Prof. Volker H Haase, M.D./Dr.med. - Vanderbilt School of Medicine - Professor of Medicine, Cancer Biology and Molecular Physiology and Biophysics

Prof. Volker H Haase

M.D./Dr.med.

Vanderbilt School of Medicine

Professor of Medicine, Cancer Biology and Molecular Physiology and Biophysics

Nashville, TN | United States

Main Specialties: Internal Medicine

Additional Specialties: Renal Medicine, Internal Medicine

Prof. Volker H Haase, M.D./Dr.med. - Vanderbilt School of Medicine - Professor of Medicine, Cancer Biology and Molecular Physiology and Biophysics

Prof. Volker H Haase

M.D./Dr.med.

Introduction

Primary Affiliation: Vanderbilt School of Medicine - Nashville, TN , United States

Specialties:

Additional Specialties:

Research Interests:

Publications

70Publications

1092Reads

7Profile Views

4007PubMed Central Citations

The Endothelial Prolyl-4-Hydroxylase Domain 2/Hypoxia-Inducible Factor 2 Axis Regulates Pulmonary Artery Pressure in Mice.

Mol Cell Biol 2016 05 2;36(10):1584-94. Epub 2016 May 2.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Medicine and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1128/MCB.01055-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859687PMC
May 2016
57 Reads
22 Citations
4.780 Impact Factor

Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension.

Am J Physiol Lung Cell Mol Physiol 2016 Feb 4;310(3):L249-62. Epub 2015 Dec 4.

Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Veterans Affairs Medical Center, Nashville, Tennessee; and.

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http://dx.doi.org/10.1152/ajplung.00258.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838140PMC
February 2016
69 Reads
18 Citations
4.080 Impact Factor

Molecular mechanisms of ischemic preconditioning in the kidney.

Am J Physiol Renal Physiol 2015 Nov 26;309(10):F821-34. Epub 2015 Aug 26.

Departments of Medicine, Cancer Biology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee; and Medicine and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee.

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http://dx.doi.org/10.1152/ajprenal.00224.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652073PMC
November 2015
23 Reads
9 Citations

Inflammation and hypoxia in the kidney: friends or foes?

Authors:
Volker H Haase

Kidney Int 2015 Aug;88(2):213-5

1] Division of Nephrology and Hypertension, Departments of Medicine, Cancer Biology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [2] Medical and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/ki.2015.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534718PMC
August 2015
2 Reads
4 Citations
8.563 Impact Factor

Anaemia in kidney disease: harnessing hypoxia responses for therapy.

Nat Rev Nephrol 2015 Jul 9;11(7):394-410. Epub 2015 Jun 9.

Division of Nephrology and Hypertension, Vanderbilt University Medical Center, D-3100, Medical Center North, Nashville, TN 37232-2358, USA.

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http://dx.doi.org/10.1038/nrneph.2015.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497972PMC
July 2015
1 Read
29 Citations
8.542 Impact Factor

Muc1 is protective during kidney ischemia-reperfusion injury.

Am J Physiol Renal Physiol 2015 Jun 29;308(12):F1452-62. Epub 2015 Apr 29.

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

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http://ajprenal.physiology.org/content/ajprenal/early/2015/0
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http://ajprenal.physiology.org/content/ajprenal/308/12/F1452
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http://ajprenal.physiology.org/lookup/doi/10.1152/ajprenal.0
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http://dx.doi.org/10.1152/ajprenal.00066.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469889PMC
June 2015
25 Reads
8 Citations

Hypoxia-inducible factor signaling in the development of kidney fibrosis.

Authors:
Volker H Haase

Fibrogenesis Tissue Repair 2012 6;5(Suppl 1):S16. Epub 2012 Jun 6.

Division of Nephrology and Hypertension, Departments of Medicine, Molecular Physiology and Biophysics, and Cancer Biology, Vanderbilt School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1186/1755-1536-5-S1-S16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368791PMC
May 2015
3 Reads
15 Citations

A breath of fresh air for diabetic nephropathy.

