Publications by authors named "Wei Piao"

17 Publications

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[Eating out behavior and its impact on obesity among Chinese residents aged 18-59 in 2015].

Wei Sheng Yan Jiu 2021 May;50(3):395-400

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To study the eating out behavior and its impact on obesity among Chinese residents aged 18-59.

Methods: Multistage stratified random sampling method was used to collect data in 302 monitoring sites of the China National Chronic Non-communicable Disease and Nutrition Surveillance of adults in 31 provinces of China from 2015. A total of 53 887 subjects were included in this study by data cleaning. The population data published by the National Bureau of Statistics in 2010 were used as a standard population of the data result for 2015. Complex sampling weighting method was adopted in data analyses. The number and percentage of cases were used to describe the eating behaviors of different characteristics of the population, Statistical analysis was conducted by using SURVEYFREQ process, and Chi-square test was used to comparative analysis. Multi-factor analysis was conducted to the relationship between eating out frequency and different characteristics and obesity by using SURVEYLOGISTIC model regression.

Results: In 2015, proportions of eating out for all the three meals was 36. 1% of Chinese residents aged 18-59 in the past week, that of were 41. 3% and 24. 3% of Chinese residents aged 18-44 and 45-59, respectively. Proportions of Chinese residents was 12. 2% for eating out 1-6 times a week, 15. 8% for eating out 7-13 times a week, and 8. 1% for eating out 14-21 times a week. Results from the multivariate Logistic regression analysis showed that 18-44 years old, male, urban, highly educated, family per capita annual income ≥ 20 000 yuan, unmarried, on the job and school students chose to eat out more commonly. No statistical association was noticed between the frequency of eating out and obesity in women, men who ate out 14-21 times a week showed higher risk of obesity than those who not ate out, with OR=1. 8(95%CI 1. 3-2. 5).

Conclusion: Proportions of eating out increased for Chinese residents aged 18-59, men who ate out 14-21 times a week showed higher risk of obesity.
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http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.03.008DOI Listing
May 2021

[Intakes of energy and macronutrients in 6-11 years old age group in 2016-2017 in China].

Wei Sheng Yan Jiu 2021 May;50(3):389-394

National Institute for Nutrition and Health of China CDC, Key Laboratory of Trace Element Nutrition of National Health Commission of the People's Republic of China, Beijing 100050, China.

Objective: To survey the intakes of energy and macronutrients in 6-11 years old age group in 2016-2017 in China.

Methods: Multi-stage cluster randomization sampling method was used to collect the data from China Nutrition and Health Surveillance of Children and Lactating Mothers in 2016-2017 in 257 surveillance sites of 31 provinces. 24-h dietary recalls for three consecutive days were used to obtain the dietary information. The intakes of energy, protein, fat and carbohydrate were calculated by the China Food Composition, and the intakes of protein were assessing by Chinese Dietary Reference Intakes(DRIs).

Results: A total of 8777 children in 6-11(9. 2±1. 6) years old group were recruited in this surveillance, the number of boys and girls were 4364 and 4413, respectively. The general intakes of energy were 1591. 7 kcal and that of boys and girls were 1624. 1 kcal and 1559. 7 kcal, respectively. The energy intakes in urban children were higher than rural children. The energy intakes in the east region were the highest and the middle region were the lowest. The general protein intakes were 50. 0 g, and that of boys and girls were 50. 9 g and 49. 1 g, respectively. The intakes of protein in urban children were higher than in rural. The intakes of protein in east region were higher than that in the middle and west regions. The ratios that above RNI of protein intakes were 52. 4%, and the ratios of urban and rural were 63. 0% and 42. 9%, respectively. The general fat intakes were 69. 6 g and that of boys and girls were 71.4 g and 67.8 g, respectively. The fat intakes in urban children were higher than in rural, but in the rural of the west the fat intakes were higher than in the urban of the east. The general intakes of carbohydrate were 196. 3 g, and that of boys and girls were 199. 5 g and 193. 2 g, respectively. The carbohydrate intakes in urban children were higher than in rural, and in the west region the intakes of carbohydrate were higher than in the east region. But in the rural populations, the carbohydrate intakes in the west region were higher than that in the east region.

