Publications by authors named "Xiaoxue Han"

11 Publications

  • Page 1 of 1

Knowledge and Attitude of the Medical Staff Concerning Cardiac Rehabilitation in Zhejiang Province, China: A Cross-Sectional Study.

Patient Prefer Adherence 2020 29;14:1771-1777. Epub 2020 Sep 29.

Department of Cardiology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, People's Republic of China.

Purpose: This study aimed to investigate the status of cardiac rehabilitation knowledge and attitude of the medical staff.

Patients And Methods: A questionnaire survey of doctors and nurses was performed in the departments of cardiology of 7 teaching hospitals with attitudes, knowledge toward CR in Zhejiang Province, China, from April to September 2018, to assess Chinese medical staff for the degree of mastery and attitude toward cardiac rehabilitation.

Results: A total of 160 questionnaires were distributed and 152 valid were collected. The responding individuals included 106 nurses (69.74%) and 46 doctors (30.26%). The scores of cardiac rehabilitation knowledge were 56.68±5.06, and those of cardiac rehabilitation attitude were 15.19±3.86. Subgroup analysis showed the lower the job title (P<0.001), the lower the educational level (P = 0.011), and the shorter the years of specialty experience (P=0.005), the more negative the attitude toward cardiac rehabilitation.

Conclusion: The medical staff has a good mastery of cardiac rehabilitation knowledge. But we also find that staffs with lower education level and job title, shorter specialty work experience were associated with a more negative attitude toward implement rehabilitation.
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http://dx.doi.org/10.2147/PPA.S270503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532901PMC
September 2020

Potential Effect of COVID-19 on Maternal and Infant Outcome: Lesson From SARS.

Front Pediatr 2020 7;8:511. Epub 2020 Aug 7.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

The coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is highly infectious and its ongoing outbreak has been declared a global pandemic by the WHO. Pregnant women are susceptible to respiratory pathogens and the development of severe pneumonia, suggesting the urgent need to assess the potential maternal and infant outcome of pregnancy with COVID-19. The intrauterine vertical transmission potential of SARS-CoV-2 also remains controversial. Herein, we discuss the potential effect of COVID-19 on maternal and infant outcomes based on current studies, including those published in Chinese, in a total of 80 mothers with COVID-19 and 80 infants. We also comprehensively explored the mother-to-child transmission routes of SARS-CoV-2, in particular the route of intrauterine vertical transmission. Given SARS-CoV-2 is a sister to SARS-CoV, of the SARS-related coronavirus species, we made a comprehensive comparison between them to learn from experiences with SARS. Although there is no evidence supporting the intrauterine vertical transmission of SARS-CoV-2, our comprehensive analysis suggests that the adverse maternal and infant outcomes caused by COVID-19 cannot be underestimated. Further, we speculated that the inconsistency between nucleic acids and serological characteristics IgM to SARS-CoV-2 of infants' specimens may be caused by the disruption of the amniotic barrier by the inflammatory factors induced by SARS-CoV-2 infection. Our review is beneficial to understand the effect of SARS-CoV-2 on maternal and infant outcomes.
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http://dx.doi.org/10.3389/fped.2020.00511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426626PMC
August 2020

Preparation and Barrier Performance of Layer-Modified Soil-Stripping/Cassava Starch Composite Films.

Polymers (Basel) 2020 Jul 20;12(7). Epub 2020 Jul 20.

Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, Nanning 530004, China.

In this study, we investigated the barrier properties of a montmorillonite-reinforced biomass material, starch. Organically modified montmorillonite materials were prepared from natural montmorillonite by reacting it with dodecyl trimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium chloride or octadecyl trimethyl ammonium chloride under ultrasonic conditions. The composite starch films incorporated with these organically modified montmorillonite samples were characterized by scanning electron microscopy, transmission electron microscopy, infrared spectroscopy and X-ray diffraction. The results showed that the introduction of montmorillonite decreases the transmittance of the composite film by 10% in the visible region and significantly inhibits UV-light transmittance. The decomposition temperature of the composite film ranges from 200 to 500 °C, with a weight loss rate of 80%. The distance between the montmorillonite layers increases from 0.14 nm in the non-magnetized state to 1.49 nm after magnetization. The oxygen permeability of the starch film modified by organic montmorillonite (0.067 cm/m·d) is lower than that of the montmorillonite starch film without magnetization (0.097cm/m·d). The oxygen barrier capacity is close to zero. Particularly in the ordered magnetic montmorillonite starch composite film, the oxygen barrier ability is the best. Therefore, modified montmorillonite could serve as an excellent reinforcing agent for cassava starch films and effectively improve the oxygen barrier performance of the films.
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http://dx.doi.org/10.3390/polym12071611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407643PMC
July 2020

Comparison of Clinical Results and Quality-of-Life in Tongue Cancer Patients Undergoing Submental Island Flap and Radial Forearm Free Flap Reconstruction.

