Publications by authors named "Waseem Qasim"

84Publications

CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells.

Commun Biol 2020 Jul 14;3(1):375. Epub 2020 Jul 14.

Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK.

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http://dx.doi.org/10.1038/s42003-020-1097-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360768PMC
July 2020

Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical Safety.

Mol Ther 2020 06 20;28(6):1422-1431. Epub 2020 Mar 20.

Université de Strasbourg, CNRS, INSERM, IGBMC, PHENOMIN-Institut Clinique de la Souris, Celphedia, Strasbourg 67404, France. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2020.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264426PMC
June 2020

'Mini' U6 Pol III promoter exhibits nucleosome redundancy and supports multiplexed coupling of CRISPR/Cas9 effects.

Gene Ther 2020 Sep 20;27(9):451-458. Epub 2020 Mar 20.

Molecular and Cellular Immunology Unit, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1038/s41434-020-0142-zDOI Listing
September 2020

Human Mesenchymal Stromal Cells Engineered to Express Collagen VII Can Restore Anchoring Fibrils in Recessive Dystrophic Epidermolysis Bullosa Skin Graft Chimeras.

J Invest Dermatol 2020 01 19;140(1):121-131.e6. Epub 2019 Jul 19.

Molecular and Cellular Immunology Unit, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jid.2019.05.031DOI Listing
January 2020

Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources.

Expert Rev Clin Immunol 2019 07 9;15(7):735-751. Epub 2019 May 9.

a Blood and bone marrow transplant unit , Great Ormond Street hospital , London , UK.

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http://dx.doi.org/10.1080/1744666X.2019.1612746DOI Listing
July 2019

New graft manipulation strategies improve the outcome of mismatched stem cell transplantation in children with primary immunodeficiencies.

J Allergy Clin Immunol 2019 07 4;144(1):280-293. Epub 2019 Feb 4.

Molecular and Cellular Immunology Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom; Blood and Bone Marrow Transplant Unit, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2019.01.030DOI Listing
July 2019

Allogeneic CAR T cell therapies for leukemia.

Authors:
Waseem Qasim

Am J Hematol 2019 05 1;94(S1):S50-S54. Epub 2019 Feb 1.

University College London, Great Ormond Street Institute of Child Health, London, United Kingdom.

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http://dx.doi.org/10.1002/ajh.25399DOI Listing
May 2019

One hundred percent survival after transplantation of 34 patients with Wiskott-Aldrich syndrome over 20 years.

J Allergy Clin Immunol 2018 11 25;142(5):1654-1656.e7. Epub 2018 Jul 25.

Blood and Marrow Transplant Unit, Great Ormond Street Hospital NHS Trust, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2018.06.042DOI Listing
November 2018

TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy.

JCI Insight 2018 07 12;3(13). Epub 2018 Jul 12.

Molecular and Cellular Immunology Unit, University College London (UCL) Great Ormond Street Institute of Child Health, London, United Kingdom.

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https://insight.jci.org/articles/view/99442
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http://dx.doi.org/10.1172/jci.insight.99442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124532PMC
July 2018

Multicenter phase 1/2 application of adenovirus-specific T cells in high-risk pediatric patients after allogeneic stem cell transplantation.

Cytotherapy 2018 06 9;20(6):830-838. Epub 2018 May 9.

Molecular and Cellular Immunology Section, Institute of Child Health, University College of London, London, United Kingdom; Department of Immunology, Great Ormond Street Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jcyt.2018.03.040DOI Listing
June 2018

Long Terminal Repeat CRISPR-CAR-Coupled "Universal" T Cells Mediate Potent Anti-leukemic Effects.

Mol Ther 2018 05 6;26(5):1215-1227. Epub 2018 Mar 6.

Molecular and Cellular Immunology Unit, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK; NIHR Great Ormond Street Hospital Biomedical Research Centre, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993944PMC
May 2018

Non-posttransplant lymphoproliferative disorder malignancy after hematopoietic stem cell transplantation in patients with primary immunodeficiency: UK experience.

