Publications by authors named "Valere Belle Mbou"

9 Publications

  • Page 1 of 1

Efficacy of rituximab in thymoma associated minimal change disease: case report.

BMC Nephrol 2021 Sep 7;22(1):303. Epub 2021 Sep 7.

CHU Limoges, Division of Nephrology, Limoges, France.

Background: Thymomas have been associated with a broad spectrum of autoimmune diseases. Minimal change disease (MCD) is the most frequent pathological lesion reported. Pathophysiological mechanisms involved in secondary MCD, and linking MCD to thymoma are not yet fully explained, although the hypothesis of T cell dysfunction has been suggested. The fundamental therapeutic principles are steroids and surgical treatment of thymoma, but failures and relapses often require immunosuppressant combinations.

Case Presentation: A 62-year-old female was admitted in our unit for a nephrotic syndrome associated with a thymoma. The diagnosis of thymoma associated MCD was confirmed by kidney biopsy. After surgical resection of the thymoma and steroid therapy, no remission was observed. Immunosuppressive therapy was then intensified with introduction of rituximab. Here, we report a steroid-resistant nephrotic syndrome secondary to MCD associated thymoma, which achieved complete remission after rituximab therapy. To the best of our knowledge, this is the first report of the use and efficacy of rituximab therapy in this pathology.

Conclusions: Our case report suggests that primary and secondary MCD may share similar pathophysiological mechanisms. It does not allow us to draw any conclusions about the mechanism of action of rituximab, but we believe this report argues for the safety and efficacy of rituximab use in thymoma-associated MCD, and therefore constitutes a rationale for future studies.
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http://dx.doi.org/10.1186/s12882-021-02479-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425126PMC
September 2021

Para-aortic Lymph Node Invasion in High-risk Endometrial Cancer: Performance of FDG PET-CT.

Anticancer Res 2019 Feb;39(2):619-625

Department of Gynecology and Obstetrics, University Hospital Center of Limoges, Limoges, France.

Aim: F-Fluorodeoxyglucose positron-emission tomography integrated with computed tomography (FDG PET-CT) is a non-invasive examination that could be helpful for the management of endometrial cancer. This study investigated the performance of FDG PET-CT in assessing para-aortic (PA) lymph-node involvement in high-risk endometrial cancer.

Materials And Methods: This was a retrospective, single-center study carried out between 2009 and 2018. The inclusion criteria were high-risk and locally advanced type 1 or 2 endometrial cancer with FDG PET-CT before PA lymphadenectomy.

Results: During the study period, among 142 patients with high-risk endometrial cancer, 35 patients (24.6%) underwent FDG PET-CT followed by PA lymphadenectomy. In 25% of cases, PA lymphadenectomy was not performed due to the discovery of metastasis. FDG PET-CT had a sensitivity of 50%, a specificity of 100%, a positive predictive value of 100%, a negative predictive value of 75%, accuracy of 80% and an area under the curve of 0.75 for the evaluation of PA involvement.

Conclusion: According to its high specificity in PA lymph-node evaluation, a positive PET scan might allow PA lymphadenectomy to be avoided.
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http://dx.doi.org/10.21873/anticanres.13155DOI Listing
February 2019

Nongenotoxic 3-Nitroimidazo[1,2-]pyridines Are NTR1 Substrates That Display Potent Antileishmanial Activity.

ACS Med Chem Lett 2019 Jan 19;10(1):34-39. Epub 2018 Dec 19.

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France.

Twenty nine original 3-nitroimidazo[1,2-]pyridine derivatives, bearing a phenylthio (or benzylthio) moiety at position 8 of the scaffold, were synthesized. evaluation highlighted compound as an antiparasitic hit molecule displaying low cytotoxicity for the human HepG2 cell line (CC > 100 μM) alongside good antileishmanial activities (IC = 1-2.1 μM) against , , and ; and good antitrypanosomal activities (IC = 1.3-2.2 μM) against and , in comparison to several reference drugs such as miltefosine, fexinidazole, eflornithine, and benznidazole (IC = 0.6 to 13.3 μM). Molecule , presenting a low reduction potential (° = -0.63 V), was shown to be selectively bioactivated by the type 1 nitroreductase (NTR1). Importantly, molecule was neither mutagenic (negative Ames test), nor genotoxic (negative comet assay), in contrast to many other nitroaromatics. Molecule showed poor microsomal stability; however, its main metabolite (sulfoxide) remained both active and nonmutagenic, making a good candidate for further studies.
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http://dx.doi.org/10.1021/acsmedchemlett.8b00347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331159PMC
January 2019

[An important pyloric wall thickening in an adult].

Ann Pathol 2015 Apr 9;35(2):190-2. Epub 2015 Mar 9.

Service de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.

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http://dx.doi.org/10.1016/j.annpat.2015.01.009DOI Listing
April 2015

[An unusual appendix lesion].