J Oral Maxillofac Surg 2020 Sep 8;78(9):1639-1644. Epub 2020 May 8.

Nurse in Charge, Professor, Department of Oromaxillofacial-Head and Neck Surgery and Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, China.

Purpose: Our goal was to compare the clinical results and quality-of-life (QoL) in tongue cancer patients undergoing submental island pedicled (SIP) flap and radial forearm free (RFF) flap reconstruction.

Materials And Methods: Patients undergoing SIP or RFF flap reconstruction for primary tongue squamous cell carcinoma were prospectively enrolled and were asked to complete the University of Washington Quality-of-Life (UW-QOL) questionnaire, version 4, at 12 months after the operation. The study's main interest was QoL as well as locoregional recurrence control.

Results: A total of 190 patients were enrolled for analysis, and the SIP and RFF groups showed significant differences in patient age, American Society of Anesthesiologists classification, and hospital cost. In the survival analysis, locoregional recurrence occurred in 35 patients in the SIP group and 48 patients in the RFF group; the difference was not significant (P = .440). In the QoL analysis, compared with patients in the SIP group, those in the RFF group had higher scores in the domains of activity and recreation. No significant differences were found with respect to the other domains.

Conclusions: The SIP flap and RFF flap have comparable survival control in tongue squamous cell carcinoma patients. The RFF flap might lead to better QoL, but the SIP flap imposes fewer limitations on patients' health status and is associated with lower hospital cost.
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http://dx.doi.org/10.1016/j.joms.2020.04.045DOI Listing
September 2020

Oxygen therapy alleviates hepatic steatosis by inhibiting hypoxia-inducible factor-2α.

J Endocrinol 2020 07;246(1):57-67

Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.

Non-alcoholic fatty liver disease (NAFLD) is difficult to manage due to the lack of effective treatments. Increased oxygen consumption caused by overnutrition, along with reduced oxygen delivery to liver cells induces hepatic steatosis. Here, we investigated the efficacy of oxygen therapy (OT) to alleviate hepatic steatosis. The effect of OT on hepatic steatosis was evaluated in high-fat-diet (HFD)-fed mice and palmitic acid (PA)-treated primary hepatocytes. Liver biopsy tissue samples were used to determine the relationship between the expression of hypoxia-inducible factor-2α (HIF-2α) and the progression of NAFLD. The role of HIF-2α in the OT group was determined based on the overexpression of HIF-2α in vitro. OT safely alleviated hepatic hypoxia and improved hepatic steatosis by inhibiting hepatic de novo lipogenesis in HFD-fed mice and PA-treated primary hepatocytes, and this was accompanied by reduced expression of HIF-2α and hepatic de novo lipogenesis. The analysis of liver tissues from individuals with or without NAFLD revealed a positive correlation between hepatic HIF-2α expression and NAFLD progression. Overexpression of HIF-2α in vitro inhibited the beneficial effect of OT against hepatic lipogenesis and steatosis. OT might be a viable treatment option for NAFLD and functions by alleviating hypoxia and inhibiting the liver HIF-2α signaling pathway.
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http://dx.doi.org/10.1530/JOE-19-0555DOI Listing
July 2020

An Oxygen Self-Evolving, Multistage Delivery System for Deeply Located Hypoxic Tumor Treatment.

Adv Healthc Mater 2020 01 10;9(2):e1901303. Epub 2019 Dec 10.

Institute of Materials Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210093, China.

The hypoxia-induced resistance to radiotherapy (RT) is a great threat to cancer patients. Therefore, overcoming the hypoxia tumor microenvironment is a vital issue. Herein, spindle-shaped [email protected] core-shell nanoparticles combining self-supplied oxygen, photothermal ability, and RT sensitive to cancer therapy are introduced. The spindle shape of [email protected] core-shell nanoparticles can potentiate their tumor penetration and subsequent internalization by cancer cells. The presence of CeO , functioning as a nanoenzyme, catalyzes the endogenous H O in tumor tissue into O , which remodels the hypoxic microenvironment into one susceptible to RT. CuS nanoparticles encapsulated in CeO undergo a steady release and deep tumor penetration, allowing the regression of lesions less affected by RT. Furthermore, in vitro and in vivo studies reveal that the design not only mitigates the dosage of RT, but more importantly allows the entire tumor to be treated without relapses.
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http://dx.doi.org/10.1002/adhm.201901303DOI Listing
January 2020

Management and prognosis of cancers in the accessory parotid gland.

J Int Med Res 2018 Dec 5;46(12):4930-4933. Epub 2018 Oct 5.