Conclusion: Comparing with 2010-2013, obvious changes of energy and macronutrients intakes in China 6-11 y children were observed in 2016-2017 surveillance. Inadequate intakes of protein were still the problem in rural children populations. The increase of fat intake was larger and more significant in the western region.
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http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.03.007DOI Listing
May 2021

[Status of undernutrition of left-behind children under 6 years old in rural China in 2013].

Wei Sheng Yan Jiu 2021 Mar;50(2):230-236

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To analyze and describe the status and characteristics of undernutrition among left-behind children under 6 years old in rural China in 2013.

Methods: Data was from the China Nutrition and Health Surveillance among 0-5 Years Old Children and Lactating Women in 2013. Stratified multistage cluster sampling method was used, and 4576 participants under 6 years old from 55 sites of 30 provinces, autonomous region and municipalities were involved. Definition of undernutrition were according to the WHO 2006 growth standard in children less than 5 years old and the WHO 2007 growth reference in children of 5 years old. Results were computed by post stratification weight based on national census from the National Bureau of Statistics in 2010.

Results: The prevalence of stunting was 10. 6% among left-behind children under 6 years old in rural China in 2013. It was 11. 6% in boys and 9. 4% in girls. The rate of general rural area and poor rural area were 7. 1% and 16. 6%. The prevalence of stunting showed a significant difference in sex(P=0. 022), general rural and poor rural(P=0. 006), three regions(P=0. 003), parental type of outing(P=0. 005), mother's education(P<0. 001), annual per capita household income(P<0. 001). The prevalence of underweight was 3. 2% among left-behind children under 6 years old in rural China in 2013. It was 3. 4% in boys and 2. 9% in girls. The rate of general rural area and poor rural area were 1. 6% and 2. 0%. The prevalence of stunting showed a significant difference in general rural and poor rural(P<0. 001), three regions(P<0. 001), annual per capita household income(P=0. 0144), mother's education(P<0. 001). The prevalence of wasting was 2. 3% among left-behind children under 6 years old in rural China in 2013. It was 2. 3% in boys and 2. 2% in girls. The rate of general rural area and poor rural area were 1. 5%, 3. 5%. The prevalence of stunting of general rural showed a significant difference in parental type of outing(P=0. 033), the prevalence of stunting of poor rural showed a significant difference in mother's education(P<0. 001), annual per capita household income(P=0. 020).

Conclusion: The undernutrition rate among left-behind children under the age of 6 in rural China should be paid attention, especially in the higher subgroups of poor rural areas, western regions, low-income families, mothers away from home and mothers with less than junior middle school education.
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http://dx.doi.org/10.19813/j.cnki.weishengyanjiu.2021.02.011DOI Listing
March 2021

[Association between the polymorphisms of TMPRSS6 and the levels of serum ferrtin and soluble transferrin receptor in pregnant women in Lüliang Area of Shanxi Province].

Wei Sheng Yan Jiu 2018 Nov;47(6):883-889

National Institute for Nutrition and Health China CDC, Key Laboratory of Trace Element Nutrition, National Health Commission of the People's Republic of China, Beijing 100050, China.

Objective: To analysis the associations between the polymorphisms of TMPRSS6 and the levels of serum ferritin( SF) and soluble transferrin receptor( s TfR) in pregnant women.

Methods: A total of 807 pregnant women were recruited by using cluster random sampling method from Lüliang in Shanxi Province in 2014. Roche Tinaquant immunoturbidimetric assay was used to measure the level of SF and s TfR, then iron deficiency( ID) was identified by the criteria of SF < 25 ng/m L and s TfR > 4. 4 mg/L, respectively. Sequenom MassArray was used to genotype the 7 targeted single-nucleotide polymorphisms( SNPs)( rs11704654, rs1421312, rs2111833, rs2235321, rs2543519, rs4820268 and rs855791) of the subjects. The t test and ANOVA analysis were used to test the different levels of SF and s TfR among SNPs, and chi-square test and Logistic regression were conducted to detect the associations between genotypes of each locus and ID.

