative activated macrophages (M2), leading to protect against Crohn's disease, known as Th1 -related inflammation, which enhances oxidative stress in the host. However, the relationship of oxidative stress and -mediated immune response is still unknown. In our study, we showed that nuclear factor erythroid 2-related factor-2 (Nrf2), a key transcription factor in antioxidant, participated in M2 polarization induced by muscle larval excretory/secretory (ES) products . ES -treated M2 were injected intravenously after TNBS challenge and we demonstrated that ES-M could alleviate the severity of the colitis in mice. Adoptive transfer of ES -treated M2 decreased the level of IFN-γ and increased the levels of IL-4 and IL-10 . However, the capacity of ES -treated Nrf2 KO macrophages to treat colitis was dramatically impaired. ES -treated Nrf2 KO macrophages was insufficient to result in the elevated levels of IL-4 and IL-10. These findings indicate that Nrf2 was required for M2 polarization induced by ES to alleviate colitis in mice.
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http://dx.doi.org/10.3389/fimmu.2021.698494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261282PMC
June 2021

Development of a magnetic MOF-based M-D-μSPE methodology combined with LC-MS/MS for the determination of fluorotelomer alcohols and its metabolites in animal derived foods.

Food Chem 2021 Jun 2;363:130205. Epub 2021 Jun 2.

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, China; Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address:

In this study, a novel modified metal organic framework (MOF) was prepared and used as adsorbent of miniaturized solid-phase extraction (M-D-μSPE) for analyzing 8-2 FTOH and its metabolites in edible tissues by LC-MS/MS. This synthesized adsorbent, named as [email protected] 101-NH (magnetic Fe-MOF), was characterized. Moreover, the effects factors on the adsorption behavior of the adsorbents for the analytes were investigated and optimized in detail, such as solution pH, adsorbent amount, extraction time, desorption condition. The adsorbtion mechanism of magnetic Fe-MOF might be electrostatic interaction, CF-π hydrophobic and Lewis acid base. Compared with conventional adsorbents (such as PSA, C18), magnetic Fe-MOF reduced matrix effect. The limits of quantification ranged 0.10-1.5 µg/kg. The recoveries of analytes ranged 78.0% - 90.3% in spiked samples, with relative standard deviations less than 12.0%. The developed method was successfully utilized to analyze incurred samples, which proves that it is a rapid, efficient, and sensitive method.
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http://dx.doi.org/10.1016/j.foodchem.2021.130205DOI Listing
June 2021

Quantifying the interaction of water and radiation use efficiency under plastic film mulch in winter wheat.

Sci Total Environ 2021 Jun 25;794:148704. Epub 2021 Jun 25.

Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546, USA.

Local natural resources, (e.g., precipitation, solar radiation) are important for developing environmentally and scientifically sound management practices in dryland agroecosystem. Maximizing water use efficiency (WUE) in dryland farming systems remains a challenge. The objectives of this study were to assessing the robustness of radiation use efficiency (RUE) during different periods and investigate the interaction between RUE and WUE from water loss pattern and canopy development during wheat growth under different agricultural practices (non-mulched control, CK; transparent film mulching, TF; and black film mulching, BF) from 2013 to 2016 on the Loess Plateau, Northwest China. Results showed that RUE was mainly improved during post-anthesis under PM treatments. PM treatments contributed to elevated canopy photosynthesis and a delayed RUE peak during the reproductive period. Due to the increased spike number and ratio of plant transpiration to soil evaporation, TF and BF treatments had relatively stable photosynthetic activity relative to the CK treatment even those during dry periods. Initially, no relationship was found between WUE and RUE under the CK treatment. On the other hand, RUE and WUE were positively related in TF and BF treatments following a power function. RUE values increased with WUE rapidly to stabilize at a plateau value of 5.5 g MJ under TF and BF treatments, and thus, the wheat WUE had a higher improvement potential than RUE as it did not have an apparent plateau value. PM treatments enhanced the wheat production by taking full advantage of local solar radiation and precipitation (improving RUE and WUE). This higher use efficiency of resources produced more photoassimilates for wheat than that under the CK management, increased source size (LAI) and sink size (spike number) during wheat growth seasons, and thus increased the final grain yield.
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http://dx.doi.org/10.1016/j.scitotenv.2021.148704DOI Listing
June 2021

Long-term vegetation restoration increases deep soil carbon storage in the Northern Loess Plateau.

