Publications by authors named "Wei Yi"

1,051 Publications

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A new biomarker for the early diagnosis of gastric cancer: gastric juice- and serum-derived SNCG.

Future Oncol 2022 Aug 10. Epub 2022 Aug 10.

Precision Clinical Laboratory, Central People's Hospital of Zhanjiang, Zhanjiang, Guangdong, China.

To explore the possibility of gastric juice (GJ)- and serum-derived SNCG as a potential biomarker for the early diagnosis of gastric cancer (GC). GJ and serum samples were collected from 87 patients with GC, 38 patients with gastric precancerous lesions and 44 healthy volunteers. The levels of SNCG in GJ and serum samples were detected by ELISA. The levels of SNCG in GJ and serum were significantly higher in the GC group when compared with the GPL group or the control group. The expression of SNCG in GJ and serum was associated with tumor node metastasis stage, lymph node metastasis, tumor size and drinking, and it is important for the diagnosis and prognosis of GC (p < 0.05). The findings highlight the significance of SNCG in GC diagnosis and prognosis and implicate SNCG as a promising candidate for GC treatment.
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http://dx.doi.org/10.2217/fon-2022-0253DOI Listing
August 2022

The mechanism of efficient photoreduction nitrate over anatase TiO in simulated sunlight.

Chemosphere 2022 Aug 3;307(Pt 2):135921. Epub 2022 Aug 3.

Department of Environmental Engineering, Peking University, The Key Laboratory of Water and Sediment Sciences, Ministry of Education, Beijing, 100871, China. Electronic address:

Revealing the activation mechanism of nitrate (NO) reduction is crucially important to design high-efficiency photocatalysts for NO removal. In this work, the performance of photoreduction NO has been thoroughly studied over different crystalline phases TiO. Photodegradation rate of NO over anatase TiO is found to be higher than that of rutile TiO at simulated sunlight, which can achieve high NO conversion of 94% and 100% nitrogen selectivity (original concentration of 50 mg/L NO-N) at reaction time of 4 h. With the aid of in situ Fourier Transform Infrared (FTIR) and density functional theory (DFT) calculations, the possible reaction paths of photoreduction NO over anatase TiO was verified from theory and practice sides. NO was adsorbed on surface Ti site to form bridging nitrate (M - O)NO model. Then, monodentate nitrite (M-O-N-O) model was the dominant intermediate in the reduction process of NO. This study presents a new opinion of photoreduction NO reaction paths.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135921DOI Listing
August 2022

YciR, a Specific 3'-Phosphodiesterase, Plays a Role in the Pathogenesis of Uropathogenic CFT073.

Front Microbiol 2022 18;13:910906. Epub 2022 Jul 18.

National Engineering Research Center for Efficient Utilization of Soil and Fertilizer Resources, College of Resources and Environment, Shandong Agricultural University, Tai'an, China.

Urinary tract infections (UTIs), with the characteristics of recurrence and resistance to antibiotics due to misuse, remain a common health and economic issue for patients. Uropathogenic (UPEC), which is capable of evading the immune response by forming intracellular bacterial communities (IBCs) in the cytoplasm of bladder epithelial cells (BECs) after invasion, has been shown to be the prevailing cause of UTIs. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small molecule responsible for eliciting the innate immune response of the host only if it has not been degraded by some phosphodiesterases (PDEs), such as YciR. The relationship between YciR and c-di-GMP levels in UPEC is inconclusive. In this study, we investigated the gene expression profile of UPEC in BECs and identified as an upregulated gene. Western blot revealed that YciR enhanced the virulence of UPEC by inhibiting the phosphorylation of NF-κB. The expression of could be repressed by HupB in a directly binding manner. We identified YciR, a novel PDE, and defined its possible function in innate immune evasion. We also demonstrated that YciR is an HupB-dependent PDE that degrades c-di-GMP and that a low concentration of c-di-GMP might make NF-κB less phosphorylated, thereby reducing the host's pro-inflammatory response. This is the first time that YciR has been identified as a virulence factor in the pathogenesis of UPEC. These findings further increase our understanding of the pathogenesis of UPEC and provide a theoretical basis for further studies.
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http://dx.doi.org/10.3389/fmicb.2022.910906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339999PMC
July 2022

The Difference of Disease Injury and Postoperative Recovery in the Occupational Characteristics of Thoracolumbar Fracture Patients: A Retrospective Study.

Orthop Surg 2022 Aug 1. Epub 2022 Aug 1.

Department of Orthopaedic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Objectives: Understanding the occupational characteristics of patients is not only related to patients' life and health, but also conducive to improving their happiness. However, there were no studies that had been conducted on the relationship between occupation characteristic and postoperative recovery in patients with spinal fractures. The purpose of this study was to explore the relationship between the occupation characteristics of patients with thoracolumbar fracture and the characteristics of disease injury, treatment, and recovery so as to reduce the incidence and improve postoperative rehabilitation.

Methods: Patients (n = 719) with thoracolumbar fractures were recruited. Patients were grouped according to the characteristic of occupations: unemployed group (n = 299), white-collar worker group (n = 20), and blue-collar worker group (n = 400). Data were collected, including the characteristics, injury and treatment information, and the recovery records for 1 year after operation. One-way ANOVA analysis, χ test, and binary logistic regression analysis was used to explore the relationship among these factors.

Results: Male, high-falling injuries and single segment injury (mainly T 11, T 12 and L2) were common in patients with thoracolumbar fractures, especially in the blue-collar worker group (70.8%, 78.3%, and 85.4%). Compared with the unemployed group, the patients in the white-collar worker group and blue-collar worker group had a higher proportion of young patients, a higher height and weight, a lesser rate of hypertension or diabetes. One week after injury, 73.4% of patients underwent surgery, with the blue-collar worker group accounted for the largest proportion. One month after surgery, 77.1% of patients were able to get out of bed, with the white-collar worker group accounted for the largest proportion. In the postoperative recovery information, patients in the blue-collar worker group were more likely to have severe low back pain (OR = 2.023, 95% CI: 1.440-2.284) and pain-disturbed sleep (OR = 2.287, 95% CI: 1.585-3.299) than those who in the unemployed group.