2 Department of Oral Maxillofacial Surgery, Affiliated Stomatology Hospital of China Medical University, Shenyang, PR China.

Objective: This study was performed to analyze the clinical management of accessory parotid gland (APG) cancer and possible risk factors for disease-related death.

Methods: Patients diagnosed with primary APG cancers in the largest medical center in Northeast China were enrolled from January 1990 to December 2016.

Results: All 43 patients underwent resection of the tumors and superficial parotid gland by a standard Blair incision. Seven (16.3%) patients also required selective neck dissection. The most common lesion was mucoepidermoid carcinoma. Temporary facial paralysis occurred in 11 (25.6%) patients, and permanent facial paralysis occurred in 3 (7.0%) patients because of surgical resection of the facial nerve, which was involved with the tumor. The 5- and 10-year disease-specific survival rates were 86.0% and 66.0%, respectively. The tumor stage, neck status, neck dissection, and tumor grade were significantly associated with disease-related death, but only the tumor grade was an independent risk factor.

Conclusion: Superficial parotidectomy is a reliable surgical procedure associated with a high survival rate and low morbidity in treating APG cancers. The tumor grade is the key prognostic factor.
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http://dx.doi.org/10.1177/0300060518767792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300960PMC
December 2018

Fabrication of metal-free two dimensional/two dimensional homojunction photocatalyst using various carbon nitride nanosheets as building blocks.

J Colloid Interface Sci 2017 Dec 2;507:209-216. Epub 2017 Aug 2.

Department of Chemistry, Zhejiang Sci-Tech University, 928 Second Avenue, Xiasha Higher Education Zone, Hangzhou 310018, China. Electronic address:

Semiconductor photocatalysis currently suffered three main problems, low solar energy utilization, high photo-generated charge recombination rate and the heavy metal ions release by the photo-corrosion. Herein, we developed a visible-light-driven homojunction photocatalyst with the metal-free two-dimensional (2D) graphitic carbon nitride nanosheets (CNNS). By employing liquid exfoliation and chemical blowing approaches, we obtained two kinds of CNNS materials (le-CNNS and cb-CNNS) with different band structures, and subsequently fabricated the homojunction photocatalyst. This 2D/2D nanocomposited homojunction photocatalyst exhibited enhanced photocatalytic performance compared to these individual 2D nanosheets materials. Moreover, its well universality and reusability were also demonstrated by photo-degradation of various organic pollutants and five successive runs. By studying the optical properties and the electrochemical behavior, the band alignment of this homojunction was illustrated and the possible mechanism was proposed, where the transmitted electrons on the conduction band (CB) of le-CNNS would transport to the CB of cb-CNNS, and the holes on the valence band (VB) of cb-CNNS transferred to the VB of le-CNNS, therefore promoting the photo-induced carrier separation. Additionally, the photoluminescence, electrochemical impendence and photocurrent measurements further demonstrated that the recombination of photo-excited electron-hole pairs had been efficiently suppressed in the homojunction and were respectively collected on different CNNS components.
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http://dx.doi.org/10.1016/j.jcis.2017.08.002DOI Listing
December 2017

MicroRNA-216a promotes the metastasis and epithelial-mesenchymal transition of ovarian cancer by suppressing the PTEN/AKT pathway.

Onco Targets Ther 2017 23;10:2701-2709. Epub 2017 May 23.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of JiNan University, Guangzhou, People's Republic of China.

MicroRNAs, a group of posttranscriptional regulators of numerous genes, are active participators during the development and progression of ovarian cancer (OC). This study confirmed for the first time that miR-216a was gradually increased in normal, benign, borderline, and OC tissues and that its expression was significantly upregulated in all OC cell lines. Analysis of its clinical association demonstrated that elevated expression of miR-216a was associated with lymph node metastasis and advanced FIGO stage and was correlated with the poor survival of OC patients. Functional experiments showed that miR-216a overexpression potentiated the migration and invasion of CAOV3 cells while miR-216a inhibition reduced the migration and invasion of SKOV-3 cells. Both gain and lose of function assay showed that miR-216a promoted epithelial-mesenchymal transition (EMT) of OC cells. Mechanistically, phosphatase and tensin homolog (PTEN) was confirmed as a direct downstream target of miR-216a in OC cells. Alerting miR-216a expression in OC cells modulated the activity of PTEN/AKT pathway in OC cells. Furthermore, this study confirmed that miR-216a exerted its promoting effects on the metastatic behaviors and EMT of OC cells by inhibiting PTEN/AKT pathway. Taken together, this study demonstrates that miR-216a exerts a promoting role in the metastasis of OC and can serve as a promising biomarker and an attractive therapeutic target of OC.
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http://dx.doi.org/10.2147/OTT.S114318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449156PMC
May 2017

Streptomyces luozhongensis sp. nov., a novel actinomycete with antifungal activity and antibacterial activity.