J Allergy Clin Immunol 2018 06 7;141(6):2319-2321.e1. Epub 2018 Mar 7.

Children's Haemopoietic Stem Cell Transplant Unit, Great North Children's Hospital, Newcastle upon Tyne Hospital NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.02.038DOI Listing
June 2018

Umbilical cord blood transplantation without in vivo T-cell depletion for children with MHC class II deficiency.

J Allergy Clin Immunol 2018 06 31;141(6):2279-2282.e2. Epub 2018 Jan 31.

Departments of Immunology and Bone Marrow Transplant, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2017.10.051DOI Listing
June 2018

Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4 T-cell reconstitution.

Blood Adv 2017 Nov 2;1(24):2206-2216. Epub 2017 Nov 2.

Molecular and Cellular Immunology Section, University College London Institute of Child Health, London, United Kingdom.

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http://dx.doi.org/10.1182/bloodadvances.2017010827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737134PMC
November 2017

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.

J Allergy Clin Immunol 2018 03 11;141(3):1036-1049.e5. Epub 2017 Dec 11.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050203PMC
March 2018

Gene Modified T Cell Therapies for Hematological Malignancies.

Hematol Oncol Clin North Am 2017 10;31(5):913-926

Molecular and Cellular Immunology Unit, University college London, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2017.06.005DOI Listing
October 2017

Emerging applications of gene edited T cells for the treatment of leukemia.

Expert Rev Hematol 2017 09 25;10(9):753-755. Epub 2017 Jul 25.

a Molecular and Cellular Immunology Unit , Institute of Child Health , London , UK.

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http://dx.doi.org/10.1080/17474086.2017.1350575DOI Listing
September 2017

Genome-Edited T Cell Therapies.

Curr Stem Cell Rep 2017 18;3(2):124-136. Epub 2017 Apr 18.

Molecular Immunology Unit, UCL Great Ormond Street Institute of Child Health, University College London (UCL), 30 Guilford Street, London, WC1N 1EH UK.

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http://dx.doi.org/10.1007/s40778-017-0077-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445182PMC
April 2017

Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency.

J Allergy Clin Immunol 2017 02 15;139(2):634-642.e5. Epub 2016 Jul 15.

Infection, Immunity, Inflammation and Physiological Medicine, UCL Institute of Child Health, London, United Kingdom; Department of Clinical Immunology, Great Ormond Street Hospital NHS Trust, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.05.036DOI Listing
February 2017

Effect of stem cell source on long-term chimerism and event-free survival in children with primary immunodeficiency disorders after fludarabine and melphalan conditioning regimen.

J Allergy Clin Immunol 2016 10 20;138(4):1152-1160. Epub 2016 Apr 20.

Department of Blood and Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom; Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.01.053DOI Listing
October 2016

Autologous Transplantation of Amniotic Fluid-Derived Mesenchymal Stem Cells into Sheep Fetuses.

Cell Transplant 2016 03;25(3):615

Prenatal Cell and Gene Therapy Group, Institute for Women's Health, University College London, London, UK.

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http://dx.doi.org/10.3727/096368916X691006DOI Listing
March 2016

Lentiviral Engineered Fibroblasts Expressing Codon-Optimized COL7A1 Restore Anchoring Fibrils in RDEB.

J Invest Dermatol 2016 Jan;136(1):284-92

UCL Institute of Child Health, Molecular and Cellular Immunology Section & Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1038/JID.2015.364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759620PMC
January 2016

Engineered T cell therapies.

Expert Rev Mol Med 2015 Nov 4;17:e19. Epub 2015 Nov 4.

Molecular Immunology Unit,Institute of Child Health (ICH),University College London (UCL),30 Guilford Street,London WC1N 1EH,UK.

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http://dx.doi.org/10.1017/erm.2015.14DOI Listing
November 2015

Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells.