Conclusions: Blue-collar workers, with a high risk of thoracolumbar fracture, have a higher incidence of low back leg pain and pain-disturbed sleep in the recovery after thoracolumbar fracture surgery, and this requires more attention.
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http://dx.doi.org/10.1111/os.13403DOI Listing
August 2022

Rh(III)-Catalyzed chemo-, regio- and stereoselective carboamination of sulfonyl allenes with -phenoxy amides or -enoxy imides.

Chem Commun (Camb) 2022 Jul 29. Epub 2022 Jul 29.

Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, P. R. China.

The Rh(III)-catalyzed chemo-, regio- and stereoselective carboamination of sulfonyl allenes has been realized by virtue of either -phenoxy amides or -enoxy imides simultaneously acting as the C- and N-sources, redox-neutral tandem C-H activation/allene insertion/oxidative addition/C-N bond formation for the direct construction of allylamine derivatives equipped with an α-quaternary carbon center. This protocol features high atom-economy with good substrate compatibility and exhibits profound synthetic potential for late-stage C-H modification of complex molecules.
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http://dx.doi.org/10.1039/d2cc02982kDOI Listing
July 2022

Structure-based analysis and rational design of human peroxiredoxin-1's C-terminus-derived peptides to target sulfiredoxin-1 in pancreatic cancer.

Biophys Chem 2022 09 18;288:106857. Epub 2022 Jul 18.

Suzhou QingYaQiRui Biotechonology Co. Ltd, Suzhou 215100, China.

Human peroxiredoxin (PRX) family of antioxidant enzymes reduces hydrogen peroxide and alkyl hydroperoxide involved in the redox signaling, among which the widely documented PRX1 is a versatile molecule regulating cell growth, differentiation and apoptosis, and has been implicated in the tumorigensis of pancreatic cancer. In this study, we systematically examined the complex crystal structure of PRX1 with its cognate interacting partner sulfiredoxin-1 (SRX1) at molecular level, and found that the PRX1-SRX1 association is a typical peptide-mediated protein-protein interaction, where a 18-mer C-terminal tail (CTT) segment of PRX1 was identified to be primarily responsible for the interaction, which contributes ~80% and ~ 55% to the total binding potency of SRX1 to PRX1 monomer and homodimer, respectively. We also demonstrated that the SRX1 exhibits a strong global selectivity for PRX1 CTT tail over other PRX family proteins. Next, the intermolecular interaction between PRX1 CTT tail and SRX1 was investigated at structural, energetic and dynamic levels, from which a 9-mer core region of PRX1 CTT tail was defined as the SRX1-binding hotspot. Biophysical assays substantiated that the CTT and CTTc peptides (out of PRX1 protein context) can bind in an independent manner and possess a close affinity to SRX1. Based on the CTTc sketch a computational combinatorial library consisting of 216 designed peptide derivatives was rationally generated, from which the top-5 hits were found to have comparable affinity with CTT peptide and improved affinity relative to CTTc peptide. They can be used as structurally reduced lead molecular entities to further develop new peptidic agents for therapeutic purpose to disrupt the native PRX1-SRX1 interaction by competing with PRX1 CTT tail for the peptide-binding pocket of SRX1.
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http://dx.doi.org/10.1016/j.bpc.2022.106857DOI Listing
September 2022

BmCDK5 Affects Cell Proliferation and Cytoskeleton Morphology by Interacting with BmCNN in .

Insects 2022 Jul 6;13(7). Epub 2022 Jul 6.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China.

The ordered cell cycle is important to the proliferation and differentiation of living organisms. Cyclin-dependent kinases (CDKs) perform regulatory functions in different phases of the cell cycle process to ensure order. We identified a homologous gene of the Cyclin-dependent kinase family, , in . BmCDK5 contains the STKc_CDK5 domain. The gene was highly expressed in S phase. Overexpression of the gene accelerates the process of the cell cycle's mitotic period (M) and promotes cell proliferation; knocking out the gene inhibited cell proliferation. Furthermore, we identified a protein, BmCNN, which can interact with BmCDK5 and represents the same express patterns as the gene in the cell cycle phase and the spatial-temporal expression of . This study revealed that BmCDK5 and BmCNN play roles in promoting cell proliferation and regulating cytoskeleton morphology, but do not induce expression changes in microtubule protein. Therefore, our findings provide a new insight; the gene has a regulatory effect on the cell cycle and proliferation of , which is presumably due to the interaction between BmCDK5 and BmCNN regulating changes in the cytoskeleton.
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http://dx.doi.org/10.3390/insects13070609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323621PMC
July 2022

Pallidus Stimulation for Chorea-Acanthocytosis: A Systematic Review and Meta-Analysis of Individual Data.

J Mov Disord 2022 Jul 26. Epub 2022 Jul 26.

Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.

