Tyler Jacks

Tyler Jacks

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Tyler Jacks

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Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation.

Proc Natl Acad Sci U S A 2019 Aug 13;116(35):17460-17469. Epub 2019 Aug 13.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1904253116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717259PMC
August 2019

Intercepting Pancreatic Cancer: Our Dream Team's Resolve to Stop Pancreatic Cancer.

Pancreas 2018 Nov/Dec;47(10):1175-1176

Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN.

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http://dx.doi.org/10.1097/MPA.0000000000001165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193263PMC
March 2019

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

Cell 2019 02 31;176(5):998-1013.e16. Epub 2019 Jan 31.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.12.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691977PMC
February 2019

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.

Cancer Metab 2018 31;6. Epub 2018 May 31.

1David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.

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https://cancerandmetabolism.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40170-018-0179-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977456PMC
May 2018

Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer.

Nano Lett 2018 04 21;18(4):2195-2208. Epub 2018 Mar 21.

Koch Institute for Integrative Cancer Research at MIT , 500 Main Street , Cambridge , Massachusetts 02139 , United States.

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http://dx.doi.org/10.1021/acs.nanolett.7b04043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957485PMC
April 2018

Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells.

Cancer Res 2018 02 26;78(4):985-1002. Epub 2017 Dec 26.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-2129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837062PMC
February 2018

Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.

Nat Protoc 2018 02 4;13(2):217-234. Epub 2018 Jan 4.

The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2017.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145089PMC
February 2018

Survival of pancreatic cancer cells lacking KRAS function.

Nat Commun 2017 10 23;8(1):1090. Epub 2017 Oct 23.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41467-017-00942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653666PMC
October 2017

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.

Cell 2017 Sep;170(6):1149-1163.e12

Stem Cell Program and Divisions of Hematology/Oncology and Pulmonary & Respiratory Diseases, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607351PMC
September 2017

Driving Rel-iant Tregs toward an Identity Crisis.

Authors:
Amy Li Tyler Jacks

Immunity 2017 09;47(3):391-393

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.08.014DOI Listing
September 2017

PKM2, cancer metabolism, and the road ahead.

EMBO Rep 2016 12 17;17(12):1721-1730. Epub 2016 Nov 17.

David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

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http://dx.doi.org/10.15252/embr.201643300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5283597PMC
December 2016

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers.

Nat Commun 2016 09 2;7:12685. Epub 2016 Sep 2.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue 75-453, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncomms12685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025814PMC
September 2016

A U.S. "Cancer Moonshot" to accelerate cancer research.

Science 2016 Sep 7;353(6304):1105-6. Epub 2016 Sep 7.

Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1126/science.aai7862DOI Listing
September 2016

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Science 2016 09;353(6304):1161-5

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaf5171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245791PMC
September 2016

Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

Cell Metab 2016 08 28;24(2):324-31. Epub 2016 Jul 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367626PMC
August 2016

BIOMEDICAL ENGINEERING. Capitalizing on convergence for health care.

Science 2016 Jun;352(6293):1522-3

Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.aag2350DOI Listing
June 2016

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Genes Dev 2016 05 28;30(9):1020-33. Epub 2016 Apr 28.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.278549.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863734PMC
May 2016

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis.

Cell 2016 May;165(4):896-909

Center for Epigenetics and Metabolism, INSERM Unit 904, Department of Biological Chemistry, University of California, Irvine (UCI), Irvine, CA 92697, USA. Electronic address:

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https://www.researchgate.net/profile/Thales_Papagiannakopoul
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http://www.cell.com/cell/pdf/S0092-8674(16)30482-2.pdf
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http://dx.doi.org/10.1016/j.cell.2016.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373476PMC
May 2016

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Cell Metab 2016 Mar 4;23(3):517-28. Epub 2016 Feb 4.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(16)00041-
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http://linkinghub.elsevier.com/retrieve/pii/S155041311600041
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http://dx.doi.org/10.1016/j.cmet.2016.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785096PMC
March 2016

Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development.

Cancer Discov 2016 Feb 19;6(2):188-201. Epub 2015 Nov 19.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/content/early/2016/0
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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-15-0854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744583PMC
February 2016

A Modular Assembly Platform for Rapid Generation of DNA Constructs.