Results: The differences of the levels of Ln SF between genotypes in rs2111833 were significant( F = 3. 57, P = 0. 0287), and the Ln SF level of T allele carrier group was lower than CC group( t = 2. 03, P = 0. 0429). The Ln SF level of A allele carrier group was lower than GG carrier group in rs855791( t = 1. 97, P = 0. 0490). For rs11704654, the ratio of SF < 25 ng/m L of T allele carriers was higher than CC carriers( χ~2= 4. 5456, P = 0. 0330). For rs211183, the ratio of SF < 25 ng/m L of T allele carriers was higher than CC carriers( χ~2= 4. 6431, P = 0. 0312). For rs855791, the ratio of SF < 25 ng/m L of GG carriers was lower than A allele carriers( χ~2= 5. 0134, P = 0. 0263). rs11704654( T) and rs855791( A) were still shown the association with SF < 25 ng/m L status in logistic analysis adjusted by age and gestational weeks. The Ln s TfR level of T allele carrier group in rs11704654 was higher than CC carrier group( t =-2. 012, P = 0. 024), and the Ln s TfR level of G allele carrier group in rs2543519 was higher than AA carrier group( t =-1. 954, P = 0. 011).

Conclusion: The associations between polymorphisms of TMPRSS6 and the levels of SF and s TfR are observed in pregnant women.
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November 2018

3D Numerical Simulation of a Z Gate Layout MOSFET for Radiation Tolerance.

Micromachines (Basel) 2018 Dec 14;9(12). Epub 2018 Dec 14.

Key Laboratory of RF Circuits and Systems, Ministry of Education, Hangzhou Dianzi University, Hangzhou 310018, China.

In this paper, for the first time, an n-channel metal-oxide-semiconductor field-effect transistor (NMOSFET) layout with a Z gate and an improved total ionizing dose (TID) tolerance is proposed. The novel layout can be radiation-hardened with a fixed charge density at the shallow trench isolation (STI) of 3.5 × 10 cm. Moreover, it has the advantages of a small footprint, no limitation in / design, and a small gate capacitance compared with the enclosed gate layout. Beside the Z gate layout, a non-radiation-hardened single gate layout and a radiation-hardened enclosed gate layout are simulated using the Sentaurus 3D technology computer-aided design (TCAD) software. First, the transfer characteristics curves (-) curves of the three layouts are compared to verify the radiation tolerance characteristic of the Z gate layout; then, the threshold voltage and the leakage current of the three layouts are extracted to compare their TID responses. Lastly, the threshold voltage shift and the leakage current increment at different radiation doses for the three layouts are presented and analyzed.
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http://dx.doi.org/10.3390/mi9120659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315489PMC
December 2018

[Meta-analysis on relationship between the Chinese maternal MTHFR gene polymorphism(C677T) and neural tube defects in offspring].

Wei Sheng Yan Jiu 2018 Mar;47(2):312-317

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To explore the association between maternal MTHFR gene polymorphism( C677T) and neural tube defects in offspring through Meta-analysis in China.

Methods: CNKI, Pub Med, Web of Science, Chinese Wan Fang Data databases, CBM, VIP for published articles were searched from the time of Database establishment to July 5 th 2017. The search strategy was based on combinations of the English and/or Chinese keywords, 'MTHFR'and 'folate pathway'and 'polymorphism'or 'SNP'and'NTDs or Neural Tube Defects'. References of reviews and retrieved studies were also scanned. All the case-control studies about MTHFR gene C677T polymorphism and susceptibility of neural tube defect were collected, which were fulfilled the followinginclusion criteria: case-control study and cohort study design, presentation of data necessary for calculating odds ratios( ORs). Data were extracted from studies and analyzed by Rev Man 5. 3 software.

Results: A total of 13 papers were selected, including1500 patients and 1654 controls. Meta-analysis result showed that the combined odds ratio values of neural tube defect for offspring with maternal TT, TT + CT and T allele genotypes were 1. 94, 1. 65 and 1. 39, respectively.

Conclusion: The present Meta-analysis suggests that MTHFR C677T is significantly associated with maternal risk for NTDs in the Chinese population, supplemental folic acid supplementation based on MTHFR polymorphisms will be an important means to further reduce the birth defects of newborns.
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March 2018

Effects of MTHFR A1298C polymorphism on peripheral blood folate concentration in healthy populations: a meta-analysis of observational studies.

Asia Pac J Clin Nutr 2018;27(3):718-727

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China.

Background And Objectives: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is the main form of folate used in the body. Previous studies suggest that MTHFR polymorphism influences folate metabolism, but conflicting results are reported. We performed a meta-analysis to accurately characterize the association between MTHFR A1298C polymorphism and peripheral blood folate concentration in healthy populations.