A significant proportion of patients with chorea-acanthocytosis (ChAc) fail to respond to standard therapies. Recent evidence suggests that globus pallidus internus (GPi) deep brain stimulation (DBS) is a promising treatment option; however, reports are few and limited by sample sizes. We conducted a systematic literature review to evaluate the clinical outcome of GPi-DBS for ChAc. PubMed, Embase, and Cochrane Library databases were searched for relevant articles published before August 2021. The improvement of multiple motor and nonmotor symptoms was qualitatively presented. Improvements in the Unified Huntington's Disease Rating Scale motor score (UHDRS-MS) were also analyzed during different follow-up periods. A multivariate linear regression analysis was conducted to identify potential predictors of clinical outcomes. Twenty articles, including 27 patients, were eligible. Ninety-six percent of patients with oromandibular dystonia reported significant improvement. GPi-DBS significantly improved the UHDRS-motor score at < 6 months (p < 0.001) and ≥ 6 months (p < 0.001). The UHDRS-motor score improvement rate was over 25% in 75% (15/20 cases) of patients at long-term follow-up (≥ 6 months). The multiple linear regression analysis showed that sex, age at onset, course of disease, and preoperative movement score had no linear relationship with motor improvement at long-term follow-up (p > 0.05). GPi-DBS is an effective and safe treatment in most patients with ChAc, but no reliable predictor of efficacy has been found. Oromandibular dystonia-dominant patients might be the best candidates for GPi-DBS.
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http://dx.doi.org/10.14802/jmd.22003DOI Listing
July 2022

Advances in encapsulating gonadotropin-releasing hormone agonists for controlled release: a review.

J Microencapsul 2022 Jul 28:1-15. Epub 2022 Jul 28.

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China.

Gonadotropin-releasing hormone (GnRH) agonists are peptides consisting of nine or ten amino acid residues. GnRH agonists have been applied in the therapy of sexual hormone disorders like prostate cancer, endometriosis, uterine myoma, central precious puberty, and in-vitro fertility. Treatment is achieved by continuous hormone intake and long-term agonists administration, which is usually associated with poor patient compliance. Because GnRH agonists that are administered with the parenteral route are broken down by peptidase, their half-life is short. As a result, developing sustained release for the drug delivery system is significant. Even though some drugs have been successfully delivered with long-acting release microspheres and approved by the Food and Drug Administration (FDA), some challenges remain. This review highlighted current approaches to encapsulate GnRH agonists into delivery systems and strategies encountered during the loading process. Moreover, the following sections provide strategies to improve the release profile, and animal and human studies were summarised.
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http://dx.doi.org/10.1080/02652048.2022.2100934DOI Listing
July 2022

Efficient and Selective of CO2 Electroreduction to HCOOH over Bismuth-Based Bromide Perovskites in Acidic Electrolytes.

Chemistry 2022 Jul 19. Epub 2022 Jul 19.

Zhejiang Normal University, College of Chemistry and Life Sciences, Yingbin Road 688, 321004, jinhua, CHINA.

Metal halide perovskites, primarily used as optoelectronic devices, have not been applied for electrochemical conversion due to their insufficient stability in moisture. Herein, we demonstrate two bismuth-based perovskites as novel electrocatalysts to convert CO2 into HCOOH in aqueous acidic media (pH 2.5), exhibiting a high Faradaic efficiency for HCOOH of >80% in a wide potential range from -0.75 to -1.25 V. Their structural evolution against water were dynamically monitored by in situ spectra. Theoretical calculations further reveal that the formation of intermediate OCHO* on bismuth sites of Cs3Bi2Br9(111) play a pivotal role toward HCOOH production, which has a lower energy barrier than that on Cs2AgBiBr6(001) surfaces. Significantly, we found that CO2 react with protons instead of water can enhance CO2 reduction rate and suppress hydrogen evolution by avoiding carbonate formation in acidic electrolytes. This work paves the way for the extensive investigation of halide perovskites in aqueous systems.
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http://dx.doi.org/10.1002/chem.202201832DOI Listing
July 2022

Efficacy and safety of tenofovir disoproxil fumarate or telbivudine used throughout pregnancy for the prevention of mother-to-child transmission of hepatitis B virus: A cohort study.

Eur J Obstet Gynecol Reprod Biol 2022 Jul 14;276:102-106. Epub 2022 Jul 14.

Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China. Electronic address:

Objective: Tenofovir disoproxil fumarate (TDF) use compared with telbivudine (LdT) use throughout pregnancy has not been adequately investigated. To compare the efficacy and safety of TDF and LdT for the prevention of mother-to-child transmission (MTCT) of hepatitis B from highly viremic mothers throughout pregnancy in real-world settings.

Study Design: This was a single-center, retrospective cohort study. From January 1, 2013, to December 31, 2018, we retrospectively enrolled 602 mothers with chronic hepatitis B (CHB) who received antiviral treatment throughout pregnancy at Beijing Ditan Hospital. A total of 562 mothers met the inclusion criteria, with 167 in the TDF group and 395 in the LdT group. Mothers and infants were followed for 28 weeks postpartum. The primary endpoint was the MTCT rate of HBV. The secondary endpoints were the safety profiles in mothers and infants.

Results: The MTCT rates were 0 % in both the TDF and LdT groups. The rates of neonatal congenital abnormalities were similar between the TDF and LdT groups (1.2 % vs 1.8 %, P = 0.896). There were no significant differences in perinatal complications between the two groups (all P > 0.05). There were also no significant differences in gestational age or infant height, weight, Apgar score. The level of HBV DNA at 28 weeks postpartum was an independent risk factor for postpartum alanine aminotransferase (ALT) flares (OR = 2.348, 95 % CI: 1.100-5.016, P = 0.027).

Conclusion: TDF and LdT treatments throughout pregnancy in mothers with CHB were equally effective in preventing MTCT and safe.
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http://dx.doi.org/10.1016/j.ejogrb.2022.07.009DOI Listing
July 2022

SegGroup: Seg-Level Supervision for 3D Instance and Semantic Segmentation.

IEEE Trans Image Process 2022 22;31:4952-4965. Epub 2022 Jul 22.

