Publications by authors named "Ton J Rabelink"

100Publications

Proteinase-3-anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) predict relapses in ANCA-associated vasculitis patients after rituximab.

Nephrol Dial Transplant 2020 Jun 30. Epub 2020 Jun 30.

Centre of Expertise for Lupus-, Vasculitis-, and Complement-Mediated Systemic Autoimmune Diseases Leiden, The Netherlands, Department of Internal Medicine, Section of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfaa066DOI Listing
June 2020

MicroRNA-132 regulates salt-dependent steady-state renin levels in mice.

Commun Biol 2020 May 14;3(1):238. Epub 2020 May 14.

Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s42003-020-0967-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224281PMC
May 2020

Assessment of Size-Selective Glomerular Sieving in Transplanted Human Induced Pluripotent Stem Cell-Derived Kidney Organoids.

J Am Soc Nephrol 2020 May;31(5):921-929

Department of Internal Medicine-Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2019060573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217406PMC
May 2020

Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling After Arterial Ischemia.

Cells 2020 Mar 29;9(4). Epub 2020 Mar 29.

The Einthoven laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.3390/cells9040824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226746PMC
March 2020

Lowering the increased intracellular pH of human-induced pluripotent stem cell-derived endothelial cells induces formation of mature Weibel-Palade bodies.

Stem Cells Transl Med 2020 Jul 12;9(7):758-772. Epub 2020 Mar 12.

The Einthoven Laboratory for Vascular and Regenerative Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/sctm.19-0392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308639PMC
July 2020

Endothelial Glycocalyx Hyaluronan: Regulation and Role in Prevention of Diabetic Complications.

Am J Pathol 2020 04 6;190(4):781-790. Epub 2020 Feb 6.

Division of Nephrology, Department of Internal Medicine, the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.07.022DOI Listing
April 2020

Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis.

Arterioscler Thromb Vasc Biol 2020 02 12;40(2):350-364. Epub 2019 Dec 12.

From the Division of Nephrology, Department of Internal Medicine (G.W., G.L.T., W.M.P.J.S., B.M.v.d.B., T.J.R.), The Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, the Netherlands.

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http://dx.doi.org/10.1161/ATVBAHA.119.313399DOI Listing
February 2020

Stem cell-derived kidney organoids: engineering the vasculature.

Cell Mol Life Sci 2020 Jun 5;77(12):2257-2273. Epub 2019 Dec 5.

Department of Internal Medicine-Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00018-019-03401-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275011PMC
June 2020

Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress-Activated FOXO1 to Trigger β-Cell Failure.

Diabetes 2020 02 15;69(2):193-204. Epub 2019 Nov 15.

Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/db19-0828DOI Listing
February 2020

Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation.

Stem Cell Reports 2019 11 31;13(5):803-816. Epub 2019 Oct 31.

The Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895683PMC
November 2019

Highly efficient ex vivo lentiviral transduction of primary human pancreatic exocrine cells.

Sci Rep 2019 11 1;9(1):15870. Epub 2019 Nov 1.

Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1038/s41598-019-51763-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825235PMC
November 2019

The Separate Contributions of Visceral Fat and Liver Fat to Chronic Kidney Disease-Related Renal Outcomes.

J Ren Nutr 2020 Jul 25;30(4):286-295. Epub 2019 Oct 25.

Division of Nephrology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1053/j.jrn.2019.09.002DOI Listing
July 2020