Methods And Study Design: Studies focusing on MTHFR A1298C polymorphism and folate concentrations were identified and subjected to a metaanalysis using Review Manager 5.1. Standard mean differences (SMD) with 95% confidence intervals (95% CI) were used to assess the association between these variables.

Results: A total of 14 studies with 5616 healthy individuals were included in this meta-analysis. Significant differences in folate concentration were found in the MTHFR homozygote model (SMD=0.12, 95% CI=0.00-0.24, I2=17%, p=0.04) and the dominant model (SMD=0.07, 95% CI=0.01-0.14, I2=22%, p=0.02) in the general population excluding the elderly. While abnormal folate concentrations are more common in elderly, no association between MTHFR A1298C polymorphism and peripheral blood folate concentration was found in the meta-analysis when elderly were included.

Conclusions: This meta-analysis indicates that, in the general population excluding the elderly, the C allele of MTHFR 1298 polymorphism is associated with the risk for an increased folate concentration.
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http://dx.doi.org/10.6133/apjcn.122017.02DOI Listing
September 2019

A single-nucleotide polymorphism in transferrin is associated with soluble transferrin receptor in Chinese adolescents.

Asia Pac J Clin Nutr 2017;26(6):1170-1178

Key Laboratory of Trace Element Nutrition of National Health and Family Planning Commission of the People's Republic of China, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China. Email:

Background And Objectives: Associations between genetic variants in the hepcidin regulation pathway and iron status have been reported in previous studies. Most of these studies were conducted in populations of European descent and relatively few studies have been conducted in Chinese populations. In this study, we evaluated associations between single-nucleotide polymorphisms (SNPs) in the hepcidin regulation pathway, serum ferritin (SF) and soluble transferrin receptor (sTfR) in Chinese adolescents.

Methods And Study Design: In total, 692 students from rural boarding schools were selected from six cities in China. The participants were divided into case and control groups according to criteria for SF and sTfR. Furthermore, 33 SNPs in TMPRSS6, TF, TFR2, BMP2, BMP4, HJV, CYBRD1, HFE, IL6, PCSK7, HAMP, KIAA1468, and SRPRB were selected. Associations between the genetic variants and SF or sTfR were detected.

Results: For SF, rs4820268 in TMPRSS6 was associated with an SF <25 ng/mL status. Carriers of the G/G genotype of rs4820268 exhibited significantly lower SF levels than A allele carriers did (p=0.047). For sTfR, rs1880669 in TF, rs4901474 in BMP4, and rs7536827 in HJV were significantly associated with an sTfR >=4.4 mg/L status. However, in general linear model analysis, after adjustment for age, sex, and location, only rs1880669 exhibited a stable association with higher sTfR levels (p=0.032).

Conclusions: We found rs4820268, in TMPRSS6 that was associated with a low SF level, as previously reported, and a new association between 1880669 in TF and sTfR.
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http://dx.doi.org/10.6133/apjcn.112016.04DOI Listing
August 2019

[Optimizing the detection of bovine milk β-Lactoglobulin with protein chip].

Wei Sheng Yan Jiu 2017 Jan;46(1):78-83

National Institute for Nutrition and Health, Chinese Center for Diease Control and Prevention, Beijing 100050, China.

Objective: To optimize the conditions of protein chip assay for bovine milk β-Lactoglobulin( β-Lg).

Methods: A microarrayer was used for printing anti-β-Lg as antibody I on each 3-dimensional-slide, another antis β-Lg antibody was used as detection antibody II and goat antibody coupled to Cy3 was used as antibody III. The standard β-Lg was detected by double antibody sandwich technique.

Results: Mouse monoclonal β-Lg antibody66# was chosen as the probe and contact printing as the printing method. The range between 42 and 92 spots was chosen as the basic printing condition. The concentration of β-Lg probes was 0. 5 mg / mL. The β-Lg detection antibody titre was 1∶2000. One percent no protein blocking solution was choosen as the blocking buffer. The lower detection limit and the biological detection limit of β-Lg were 17. 54 ng / m L and 55. 31 ng / m L respectively. The linear range was determined according to the S type curve of β-Lg and the best fitting models and standard curve were established for β-Lg( R~2=0. 9993).

Conclusion: The study optimizes conditions of a quantitative analysis system for measurement of β-Lg with protein chip, thus establishing the protein chip platform for quantitative detection of bovine milk β-Lactoglobulin.
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January 2017

[Iron status of first-year junior high school students in rural boarding school among nine provinces in China].