Most existing point cloud instance and semantic segmentation methods rely heavily on strong supervision signals, which require point-level labels for every point in the scene. However, such strong supervision suffers from large annotation costs, arousing the need to study efficient annotating. In this paper, we discover that the locations of instances matter for both instance and semantic 3D scene segmentation. By fully taking advantage of locations, we design a weakly-supervised point cloud segmentation method that only requires clicking on one point per instance to indicate its location for annotation. With over-segmentation for pre-processing, we extend these location annotations into segments as seg-level labels. We further design a segment grouping network (SegGroup) to generate point-level pseudo labels under seg-level labels by hierarchically grouping the unlabeled segments into the relevant nearby labeled segments, so that existing point-level supervised segmentation models can directly consume these pseudo labels for training. Experimental results show that our seg-level supervised method (SegGroup) achieves comparable results with the fully annotated point-level supervised methods. Moreover, it outperforms the recent weakly-supervised methods given a fixed annotation budget. Code is available at https://github.com/antao97/SegGroup.
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http://dx.doi.org/10.1109/TIP.2022.3190709DOI Listing
July 2022

Surrogate Endpoints for Overall Survival in Immune-Oncology Trials of Advanced Gastro-Esophageal Carcinoma.

World J Oncol 2022 Jun 16;13(3):126-135. Epub 2022 Jun 16.

Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.

Background: We aimed to assess whether the Response Evaluation Criteria in Solid Tumors (RECIST)-based objective response rate (ORR), disease control rate (DCR) and progression-free survival (PFS) could serve as surrogate endpoints for overall survival (OS) in immune-oncology (IO) trials of advanced gastro-esophageal (GE) carcinoma.

Methods: Randomized controlled trials (RCTs) of IO that reported RECIST-based endpoints and OS in advanced GE carcinoma were screened. Surrogacy of endpoints for OS was assessed based on the correlation between endpoints with OS (arm-level), and between treatment effects on endpoints (trial-level). The correlations were quantified by Pearson correlation coefficient (R). Leave-one-out cross-validation was used to assess the prediction accuracy of surrogate model.

Results: Seventeen RCTs (9,657 subjects) with 20 comparisons were included. The correlations between DCR and OS were not strong at arm- (R = 0.80) and trial-levels (R = 0.45), but strong correlations between ORR (R = 0.91), PFS (R = 0.89) and OS at arm-level were observed. Treatment effect on ORR and PFS (both R = 0.71) was moderately correlated with treatment effect on OS. Leave-one-out cross-validation approach further validated the surrogacy of PFS. Our analysis showed that 3-month PFS could reliably predict 6-month OS, 6-month PFS could reliably predict 12-month OS, and 12-month PFS could reliably predict 18-month OS. The conservative minimum threshold effect of HR was 0.73.

Conclusions: PFS may be the appropriate surrogate for OS in IO trials of GE carcinoma. A conservative minimum threshold effect of HR ≤ 0.73 has the potential to predict a significant improvement in OS.
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http://dx.doi.org/10.14740/wjon1481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239497PMC
June 2022

Impact of Freeze-Thaw Cycles on the Long-Term Performance of Concrete Pavement and Related Improvement Measures: A Review.

Materials (Basel) 2022 Jun 29;15(13). Epub 2022 Jun 29.

College of Civil Engineering and Mechanics, Xiangtan University, Xiangtan 411105, China.

Freeze-thaw damage is one of the most severe threats to the long-term performance of concrete pavement in cold regions. Currently, the freeze-thaw deterioration mechanism of concrete pavement has not been fully understood. This study summarizes the significant findings of concrete pavement freeze-thaw durability performance, identifies existing knowledge gaps, and proposes future research needs. The concrete material deterioration mechanism under freeze-thaw cycles is first critically reviewed. Current deterioration theories mainly include the hydrostatic pressure hypothesis, osmolarity, and salt crystallization pressure hypothesis. The critical saturation degree has been proposed to depict the influence of internal saturation on freeze-thaw damage development. Meanwhile, the influence of pore solution salinity on freeze-thaw damage level has not been widely investigated. Additionally, the deterioration mechanism of the typical D-cracking that occurs in concrete pavement has not been fully understood. Following this, we investigate the coupling effect between freeze-thaw and other loading or environmental factors. It is found that external loading can accelerate the development of freeze-thaw damage, and the acceleration becomes more evident under higher stress levels. Further, deicing salts can interact with concrete during freeze-thaw cycles, generating internal pores or leading to crystalline expansion pressure. Specifically, freeze-thaw development can be mitigated under relatively low ion concentration due to increased frozen points. The interactive mechanism between external loading, environmental ions, and freeze-thaw cycles has not been fully understood. Finally, the mitigation protocols to enhance frost resistance of concrete pavement are reviewed. Besides the widely used air-entraining process, the freeze-thaw durability of concrete can also be enhanced by using fiber reinforcement, pozzolanic materials, surface strengthening, Super Absorbent Polymers (SAPs), and Phase Change Materials. This study serves as a solid base of information to understand how to enhance the freeze-thaw durability of concrete pavement.
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http://dx.doi.org/10.3390/ma15134568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267915PMC
June 2022

Efficient Xe selective separation from Xe/Kr/N mixtures over a microporous CALF-20 framework.

RSC Adv 2022 Jun 22;12(28):18224-18231. Epub 2022 Jun 22.