Sci Rep 2016 Feb 18;6:16836. Epub 2016 Feb 18.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/srep16836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757859PMC
February 2016

Recombinase-based conditional and reversible gene regulation via XTR alleles.

Nat Commun 2015 Nov 5;6:8783. Epub 2015 Nov 5.

Department of Cancer Biology, Abramson Family Cancer Research Institute and Perelman School of Medicine at the University of Pennsylvania, 421 Curie Boulevard, 751 Biomedical Research Building II/III, Philadelphia, Pennsylvania 19004, USA.

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http://dx.doi.org/10.1038/ncomms9783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635517PMC
November 2015

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

Immunity 2015 Sep 1;43(3):579-90. Epub 2015 Sep 1.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826619PMC
September 2015

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Genes Dev 2015 Sep;29(17):1850-62

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.267393.115
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http://dx.doi.org/10.1101/gad.267393.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573857PMC
September 2015

Applications of the CRISPR-Cas9 system in cancer biology.

Nat Rev Cancer 2015 Jul 4;15(7):387-95. Epub 2015 Jun 4.

1] David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA. [2] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrc3950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530801PMC
July 2015

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature.

Nano Lett 2015 May 2;15(5):3008-16. Epub 2015 Apr 2.

†Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

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http://dx.doi.org/10.1021/nl5048972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825876PMC
May 2015

A versatile reporter system for CRISPR-mediated chromosomal rearrangements.

Genome Biol 2015 May 28;16:111. Epub 2015 May 28.

RNA Therapeutics Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA.

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http://dx.doi.org/10.1186/s13059-015-0680-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465146PMC
May 2015

The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.

J Thorac Oncol 2015 Apr;10(4):553-64

*Hamon Center for Therapeutic Oncology Research and Department of Pathology, UT Southwestern Medical Center, Dallas, TX; †Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX; ‡Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands; §Departments of Pediatrics and Genetics, Stanford University, Stanford, CA; ‖Center for Cancer Research, National Cancer Institute, Bethesda, MD; ¶Division of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; #David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142; **Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY; and ††Departementd'Anatomie et Cytologie Pathologiques, INSERM Unit 823, Centre Hospitalier Universitaire Albert Michallon, and Institut Albert Bonniot University, Grenoble, France.

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http://dx.doi.org/10.1097/JTO.0000000000000459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523224PMC
April 2015

Rapid modelling of cooperating genetic events in cancer through somatic genome editing.

Nature 2014 Dec 22;516(7531):428-31. Epub 2014 Oct 22.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature13906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292871PMC
December 2014

CRISPR-mediated direct mutation of cancer genes in the mouse liver.

Nature 2014 Oct 6;514(7522):380-4. Epub 2014 Aug 6.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [3] Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature13589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199937PMC
October 2014

Autophagy is required for glucose homeostasis and lung tumor maintenance.

Cancer Discov 2014 Aug 29;4(8):914-27. Epub 2014 May 29.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey. Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125614PMC
August 2014

Small RNA combination therapy for lung cancer.

Proc Natl Acad Sci U S A 2014 Aug 11;111(34):E3553-61. Epub 2014 Aug 11.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139; Departments of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1412686111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151750PMC
August 2014

KRAS and YAP1 converge to regulate EMT and tumor survival.

Cell 2014 Jul 19;158(1):171-84. Epub 2014 Jun 19.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110062PMC
July 2014

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Nat Biotechnol 2014 Jun 30;32(6):551-3. Epub 2014 Mar 30.

1] David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [3] Harvard-MIT Division of Health Sciences & Technology, Cambridge, Massachusetts, USA. [4] Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157757PMC
June 2014

LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint.

Mol Cell 2014 Jun 22;54(5):777-90. Epub 2014 May 22.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103188PMC
June 2014

A conditional system to specifically link disruption of protein-coding function with reporter expression in mice.

Cell Rep 2014 Jun 12;7(6):2078-86. Epub 2014 Jun 12.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5324, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305-5456, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113058PMC
June 2014

Strategies to achieve conditional gene mutation in mice.