Authors:
Volker H Haase

J Am Soc Nephrol 2015 Feb 2;26(2):239-41. Epub 2014 Sep 2.

Division of Nephrology and Hypertension, Departments of Medicine, Cancer Biology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, and Medicine and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee

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http://dx.doi.org/10.1681/ASN.2014080754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310668PMC
February 2015
1 Read
5 Citations
9.343 Impact Factor

Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy.

J Am Heart Assoc 2013 Dec 10;2(6):e000548. Epub 2013 Dec 10.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1161/JAHA.113.000548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886757PMC
December 2013
7 Reads
9 Citations
2.882 Impact Factor

Mechanisms of hypoxia responses in renal tissue.

Authors:
Volker H Haase

J Am Soc Nephrol 2013 Mar 18;24(4):537-41. Epub 2013 Jan 18.

Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, C-3119A, MCN, 1161 21st Avenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1681/ASN.2012080855DOI Listing
March 2013
28 Citations
9.343 Impact Factor

Regulation of erythropoiesis by hypoxia-inducible factors.

Authors:
Volker H Haase

Blood Rev 2013 Jan 3;27(1):41-53. Epub 2013 Jan 3.

Department of Medicine, Vanderbilt School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1016/j.blre.2012.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731139PMC
January 2013
3 Reads
82 Citations
5.570 Impact Factor

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis.

J Clin Invest 2012 Dec 1;122(12):4635-44. Epub 2012 Nov 1.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1172/JCI63924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533545PMC
December 2012
24 Reads
56 Citations
13.215 Impact Factor

Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia.

Kidney Int 2012 Oct 13;82(8):878-91. Epub 2012 Jun 13.

Department of Anesthesiology, Columbia University, New York, New York 10032-3784, USA.

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http://dx.doi.org/10.1038/ki.2012.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443517PMC
October 2012
14 Reads
11 Citations
8.563 Impact Factor

Renal cancer: oxygen meets metabolism.

Authors:
Volker H Haase

Exp Cell Res 2012 May 3;318(9):1057-67. Epub 2012 Mar 3.

Department of Medicine, Vanderbilt School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.yexcr.2012.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334413PMC
May 2012
12 Citations
3.250 Impact Factor

AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.

Cell Metab 2011 Apr;13(4):469-475

Division of Nephrology, Department of Medicine, Duke University and Durham, VA Medical Centers, Durham, NC 27710, USA; Cardiovascular and Metabolic Disorders Research Program, Duke-NUS Graduate Medical School, Singapore 169857. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2011.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070917PMC
April 2011
22 Reads
86 Citations
17.570 Impact Factor

Angiotensin II: breathtaking in the renal medulla.

Authors:
Volker H Haase

Kidney Int 2011 Feb;79(3):269-71

Division of Nephrology and Hypertension, Departments of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/ki.2010.434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621768PMC
February 2011
2 Reads
8.563 Impact Factor

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.

J Clin Invest 2010 Nov 18;120(11):4040-54. Epub 2010 Oct 18.

Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, New York, New York 10461, USA.

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http://dx.doi.org/10.1172/JCI43025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964979PMC
November 2010
25 Reads
116 Citations
13.215 Impact Factor

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

Blood 2010 Oct 13;116(16):3039-48. Epub 2010 Jul 13.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA.

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http://dx.doi.org/10.1182/blood-2010-02-270322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974609PMC
October 2010
21 Reads
83 Citations
10.452 Impact Factor

Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress.

Mol Cell Biol 2010 Oct 2;30(19):4595-603. Epub 2010 Aug 2.

Department of Radiation Oncology, Stanford University School of Medicine, 1235 CCSR, 269 Campus Drive, Stanford, CA 93025, USA.