Marine Engineering College, Dalian Maritime University Dalian 116026 China

Capture and separation of xenon and krypton by adsorption are particularly important issues at room temperature in both industry and environmental security. Herein, hydrophobic zinc-based frameworks (CALF-20) were synthesized to separate mixtures of Xe, Kr and N, and adsorptive properties and stability of as-prepared samples were investigated in detail. CALF-20 with the 1,2,4-triazole and oxalate as the ligand and Zn metal centers showed a surface area of 442 m g and average pore size of 6-7 Å, and exhibited excellent stability in a high-temperature acidic solution. The single and binary adsorption datum represented that CALF-20 has a high Xe uptake of 2.45 mmol g and Xe/Kr selectivity of 13.2, as well as high Xe/N selectivity of 62 at 298 K and 1.0 bar. The initial adsorption heat and Henry's constant of Xe on the CALF-20 were determined to be 31.7 kJ mol and 21.77 mmol g bar by isotherms, indicating a suitable affinity for Xe capture and Xe/Kr separation. In addition, simulation results indicated that the simulated adsorption isotherms and adsorption heats are well-matched with experimental results, and the adsorption affinity from the C-H groups of 1,2,4-trizole ring for Xe is significantly stronger than that for Kr.
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http://dx.doi.org/10.1039/d2ra02768bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214609PMC
June 2022

Trends and risk factors of extended-spectrum beta-lactamase urinary tract infection in Chinese children: a nomogram is built and urologist should act in time.

Transl Pediatr 2022 Jun;11(6):859-868

Department of Urology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics Chongqing, Chongqing, China.

Background: To investigate the etiological characteristics and risk factors of extended-spectrum beta-lactamase (ESBL) urinary tract infection (UTI) and construct a corresponding nomogram to predict the probability of ESBL(+) UTI.

Methods: We retrospectively reviewed the records among patients experiencing UTI events in Chongqing Medical University Affiliated Children's Hospital from 1994 and 2019.

Results: A total of 854 patients with UTI were evaluated and ESBL-producing bacteria increased significantly. Significant potential risk factors of ESBL-UTI were congenital urological abnormalities, vesicoureteral reflux, neurologic disorder, age <12 months, fever and previous use of antibiotics. On logistic regression analysis, neurological disorder (OR =8, 95% CI: 1.845-34.695) and antibiotics administration in the last 3 months (OR =4.764, 95% CI: 3.114-7.289) were identified as an independent significant risk factor for ESBL-UTI. The nomogram generated was well calibrated for all predictions of ESBL+ probability, and the accuracy of the model nomogram measured by Harrell's C statistic (C-index) was 0.741.

Conclusions: The current situation of multiple bacterial antibiotic resistance has become a worrisome issue in UTI and early identification of ESBL production is important in terms of appropriate treatment and effective infection control. We may choose broad-spectrum antibiotics as empirical antibiotics for UTI among children with neurological disease and used antibiotic in the last three months.
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http://dx.doi.org/10.21037/tp-21-523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253944PMC
June 2022

Energy values evaluation and improvement of soybean meal in broiler chickens through supplemental mutienzyme.

Poult Sci 2022 Aug 28;101(8):101978. Epub 2022 May 28.

State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, 100193, China. Electronic address:

This study measured the metabolizable energy of soybean meal (SBM) and evaluated effects of soybean meal specific enzymes supplementation in corn-soybean diets on growth performance, intestinal digestion properties and energy values of 28-day-old broilers. A total of 336 one-day-old male AA broiler chickens were distributed to 7 groups in a completely random design. The birds were given 7 diets containing 6 diets with different combined soybean meals and a fasting treatment, 8 replicates per treatment and 6 birds per replicate (Trial 1). A total of 672 one-day-old male AA broiler chickens were randomly allocated to 7 dietary treatments including a control diet and 6 diets supplemented with 300 mg/kg α-galactosidase, 200 mg/kg β-mannanase, and 300 mg/kg protease individually or in combination (Trial 2). Apparent metabolizable energy (AME) of broilers was measured from d 25 to 27 in both trial 1 and trial 2. The results showed that AME values of combined soybean meals averaged 2,894 kcal/kg. Dietary β-mannanase and protease supplementation increased body weight gain (P < 0.05) during d 0 to 14, whereas did not affect the growth performance (P > 0.05) during d 14 to 28. Addition of β-mannanase in combination with other enzymes significantly increased lipase and trypsin content (P < 0.05) in ileum. In addition, dietary β-mannanase and protease supplementation individually or in combination enhanced trypsin enzyme content in jejunum (P < 0.05). The β-mannanase enzyme enhanced villus height and villus height to crypt depth ratio (P < 0.05) of ileum compared with control diet. Moreover, supplementation of enzyme except for protease enhanced raffinose and stachyose degradation ratio (P < 0.05). Dietary β-mannanase supplementation individually or in combination enhanced AME and AMEn values (P < 0.05). This study demonstrated that dietary enzyme supplementation especially β-mannanase improved intestinal digestion properties and contributed to high energy values.
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http://dx.doi.org/10.1016/j.psj.2022.101978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260631PMC
August 2022

PVA-integrated graphene oxide-attapulgite composite membrane for efficient removal of heavy metal contaminants.

Environ Sci Pollut Res Int 2022 Jul 2. Epub 2022 Jul 2.

Beijing Key Laboratory of Electrochemical Process and Technology for Materials, Beijing University of Chemical Technology, Beijing, 100029, China.

Graphene oxide (GO) is an excellent membrane-forming material with unique two-dimensional transport channels and excellent adsorption properties for heavy metal contaminants. However, swelling under cross-flow conditions and long-term water immersion leads to poor separation performances. To improve the stability of GO membrane materials, we propose a PVA-integrated graphene oxide/attapulgite membrane (GOAP) with a 3D microstructural arrangement of "brick-mortar-brick." The addition of PVA as mortar reinforces the strength of the structures via induced hydrogen bonding within the 3D water transport network. Furthermore, the AlO ceramic substrate pre-treated with (3-aminopropyl) triethoxysilane (APTES) provided high mechanical stability to the composite membrane, extending the membrane's stability beyond a month of immersion without swelling or shedding. The PVA-integrated GO/ATP composite membrane maintained a rejection rate of 99% for Cu solution (100 mg/L) in a 26-h continuous with nearly 100% rejection for various metals ions such as Cu, Ni, Pb, and Cd. The membrane exhibited a water flux of 20.7 L·m·h, which was 15.9-fold high than the pure GO membrane (GOM). The high water flux and heavy metal filtration rate with superior stability proved the practical suitability of the composite film for removing heavy metal ions.
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http://dx.doi.org/10.1007/s11356-022-20810-0DOI Listing
July 2022

Impact of in vitro fertilization-embryo transfer on mother-to-infant transmission in women with chronic HBV infection.

