Warren J Strittmatter

Warren J Strittmatter

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Warren J Strittmatter

Warren J Strittmatter

Publications by authors named "Warren J Strittmatter"

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Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases.

Neurotherapeutics 2013 Jul;10(3):440-6

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 187-8502, Japan.

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http://dx.doi.org/10.1007/s13311-013-0184-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701761PMC
July 2013

Bathing the brain.

J Clin Invest 2013 Mar 22;123(3):1013-5. Epub 2013 Feb 22.

Department of Medicine (Neurology), Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1172/JCI68241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582153PMC
March 2013

The Aggregation Inhibitor Peptide QBP1 as a Therapeutic Molecule for the Polyglutamine Neurodegenerative Diseases.

J Amino Acids 2011 30;2011:265084. Epub 2011 Jun 30.

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan.

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https://www.hindawi.com/archive/2011/265084/
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http://dx.doi.org/10.4061/2011/265084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268222PMC
August 2012

Alzheimer’s disease: the new promise.

J Clin Invest 2012 Apr;122(4):1191

Department of Medicine and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314477PMC
http://dx.doi.org/10.1172/jci62745DOI Listing
April 2012

Medicine. Old drug, new hope for Alzheimer's disease.

Science 2012 Mar;335(6075):1447-8

Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1126/science.1220725DOI Listing
March 2012

Genome-wide scan of copy number variation in late-onset Alzheimer's disease.

J Alzheimers Dis 2010 ;19(1):69-77

Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA.

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http://dx.doi.org/10.3233/JAD-2010-1212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883723PMC
August 2010

Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice.

Neurobiol Aging 2007 Dec 16;28(12):1853-62. Epub 2006 Oct 16.

Neuroproteomics Laboratory, Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.08.011DOI Listing
December 2007

Optimization of a polyglutamine aggregation inhibitor peptide (QBP1) using a thioflavin T fluorescence assay.

Assay Drug Dev Technol 2007 Oct;5(5):629-36

Provid Pharmaceuticals, Inc., North Brunswick, NJ 08902, USA.

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http://dx.doi.org/10.1089/adt.2007.083DOI Listing
October 2007

High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL.

J Lipid Res 2007 Apr 30;48(4):806-15. Epub 2007 Jan 30.

Deane Laboratory, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1194/jlr.M600201-JLR200DOI Listing
April 2007

Phage display screening for peptides that inhibit polyglutamine aggregation.

Methods Enzymol 2006 ;413:253-73

Duke University Medical Center, Department of Medicine (Neurology) and Deane Laboratory, Durham, North Carolina, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790613014
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http://dx.doi.org/10.1016/S0076-6879(06)13014-1DOI Listing
November 2006

APOE2 allele increased in tardive dyskinesia.

Mov Disord 2006 Apr;21(4):540-2

Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1002/mds.20768DOI Listing
April 2006

Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria.

Biochem Biophys Res Commun 2006 Mar 13;341(2):607-13. Epub 2006 Jan 13.

Deane Laboratory, Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.01.007DOI Listing
March 2006

Apolipoprotein E and brain injury: implications for children.

Dev Med Child Neurol 2005 Jan;47(1):64-70

Department of Pediatrics, Kluge Children's Rehabilitation Center and Research Institute, University of Virginia, 2270 Ivy Rd, Charlottesville, VA 22903, USA.

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http://dx.doi.org/10.1017/s0012162205000113DOI Listing
January 2005

Disruption of the toxic conformation of the expanded polyglutamine stretch leads to suppression of aggregate formation and cytotoxicity.

Biochem Biophys Res Commun 2004 May;317(4):1200-6

Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, 2-2-B9 Yamadaoka, Suita, Osaka, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0400662
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http://dx.doi.org/10.1016/j.bbrc.2004.03.161DOI Listing
May 2004

APOE genotype-specific differences in human and mouse macrophage nitric oxide production.

J Neuroimmunol 2004 Feb;147(1-2):62-7

Division of Neurology and the Alzheimer's Disease Research Center, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2003.10.015DOI Listing
February 2004

ApoE genotype-specific inhibition of apoptosis.

J Lipid Res 2003 Aug 16;44(8):1566-73. Epub 2003 May 16.

Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1194/jlr.M300097-JLR200DOI Listing
August 2003

Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila.

Hum Mol Genet 2003 Jun;12(11):1253-9

Division of Functional Genomics, Department of Post-Genomics and Diseases, Osaka University Graduate School of Medicine, 2-2-B9 Yamadaoka, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1093/hmg/ddg144DOI Listing
June 2003

In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.

Arch Biochem Biophys 2003 Feb;410(1):1-6

Emory Center for Neurodegenerative Diseases, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Room 575, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/s0003-9861(02)00585-4DOI Listing
February 2003

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

Nat Neurosci 2002 Aug;5(8):731-6

Department of Neurology, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/nn884DOI Listing
August 2002

Expanded polyglutamine stretches form an 'aggresome'.

Neurosci Lett 2002 May;323(3):215-8

Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata 951-8181, Japan.

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http://dx.doi.org/10.1016/s0304-3940(02)00162-3DOI Listing
May 2002

Molecular biology of apolipoprotein E.

Curr Opin Lipidol 2002 Apr;13(2):119-23

Deane Laboratory, Division of Neurology, Duke Medical Center, Durham, North Carolina 27710, USA.

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April 2002