Antonie Van Leeuwenhoek 2017 Feb 17;110(2):195-203. Epub 2016 Oct 17.

College of Life Science, Tarim University/Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Corps, 843300, Alar, People's Republic of China.

A novel actinomycete strain, designated TRM 49605, was isolated from a desert soil sample from Lop Nur, Xinjiang, north-west China, and characterised using a polyphasic taxonomic approach. The strain exhibited antifungal activity against the following strains: Saccharomyces cerevisiae, Curvularia lunata, Aspergillus flavus, Aspergillus niger, Fusarium oxysporum, Penicillium citrinum, Candida albicans and Candida tropicalis; Antibacterial activity against Bacillus subtilis, Staphylococcus epidermidis and Micrococcus luteus; and no antibacterial activity against Escherichia coli. Phylogenetic analysis based on 16S rRNA gene sequences affiliated strain TRM 49605 to the genus Streptomyces. Strain TRM 49605 shows high sequence similarities to Streptomyces roseolilacinus NBRC 12815 (98.62 %), Streptomyces flavovariabilis NRRL B-16367 (98.45 %) and Streptomyces variegatus NRRL B-16380 (98.45 %). Whole cell hydrolysates of strain TRM 49605 were found to contain LL-diaminopimelic acid as the diagnostic diamino acid and galactose, glucose, xylose and mannose as the major whole cell sugars. The major fatty acids in strain TRM 49605 were identified as iso C, anteiso C, C and Summed Feature 5 as defined by MIDI. The main menaquinones were identified as MK-9(H), MK-9(H), MK-9(H) and MK-10(H). The polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol and phosphatidylinositol mannoside. The G+C content of the genomic DNA was determined to be 71.2 %. The DNA-DNA relatedness between strain TRM 49605 and the phylogenetically related strain S. roseolilacinus NBRC 12815 was 60.12 ± 0.06 %, which is lower than the 70 % threshold value for delineation of genomic prokaryotic species. Based on the phenotypic, chemotaxonomic and phylogenetic data, strain TRM 49605 (=CCTCC AA2015026 = KCTC 39666) should be designated as the type strain of a novel species of the genus Streptomyces, for which the name Streptomyces luozhongensis sp. nov. is proposed.
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http://dx.doi.org/10.1007/s10482-016-0790-6DOI Listing
February 2017

Impact of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of stage IA adenocarcinoma of the lung: Correlation between computed tomography images and EGFR and KRAS gene mutations.

Exp Ther Med 2015 Jun 14;9(6):2095-2103. Epub 2015 Apr 14.

Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing 100853, P.R. China.

The aim of the present study was to compare pathological diagnoses, as determined by the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification, with conventional radiological features. In addition, the present study aimed to evaluate the correlation among clinical characteristics, computed tomography (CT) images and gene mutation status in patients with stage IA adenocarcinoma of the lung. A total of 212 patients with stage IA lung adenocarcinoma were included in the study. The patients were classified into pure ground-glass opacity (pGGO), mixed GGO (mGGO) and solid GGO (sGGO) by CT imaging. Histological subtype was classified according to the IASLC/ATS/ERS classification of lung adenocarcinoma. In addition, epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma (KRAS) mutation assays were performed, and 36.8% of patients (78/212) were determined to have an EGFR mutation, while 8.5% of patients (18/212) were found to have a KRAS mutation. According to the IASLC/ATS/ERS classification, 44 cases were diagnosed as adenocarcinoma (AIS; 20.8%), 62 cases were diagnosed as minimally invasive adenocarcinoma (MIA; 29.2%) and 106 cases were classified as invasive adenocarcinoma (IAC; 50.0%). pGGO image patterns were observed in 39.2% of patients (n=83), while mGGO and sGGO patterns were observed in 28.8% (n=61) and 32.0% (n=68) of patients, respectively. From pGGO to sGGO, cases of AIS and MIA were shown to have a decreasing trend, while IAC cases exhibited an increasing trend (P=0.036). Analysis of the correlation between CT image patterns and gene mutations demonstrated that L858R point mutations, exon 19 deletions and KRAS mutations were more common in lesions with a lower GGO proportion (P=0.029, 0.027 and 0.018, respectively). Therefore, according to the IASLC/ATS/ERS classification, GGO imaging patterns were shown to correlate with subtypes of adenocarcinomas. In addition, EGFR and KRAS mutations were found to be associated with lesions with a low GGO proportion. Therefore, analysis of GGO lesions may offer useful indications of the histological subtype of an adenocarcinoma in patients with stage IA lung adenocarcinoma, and predictive value for EGFR and KRAS mutations.
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http://dx.doi.org/10.3892/etm.2015.2422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473664PMC
June 2015
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