Liver Int 2022 Jun 27. Epub 2022 Jun 27.

Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Background And Aims: In vitro fertilization-embryo transfer (IVF-ET) may increase the risk of mother-to-child transmission (MTCT) of hepatitis B virus (HBV). The purpose of this study was to investigate the impact and safety of IVF-ET on MTCT in women with chronic HBV infection (CHB).

Methods: The data of 298 women who got pregnant by IVF-ET and their 375 children were collected retrospectively. Mothers were divided into the CHB group (n = 224) and the control group (HBsAg negative, n = 74). After birth, newborns were routinely vaccinated with the hepatitis B vaccine, and infants in the CHB group were injected with hepatitis B immunoglobulin within 2 h after birth. Demographic information, clinical data and laboratory test results were collected. The primary outcome measures were the MTCT rate of HBV, and the secondary outcome measures were the safety of the mother and infant.

Results: There was no case of HBV MTCT in all 282 newborns born in the CHB group and 93 neonates born in the control group. Of the two groups, the birth weight (3056.74 ± 601.65 vs. 2926.24 ± 704.86, P = .083), length (49.22 ± 1.97 vs. 48.74 ± 3.09, P = .167), 5-min Apgar score (9.97 ± 0.21 vs. 9.90 ± 0.51, P = .212), days of pregnancy (265.70 ± 12.73 vs. 262.02 ± 17.50, P = .064) and neonatal malformation rate (0.71% vs. 0, P = 1.000) were similar. Two cases of neonatal malformation occurred in the CHB group. The incidences of pregnancy and childbirth complications were similar between the two groups.

Conclusion: IVF-ET does not increase the risk of MTCT in women with chronic HBV infection, and it is safe for mothers and infants.
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http://dx.doi.org/10.1111/liv.15349DOI Listing
June 2022

Pathway of Cell Death and Its Role in Virus Infection.

Viral Immunol 2022 Jun 27. Epub 2022 Jun 27.

Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

The global pandemic of SARS-CoV-2 in the past 2 years has aroused great attention to infectious diseases, and emerging virus outbreaks have brought huge challenges to the global health system. Viruses are specific pathogens that completely rely on host cells for their own survival and disease transmission. At present, a growing number of studies have proved that inducing the death of virus-infected cells can prevent the spread of virus and promote disease recovery. Therefore, many ways to induce the death of infected cells are considered to be beneficial to host immunity. Cell death is a basic biological phenomenon. Programmed cell death (PCD), as an important part of the host's innate immune response, provides effective protection against virus transmission. Pyroptosis, apoptosis, and necroptosis are the most commonly studied pathways of PCD. Recent studies have found that three pathways of cell death can be activated during virus infection. More and more studies have shown the existence of extensive connections between PCDs, and this complex relationship is defined as PANoptosis, an inflammatory PCD pathway regulated by the PANoptosome complex, whose characteristics cannot be explained by any of the three PCD pathways. During viral infection, PANoptosis can promote inflammatory response by inducing the production of inflammatory cytokines and cell death to exert an antiviral mechanism. This article reviews the various effects of cell death pathways during viral infection and provides new ideas for clinical antiviral therapy and related immunotherapy.
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http://dx.doi.org/10.1089/vim.2022.0010DOI Listing
June 2022

Collaborative Action of Microglia and Astrocytes Mediates Neutrophil Recruitment to the CNS to Defend against K1 Infection.

Int J Mol Sci 2022 Jun 11;23(12). Epub 2022 Jun 11.

The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.

K1 is a leading cause of neonatal bacterial meningitis. Recruitment of neutrophils to the central nervous system (CNS) via local immune response plays a critical role in defense against K1 infection; however, the mechanism underlying this recruitment remains unclear. In this study, we report that microglia and astrocytes are activated in response to stimulation by K1 and/or K1-derived outer membrane vesicles (OMVs) and work collaboratively to drive neutrophil recruitment to the CNS. Microglial activation results in the release of the pro-inflammatory cytokine TNF-α, which activates astrocytes, resulting in the production of CXCL1, a chemokine critical for recruiting neutrophils. Mice lacking either microglia or TNF-α exhibit impaired production of CXCL1, impaired neutrophil recruitment, and an increased CNS bacterial burden. C-X-C chemokine receptor 2 (CXCR2)-expressing neutrophils primarily respond to CXCL1 released by astrocytes. This study provides further insights into how immune responses drive neutrophil recruitment to the brain to combat K1 infection. In addition, we show that direct recognition of K1 by microglia is prevented by the K1 capsule. This study also reveals that OMVs are sufficient to induce microglial activation.
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http://dx.doi.org/10.3390/ijms23126540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9223767PMC
June 2022

Urine Proteome in Distinguishing Hepatic Steatosis in Patients with Metabolic-Associated Fatty Liver Disease.

Diagnostics (Basel) 2022 Jun 7;12(6). Epub 2022 Jun 7.

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: In patients with metabolic-associated fatty liver disease (MAFLD), hepatic steatosis is the first step of diagnosis, and it is a risk predictor that independently predicts insulin resistance, cardiovascular risk, and mortality. Urine biomarkers have the advantage of being less complex, with a lower dynamic range and fewer technical challenges, in comparison to blood biomarkers.

