Publications by authors named "Torben Aagaard"

2 Publications

  • Page 1 of 1

Assessment of radiation doses to the para-aortic, pelvic, and inguinal lymph nodes delivered by image-guided adaptive brachytherapy in locally advanced cervical cancer.

Brachytherapy 2015 Jan-Feb;14(1):56-61. Epub 2014 Aug 28.

Department of Medical Physics, Aarhus University Hospital, Aarhus, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Purpose: This study evaluated the dose delivered to lymph nodes (LNs) by brachytherapy (BT) and the effect of BT image-guided optimization on the LN dose.

Methods And Materials: Twenty-five patients with locally advanced cervical cancer were retrospectively analyzed, 16 patients of them had LN involvement. The patients received whole pelvis intensity-modulated radiation therapy (45-50 Gy/25-30 fx) to whole pelvis and two fractions of MRI pulsed-dose-rate BT. The delineated LN groups were para-aortic, inguinal, common iliac (CI), external iliac, internal iliac, obturator, and presacral. For each LN group, D98%, D50%, and D2% (the dose that covers 98%, 50%, and 2% of the volume, respectively) were evaluated for optimized and standard BT plans. The correlation between total reference air kerma (TRAK) and D50% of the LN groups was evaluated.

Results: BT contributed considerable dose (mean D50% was 3.8-6.2 Gy equivalent total dose in 2-Gy fractions) to the pelvic LN (external iliac, internal iliac, obturator, and presacral) in optimized plans, whereas less-dose contribution to CI, para-aortic, and inguinal (mean D50% was 0.5-1.9 Gy equivalent total dose in 2-Gy fractions) was observed. Optimized plans delivered less dose to the LNs as compared with standard plans, although differences only amounted to a mean of 0.2-0.9 Gy (D50%). TRAK showed a significant correlation with LN D50% for all LN groups except CI, although only 19-38% of the dose variation could be explained by the TRAK.

Conclusions: BT contributes considerable dose to pelvic LNs and should be considered in the evaluation of total LN doses.
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http://dx.doi.org/10.1016/j.brachy.2014.07.005DOI Listing
June 2015

From point A to the sculpted pear: MR image guidance significantly improves tumour dose and sparing of organs at risk in brachytherapy of cervical cancer.

Radiother Oncol 2010 Feb;94(2):173-80

Department of Oncology, Aarhus University Hospital, Noerrebrogade, Aarhus, Denmark.

Background And Purpose: Brachytherapy in locally advanced cervical cancer is still widely based on 2D standard dose planning, although 3D image guidance is available. The purpose of this study was to compare point doses to 3D dose volume parameters for tumour and organs at risk (OARs), and to evaluate the improvement of dose parameters with MR image guided adaptive brachytherapy (IGABT).

Material And Methods: MRI-based IGABT was performed in 72 consecutive patients. HR-CTV, IR-CTV, bladder, rectum and sigmoid were contoured according to GEC-ESTRO recommendations. BT standard dose planning was compared to MRI-based dose optimisation.

Results: HR-CTV dose (D90) was highly variable in standard plans with point A dose prescription. In small tumours (<31 cc) HR-CTV was well covered by standard plans in 94% of patients, while OAR constraints were exceeded in 72% of patients. Optimisation decreased violation of OAR constraints to only 6% of patients while maintaining excellent target coverage. In large tumours (>31 cc) the dose optimisation improved the HR-CTV D90 by a mean of 7 Gy resulting in full coverage in 72% of patients as compared to 25% for standard plans, even while reducing violation of OAR constraints.

Conclusion: Point A dose is a poor surrogate of HR-CTV dose, and the use of 3D image-based dose planning is encouraged. MRI-based IGABT significantly improves target coverage and OAR dose.
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http://dx.doi.org/10.1016/j.radonc.2010.01.001DOI Listing
February 2010
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