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http://dx.doi.org/10.1128/MCB.01618-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950534PMC
October 2010
7 Reads
17 Citations
4.780 Impact Factor

HO-1 in control of a self-eating kidney.

J Am Soc Nephrol 2010 Oct 9;21(10):1600-2. Epub 2010 Sep 9.

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http://dx.doi.org/10.1681/ASN.2010080876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530623PMC
October 2010
1 Read
9.343 Impact Factor

Sirtuins and their relevance to the kidney.

J Am Soc Nephrol 2010 Oct 1;21(10):1620-7. Epub 2010 Jul 1.

Division of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1681/ASN.2010010046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527176PMC
October 2010
22 Reads
29 Citations
9.343 Impact Factor

The sweet side of HIF.

Authors:
Volker H Haase

Kidney Int 2010 Jul;78(1):10-3

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/ki.2010.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789845PMC
July 2010
2 Reads
8 Citations
8.563 Impact Factor

Hypoxic regulation of erythropoiesis and iron metabolism.

Authors:
Volker H Haase

Am J Physiol Renal Physiol 2010 Jul 5;299(1):F1-13. Epub 2010 May 5.

Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1152/ajprenal.00174.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904169PMC
July 2010
1 Read
60 Citations

Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.

J Am Soc Nephrol 2010 Jun 25;21(6):955-65. Epub 2010 Mar 25.

Department of Medicine, Division of Nephrology, Box 800133, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1681/ASN.2009060662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900956PMC
June 2010
34 Reads
38 Citations
9.343 Impact Factor

VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.

Am J Pathol 2010 May 9;176(5):2269-82. Epub 2010 Apr 9.

Department of Pathology and Laboratory Medicine, Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861092PMC
May 2010
3 Reads
9 Citations
4.591 Impact Factor

Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury.

J Am Soc Nephrol 2010 May 1;21(5):756-61. Epub 2010 Apr 1.

Department of Cellular Biology and Anatomy, Medical College of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1681/ASN.2009070718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865746PMC
May 2010
1 Read
84 Citations
9.343 Impact Factor

Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.

Carcinogenesis 2010 Mar 30;31(3):427-34. Epub 2009 Dec 30.

Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1093/carcin/bgp326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832548PMC
March 2010
18 Reads
27 Citations
5.334 Impact Factor

The VHL tumor suppressor: master regulator of HIF.

Authors:
Volker H Haase

Curr Pharm Des 2009 ;15(33):3895-903

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622710PMC
http://dx.doi.org/10.2174/138161209789649394DOI Listing
January 2010
2 Reads
17 Citations
3.452 Impact Factor

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

J Clin Invest 2009 Nov 5;119(11):3373-83. Epub 2009 Oct 5.

Division of Biology, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1172/JCI39378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769183PMC
November 2009
20 Reads
39 Citations
13.215 Impact Factor

Pathophysiological Consequences of HIF Activation: HIF as a modulator of fibrosis.

Authors:
Volker H Haase

Ann N Y Acad Sci 2009 Oct;1177:57-65

Departments of Medicine, Vanderbilt School of Medicine, Nashville, TN37232, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05030.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529330PMC
October 2009
2 Reads
28 Citations
4.313 Impact Factor

Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease.

Authors:
Volker H Haase

Kidney Int 2009 Sep 17;76(5):492-9. Epub 2009 Jun 17.

Department of Medicine, Vanderbilt University Medical Center, C-3119A, MCN, 1161 21stAvenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1038/ki.2009.222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623274PMC
September 2009
7 Reads
32 Citations
8.563 Impact Factor

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.

Mol Cell Biol 2009 Aug 15;29(16):4527-38. Epub 2009 Jun 15.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.00200-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725738PMC
August 2009
37 Reads
94 Citations
4.780 Impact Factor

Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.

Am J Physiol Renal Physiol 2008 Oct 30;295(4):F1023-9. Epub 2008 Jul 30.