Methods: Hepatic steatosis was measured by magnetic resonance imaging (MRI), which measured the proton density fat fraction (MRI-PDFF). Mild hepatic steatosis was defined as MRI-PDFF 5-10% and severe hepatic steatosis was defined as MRI-PDFF > 10%.

Results: MAFLD patients with any kidney diseases were excluded. There were 53 proteins identified by mass spectrometry with significantly different expressions among the healthy control, mild steatosis, and severe steatosis patients. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of these significantly changed urinary molecular features correlated with the liver, resulting in the dysregulation of carbohydrate derivative/catabolic/glycosaminoglycan/metabolic processes, insulin-like growth factor receptor levels, inflammatory responses, the PI3K-Akt signaling pathway, and cholesterol metabolism. Urine alpha-1-acid glycoprotein 1 (ORM1) and ceruloplasmin showed the most significant correlation with the clinical parameters of MAFLD status, including liver fat content, fibrosis, ALT, triglycerides, glucose, HOMA-IR, and C-reactive protein. According to ELISA and western blot (30 urine samples, normalized to urine creatinine), ceruloplasmin (ROC 0.78, = 0.034) and ORM1 (ROC 0.87, = 0.005) showed moderate diagnostic accuracy in distinguishing mild steatosis from healthy controls. Ceruloplasmin (ROC 0.79, = 0.028) and ORM1 (ROC 0.81, = 0.019) also showed moderate diagnostic accuracy in distinguishing severe steatosis from mild steatosis.

Conclusions: Ceruloplasmin and ORM1 are potential biomarkers in distinguishing mild and severe steatosis in MAFLD patients.
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http://dx.doi.org/10.3390/diagnostics12061412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9222194PMC
June 2022

Providing higher value care for hepatocellular carcinoma rather than diagnosis: What can current radiologists do?

World J Gastrointest Surg 2022 May;14(5):525-527

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Medical imaging is of great value for the comprehensive evaluation of hepatocellular carcinoma from diagnosis to prognosis, which contributes to optimal clinical management making.
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http://dx.doi.org/10.4240/wjgs.v14.i5.525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160683PMC
May 2022

Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway.

Ann Transl Med 2022 May;10(10):540

Department of Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: There is currently no effective treatment for vascular dementia (VaD). Scalp electroacupuncture (EA) has served clinically as an alternative treatment for VaD, but its mechanism is still unclear. In this study, we investigated the effect of EA at the Baihui (GV 20) and Shenting (GV 24) acupoints on spatial learning and memory ability, and the expression level of (), (), and postsynaptic density protein-95 (PSD-95) in the frontal cortex of VaD rats.

Methods: Male Sprague-Dawley rats were randomly divided into four groups, sham, VaD, non-acupuncture (non-AP) and EA group. The VaD model was established by permanent bilateral occlusion of the common carotid arteries. Morris Water Maze was used to assess the rats' spatial learning and memory. Immunochemistry (IHC), quantitative reverse transcription polymerase chain reaction (qRT-PCR), and western blot analysis were performed to detect the expression level of , , and PSD-95. Finally, luciferase assay was used to determine the effect of on expression in PC12 cells.

Results: The space exploration experiment of MWM showed the time and distance of the rat's activities around the platform were decreased in the EA group. Compared to the VaD and non-AP group, the number of terminal deoxynucleotidyl transferase-mediated dUDP nick-end labeling (TUNEL)-positive frontal cortical neurons was significantly decreased in EA group. The number of the PSD-95-positive cells and the expression level in the frontal cortical in the EA group was dramatically increased in comparison with the other groups. In the PC12 cell validation experiment, expression level was reduced under the condition of the mimic treatment, while increased in the inhibitor group. The PSD-95 protein level was up-regulated in the small interfering () group compared to the groups with or without oxygen/glucose deprivation/reperfusion (OGD/R) conditions (P<0.05). However, this was abolished by mimic.

Conclusions: In VaD rats, EA may improve spatial learning and memory through miR-81/IL-16/PSD-95 pathway.
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http://dx.doi.org/10.21037/atm-22-2068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201176PMC
May 2022

Detection of Genus and Three Important Species of Using Novel Genus- and Species-Specific Genes Identified by Large-Scale Comparative Genomic Analysis.

Front Microbiol 2022 2;13:885543. Epub 2022 Jun 2.

TEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, China.

The genus includes seven species; however, the strains of , , and were highly correlated with clinical infections. Rapid and reliable identification of these three species of is important in monitoring and controlling diseases caused by these bacteria. Here, we identified four pairs of novel marker genes for the genus, , , and based on large-scale comparative genomic analysis from 799 and 136,146 non- genomes, including 10 and eight , which are close relatives of . Duplex and multiplex PCR methods were established based on these newly identified marker genes. The reliability of duplex and multiplex PCR methods was validated with 74 and 90 non- strains. Strains of , , and could be detected accurately at both the genus and species level. Moreover, the newly developed methods enable us to detect 2.5 × 10 CFU/ml in pure culture. These data indicate that the accurate and sensitive established methods for can serve as valuable tools for the identification of these strains recovered from food, environmental, and clinical samples.
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http://dx.doi.org/10.3389/fmicb.2022.885543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201440PMC
June 2022

Consideration of the treatment of a case of adrenocortical sarcomatoid carcinoma.

Asian J Surg 2022 Jun 16. Epub 2022 Jun 16.

Department of Robotic Minimally Invasive Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, 610072, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2022.05.161DOI Listing
June 2022

Effects of organic fertilization on functional microbial communities associated with greenhouse gas emissions in paddy soils.

Environ Res 2022 Oct 14;213:113706. Epub 2022 Jun 14.

Wenzhou University, Wenzhou, Zhejiang Province, 325027, PR China.