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Authors:
Adrienne Tin Jonathan Marten Victoria L Halperin Kuhns Yong Li Matthias Wuttke Holger Kirsten Karsten B Sieber Chengxiang Qiu Mathias Gorski Zhi Yu Ayush Giri Gardar Sveinbjornsson Man Li Audrey Y Chu Anselm Hoppmann Luke J O'Connor Bram Prins Teresa Nutile Damia Noce Masato Akiyama Massimiliano Cocca Sahar Ghasemi Peter J van der Most Katrin Horn Yizhe Xu Christian Fuchsberger Sanaz Sedaghat Saima Afaq Najaf Amin Johan Ärnlöv Stephan J L Bakker Nisha Bansal Daniela Baptista Sven Bergmann Mary L Biggs Ginevra Biino Eric Boerwinkle Erwin P Bottinger Thibaud S Boutin Marco Brumat Ralph Burkhardt Eric Campana Archie Campbell Harry Campbell Robert J Carroll Eulalia Catamo John C Chambers Marina Ciullo Maria Pina Concas Josef Coresh Tanguy Corre Daniele Cusi Sala Cinzia Felicita Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Graciela Delgado Ayşe Demirkan Olivier Devuyst Katalin Dittrich Kai-Uwe Eckardt Georg Ehret Karlhans Endlich Michele K Evans Ron T Gansevoort Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Martin Gögele Scott D Gordon Daniel F Gudbjartsson Vilmundur Gudnason Toomas Haller Pavel Hamet Tamara B Harris Caroline Hayward Andrew A Hicks Edith Hofer Hilma Holm Wei Huang Nina Hutri-Kähönen Shih-Jen Hwang M Arfan Ikram Raychel M Lewis Erik Ingelsson Johanna Jakobsdottir Ingileif Jonsdottir Helgi Jonsson Peter K Joshi Navya Shilpa Josyula Bettina Jung Mika Kähönen Yoichiro Kamatani Masahiro Kanai Shona M Kerr Wieland Kiess Marcus E Kleber Wolfgang Koenig Jaspal S Kooner Antje Körner Peter Kovacs Bernhard K Krämer Florian Kronenberg Michiaki Kubo Brigitte Kühnel Martina La Bianca Leslie A Lange Benjamin Lehne Terho Lehtimäki Jun Liu Markus Loeffler Ruth J F Loos Leo-Pekka Lyytikäinen Reedik Magi Anubha Mahajan Nicholas G Martin Winfried März Deborah Mascalzoni Koichi Matsuda Christa Meisinger Thomas Meitinger Andres Metspalu Yuri Milaneschi Christopher J O'Donnell Otis D Wilson J Michael Gaziano Pashupati P Mishra Karen L Mohlke Nina Mononen Grant W Montgomery Dennis O Mook-Kanamori Martina Müller-Nurasyid Girish N Nadkarni Mike A Nalls Matthias Nauck Kjell Nikus Boting Ning Ilja M Nolte Raymond Noordam Jeffrey R O'Connell Isleifur Olafsson Sandosh Padmanabhan Brenda W J H Penninx Thomas Perls Annette Peters Mario Pirastu Nicola Pirastu Giorgio Pistis Ozren Polasek Belen Ponte David J Porteous Tanja Poulain Michael H Preuss Ton J Rabelink Laura M Raffield Olli T Raitakari Rainer Rettig Myriam Rheinberger Kenneth M Rice Federica Rizzi Antonietta Robino Igor Rudan Alena Krajcoviechova Renata Cifkova Rico Rueedi Daniela Ruggiero Kathleen A Ryan Yasaman Saba Erika Salvi Helena Schmidt Reinhold Schmidt Christian M Shaffer Albert V Smith Blair H Smith Cassandra N Spracklen Konstantin Strauch Michael Stumvoll Patrick Sulem Salman M Tajuddin Andrej Teren Joachim Thiery Chris H L Thio Unnur Thorsteinsdottir Daniela Toniolo Anke Tönjes Johanne Tremblay André G Uitterlinden Simona Vaccargiu Pim van der Harst Cornelia M van Duijn Niek Verweij Uwe Völker Peter Vollenweider Gerard Waeber Melanie Waldenberger John B Whitfield Sarah H Wild James F Wilson Qiong Yang Weihua Zhang Alan B Zonderman Murielle Bochud James G Wilson Sarah A Pendergrass Kevin Ho Afshin Parsa Peter P Pramstaller Bruce M Psaty Carsten A Böger Harold Snieder Adam S Butterworth Yukinori Okada Todd L Edwards Kari Stefansson Katalin Susztak Markus Scholz Iris M Heid Adriana M Hung Alexander Teumer Cristian Pattaro Owen M Woodward Veronique Vitart Anna Köttgen