Wei Sheng Yan Jiu 2016 Nov;45(6):911-937

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To assess the iron status among boarding school students in a cross-sectional study performed in 9 provinces which were Beijing, Guangdong, Guangxi, Zhejiang, Tianjin, Ningxia, Sichuan, Shanghai and Shandong provinces.

Methods: A multi-stage cluster sampling survey on iron status of first-year junior high school students in rural boarding school in 9 provinces was used. Iron status was defined utilising biochemical indicators. Hemoglobin was measured by cyanmethemoglobin method. WS/T441-2013's hemoglobin thresholds used to define anemia. Immunoturbidimetric assay was used as analytical method for serum ferritin( SF), Serum soluble transferrin receptor( sTfR) and high sensitive C-reactive protein( hsCRP). BI was calculated by SF andsTfR. Storage iron depletion( SID) was defined as low SF( SF < 25 ng/mL) and low sTfR( sTfR < 4. 4 mg/L) without anemia. Iron deficient erythropoiesis( IDE) was defined as low SF( SF < 25 ng/mL) and high sTfR( sTfR > 4. 4 mg/L) without anemia. Iron deficiency anemia( IDA) was defined as low SF( SF < 25 ng/mL) with anemia. Subjects with indication of inflammation( hsCRP > 5 mg/L) were excluded from the analyses.

Results: A total of 1263 adolescents aged 10-18 years( 696 boys and 567 girls) were involved. The levels of hemoglobin, serum ferritin, sTfR and BI concentration were( 144. 6 ± 13. 2) g/L, 52. 2 ng/mL, 3. 34 mg/L and( 6. 72 ± 2. 61) mg/kg for students, respectively. The overall prevalence of anemia was 4. 8%. The percentage of iron deficiency was 10. 5%, significantly higher in girls compared with boys. The overall percentage of SID, IDE and IDA was 6. 6%, 2. 5% and 1. 4%, respectively, with significant differences between boys and girls.

Conclusion: To ensure adequate iron stores, specific attention should be given to girls to ensure that their dietary intake of iron is adequate.
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November 2016

[Survey and analysis of the intakes of energy and macronutrients in rural boarding school students].

Wei Sheng Yan Jiu 2016 May;45(3):414-9

Objective: To preliminarily survey the intakes of energy and macronutrients in rural boarding school students and analyse the affect factors of discrepancies between different sex and age groups.

Methods: A total of 1834 rural boarding junior high school first grade students were selected from 16 provinces, and stratified cluster sampling method was used. The method of weight recording and three days dietary recall were used to investigate the diet of boarding school students.

Results: The ratios which reached the EER of energy intakes in boy and girl groups were 37.0% and 46.7% (P < 0.05) respectively, and the proportion of the intakes level of EER among the age groups of 11y ~ and 14y ~ for both boys and girls were 93.4%, 81.1% (P < 0.05) and 102.1%, 87.1% (P < 0.05) respectively. The ratios which reached the EAR of protein intakes in boy and girl groups were 57.7% and 61.4% ( P > 0.05) respectively, and the proportion of the intakes level of EAR among the age groups of 11y ~ and 14y ~ for both boys and girls were 124.8%, 107.3% (P > 0.05) and 134.8%, 112.1% (P < 0.05) respectively. The ratios which reached the EAR of total carbohydrate intakes in boy and girl groups were 85.0% and 77.5% (P < 0.05) respectively, and the proportion of the intakes level of EAR among the age groups of 11y ~ and 14y ~ for both boys and girls were 202.0% and 240.0% (P < 0.05), 180.1% and 205.4% (P < 0.05 ) respectively. The ratios which reached the AMDR of total fat intakes in boy and girl groups were 25.4% and 22.0% (P > 0.05) respectively, and among the age groups of 11y ~ and 14y ~ for both boys and girls were 21.8% and 30.5% (P < 0.05), 20.2% and 25.5% (P > 0.05) respectively.

Conclusions: Double burden of nutrient might exist in the rural boarding schools. The status of nutrition could be improved evidently, by fulfilling the relative national policies, promoting the balance of the nutrition supplying in schools, and enriching the boarding students' knowledge of nutrition.
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May 2016

[Effects of the iron fortified soy sauce on improving students' anemia in boarding schools].