Ann Pathol 2014 Dec 13;34(6):486-9. Epub 2014 Nov 13.

Service de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; Université Paris Diderot, 10, rue Françoise-Dolto, 75205 Paris cedex 13, France; Inserm UMR-S-1165, HAYEM, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.

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http://dx.doi.org/10.1016/j.annpat.2014.09.009DOI Listing
December 2014

Infant Odontogenic Myxoma: a specific entity.

J Craniomaxillofac Surg 2014 Dec 12;42(8):2082-6. Epub 2014 Jan 12.

APHP (Head: Prof. Vazquez), Hôpital Necker Enfants Malades, Service de chirurgie Maxillofaciale, Paris 75015, France; Centre de références des malformations de la face et de la cavité buccale (Head: Prof. Vazquez), Paris 75015, France; Laboratoire de Physiopathologie orale et Moléculaire (Head: Prof. Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France; Université Paris VI, UFR médecine Pierre et Marie Curie, Paris 75005, France.

Introduction: In children, and specifically in infants, odontogenic myxomas are extremely rare. In infants, myxoma seems to display mostly the same clinical, radiological and pathological characteristics. This paper presents a series of odontogenic myxomas in infant patients.

Materials And Methods: Four infant patients were included in this retrospective study. The clinical, radiological and pathological presentation was characterized and the treatment analysed.

Results: All patients presented with a rapidly evolving paranasal swelling. CT-scan showed a maxillary homogeneous unilocular and intraosseous tumour. In all cases, pathological examination revealed a loose myxoid stroma within stellate and spindle shaped cells. All patients underwent conservative surgery through a vestibular approach.

Conclusion: This patient series and a review of the literature demonstrates that odontogenic myxoma is specific in infant. We propose the name of Infant Odontogenic Myxoma for this entity.
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http://dx.doi.org/10.1016/j.jcms.2013.07.019DOI Listing
December 2014

Specificity of paediatric jawbone lesions: tumours and pseudotumours.

J Craniomaxillofac Surg 2014 Mar 27;42(2):125-31. Epub 2013 May 27.

APHP, Hôpital Necker Enfant Malades (Head of the Department: Vazquez), Service de chirurgie maxillo-faciale, Paris F75015, France; Université Paris 5, UFR médecine Paris Descartes, Paris F75006, France; Centre de références des malformations de la face et de la cavité buccale (Head of the Department: Vazquez), France; Laboratoire de Physiopathologie orale et Moléculaire (Head of the Department: Berdal), INSERM, UMRS 872, Equipe 5, Centre de recherche des Cordeliers, Paris 75006, France.

Introduction: Characteristics and epidemiology of jaw tumours have been described mostly in adults. Compared with their adult counterparts, childhood jaw tumours show considerable differences. The aim of this study was to describe the different jaw tumours in children, define diagnostic tools to determine their specificity and describe optimal treatment.

Methods: All children patients with jaw lesions, excluding cysts, apical granuloma and osteitis were included in our study between 1999 and 2009. The medical records were analyzed for clinical, radiological, and pathological findings, treatments and recurrences.

Results: Mean patient age was 10.9 years old, ranging from 2 months to 18 years old. Of the 63 lesions, 18 were odontogenic and 45 non-odontogenic lesions. 6% of all cases were malignant tumours; the mean age of presentation was 7.25 years old, [ranging from 0.2 to 18 years old]. Approximately 80% of the tumours developed after 6 years of age. Odontogenic tumours occurred more often after the age of 6.

Conclusion: Compared with their adult counterpart, childhood jaw tumours show considerable differences in their clinical behaviour and radiological and pathological characteristics. Clinical features of some tumours can be specific to children. Tumourigenesis is related to dental development and facial growth. Conservative treatment should be considered.
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http://dx.doi.org/10.1016/j.jcms.2013.03.007DOI Listing
March 2014

Advocacy for renal biopsy based on two cases of mixed epithelial and stromal tumour.

Urol Int 2014 25;92(1):116-8. Epub 2013 May 25.

Departments of Urology and Pathology, CHU Saint-Louis, APHP, Paris, France.

We report 2 cases of mixed epithelial and stromal tumours revealed by flank pain in a 56-year-old woman and by a renal biopsy in another asymptomatic woman. A greater awareness among urologists and radiologists of the features of mixed epithelial and stromal tumours could help evoke this diagnosis preoperatively leading to needle biopsy and to the most appropriate type of renal surgery.
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http://dx.doi.org/10.1159/000348749DOI Listing
September 2014

[A particular form of pyelonephritis].

Ann Pathol 2012 Jun 18;32(3):237-8. Epub 2012 May 18.

Service d'anatomie pathologique, hôpital Saint-Louis, AP-HP, 1 avenue Claude-Vellefaux, Paris cedex 10, France.

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http://dx.doi.org/10.1016/j.annpat.2012.01.005DOI Listing
June 2012
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