Publications by authors named "Weizhong Han"

13 Publications

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Current status and influencing factors of nursing interruption events.

Am J Manag Care 2021 Jun 1;27(6):e188-e194. Epub 2021 Jun 1.

Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Rd, Ji'nan, Shandong, China 250021. Email:

Objectives: To investigate the status of nursing interruption events during medicine administration and to analyze the factors influencing interruptions.

Study Design: The nursing drug delivery process was divided into 3 segments: the processing of doctors' orders, drug allocation, and bedside drug administration. The frequency, source, type, and outcome of interruption events during these 3 segments were observed. The interruption time and medication errors caused by interruptions were analyzed.

Methods: The structural observation method was used to observe the 3 steps of the drug delivery process. The observations were performed between 8:30 and 10:30 and between 13:30 and 14:30. Count data are described as frequency, composition ratio, and cumulative percentage. R×C contingency table, t tests, and analysis of variance were used to analyze the data.

Results: In 270 hours of observation, 3424 nursing interruptions occurred, for a mean of 12.68 interruptions per hour. The mean (SD) interruption time was 28.03 (11.01) seconds, and the total duration of drug administration interruptions was 26.65 hours, accounting for 9.87% of the total observation time. The sources of interruption events were as follows: family members, the environment, doctors, patients, colleagues, the nurses themselves, and others; of these interruptions, 2340 were low-priority events (eg, visitor inquiry, telephone call, consultation, discharge questions), accounting for 68.34%. The incidence of medication errors due to interruptions was 1.139%.

Conclusions: Nursing interruption events occur frequently, come from many sources, have complex causes, and commonly lead to negative outcomes. Interruption also has a time cost and can directly lead to medication errors.
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http://dx.doi.org/10.37765/ajmc.2021.88667DOI Listing
June 2021

Long non-coding RNA CCAT1 sponges miR-490 to enhance cell proliferation and migration of non-small cell lung cancer.

Thorac Cancer 2021 02 15;12(3):364-371. Epub 2020 Dec 15.

Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China.

Background: Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer which is the most frequently diagnosed malignancy in China. Colon cancer associated transcript 1 (CCAT1) acts as an oncogene in enhancing tumor progression. However, the effects of CCAT1 in NSCLC remain unclear. The purpose of this study was to explore the role of CCAT1 in NSCLC.

Methods: Wound healing and transwell assays were performed to measure cell migration. RT-qPCR was employed to calculate the mRNA level of CCAT1 and miR-490.

Results: High expression of CCAT1 was observed in NSCLC tissues and cells, with low expression of miR-490. CCAT1 promoted the proliferation and metastasis of H1299 and A549 cells, while miR-490 had the opposite effect. CCAT1 could specifically bind to miR-490 and regulate its expression. MiR-490 partially reversed the inhibitory effect of CCAT1 on cell proliferation and metastasis.

Conclusions: The CCAT1/miR-490 molecular axis has been shown to be important for the treatment of NSCLC.
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http://dx.doi.org/10.1111/1759-7714.13758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862790PMC
February 2021

Solitary fibrous tumor of the pleura in a 22-year-old woman: a case report.

J Int Med Res 2020 Sep;48(9):300060520959495

Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Solitary fibrous tumor of the pleura (SFTP) is a rare disease, and most published case reports are in patients over 40 years old. We report a case of SFTP in a 22-year-old woman. The imaging features were observed using contrast-enhanced computed tomography (CT), and histomorphological features were evaluated using pathology and immunohistochemistry. The CT showed a mass in the pleura inside the ninth rib on the left. Pathological results of percutaneous puncture in the chest suggested the possibility of solitary fibroma. The patient underwent surgical resection, and the tumor measured 2.5 × 1.5 × 1.5 cm with an intact capsule. Pathological examination revealed a spindle cell tumor, and immunohistochemistry showed strong positive staining for CD34 and STAT6, consistent with typical solitary fibroma. Although SFTP is rare in young patients, early diagnosis and intervention are needed to avoid the possibility of future complications.
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http://dx.doi.org/10.1177/0300060520959495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522835PMC
September 2020

microRNA-100 functions as a tumor suppressor in non-small cell lung cancer via regulating epithelial-mesenchymal transition and Wnt/β-catenin by targeting HOXA1.

Thorac Cancer 2020 06 4;11(6):1679-1688. Epub 2020 May 4.