Nat Genet 2019 10 2;51(10):1459-1474. Epub 2019 Oct 2.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41588-019-0504-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858555PMC
October 2019

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Authors:
Alexander Teumer Yong Li Sahar Ghasemi Bram P Prins Matthias Wuttke Tobias Hermle Ayush Giri Karsten B Sieber Chengxiang Qiu Holger Kirsten Adrienne Tin Audrey Y Chu Nisha Bansal Mary F Feitosa Lihua Wang Jin-Fang Chai Massimiliano Cocca Christian Fuchsberger Mathias Gorski Anselm Hoppmann Katrin Horn Man Li Jonathan Marten Damia Noce Teresa Nutile Sanaz Sedaghat Gardar Sveinbjornsson Bamidele O Tayo Peter J van der Most Yizhe Xu Zhi Yu Lea Gerstner Johan Ärnlöv Stephan J L Bakker Daniela Baptista Mary L Biggs Eric Boerwinkle Hermann Brenner Ralph Burkhardt Robert J Carroll Miao-Li Chee Miao-Ling Chee Mengmeng Chen Ching-Yu Cheng James P Cook Josef Coresh Tanguy Corre John Danesh Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Katalin Dittrich Jasmin Divers Kai-Uwe Eckardt Georg Ehret Karlhans Endlich Janine F Felix Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Ron T Gansevoort Vilmantas Giedraitis Martin Gögele Franziska Grundner-Culemann Daniel F Gudbjartsson Vilmundur Gudnason Pavel Hamet Tamara B Harris Andrew A Hicks Hilma Holm Valencia Hui Xian Foo Shih-Jen Hwang M Arfan Ikram Erik Ingelsson Vincent W V Jaddoe Johanna Jakobsdottir Navya Shilpa Josyula Bettina Jung Mika Kähönen Chiea-Chuen Khor Wieland Kiess Wolfgang Koenig Antje Körner Peter Kovacs Holly Kramer Bernhard K Krämer Florian Kronenberg Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jianjun Liu Markus Loeffler Leo-Pekka Lyytikäinen Anubha Mahajan Joseph C Maranville Deborah Mascalzoni Barbara McMullen Christa Meisinger Thomas Meitinger Kozeta Miliku Dennis O Mook-Kanamori Martina Müller-Nurasyid Josyf C Mychaleckyj Matthias Nauck Kjell Nikus Boting Ning Raymond Noordam Jeffrey O' Connell Isleifur Olafsson Nicholette D Palmer Annette Peters Anna I Podgornaia Belen Ponte Tanja Poulain Peter P Pramstaller Ton J Rabelink Laura M Raffield Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Fernando Rivadeneira Heiko Runz Kathleen A Ryan Charumathi Sabanayagam Kai-Uwe Saum Ben Schöttker Christian M Shaffer Yuan Shi Albert V Smith Konstantin Strauch Michael Stumvoll Benjamin B Sun Silke Szymczak E-Shyong Tai Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Unnur Thorsteinsdottir Anke Tönjes Johanne Tremblay André G Uitterlinden Pim van der Harst Niek Verweij Suzanne Vogelezang Uwe Völker Melanie Waldenberger Chaolong Wang Otis D Wilson Charlene Wong Tien-Yin Wong Qiong Yang Masayuki Yasuda Shreeram Akilesh Murielle Bochud Carsten A Böger Olivier Devuyst Todd L Edwards Kevin Ho Andrew P Morris Afshin Parsa Sarah A Pendergrass Bruce M Psaty Jerome I Rotter Kari Stefansson James G Wilson Katalin Susztak Harold Snieder Iris M Heid Markus Scholz Adam S Butterworth Adriana M Hung Cristian Pattaro Anna Köttgen

Nat Commun 2019 09 11;10(1):4130. Epub 2019 Sep 11.