Wei Sheng Yan Jiu 2016 Mar;45(2):221-5

Objective: To evaluate the effect of iron fortified soy sauce on improving the anemia of boarding school students.

Methods: A total of 3029 students of the boarding schools in the 27 provinces in China including 1576 boys and 1453 girls were treat with the iron-fortified soy sauce for 12 months. The concentration of hemoglobin was detected before and after intervention. The statistical analysis was conducted to analyze the anemia rate and the hemoglobin concentration in boarding school students.

Results: After the intervention, the average hemoglobin of students were increased from 142.1 g/L to 146.5 g/L compared to the baseline. The boys average haemoglobin concentration increased 6.7 g/L, girls average haemoglobin concentration increased 1.9 g/L. They were significantly higher than those of the baseline (P < 0.001 ). The total anemia prevalence were significantly difference than the baseline (P < 0.001). Anemia among both boys and girls fell to 1.1% and 4.7% respectively.

Conclusion: Iron-fortified soy sauce could be effective for the improvement the hemoglobin level of boarding school students, reduce anemia prevalence of students significantly.
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March 2016

[Association of genetic polymorphisms in HjV-BMPs-SMADs pathway of hepcidin regulation with the incidence of anemia in Chinese adolescent aged 12 -18 years old].

Wei Sheng Yan Jiu 2016 Mar;45(2):173-8

Objective: To investigate the associations of the genetic polymorphisms in HjV-BMPs-SMADs pathway of hepcidin regulation with the incidence of anemia in Chinese adolescent.

Methods: 657 boarding school students aged 12 -18 were recruited by using cluster random sampling method from Chengdu Sichuan Province, Baicheng Jilin Province, Zhaoqing Guangdong Province, Puding Guizhou Province, Wenshang Shandong Province and Songyang Zhejiang Province. Cyanomethemoglobin determination test was used to measured the concentration of Hb, and then the subjects were classified by "Method for anemia screen" into corresponding groups. Magnetic heads for DNA extraction was selected, and 29 variants were genotyped by conducted by Sequenom MassArray. The Hb levels and anemia in different groups were compared with the genotype of each locus by chi-square test and t test aimed to study the associations between them.

Results: The risk of homozygote of T on rs173 107 to anemia was 5.80 times higher than homozygote of G (P < 0.05, OR = 5.80, 95% CI 1.34 - 25.04), and the concentrations of H b were (143.7 ± 14.6) g/L and (145.6 ± 12.0) g/L, respectively. The risk of heterozygote on rs855791 to anemia was 4.00 times higher than homozygote of A (P < 0.05, OR = 4.00, 95% CI 1.35 - 11.82), and the concentrations of Hb were (144.2 ± 14.8) g/L and 145.8 ± 12.0 g/L, respectively. The risk of G allele carriers was 3.68 times higher than homozygote of A (P < 0.05, OR = 3.68, 95% CI 1.27 - 10.66), and the concentrations of Hb were (144.3 ± 14.4) g/L and ( 145.8 ± 12.0) g/L, respectively. The levels of Hb among groups of the two loci were shown no different (P > 0.05), but the lowering trends were observed in the homozygote of T on rs173107 and G allele carriers on rs855791 groups.

Conclusion: Variants rs173107 and rs855791 in HjV-BMPs-SMADs pathway are associate with anemia in Chinese adolescent.
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March 2016

Social determinants of health behaviors in primary school children: A cross-sectional study of both migrant and resident children in Beijing, China.

J Huazhong Univ Sci Technolog Med Sci 2016 Apr 13;36(2):289-294. Epub 2016 Apr 13.

Department of Social Medicine and Health Education, School of Public Health, Peking University, Beijing, 100191, China.

Childhood risky behaviors always result in adverse health outcomes. These behaviors are greatly affected by social environment and individual factors. However, few studies explored the social determinants of schoolchildren's health behaviors. In this cross-sectional study, the social determinants of health behaviors were examined among both migrant and resident students in Beijing, China. Data of 967 children from six urban and suburban primary schools were analyzed using multiple linear regression analysis. The results showed that less than 60% of children performed some healthy behaviors, although their health knowledge was generally good. Children's health behavior scores were greatly determined by school characteristics, health knowledge, demographic characteristics, and family context. Therefore, improving health education and conditions in primary schools is the priority to promote children's healthy behaviors, especially for disadvantaged children.
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http://dx.doi.org/10.1007/s11596-016-1582-yDOI Listing
April 2016

Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han Population.