Sci Rep 2021 Jul 2;11(1):13758. Epub 2021 Jul 2.

College of Resources and Environmental Engineering, Ludong University, YANTAI, 264025, China.

Afforestation plays an important role in soil carbon storage and water balance. However, there is a lack of information on deep soil carbon and water storage. The study investigates the effect of returning farmland to the forest on soil carbon accumulation and soil water consumption in 20-m deep soil profile in the hilly and gully region of the Chinese Loess Plateau. Four sampling sites were selected: Platycladus orientalis (Linn.) Franco forest (PO: oriental arborvitae), Pinus tabulaeformis Carr. Forest (PT: southern Chinese pine), apple orchard (AO) and farmland (FL, as a control). Soil organic carbon (SOC) and soil inorganic carbon (SIC) content were measured in 50-cm sampling intervals of 20-m soil profiles, as well as the associated factors (e.g. soil water content). The mean SOC content of PT was the highest in the 1-5 m layer and that of FL was the lowest (p < 0.05). Compared with FL, the SOC storages of PO, PT and AO increased by 2.20, 6.33 and 0.90 kg m (p > 0.05), respectively, in the whole profile. The SIC content was relatively uniform throughout the profile at all land-use types and SIC storage was 9-10 times higher than SOC storage. The soil water storage of PO, PT and AO was significantly different from that of FL with a decrease of 1169.32, 1161.60 and 1139.63 mm, respectively. After the 36-yrs implementation of the "Grain for Green" Project, SOC in 20 m soil profiles increased as a water depletion cost compared with FL. Further investigation is still needed to understand the deep soil water and carbon interactions regarding ecological restoration sustainability in the Northern Loess Plateau.
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http://dx.doi.org/10.1038/s41598-021-93157-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253830PMC
July 2021

Preparation and characterization of boron-doped corn straw biochar: Fe (Ⅱ) removal equilibrium and kinetics.

J Environ Sci (China) 2021 Aug 31;106:116-123. Epub 2021 Jan 31.

Joint laboratory of Northeast Agricultural University and Max Planck Institute of Colloids and Interfaces (NEAU-MPICI), Harbin 150030, China; School of Water Conservancy and Civil Engineering, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Nowadays, iron ions as a ubiquitous heavy metal pollutant are gradually concerned and the convenient and quick removal of excessive iron ions in groundwater has become a major challenge for the safety of drinking water. In this study, boron-doped biochar (B-BC) was successfully prepared at various preparation conditions with the addition of boric acid. The as-prepared material has a more developed pore structure and a larger specific surface area (up to 897.97 m²/g). A series of characterization results shows that boric acid effectively activates biochar, and boron atoms are successfully doped on biochar. Compared with the ratio of raw materials, the pyrolysis temperature has a greater influence on the amount of boron doping. Based on Langmuir model, the maximum adsorption capacity of 800B-BC at 25 °C, 40 °C, 55 °C are 50.02 mg/g, 95.09 mg/g, 132.78 mg/g, respectively. Pseudo-second-order kinetic model can better describe the adsorption process, the adsorption process is mainly chemical adsorption. Chemical complexation, ions exchange, and co-precipitation may be the main mechanisms for Fe removal.
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http://dx.doi.org/10.1016/j.jes.2021.01.001DOI Listing
August 2021

Transforming Growth Factor Beta 1 and p44/42 Expression in Cardinal Ligament Tissues of Patients with Pelvic Organ Prolapse.

Med Sci Monit 2021 Jun 28;27:e930433. Epub 2021 Jun 28.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).