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41467-019-11576-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370PMC
September 2019

New insights into energy and protein homeostasis by the kidney.

Nat Rev Nephrol 2019 10;15(10):596-598

Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.1038/s41581-019-0192-xDOI Listing
October 2019

Low Birth Weight and Kidney Function in Middle-Aged Men and Women: The Netherlands Epidemiology of Obesity Study.

Am J Kidney Dis 2019 12 26;74(6):751-760. Epub 2019 Jul 26.

Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Nephrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands.

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http://dx.doi.org/10.1053/j.ajkd.2019.05.007DOI Listing
December 2019

A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Authors:
Matthias Wuttke Yong Li Man Li Karsten B Sieber Mary F Feitosa Mathias Gorski Adrienne Tin Lihua Wang Audrey Y Chu Anselm Hoppmann Holger Kirsten Ayush Giri Jin-Fang Chai Gardar Sveinbjornsson Bamidele O Tayo Teresa Nutile Christian Fuchsberger Jonathan Marten Massimiliano Cocca Sahar Ghasemi Yizhe Xu Katrin Horn Damia Noce Peter J van der Most Sanaz Sedaghat Zhi Yu Masato Akiyama Saima Afaq Tarunveer S Ahluwalia Peter Almgren Najaf Amin Johan Ärnlöv Stephan J L Bakker Nisha Bansal Daniela Baptista Sven Bergmann Mary L Biggs Ginevra Biino Michael Boehnke Eric Boerwinkle Mathilde Boissel Erwin P Bottinger Thibaud S Boutin Hermann Brenner Marco Brumat Ralph Burkhardt Adam S Butterworth Eric Campana Archie Campbell Harry Campbell Mickaël Canouil Robert J Carroll Eulalia Catamo John C Chambers Miao-Ling Chee Miao-Li Chee Xu Chen Ching-Yu Cheng Yurong Cheng Kaare Christensen Renata Cifkova Marina Ciullo Maria Pina Concas James P Cook Josef Coresh Tanguy Corre Cinzia Felicita Sala Daniele Cusi John Danesh E Warwick Daw Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Graciela Delgado Ayse Demirkan Emanuele Di Angelantonio Katalin Dittrich Jasmin Divers Rajkumar Dorajoo Kai-Uwe Eckardt Georg Ehret Paul Elliott Karlhans Endlich Michele K Evans Janine F Felix Valencia Hui Xian Foo Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Yechiel Friedlander Philippe Froguel Ron T Gansevoort He Gao Paolo Gasparini J Michael Gaziano Vilmantas Giedraitis Christian Gieger Giorgia Girotto Franco Giulianini Martin Gögele Scott D Gordon Daniel F Gudbjartsson Vilmundur Gudnason Toomas Haller Pavel Hamet Tamara B Harris Catharina A Hartman Caroline Hayward Jacklyn N Hellwege Chew-Kiat Heng Andrew A Hicks Edith Hofer Wei Huang Nina Hutri-Kähönen Shih-Jen Hwang M Arfan Ikram Olafur S Indridason Erik Ingelsson Marcus Ising Vincent W V Jaddoe Johanna Jakobsdottir Jost B Jonas Peter K Joshi Navya Shilpa Josyula Bettina Jung Mika Kähönen Yoichiro Kamatani Candace M Kammerer Masahiro Kanai Mika Kastarinen Shona M Kerr Chiea-Chuen Khor Wieland Kiess Marcus E Kleber Wolfgang Koenig