Soil microbial communities play a key role in the biochemical processes and nutrient cycles of the soil ecosystem and their byproducts, including greenhouse gases (GHGs). Organic fertilization influences bacterial soil biodiversity and is an essential emission source of GHGs in paddy soil ecosystems. However, the impact of organic fertilization on the functional microorganisms associated with the GHGs methane and nitrous oxide remains unknown. We conducted paddy soil field experiments under three different treatments (no fertilization, base fertilization, and organic fertilization) to investigate the contribution of organic fertilization to soil nutrients and the functional microorganisms associated with GHG emissions. We found that organic fertilization effectively increased the soil organic matter (P < 0.001), soil organic carbon (P < 0.001), and total nitrogen (P < 0.05) as well as the richness (operational taxonomic units and abundance-based coverage estimators) of the methanogenic communities. Correlation analyses showed that methanogenic communities that were present in abundance were more vulnerable to perturbations in soil properties compared to nitrifying bacterial communities. Partial least squares path model analyses elucidated that organic fertilization directly affected both methanogenic communities and nitrifying bacterial communities (P < 0.05), thereby accelerating methane emissions. Strong co-occurrence networks were observed within the soil-dominant phyla Acidobacteria, Bacteroidetes, and Proteobacteria. Our findings highlight the impact of organic fertilization on soil nutrients and functional microorganisms and guide mitigating GHG emissions from paddy soil agroecosystems.
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http://dx.doi.org/10.1016/j.envres.2022.113706DOI Listing
October 2022

A New Creep-Fatigue Interaction Model for Predicting Deformation of Coarse-Grained Soil.

Materials (Basel) 2022 May 30;15(11). Epub 2022 May 30.

School of Civil Engineering, Central South University, Changsha 410075, China.

Studying the creep-fatigue interaction of the coarse-grained soil (CGS) is very important for safety assessment and disaster prevention in subgrade engineering. Current research work is mainly focused on single creep or fatigue deformation. In this paper, a new creep-fatigue interaction model is established to predict the creep-fatigue interaction deformation of different gradation CGS based on the rheological mechanics and the interactive relationship between creep and fatigue complex compliance method. Triaxial creep-fatigue interaction tests of different gradations CGS under different average stresses and frequencies were conducted to verify the new creep-fatigue interaction model. Research results show that for the creep-fatigue and fatigue-creep interaction, the fatigue deformation is always larger than the creep deformation under the same stress level. For the creep-fatigue multi-interaction, the second creep and fatigue deformation are always smaller than the first creep and fatigue deformation. The results of the triaxial creep-fatigue interaction tests verify the validity of this new model.
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http://dx.doi.org/10.3390/ma15113904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182435PMC
May 2022

Urinary Tract Tumor Organoids Reveal Eminent Differences in Drug Sensitivities When Compared to 2-Dimensional Culture Systems.

Int J Mol Sci 2022 Jun 4;23(11). Epub 2022 Jun 4.

Department of Urology, University Hospital, 72076 Tuebingen, Germany.

Generation of organoids from urinary tract tumor samples was pioneered a few years ago. We generated organoids from two upper tract urothelial carcinomas and from one bladder cancer sample, and confirmed the expression of cytokeratins as urothelial antigens, vimentin as a mesenchymal marker, and fibroblast growth factor receptor 3 by immunohistochemistry. We investigated the dose response curves of two novel components, venetoclax versus S63845, in comparison to the clinical standard cisplatin in organoids in comparison to the corresponding two-dimensional cultures. Normal urothelial cells and tumor lines RT4 and HT1197 served as controls. We report that upper tract urothelial carcinoma cells and bladder cancer cells in two-dimensional cultures yielded clearly different sensitivities towards venetoclax, S63845, and cisplatin. Two-dimensional cultures were more sensitive at low drug concentrations, while organoids yielded higher drug efficacies at higher doses. In some two-dimensional cell viability experiments, colorimetric assays yielded different IC toxicity levels when compared to chemiluminescence assays. Organoids exhibited distinct sensitivities towards cisplatin and to a somewhat lesser extent towards venetoclax or S63845, respectively, and significantly different sensitivities towards the three drugs investigated when compared to the corresponding two-dimensional cultures. We conclude that organoids maintained inter-individual sensitivities towards venetoclax, S63845, and cisplatin. The preclinical models and test systems employed may bias the results of cytotoxicity studies.
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http://dx.doi.org/10.3390/ijms23116305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181330PMC
June 2022

Deep Learning Using CT Images to Grade Clear Cell Renal Cell Carcinoma: Development and Validation of a Prediction Model.

Cancers (Basel) 2022 May 24;14(11). Epub 2022 May 24.

West China Hospital, Sichuan University, Chengdu 610000, China.

This retrospective study aimed to develop and validate deep-learning-based models for grading clear cell renal cell carcinoma (ccRCC) patients. A cohort enrolling 706 patients ( = 706) with pathologically verified ccRCC was used in this study. A temporal split was applied to verify our models: the first 83.9% of the cases (years 2010-2017) for development and the last 16.1% (year 2018-2019) for validation (development cohort: = 592; validation cohort: = 114). Here, we demonstrated a deep learning(DL) framework initialized by a self-supervised pre-training method, developed with the addition of mixed loss strategy and sample reweighting to identify patients with high grade for ccRCC. Four types of DL networks were developed separately and further combined with different weights for better prediction. The single DL model achieved up to an area under curve (AUC) of 0.864 in the validation cohort, while the ensembled model yielded the best predictive performance with an AUC of 0.882. These findings confirms that our DL approach performs either favorably or comparably in terms of grade assessment of ccRCC with biopsies whilst enjoying the non-invasive and labor-saving property.
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http://dx.doi.org/10.3390/cancers14112574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9179576PMC
May 2022
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