BACKGROUND Pelvic organ prolapse (POP) is a disease associated with collagen loss and decreased fibroblast proliferation. Transforming growth factor beta 1 (TGF-ß1) controls collagen synthesis and degradation in pelvic connective tissue. Although the p44/42 MAPK pathway has been implicated in collagen production and extracellular matrix disorders, its expression in POP remains unknown. This study aimed to investigate TGF-ß1 and p44/42 expression in cardinal ligament tissues in patients with POP. MATERIAL AND METHODS Cardinal ligament tissues were obtained from 30 patients with POP (POP group) and 30 patients with benign gynecological disorders who had undergone total hysterectomy (control group). The clinical characteristics of the 2 groups were summarized. Immunohistochemical staining and western blotting analysis were performed to measure the expression of TGF-ß1, p44/42, phospho-p44/42, MMP9, TIMP1, caspase 3, collagen I, and collagen III in the cardinal ligament tissues. RESULTS Patients with POP had significantly lower TGF-ß1 and phospho-p44/42 levels than did control patients (P<0.05). The expression of TIMP1, collagen I, and collagen III was significantly lower, and the expression of MMP9 and caspase 3 was significantly higher in the POP group than in the control group (P<0.05). Moreover, the expression of phospho-p44/42 was positively correlated with the expression of TGF-ß1, collagen I, and collagen III. CONCLUSIONS The expression levels of phospho-p44/42 and TGF-ß1 were decreased in patients with POP and were positively correlated with collagen expression. Low levels of TGF-ß1 and phospho-p44/42 expression in patients with POP may be associated with the occurrence of POP.
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http://dx.doi.org/10.12659/MSM.930433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252891PMC
June 2021

Mirtazapine use may increase the risk of hypothyroxinaemia in patients affected by major depressive disorder.

Br J Clin Pharmacol 2021 Jun 21. Epub 2021 Jun 21.

School of Public Health, Xinxiang Medical University, Xinxiang, China.

Aims: Hypothyroxinaemia could be easily neglected if attention is paid only to patients with elevated thyroid-stimulating hormone. We aimed to assess the association between mirtazapine use and hypothyroxinaemia in patients affected by major depressive disorder.

Methods: We conducted a retrospective cohort study in the Second Affiliated Hospital of Xinxiang Medical University between January 2016 and December 2018. Patients affected by major depression disorder and admitted to the hospital for treatment during the study period and who had thyroid tests at admission and after treatment were included. Mirtazapine use during hospitalization was the exposure measure and newly developed hypothyroxinaemia was as the primary outcome and structure parameters of thyroid homeostasis were the secondary outcomes of this study. Log-binomial model was used to estimate the association between mirtazapine use and hypothyroxinaemia, after adjusting for potential confounding factors.

Results: A total of 220 eligible patients were included in the final analysis. The incidence of hypothyroxinaemia in patients who used mirtazapine was higher (37.5%) than those patients who did not use (19.7%). The relative risk of developing hypothyroxinaemia was 1.70 (95% confidence interval: 1.21-2.43) for mirtazapine use, after adjusting for confounding factors. The degree of reduction in thyroid feedback quantile-based index in mirtazapine group was significantly greater than that in nonmirtazapine group.

Conclusion: Mirtazapine use was associated with the increased risk of developing hypothyroxinaemia. The underlying mechanism may be involved the changed central set point of thyroid homeostasis, in which pituitary was in a possibly impaired sensitivity to the lower level of thyroid hormones.
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http://dx.doi.org/10.1111/bcp.14949DOI Listing
June 2021

Self-Esteem and Academic Engagement Among Adolescents: A Moderated Mediation Model.

Front Psychol 2021 3;12:690828. Epub 2021 Jun 3.

School of Education, Hengshui University, Hengshui, China.

As an important predictor of academic achievement and an effective indicator of learning quality, academic engagement has attracted the attention of researchers. The present study explores the relationship among adolescent self-esteem and academic engagement, the mediating effect of academic self-efficacy, and the moderating effect of perceived social support. Four-hundred and eighty adolescents ( = 14.92) from the Hebei Province of China were recruited to complete anonymous questionnaires. The results show that self-esteem positively predicted adolescent academic engagement through the indirect mediating role of academic self-efficacy, and the percentage of this mediation effect of the total effect was 73.91%. As a second-stage moderator, perceived social support moderated the mediating effect of academic self-efficacy. Specifically, when students felt more perceived social support, the impact of academic self-efficacy on their academic engagement was greater. Our findings suggest that adolescent self-esteem, academic self-efficacy, and perceived social support are key factors that should be considered together to improve adolescent academic engagement. Therefore, parents and school educators should actively guide adolescents to improve their self-esteem and academic self-efficacy. Parents and educators should also construct an effective social support system to improve students' perceived social support and enhance their academic engagement.
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http://dx.doi.org/10.3389/fpsyg.2021.690828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209251PMC
June 2021

Exploitation of nanocrystal suspension as an effective oral formulation for oxfendazole.