Jaspal S Kooner Antje Körner Peter Kovacs Aldi T Kraja Alena Krajcoviechova Holly Kramer Bernhard K Krämer Florian Kronenberg Michiaki Kubo Brigitte Kühnel Mikko Kuokkanen Johanna Kuusisto Martina La Bianca Markku Laakso Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Benjamin Lehne Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jun Liu Jianjun Liu Markus Loeffler Ruth J F Loos Susanne Lucae Mary Ann Lukas Leo-Pekka Lyytikäinen Reedik Mägi Patrik K E Magnusson Anubha Mahajan Nicholas G Martin Jade Martins Winfried März Deborah Mascalzoni Koichi Matsuda Christa Meisinger Thomas Meitinger Olle Melander Andres Metspalu Evgenia K Mikaelsdottir Yuri Milaneschi Kozeta Miliku Pashupati P Mishra Karen L Mohlke Nina Mononen Grant W Montgomery Dennis O Mook-Kanamori Josyf C Mychaleckyj Girish N Nadkarni Mike A Nalls Matthias Nauck Kjell Nikus Boting Ning Ilja M Nolte Raymond Noordam Jeffrey O'Connell Michelle L O'Donoghue Isleifur Olafsson Albertine J Oldehinkel Marju Orho-Melander Willem H Ouwehand Sandosh Padmanabhan Nicholette D Palmer Runolfur Palsson Brenda W J H Penninx Thomas Perls Markus Perola Mario Pirastu Nicola Pirastu Giorgio Pistis Anna I Podgornaia Ozren Polasek Belen Ponte David J Porteous Tanja Poulain Peter P Pramstaller Michael H Preuss Bram P Prins Michael A Province Ton J Rabelink Laura M Raffield Olli T Raitakari Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Paul M Ridker Fernando Rivadeneira Federica Rizzi David J Roberts Antonietta Robino Peter Rossing Igor Rudan Rico Rueedi Daniela Ruggiero Kathleen A Ryan Yasaman Saba Charumathi Sabanayagam Veikko Salomaa Erika Salvi Kai-Uwe Saum Helena Schmidt Reinhold Schmidt Ben Schöttker Christina-Alexandra Schulz Nicole Schupf Christian M Shaffer Yuan Shi Albert V Smith Blair H Smith Nicole Soranzo Cassandra N Spracklen Konstantin Strauch Heather M Stringham Michael Stumvoll Per O Svensson Silke Szymczak E-Shyong Tai Salman M Tajuddin Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Gudmar Thorleifsson Daniela Toniolo Anke Tönjes Johanne Tremblay Ioanna Tzoulaki André G Uitterlinden Simona Vaccargiu Rob M van Dam Pim van der Harst Cornelia M van Duijn Digna R Velez Edward Niek Verweij Suzanne Vogelezang Uwe Völker Peter Vollenweider Gerard Waeber Melanie Waldenberger Lars Wallentin Ya Xing Wang Chaolong Wang Dawn M Waterworth Wen Bin Wei Harvey White John B Whitfield Sarah H Wild James F Wilson Mary K Wojczynski Charlene Wong Tien-Yin Wong Liang Xu Qiong Yang Masayuki Yasuda Laura M Yerges-Armstrong Weihua Zhang Alan B Zonderman Jerome I Rotter Murielle Bochud Bruce M Psaty Veronique Vitart James G Wilson Abbas Dehghan Afshin Parsa Daniel I Chasman Kevin Ho Andrew P Morris Olivier Devuyst Shreeram Akilesh Sarah A Pendergrass Xueling Sim Carsten A Böger Yukinori Okada Todd L Edwards Harold Snieder Kari Stefansson Adriana M Hung Iris M Heid Markus Scholz Alexander Teumer Anna Köttgen Cristian Pattaro