Cold Spring Harb Protoc 2014 Apr 1;2014(4):339-49. Epub 2014 Apr 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://dx.doi.org/10.1101/pdb.top069807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142476PMC
April 2014

Whole-mount X-Gal staining of mouse tissues.

Cold Spring Harb Protoc 2014 Apr 1;2014(4):417-9. Epub 2014 Apr 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://www.cshprotocols.org/lookup/doi/10.1101/pdb.prot07345
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http://dx.doi.org/10.1101/pdb.prot073452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169236PMC
April 2014

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.

Proc Natl Acad Sci U S A 2014 Apr 7;111(16):E1600-9. Epub 2014 Apr 7.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142.

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http://dx.doi.org/10.1073/pnas.1404357111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000830PMC
April 2014

Producing and concentrating lenti-Cre for mouse infections.

Cold Spring Harb Protoc 2014 Mar 1;2014(3):304-6. Epub 2014 Mar 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://dx.doi.org/10.1101/pdb.prot073437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169239PMC
March 2014

In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation.

Cold Spring Harb Protoc 2014 Mar 1;2014(3):307-9. Epub 2014 Mar 1.

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129;

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http://dx.doi.org/10.1101/pdb.prot073445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169259PMC
March 2014

Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.

Cell 2014 Mar;156(6):1298-1311

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040459PMC
March 2014

A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo.

Cell Rep 2013 Nov 14;5(4):868-77. Epub 2013 Nov 14.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962842PMC
November 2013

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Authors:
David B Agus Jenolyn F Alexander Wadih Arap Shashanka Ashili Joseph E Aslan Robert H Austin Vadim Backman Kelly J Bethel Richard Bonneau Wei-Chiang Chen Chira Chen-Tanyolac Nathan C Choi Steven A Curley Matthew Dallas Dhwanil Damania Paul C W Davies Paolo Decuzzi Laura Dickinson Luis Estevez-Salmeron Veronica Estrella Mauro Ferrari Claudia Fischbach Jasmine Foo Stephanie I Fraley Christian Frantz Alexander Fuhrmann Philippe Gascard Robert A Gatenby Yue Geng Sharon Gerecht Robert J Gillies Biana Godin William M Grady Alex Greenfield Courtney Hemphill Barbara L Hempstead Abigail Hielscher W Daniel Hillis Eric C Holland Arig Ibrahim-Hashim Tyler Jacks Roger H Johnson Ahyoung Joo Jonathan E Katz Laimonas Kelbauskas Carl Kesselman Michael R King Konstantinos Konstantopoulos Casey M Kraning-Rush Peter Kuhn Kevin Kung Brian Kwee Johnathon N Lakins Guillaume Lambert David Liao Jonathan D Licht Jan T Liphardt Liyu Liu Mark C Lloyd Anna Lyubimova Parag Mallick John Marko Owen J T McCarty Deirdre R Meldrum Franziska Michor Shannon M Mumenthaler Vivek Nandakumar Thomas V O'Halloran Steve Oh Renata Pasqualini Matthew J Paszek Kevin G Philips Christopher S Poultney Kuldeepsinh Rana Cynthia A Reinhart-King Robert Ros Gregg L Semenza Patti Senechal Michael L Shuler Srimeenakshi Srinivasan Jack R Staunton Yolanda Stypula Hariharan Subramanian Thea D Tlsty Garth W Tormoen Yiider Tseng Alexander van Oudenaarden Scott S Verbridge Jenny C Wan Valerie M Weaver Jonathan Widom Christine Will Denis Wirtz Jonathan Wojtkowiak Pei-Hsun Wu

Sci Rep 2013 ;3:1449

Center for Applied Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1038/srep01449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636513PMC
October 2013

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.

Cancer Discov 2013 Sep 3;3(9):993-1001. Epub 2013 Jun 3.

1Department of Pediatrics and 2Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California; 3Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, 4Department of Biology, David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts; 5Department of Pathology, Institute for Genomics and Systems Biology, 6Ben May Department for Cancer Research, 7Section of Hematology/Oncology and Comprehensive Cancer Center, University of Chicago, Chicago, Illinois; 8Department of Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan; and 9Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770749PMC
September 2013

Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.