Drug Deliv Transl Res 2021 Jun 20. Epub 2021 Jun 20.

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, 430070, Hubei, China.

An oxfendazole (OFZ) nanocrystal suspension was prepared by acid-base neutralization and crystallization combined with ultrasonic dispersion to overcome the challenge of its poor oral bioavailability. The nanosuspensions were screened and optimized by single-factor experiments and an orthogonal design using size and appearance as indices. The morphology (differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD)) properties and pharmacokinetics of the best formulation were further developed. The results showed that the best cosolvent and stabilizer were malic acid and hydrogenated castor oil polyoxyethylene ether (HEL-40), respectively. Scanning electron microscopy demonstrated that the oxfendazole nanocrystals are irregular sheets with relative uniformity. The prepared nanocrystals have an average particle diameter of 431 ± 18 nm, a polydispersity index (PDI) of 0.376 ± 0.128, a zeta potential of 2.30 ± 0.44 mV, and a sedimentation coefficient of 0.993. The equilibrium solubility of nanocrystals in different solvents was significantly improved by 2.02-109.99-fold compared to OFZ crude. In 0.5% SDS-PBS (pH 2) and 0.5% SDS-PBS (pH 8) solution, oxfendazole nanocrystals were completely released within 5 min, while the OFZ crude only released 60.26% and 28.31%, respectively. The pharmacokinetics showed that the C, T, and AUC of OFZ nanosuspension and OFZ granules in rats after oral dosage at 50 mg/kg were 4.23 and 13.63 μg/mL, 2.04 and 1.67 h, and 111.36 and 295.80 μg*h/mL, respectively. The relative bioavailability of the oxfendazole nanosuspension was 265.61% compared to the OFZ granules. These results showed that the nanosuspension might be a promising oral formulation for the hardly soluble OFZ.
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http://dx.doi.org/10.1007/s13346-021-01012-6DOI Listing
June 2021

Association Between Bone Cement Augmentation and New Vertebral Fractures in Patients with Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis.

World Neurosurg 2021 Jun 15. Epub 2021 Jun 15.

Department of Osteoporosis, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, P. R. China. Electronic address:

Purpose: To investigate the association between bone cement augmentation and new vertebral fractures (VF) in patients with osteoporotic vertebral compression fractures (OVCFs).

Methods: A literature search of PubMed, EMBASE, and the Cochrane Library was conducted from 1987 to December 31, 2020, to identify randomized controlled trials that compared bone cement augmentation with non-bone cement treatments in patients with OVCFs. The clinical incidence of new VF and the risk of new adjacent vertebral fractures (AVF) after treatment were calculated. The indexes of the risk ratio or odds ratio, and 95% confidence intervals were determined with RevMan 5.2 software.

Results: A total of 13 randomized controlled trials involving 1949 participants were included in the final quantitative analysis. There was no significant association between bone cement augmentation and the clinical incidence of new VF during the 6-month and 12-month follow-ups or the whole follow-up period. However, there was a significantly lower clinical incidence of new VF in patients who received bone cement augmentation compared with non-bone cement treatments during 24 months or more of follow-up. Pooled data from the relevant trials demonstrated that the risk of new AVF in bone cement augmentation was significantly higher than that in non-bone cement treatments.

Conclusions: Although the use of bone cement augmentation in OVCFs significantly increased the risk of new AVF compared with non-bone cement treatments, it was not significantly associated with a higher clinical incidence of new VF.
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http://dx.doi.org/10.1016/j.wneu.2021.06.023DOI Listing
June 2021

Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light.

Nanomicro Lett 2020 Sep 2;12(1):180. Epub 2020 Sep 2.

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun, 130022, People's Republic of China.

In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS nanocomposites modified by bovine serum albumin (FeO/MoS-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS nanosheets not only can accelerate the conversion of Fe ions to Fe ions by Mo ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.
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http://dx.doi.org/10.1007/s40820-020-00516-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770794PMC
September 2020
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