First Department of Internal Medicine, Nara Medical University, 840 Shijo, Kashihara, Nara 634-8522, Japan.

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http://dx.doi.org/10.1152/ajprenal.90209.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250235PMC
October 2008
47 Reads
73 Citations

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.

Oncogene 2008 Sep 19;27(40):5354-8. Epub 2008 May 19.

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6144, USA.

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http://dx.doi.org/10.1038/onc.2008.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575082PMC
September 2008
25 Reads
54 Citations
8.460 Impact Factor

Hemoglobin in the kidney: breaking with traditional dogma.

Authors:
Volker H Haase

J Am Soc Nephrol 2008 Aug 9;19(8):1440-1. Epub 2008 Jul 9.

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http://dx.doi.org/10.1681/ASN.2008060594DOI Listing
August 2008
2 Citations
9.343 Impact Factor

Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.

Gastroenterology 2008 Jun 10;134(7):2036-48, 2048.e1-3. Epub 2008 Mar 10.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533811PMC
June 2008
8 Reads
64 Citations
16.720 Impact Factor

Hypoxia-inducible factor signaling in the development of tissue fibrosis.

Cell Cycle 2008 May 11;7(9):1128-32. Epub 2008 Feb 11.

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784650PMC
http://dx.doi.org/10.4161/cc.7.9.5804DOI Listing
May 2008
8 Reads
62 Citations

Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease.

PLoS Genet 2008 Apr 25;4(4):e1000061. Epub 2008 Apr 25.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291193PMC
April 2008
26 Reads
52 Citations

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition.

J Clin Invest 2007 Dec;117(12):3810-20

Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI30487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2082142PMC
December 2007
23 Reads
251 Citations
13.215 Impact Factor

Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease.

Am J Physiol Renal Physiol 2007 Oct 3;293(4):F1397-407. Epub 2007 Jul 3.

Renal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1152/ajprenal.00133.2007DOI Listing
October 2007
7 Reads
25 Citations

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

J Clin Invest 2007 Jul;117(7):1926-32

Molecular Biology Section, Division of Biological Sciences, UCSD School of Medicine, La Jolla, CA 92093-0377, USA.

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http://dx.doi.org/10.1172/JCI31370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884690PMC
July 2007
5 Reads
166 Citations
13.215 Impact Factor

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.

J Clin Invest 2007 Apr;117(4):1068-77

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6144, USA.

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http://dx.doi.org/10.1172/JCI30117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838939PMC
April 2007
2 Reads
171 Citations
13.215 Impact Factor

von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase.

Int J Oncol 2007 Feb;30(2):341-8

Division of Biological Sciences, University of California, San Diego, La Jolla 92093-0366, USA.

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February 2007
5 Reads
12 Citations
3.025 Impact Factor

Hypoxia-inducible factors in the kidney.

Authors:
Volker H Haase

Am J Physiol Renal Physiol 2006 Aug 22;291(2):F271-81. Epub 2006 Mar 22.

Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6144, USA.

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http://dx.doi.org/10.1152/ajprenal.00071.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232221PMC
August 2006
2 Reads
93 Citations

Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression.

J Am Soc Nephrol 2006 Jul 8;17(7):1875-85. Epub 2006 Jun 8.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1681/ASN.2005121371DOI Listing
July 2006
3 Reads
23 Citations
9.343 Impact Factor

Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo.

Blood 2006 Jul 9;108(1):123-33. Epub 2006 Mar 9.

Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1182/blood-2005-11-4458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895827PMC
July 2006
2 Reads
79 Citations
10.452 Impact Factor

The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.

Authors:
Volker H Haase

Semin Cell Dev Biol 2005 Aug-Oct;16(4-5):564-74. Epub 2005 Apr 26.

Department of Medicine, University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Boulevard, Philadelphia, PA 19104-6144, USA.