Blood 2015 Dec 8;126(26):2882-91. Epub 2015 Oct 8.

Molecular and Cellular Immunology Section, University College London Institute of Child Health, London, United Kingdom; Department of Bone Marrow Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2015-06-654780DOI Listing
December 2015

T cell receptor-therapy in HBV-related hepatocellularcarcinoma.

Oncoimmunology 2015 Jun 19;4(6):e1008354. Epub 2015 Mar 19.

Division of Infection & Immunity; Institute of Immunity & Transplantation; University College London ; London, UK.

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http://dx.doi.org/10.1080/2162402X.2015.1008354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485715PMC
June 2015

Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.

Brain 2015 Oct 29;138(Pt 10):2834-46. Epub 2015 Jun 29.

1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK 1 Mitochondrial Research Group, Genetics and Genomic Medicine, UCL Institute of Child Health, Guilford Street, London, UK.

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http://dx.doi.org/10.1093/brain/awv182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808733PMC
October 2015

Reply to: "To target or not to target viral antigens in HBV related HCC?".

J Hepatol 2015 Jun 21;62(6):1450-2. Epub 2015 Feb 21.

Program Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; Singapore Institute for Clinical Sciences, A(∗)STAR, Singapore; School of Immunity and Infection, College of Medical and Dental Science, University of Birmingham, Edgbaston Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.02.026DOI Listing
June 2015

Variable phenotype of severe immunodeficiencies associated with RMRP gene mutations.

J Clin Immunol 2015 Feb 8;35(2):147-57. Epub 2015 Feb 8.

Molecular and Cellular Immunology Section, Institute of Child Health, University College of London, London, UK,

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http://dx.doi.org/10.1007/s10875-015-0135-7DOI Listing
February 2015

Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient.

J Hepatol 2015 Feb 13;62(2):486-91. Epub 2014 Oct 13.

Singapore Institute for Clinical Sciences, A(∗)STAR, Singapore; Program Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; School of Immunity and Infection, College of Medical and Dental Science, University of Birmingham, Edgbaston Birmingham, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.10.001DOI Listing
February 2015

Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases.

Sci Rep 2014 Sep 18;4:6409. Epub 2014 Sep 18.

Research Dept. Cell and Gene Therapy, Clinic for Stem Cell Transplantation, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1038/srep06409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166709PMC
September 2014

"Darwinian" tumor-suppression model unsupported in clinical experience.

Mol Ther 2014 Sep;22(9):1562-3

Molecular and Cellular Immunology Unit, Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, London, UK.

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http://dx.doi.org/10.1038/mt.2014.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435491PMC
September 2014

Gene therapies for inherited skin disorders.

Semin Cutan Med Surg 2014 Jun;33(2):83-90

St John's Institute of Dermatology, King's College London (Guy's Campus), United Kingdom. Email:

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http://dx.doi.org/10.12788/j.sder.0085DOI Listing
June 2014

Progress and prospects for engineered T cell therapies.

Br J Haematol 2014 Sep 17;166(6):818-29. Epub 2014 Jun 17.

Molecular & Cellular Immunology, Institute of Child Health, University College London, London, UK; Great Ormond Street Hospital Trust, London, UK.

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http://dx.doi.org/10.1111/bjh.12981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282038PMC
September 2014

Gene therapy for primary immunodeficiencies: current status and future prospects.

Drugs 2014 Jun;74(9):963-9

Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1007/s40265-014-0223-7DOI Listing
June 2014

Gene therapy strategies to exploit TRIM derived restriction factors against HIV-1.

Viruses 2014 Jan 14;6(1):243-63. Epub 2014 Jan 14.

Centre for Gene Therapy, Institute of Child Health, University College London, London WC1N 1EH, UK.

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http://dx.doi.org/10.3390/v6010243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917441PMC
January 2014

Management of adenovirus in children after allogeneic hematopoietic stem cell transplantation.

Adv Hematol 2013 28;2013:176418. Epub 2013 Oct 28.