Department of Clinical Laboratory, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.

Background: Non-small cell lung cancer (NSCLC) is a leading subtype in lung cancer, with high morbidities and mortalities worldwide. microRNA (miRNA) has appeared to play indispensable roles in a variety of solid carcinomas. The current study focused on the functions of miR-100 in NSCLC.

Methods: qRT-PCR was performed to detect miR-100 and HOXA1 expressions in NSCLC tissues and cells. MTT and transwell assays were used to determine the functions of miR-100 in NSCLC cell proliferation, invasion and migration abilities. Western blot was used to measure related protein expressions.

Results: qRT-PCR results showed that miR-100 expressions were dramatically decreased in NSCLC tissues. MTT assays indicated that miR-100 restoration inhibited NSCLC cell proliferation. Furthermore, transwell assay was performed to determine the impacts of miR-100 on NSCLC invasion and migration abilities. As expected, the invasion and migration capacities were significantly repressed. Direct interactions between HOXA1 and miR-100 were also verified via dual-luciferase reporter assays. Western blot analysis demonstrated that miR-100 exerted suppressive functions via regulating EMT and Wnt/β-catenin in NSCLC cells.

Conclusions: Our results showed that miR-100 served antitumor roles in NSCLC, providing new evidence of miR-100 as a promising therapeutic biomarker in NSCLC.
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http://dx.doi.org/10.1111/1759-7714.13459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262897PMC
June 2020

Relationship between 24-hour urinary sodium excretion and blood pressure in the adult population in Shandong, China.

J Clin Hypertens (Greenwich) 2019 09 26;21(9):1370-1376. Epub 2019 Jul 26.

Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan, China.

The main objective of this study was to determine baseline salt intake levels in a sample of the adult population of Shandong province and to establish the relationship between urinary sodium excretion and blood pressure. A total of 512 participants were recruited, and all the participants provided complete 24-hour urine collections. Physical assessment and socioeconomic status of participants were collected at the same time. The mean 24-hour urinary sodium excretion of all subjects was 228.0 ± 127.5 mmol/24 hours. Estimated salt intake was higher in obese subjects (17.6 ± 8.8 g/d) compared with overweight subjects (15.6 ± 8.0 g/d) and those with a normal BMI (13.9 ± 6.8 g/d). Likewise, urinary sodium excretion of hypertensive participants was dramatically higher than that of non-hypertensive ones, the equivalent of 18.2 ± 9.1 g/d vs 13.3 ± 6.8 g/d. Urinary sodium was significantly associated with SBP (β = 1.08, P = .018) after adjustment for potential confounders. In summary, we found significantly high levels of salt intake in Shandong Province, particularly in obese and hypertension subjects. It is quite important to improve public education about reducing salt intake to control blood pressure among Shandong people.
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http://dx.doi.org/10.1111/jch.13644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771517PMC
September 2019

Liquid-Like, Self-Healing Aluminum Oxide during Deformation at Room Temperature.

Nano Lett 2018 04 14;18(4):2492-2497. Epub 2018 Mar 14.

Department of Nuclear Science and Engineering , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

Effective protection from environmental degradation relies on the integrity of oxide as diffusion barriers. Ideally, the passivation layer can repair its own breaches quickly under deformation. While studies suggest that the native aluminum oxide may manifest such properties, it has yet to be experimentally proven because direct observations of the air-environmental deformation of aluminum oxide and its initial formation at room temperature are challenging. Here, we report in situ experiments to stretch pure aluminum nanotips under O gas environments in a transmission electron microscope (TEM). We discovered that aluminum oxide indeed deforms like liquid and can match the deformation of Al without any cracks/spallation at moderate strain rate. At higher strain rate, we exposed fresh metal surface, and visualized the self-healing process of aluminum oxide at atomic resolution. Unlike traditional thin-film growth or nanoglass consolidation processes, we observe seamless coalescence of new oxide islands without forming any glass-glass interface or surface grooves, indicating greatly accelerated glass kinetics at the surface compared to the bulk.
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http://dx.doi.org/10.1021/acs.nanolett.8b00068DOI Listing
April 2018

Ox-LDL induces endothelial cell apoptosis and macrophage migration by regulating caveolin-1 phosphorylation.

J Cell Physiol 2018 10 9;233(10):6683-6692. Epub 2018 May 9.

Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Oxidative low-density lipoprotein (ox-LDL) is a risk factor for atherosclerosis. Ox-LDL leads to endothelial injury in the initial stage of atherosclerosis. In this study, we investigated the role of ox-LDL in endothelial injury and macrophage recruitment. We demonstrated that ox-LDL promoted a dose-dependent phosphorylation of caveolin-1 in human umbilical vein endothelial cells. Phosphorylated caveolin-1 increased ox-LDL uptake. Intracellular accumulation of ox-LDL induced NF-κB p65 phosphorylation, promoted HMGB1 translocation from nucleus to cytoplasm and cytochrome C release from mitochondria to cytoplasm, and activated caspase 3, resulting in cell apoptosis. NF-κB activation also facilitated cavolin-1 phosphorylation and HMGB1 expression. In addition, caveolin-1 phosphorylation favored HMGB1 release and nuclear translocation of EGR1. Nuclear translocation of EGR1 contributed to cytoplasmic translocation of HMGB1. The extracellular HMGB1 induced the migration of PMBC-derived macrophages toward HUVECs in a TLR4-dependent manner. Our results suggested that ox-LDL promoted HUVECs apoptosis and macrophage recruitment by regulating caveolin-1 phosphorylation.
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http://dx.doi.org/10.1002/jcp.26468DOI Listing
October 2018

Relationship of renin-angiotensin system polymorphisms with ambulatory and central blood pressure in patients with hypertension.

J Clin Hypertens (Greenwich) 2017 Nov 20;19(11):1081-1087. Epub 2017 Aug 20.

Department of Shandong Cancer Hospital Affiliated to Shandong University, Ji'nan, Shandong, China.

This study was conducted to explore whether the renin C-5312T, angiotensin II type 1 receptor A1166C, and angiotensin-converting enzyme I/D polymorphisms were associated with ambulatory blood pressure (BP) and central hemodynamics in an untreated hypertensive population. A total of 471 participants with no previous treatment for raised BP were eligible for the study. Ambulatory and central BP were measured. DD carriers had the highest daytime systolic/diastolic BP, nighttime systolic BP, 24-hour systolic BP, and 24-hour diastolic BP values, whereas carriers of DD had higher central systolic BP and augmentation index compared with those with the II genotype. Multivariate regression analysis demonstrated that DD genotype was independently associated with 24-hour systolic BP, 24-hour diastolic BP, central systolic BP, and central augmentation index. There was an independent association of the angiotensin-converting enzyme polymorphism with central and ambulatory BP in Chinese patients with hypertension.
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http://dx.doi.org/10.1111/jch.13061DOI Listing
November 2017

Relationships between urinary electrolytes excretion and central hemodynamics, and arterial stiffness in hypertensive patients.

Hypertens Res 2017 Aug 2;40(8):746-751. Epub 2017 Mar 2.

Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong, China.

High sodium intake plays an important role in the onset and exacerbation of hypertension. However, the relationships between urinary electrolytes excretion and central hemodynamics and between urinary electrolyte excretion and arterial stiffness are still the subject of debate. This study sought to clarify the associations of salt intake with central aortic pressure and arterial stiffness indicators. A total of 431 untreated hypertensive individuals were recruited into the study. Twenty-four-hour urinary samples were collected to measure the excretion of urinary electrolytes. Central hemodynamics parameters and brachial-ankle pulse wave velocity (baPWV) were measured. We evaluated the independent relationship between urinary sodium or potassium excretion and the abovementioned indices. The mean 24-h urinary sodium of all subjects was 166.6±70.0 mmol/24 h. With increases in urinary sodium excretion, central blood pressure and baPWV values markedly increased. Multiple regression analysis showed that urinary sodium was independently associated with increases in central systolic blood pressure, central diastolic blood pressure, the augmentation index, and baPWV. Significant correlations were identified between high dietary sodium and central hemodynamics and between high dietary sodium and arterial elasticity. Prospective interventional studies in hypertensive patients may be required to determine the effect of salt intake on central hemodynamics.
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http://dx.doi.org/10.1038/hr.2017.29DOI Listing
August 2017

Bi-crystallographic lattice structure directs grain boundary motion under shear stress.

Sci Rep 2015 Aug 25;5:13441. Epub 2015 Aug 25.