Nat Genet 2019 06 31;51(6):957-972. Epub 2019 May 31.

Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.

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http://dx.doi.org/10.1038/s41588-019-0407-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698888PMC
June 2019

Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis.

Front Pharmacol 2019 11;10:215. Epub 2019 Mar 11.

Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Experimental Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.3389/fphar.2019.00215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421975PMC
March 2019

Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases.

Kidney Int Rep 2019 Feb 19;4(2):196-211. Epub 2018 Nov 19.

Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ekir.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365354PMC
February 2019

A High-throughput Assay to Assess and Quantify Neutrophil Extracellular Trap Formation.

J Vis Exp 2019 01 29(143). Epub 2019 Jan 29.

Department of Nephrology, Leiden University Medical Center;

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http://dx.doi.org/10.3791/59150DOI Listing
January 2019

Neutral endopeptidase inhibitors blunt kidney fibrosis by reducing myofibroblast formation.

Clin Sci (Lond) 2019 01 22;133(2):239-252. Epub 2019 Jan 22.

Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands

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http://clinsci.org/lookup/doi/10.1042/CS20180882
Publisher Site
http://dx.doi.org/10.1042/CS20180882DOI Listing
January 2019

Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair.

Stem Cells Transl Med 2019 04 11;8(4):375-382. Epub 2018 Dec 11.

The Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/sctm.18-0155
Publisher Site
http://dx.doi.org/10.1002/sctm.18-0155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431685PMC
April 2019

Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease.

Stem Cell Res Ther 2018 08 14;9(1):220. Epub 2018 Aug 14.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Via Stezzano 87, 24126, Bergamo, Italy.

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http://dx.doi.org/10.1186/s13287-018-0960-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092807PMC
August 2018

MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.

Am J Physiol Renal Physiol 2018 10 30;315(4):F1129-F1138. Epub 2018 May 30.

Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands.

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http://dx.doi.org/10.1152/ajprenal.00087.2018DOI Listing
October 2018

The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment.

Sci Rep 2018 05 16;8(1):7716. Epub 2018 May 16.

Department of Cell Biology Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-25700-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956003PMC
May 2018

Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA.

Kidney Int 2018 07 30;94(1):139-149. Epub 2018 Mar 30.

Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands; Clinic for Lupus, Vasculitis and Complement-mediated Systemic Diseases, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.01.013DOI Listing
July 2018

Associations between normal range albuminuria, renal function and cardiovascular function in a population-based imaging study.

Atherosclerosis 2018 05 16;272:94-100. Epub 2018 Mar 16.

Leiden University Medical Center, Dept. of Internal Medicine, Div. of Nephrology and Transplant Medicine Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.03.029DOI Listing
May 2018

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo.

Stem Cell Reports 2018 03 1;10(3):751-765. Epub 2018 Mar 1.

Department of Internal Medicine - Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands; Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.stemcr.2018.01.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918682PMC
March 2018

Renal metabolism in 2017: Glycolytic adaptation and progression of kidney disease.

Nat Rev Nephrol 2018 02 18;14(2):75-76. Epub 2017 Dec 18.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Vesalius Research Center, VIB; and the Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, Campus Gasthuisberg Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/nrneph.2017.173DOI Listing
February 2018

The human kidney capsule contains a functionally distinct mesenchymal stromal cell population.

PLoS One 2017 5;12(12):e0187118. Epub 2017 Dec 5.

Department of Internal Medicine, division of Nephrology, Einthoven laboratory of Vascular and Regenerative Medicine; Leiden University Medical Centre, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187118PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716605PMC
December 2017

An evidence-based approach to pre-pregnancy counselling for patients with systemic lupus erythematosus.

Rheumatology (Oxford) 2018 10;57(10):1707-1720

Department of Gynaecology and Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/rheumatology/kex374DOI Listing
October 2018

Self-Monitoring Kidney Function Post Transplantation: Reliability of Patient-Reported Data.

J Med Internet Res 2017 09 26;19(9):e316. Epub 2017 Sep 26.

Leiden University Medical Center, Department of Nephrology, Leiden, Netherlands.

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http://dx.doi.org/10.2196/jmir.7542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640424PMC
September 2017

Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.

Am J Pathol 2017 Nov 22;187(11):2430-2440. Epub 2017 Aug 22.

Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Division of Nephrology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.07.020DOI Listing
November 2017

Lupus nephritis: Mesenchymal stromal cells in lupus nephritis.

Nat Rev Nephrol 2017 07;13(8):452-453

Department of Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands.

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http://dx.doi.org/10.1038/nrneph.2017.100DOI Listing
July 2017

Mesenchymal Stromal Cell Therapy for Solid Organ Transplantation.