Cancer Discov 2013 Aug 29;3(8):908-21. Epub 2013 May 29.

Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston , MA 02115, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743121PMC
August 2013

Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma.

Genes Dev 2013 Jul;27(14):1557-67

David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.222745.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731545PMC
July 2013

Characterizing deformability and surface friction of cancer cells.

Proc Natl Acad Sci U S A 2013 May 22;110(19):7580-5. Epub 2013 Apr 22.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1218806110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651488PMC
May 2013

Genetically engineered mouse models of cancer reveal new insights about the antitumor immune response.

Curr Opin Immunol 2013 Apr 4;25(2):192-9. Epub 2013 Mar 4.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.coi.2013.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910114PMC
April 2013

Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma.

Mol Cell 2013 Apr 21;50(2):185-99. Epub 2013 Mar 21.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721642PMC
April 2013

Immunology. Guilty by association.

Science 2013 Mar;339(6124):1160-1

Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1235528DOI Listing
March 2013

SnapShot: Lung cancer models.

Cell 2012 Mar;149(1):246-246.e1

MIT, Cambridge, MA 02139, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674120034
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http://dx.doi.org/10.1016/j.cell.2012.03.015DOI Listing
March 2012

Optimality in the development of intestinal crypts.

Cell 2012 Feb;148(3):608-19

Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cell.2011.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696183PMC
February 2012

Expression of tumour-specific antigens underlies cancer immunoediting.

Nature 2012 Feb 8;482(7385):405-9. Epub 2012 Feb 8.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature10803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288744PMC
February 2012

Treating metastatic cancer with nanotechnology.

Nat Rev Cancer 2011 Dec 23;12(1):39-50. Epub 2011 Dec 23.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrc3180DOI Listing
December 2011

Single-molecule transcript counting of stem-cell markers in the mouse intestine.

Nat Cell Biol 2011 Nov 27;14(1):106-14. Epub 2011 Nov 27.

Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncb2384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292866PMC
November 2011

Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer.

Mol Cancer Res 2011 Oct 1;9(10):1339-45. Epub 2011 Aug 1.

Helen Diller Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196775PMC
October 2011

Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma.

Cancer Discov 2011 Aug 16;1(3):236-47. Epub 2011 Jun 16.

Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160630PMC
August 2011

Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.

Cancer Res 2011 Jun 21;71(11):4040-7. Epub 2011 Apr 21.

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160277PMC
June 2011

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.

Proc Natl Acad Sci U S A 2011 May 9;108(21):8773-8. Epub 2011 May 9.

Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1105941108
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http://dx.doi.org/10.1073/pnas.1105941108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102385PMC
May 2011

Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.

Mol Cell Biol 2011 Apr 31;31(7):1565-76. Epub 2011 Jan 31.

Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1128/MCB.01122-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135291PMC
April 2011

Targeting cancer: an interview with Tyler Jacks. Interview by Kathy Weston.

Authors:
Tyler Jacks

Dis Model Mech 2010 Nov-Dec;3(11-12):672-5. Epub 2010 Oct 12.

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http://dx.doi.org/10.1242/dmm.006882DOI Listing
February 2011

Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression.

Cancer Cell 2011 Jan;19(1):72-85

Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069809PMC
January 2011

Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy.

Proc Natl Acad Sci U S A 2010 Nov 10;107(48):20786-91. Epub 2010 Nov 10.

The Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1011409107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996428PMC
November 2010

Stage-specific sensitivity to p53 restoration during lung cancer progression.

Nature 2010 Nov;468(7323):572-5

Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/doifinder/10.1038/nature09535
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http://dx.doi.org/10.1038/nature09535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003305PMC
November 2010

HIF-2alpha deletion promotes Kras-driven lung tumor development.

Proc Natl Acad Sci U S A 2010 Aug 21;107(32):14182-7. Epub 2010 Jul 21.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1001296107
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http://dx.doi.org/10.1073/pnas.1001296107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922515PMC
August 2010

Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras.

Proc Natl Acad Sci U S A 2010 Jun 17;107(22):10184-9. Epub 2010 May 17.

Koch Institute for Integrative Cancer Research and Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1004796107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890471PMC
June 2010