Molecular Immunology Unit, UCL Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UK.

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http://dx.doi.org/10.1155/2013/176418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830830PMC
November 2013

Management of adenovirus in children after allogeneic hematopoietic stem cell transplantation.

Adv Hematol 2013 28;2013:176418. Epub 2013 Oct 28.

Molecular Immunology Unit, UCL Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UK.

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http://dx.doi.org/10.1155/2013/176418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830830PMC
November 2013

How I treat severe combined immunodeficiency.

Blood 2013 Nov 10;122(23):3749-58. Epub 2013 Oct 10.

Centre for Immunodeficiency, Molecular Immunology Unit, University College London Institute of Child Health, London, United Kingdom; and.

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http://dx.doi.org/10.1182/blood-2013-02-380105DOI Listing
November 2013

22q11.2 deletion syndrome with life-threatening adenovirus infection.

J Pediatr 2013 Sep 6;163(3):908-10. Epub 2013 May 6.

Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jpeds.2013.03.070DOI Listing
September 2013

Clinical and immunological manifestations of patients with atypical severe combined immunodeficiency.

Clin Immunol 2011 Oct 30;141(1):73-82. Epub 2011 May 30.

Centre of Chronic Immunodeficiency, University Hospital Freiburg, Breisacher Str. 117, D-79106 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.clim.2011.05.007DOI Listing
October 2011

Autologous transplantation of amniotic fluid-derived mesenchymal stem cells into sheep fetuses.

Cell Transplant 2011 19;20(7):1015-31. Epub 2010 Nov 19.

Prenatal Cell and Gene Therapy Group, Institute for Women’s Health, University College London, London, UK.

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http://dx.doi.org/10.3727/096368910X543402DOI Listing
February 2012

Hybrid lentiviral vectors.

Mol Ther 2010 Jul 20;18(7):1263-7. Epub 2010 Apr 20.

Molecular Immunology Unit, Institute of Child Health, University College London, London, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S152500161631070
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http://dx.doi.org/10.1038/mt.2010.76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911257PMC
July 2010

Sleeping beauty transposition from nonintegrating lentivirus.

Mol Ther 2009 Jul 5;17(7):1197-204. Epub 2009 May 5.

Institute of Child Health, University College London, UK.

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http://dx.doi.org/10.1038/mt.2009.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835211PMC
July 2009

Update on clinical gene therapy in childhood.

Arch Dis Child 2007 Nov;92(11):1028-31

Molecular Immunology Unit, Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1136/adc.2006.108787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083628PMC
November 2007

Update on clinical gene therapy in childhood.

Arch Dis Child 2007 Nov;92(11):1028-31

Molecular Immunology Unit, Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1136/adc.2006.108787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083628PMC
November 2007

Capture and generation of adenovirus specific T cells for adoptive immunotherapy.

Br J Haematol 2007 Jan 8;136(1):117-26. Epub 2006 Nov 8.

Molecular Immunology Unit, Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1111/j.1365-2141.2006.06386.xDOI Listing
January 2007

RISC control for gene therapy.

Nat Biotechnol 2006 Jun;24(6):661-2

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http://dx.doi.org/10.1038/nbt0606-661DOI Listing
June 2006

Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene-transduced human T cells.

Blood 2005 Nov 14;106(9):3062-7. Epub 2005 Jul 14.

Department of Immunology and Molecular Pathology, University College London, Royal Free Hospital, Rowland Hill Street, London, NW3 2PF, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-01-0146DOI Listing
November 2005

Gene therapy for severe combined immune deficiency.

Expert Rev Mol Med 2004 Jul 2;6(13):1-15. Epub 2004 Jul 2.

Molecular Immunology Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1017/S1462399404007884DOI Listing
July 2004

Gene therapy for severe combined immune deficiency.

Expert Rev Mol Med 2004 Jul 2;6(13):1-15. Epub 2004 Jul 2.

Molecular Immunology Unit, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1017/S1462399404007884DOI Listing
July 2004