Center for Advancing Materials Performance from the Nanoscale, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.

Shear stress driven grain boundary (GB) migration was found to be a ubiquitous phenomenon in small grained polycrystalline materials. Here we show that the GB displacement shift complete (DSC) dislocation mechanism for GB shear coupled migration is still functioning even if the geometry orientation of the GBs deviates a few degrees from the appropriate coincidence site lattice (CSL) GBs. It means that any large angle GB can have a considerable chance to be such a "CSL-related GB" for which the shear coupled GB migration motion can happen by the GB DSC dislocation mechanism. We conclude that the CSL-DSC bi-crystallographic lattice structure in GB is the main reason that GB can migrate under shear stress.
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http://dx.doi.org/10.1038/srep13441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548247PMC
August 2015

Validation of the Spot Urine in Evaluating 24-Hour Sodium Excretion in Chinese Hypertension Patients.

Am J Hypertens 2015 Nov 25;28(11):1368-75. Epub 2015 May 25.

Hypertension Research Center of Peking University People's Hospital, Xicheng District, Beijing, P. R. China;

Background: The spot urine method as an alternative approach in estimating daily urine sodium excretion has been proposed for many years. Kawasaki has created an equation to predict daily urinary sodium excretion using second morning urine (SMU) samples which was obtained before breakfast after initial voiding upon arising. Tanaka has developed another equation by examining spot urine samples submitted at random times during the day. A newly published study proposed that the "PM sample," collected in the late afternoon or early evening before dinner, showed a stronger relationship with actual sodium excretion. We aimed to verify the effectiveness of these methods in evaluating 24-hour urinary sodium in Chinese hypertensive patients.

Methods: A total of 334 hypertensive participants were eligible to participate in this study. A total of 222 patients provided qualified SMU samples, Post Meridiem (PM) samples, and complete 24-hour urine collections.

Results: Biases using the Kawasaki formula were 2.1 mmol/day for the SMU specimens; for the Tanaka equation, biases of SMU and PM samples were 21.1 and 30.1 mmol/day, respectively. The highest intraclass correlation coefficient (ICC) was 0.64 when the Kawasaki formula was used in PM specimens, with the lowest ICC 0.17 when it is used in SMUs.

Conclusions: Spot urine method is acceptable for estimating 24-hour urinary sodium excretion in hypertensive individuals. Kawasaki's formula is useful for estimating population mean levels of sodium excretion from SMU, although it is not suitable for estimating individual sodium excretion.
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http://dx.doi.org/10.1093/ajh/hpv037DOI Listing
November 2015

Design of radiation tolerant materials via interface engineering.

Adv Mater 2013 Dec 24;25(48):6975-9. Epub 2013 Sep 24.

Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.

A novel interface engineering strategy is proposed to simultaneously achieve superior irradiation tolerance, high strength, and high thermal stability in bulk nanolayered composites of a model face-centered-cubic (Cu)/body-centered-cubic (Nb) system. By synthesizing bulk nanolayered Cu-Nb composites containing interfaces with controlled sink efficiencies, a novel material is designed in which nearly all irradiation-induced defects are annihilated.
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http://dx.doi.org/10.1002/adma.201303400DOI Listing
December 2013

High-strength and thermally stable bulk nanolayered composites due to twin-induced interfaces.

Nat Commun 2013 ;4:1696

Materials Physics and Applications Division, Center for Integrated Nanotechnologies, MPA-CINT, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

Bulk nanostructured metals can attribute both exceptional strength and poor thermal stability to high interfacial content, making it a challenge to utilize them in high-temperature environments. Here we report that a bulk two-phase bimetal nanocomposite synthesised via severe plastic deformation uniquely possesses simultaneous high-strength and high thermal stability. For a bimetal spacing of 10 nm, this composite achieves an order of magnitude increase in hardness of 4.13 GPa over its constituents and maintains it (4.07 GPa), even after annealing at 500 °C for 1 h. It owes this extraordinary property to an atomically well-ordered bimaterial interface that results from twin-induced crystal reorientation, persists after extreme strains and prevails over the entire bulk. This discovery proves that interfaces can be designed within bulk nanostructured composites to radically outperform previously prepared bulk nanocrystalline materials, with respect to both mechanical and thermal stability.
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http://dx.doi.org/10.1038/ncomms2651DOI Listing
October 2013
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