Birth Defects Res A Clin Mol Teratol 2016 Apr 22;106(4):232-9. Epub 2016 Mar 22.

Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.

Background: The polymorphism of genes involved in folate-mediated one-carbon metabolism may be a risk factor for neural tube defects (NTDs). In the present study, we aimed to investigate the single nucleotide polymorphisms (SNPs) of the genes BHMT, CUBN, FTCD, GAMT, GART, SARDH, SHMT1, and MUT, and their effect on NTDs in the Chinese Han population.

Methods: A total of 270 NTDs cases and 192 controls were enrolled in this study. The SNPs were analyzed with the next-generation sequencing method. The folate levels of brain tissues from 113 available NTDs cases and 123 available controls were measured.

Results: Next-generation sequencing identified 818 single nucleotide variants, including 214 SNPs used for further analysis. Statistical analysis showed that two independent SNP loci, rs2797840 and rs2073817 in SARDH, may be associated with the susceptibility of NTDs. Specifically, the minor allele G of rs2797840 was significantly associated with NTDs risk in spina bifida subgroup (p value = 0.0348). For subjects whose folate content was measured, the protective allele G of rs2797840 was significantly associated with increased folate content of brain. rs2797840 is within several ENCODE regulatory regions, indicating this SNPs may influence expression of SARDH.

Conclusion: The SNPs rs2797840 and rs2073817 in SARDH may serve as an indicator for the occurrence of NTDs in the Chinese Han population, and rs2797840 may also be an indicator for folate content of brain.
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http://dx.doi.org/10.1002/bdra.23478DOI Listing
April 2016

[Study of DHA algal oil compound preparation on improving memory in mice].

Wei Sheng Yan Jiu 2015 Jan;44(1):86-90

Objective: To investigate the effects of docosahexaenoic acid (DHA) algal oil compound preparation on improving memory in mice.

Methods: A total of 144 KM mice weighed 18 - 22 gram were classified into three groups randomized for the step - down test, passive avoidance test and water maze test respectively. For each test, we select 48 mice initially, then allocated the mice into 4 groups at random, each with 12 mice. According to the recommended dose of DHA algae oil soft capsule (600 mg/d) for human, each adult weight calculating on 60 kg meters, then we calibrate the dose to 50, 100 and 300 mg/kg BW (the equivalent doses of 5, 10 and 30 times to human) for three groups, respectively. The dose for intragastric injection administration is 10 ml/kg BW DHA algae oil, equivalent amount of edible vegetable oil for the control group, once per day for continuous 30 days. Just after the last lavage, we conduct the step - down test, passive avoidance test and water maze test respectively.

Results: DHA algal oil compound preparation has obvious effect on improving the reappearance ability of passive avoidance and the response of the avoiding darkness (P < 0.05). The indicators of water maze test were different statistically between DHA algal oil compound preparation groups and control group (P < 0.05).

Conclusion: DHA algal oil compound preparation may play an important role in memory improvement in mice.
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January 2015

[Effects of the SNPs on rs855791 and rs3811647 on the levels of SF and sTfR in the group of 8 - 14].

Wei Sheng Yan Jiu 2014 Nov;43(6):900-5

Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To investigate effects on the levels of SF and sTfR by the SNPs of rs855791 on TMPRSS6 and rs3811647 on TF in adolescent.

Methods: DNA was extracted from venous blood which were drawn from 50 subjects, and then the two SNPs of each sample were identified by Sequenom MassArray. T test and chi-square test were selected to identify the relationship between the levels of SF and sTfR in each allele carriers, and then the effects of each SNP on the levels of SF and sTfR would be assessed.

Results: The level of SF of A allele carriers on rs855791 (54.0 ± 28.2 ng/ml) was higher than GG carriers (33.1 ± 20.2 ng/ml) (P < 0.05), and the discrimination of the level of sTfR between each allele carrier was not observed. The discriminations of the different levels of SF and sTfR among each SNP on rs3811647 were not observed.

Conclusions: The level of SF may be affected by the SNP of rs855791 on TMPRSS6, and the effect of rs3811647 on TF may be weakened by the former one.
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November 2014