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http://dx.doi.org/10.1016/j.semcdb.2005.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787877PMC
July 2006
6 Reads
30 Citations
6.265 Impact Factor

pVHL function is essential for endothelial extracellular matrix deposition.

Mol Cell Biol 2006 Apr;26(7):2519-30

Molecular Biology Section, MC-0377, Division of Biological Sciences, University of California--San Diego, La Jolla, California 92093-0377, USA.

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http://dx.doi.org/10.1128/MCB.26.7.2519-2530.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430327PMC
April 2006
4 Reads
29 Citations
4.780 Impact Factor

Renal cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor.

Cancer Res 2006 Mar;66(5):2576-83

Department of Medicine and Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6144, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514875PMC
March 2006
15 Reads
130 Citations
9.330 Impact Factor

Protection of HIF-1-deficient primary renal tubular epithelial cells from hypoxia-induced cell death is glucose dependent.

Am J Physiol Renal Physiol 2005 Dec 26;289(6):F1217-26. Epub 2005 Jul 26.

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104-6144, USA.

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http://dx.doi.org/10.1152/ajprenal.00233.2005DOI Listing
December 2005
7 Reads
11 Citations

Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction.

Proc Natl Acad Sci U S A 2005 Nov 14;102(47):17071-6. Epub 2005 Nov 14.

Department of Medicine and Immunology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0506070102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287984PMC
November 2005
4 Reads
36 Citations
9.810 Impact Factor

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.

Mol Cell Biol 2005 Jun;25(11):4565-78

University of Pennsylvania School of Medicine, Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.25.11.4565-4578.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1140627PMC
June 2005
13 Reads
34 Citations
4.780 Impact Factor

Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice.

Mol Cell Biol 2005 Apr;25(8):3163-72

Department of Medicine, 700 Clinical Research Bldg., 415 Curie Blvd., Philadelphia, PA 19104-6144, USA.

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http://dx.doi.org/10.1128/MCB.25.8.3163-3172.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069599PMC
April 2005
10 Reads
58 Citations
4.780 Impact Factor

Inflammatory hypoxia: role of hypoxia-inducible factor.

Cell Cycle 2005 Feb 1;4(2):256-8. Epub 2005 Mar 1.

Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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February 2005
7 Reads
45 Citations

Hypoxic induction of Ctgf is directly mediated by Hif-1.

Am J Physiol Renal Physiol 2004 Dec 17;287(6):F1223-32. Epub 2004 Aug 17.

Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6144, USA.

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http://dx.doi.org/10.1152/ajprenal.00245.2004DOI Listing
December 2004
15 Reads
85 Citations

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.

Mol Cell Biol 2004 Oct;24(20):9038-47

Department of Medicine, 700 Clinical Research Building, 415 Curie Blvd., Philadelphia, PA 19104-6144, USA.

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http://dx.doi.org/10.1128/MCB.24.20.9038-9047.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517905PMC
October 2004
8 Reads
41 Citations
4.780 Impact Factor

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

J Clin Invest 2004 Oct;114(8):1098-106

Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1172/JCI21086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522241PMC
October 2004
46 Reads
197 Citations
13.215 Impact Factor

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

Development 2004 May;131(10):2497-508

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1242/dev.01138DOI Listing
May 2004
8 Reads
49 Citations
6.462 Impact Factor

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.

Mol Cell Biol 2003 Jul;23(14):4959-71

Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093-0366, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162224PMC
http://dx.doi.org/10.1128/mcb.23.14.4959-4971.2003DOI Listing
July 2003
5 Reads
50 Citations
4.780 Impact Factor

HIF-1alpha is essential for myeloid cell-mediated inflammation.

Cell 2003 Mar;112(5):645-57

Molecular Biology Section, Division of Biological Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480774PMC
http://dx.doi.org/10.1016/s0092-8674(03)00154-5DOI Listing
March 2003
130 Reads
519 Citations
32.242 Impact Factor