Transplantation 2018 01;102(1):35-43

Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1097/TP.0000000000001879DOI Listing
January 2018

The Cognitive decline in Older Patients with End stage renal disease (COPE) study - rationale and design.

Curr Med Res Opin 2017 11 11;33(11):2057-2064. Epub 2017 Jul 11.

a Department of Nephrology , Leiden University Medical Center , Leiden , The Netherlands.

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http://dx.doi.org/10.1080/03007995.2017.1341404DOI Listing
November 2017

Renal physiology: Burning calories to excrete salt.

Authors:
Ton J Rabelink

Nat Rev Nephrol 2017 06 8;13(6):323-324. Epub 2017 May 8.

Department of Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands.

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http://dx.doi.org/10.1038/nrneph.2017.62DOI Listing
June 2017

Pancreatic α-cell mass in obesity.

Diabetes Obes Metab 2017 12 13;19(12):1810-1813. Epub 2017 Jul 13.

Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/dom.12997DOI Listing
December 2017

Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.

Nat Rev Nephrol 2017 04 6;13(4):201-212. Epub 2017 Feb 6.

Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein 10, 6525 GA Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/nrneph.2017.6DOI Listing
April 2017

TAC-TIC use of tacrolimus-based regimens in lupus nephritis.

Lupus Sci Med 2016 29;3(1):e000169. Epub 2016 Dec 29.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands; Clinic for Lupus-, Vasculitis and Complement-Mediated Systemic Diseases, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/lupus-2016-000169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237713PMC
December 2016

Direct Observation of Enhanced Nitric Oxide in a Murine Model of Diabetic Nephropathy.

PLoS One 2017 19;12(1):e0170065. Epub 2017 Jan 19.

Einthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170065PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245862PMC
August 2017

Emerging roles for RNA-binding proteins as effectors and regulators of cardiovascular disease.

Eur Heart J 2017 May;38(18):1380-1388

Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, Leiden 2300RC, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehw567DOI Listing
May 2017

RNA Contaminates Glycosaminoglycans Extracted from Cells and Tissues.

PLoS One 2016 29;11(11):e0167336. Epub 2016 Nov 29.

Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167336PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127559PMC
June 2017

miRNA-Coordinated Networks as Promising Therapeutic Targets for Acute Kidney Injury.

Am J Pathol 2017 Jan 17;187(1):20-24. Epub 2016 Nov 17.

Einthoven Laboratory for Experimental Vascular Medicine, Department of Internal Medicine (Nephrology), Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.10.017DOI Listing
January 2017

Mesenchymal stromal cells in clinical kidney transplantation: how tolerant can it be?

Curr Opin Organ Transplant 2016 Dec;21(6):550-558

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MOT.0000000000000364DOI Listing
December 2016

Promoting Tropoelastin Expression in Arterial and Venous Vascular Smooth Muscle Cells and Fibroblasts for Vascular Tissue Engineering.

Tissue Eng Part C Methods 2016 10 28;22(10):923-931. Epub 2016 Sep 28.

1 Department of Internal Medicine, Section Nephrology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center , Leiden, The Netherlands .

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http://dx.doi.org/10.1089/ten.TEC.2016.0173DOI Listing
October 2016

Cathepsin L is crucial for the development of early experimental diabetic nephropathy.

Kidney Int 2016 11 26;90(5):1012-1022. Epub 2016 Aug 26.

Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.06.035DOI Listing
November 2016

Macrophages in diabetic nephropathy in patients with type 2 diabetes.

Nephrol Dial Transplant 2017 Aug;32(8):1322-1329

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/ndt/gfw260DOI Listing
August 2017

Functional and Cognitive Impairment, Frailty, and Adverse Health Outcomes in Older Patients Reaching ESRD-A Systematic Review.

Clin J Am Soc Nephrol 2016 09 24;11(9):1624-39. Epub 2016 Jun 24.

Gerontology and Geriatrics, and Institute for Evidence-Based Medicine in Old Age, Leiden, The Netherlands.

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http://dx.doi.org/10.2215/CJN.13611215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012494PMC
September 2016

Modelling the Cost-Effectiveness of Delaying End-Stage Renal Disease.

Nephron 2016 8;133(2):89-97. Epub 2016 Jun 8.

Department of Nephrology and Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1159/000446548DOI Listing
February 2017

Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy.

Diabetes 2016 08 25;65(8):2429-39. Epub 2016 Mar 25.

Einthoven Laboratory for Experimental Vascular Medicine, Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/db15-1413DOI Listing
August 2016

Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation.

Kidney Int 2016 06 8;89(6):1268-80. Epub 2016 Apr 8.

Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.kint.2016.01.029DOI Listing
June 2016

Is the prevalence of hypertension in overweight children overestimated?

Arch Dis Child 2016 Nov 31;101(11):998-1003. Epub 2016 Mar 31.

Department of Public and Occupational Health, VU University Medical Center, EMGO Institute for Health and Care Research, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2015-309969DOI Listing
November 2016

Azathioprine-induced eosinophilic myocarditis in a patient with ANCA-associated vasculitis.

Clin Exp Rheumatol 2016 May-Jun;34(3 Suppl 97):S146. Epub 2016 Mar 7.

Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands.

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September 2016

A novel method for high-throughput detection and quantification of neutrophil extracellular traps reveals ROS-independent NET release with immune complexes.

Autoimmun Rev 2016 Jun 27;15(6):577-84. Epub 2016 Feb 27.

Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.autrev.2016.02.018DOI Listing
June 2016

The RNA-binding protein quaking maintains endothelial barrier function and affects VE-cadherin and β-catenin protein expression.

Sci Rep 2016 Feb 24;6:21643. Epub 2016 Feb 24.

Einthoven Laboratory of Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1038/srep21643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764852PMC
February 2016

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis.

Am J Pathol 2016 Apr 9;186(4):805-15. Epub 2016 Feb 9.

Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2015.12.008DOI Listing
April 2016

A Novel Murine Model of Arteriovenous Fistula Failure: The Surgical Procedure in Detail.

J Vis Exp 2016 Feb 3(108):e53294. Epub 2016 Feb 3.

Department of Nephrology, Leiden University Medical Center; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center;

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http://dx.doi.org/10.3791/53294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781715PMC
February 2016

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.

J Biol Chem 2016 Mar 4;291(10):4974-81. Epub 2016 Jan 4.

From the Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands,

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http://dx.doi.org/10.1074/jbc.M115.702506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777835PMC
March 2016

Patient experiences with self-monitoring renal function after renal transplantation: results from a single-center prospective pilot study.

Patient Prefer Adherence 2015 7;9:1721-31. Epub 2015 Dec 7.

Department of Nephrology, Leiden University Medical Centre (LUMC), Leiden, the Netherlands ; Department of Health, Medical and Neuropsychology, Faculty of Social and Behavioural Sciences, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.2147/PPA.S92108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676625PMC
December 2015

Candidate Gene Analysis of Mortality in Dialysis Patients.

PLoS One 2015 20;10(11):e0143079. Epub 2015 Nov 20.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143079PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654483PMC
June 2016

The glycocalyx--linking albuminuria with renal and cardiovascular disease.

Nat Rev Nephrol 2015 Nov 13;11(11):667-76. Epub 2015 Oct 13.

Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen, Netherlands.

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http://www.nature.com/articles/nrneph.2015.162
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http://dx.doi.org/10.1038/nrneph.2015.162DOI Listing
November 2015

Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte.

J Pathol 2015 Dec 31;237(4):472-81. Epub 2015 Aug 31.

Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/path.4593DOI Listing
December 2015

A microscopic view on the renal endothelial glycocalyx.

Am J Physiol Renal Physiol 2015 May 11;308(9):F956-66. Epub 2015 Feb 11.

Department of Nephrology, Einthoven laboratory for Vascular Medicine, LUMC, Leiden University Medical Center, Leiden, The Netherlands;

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http://www.physiology.org/doi/10.1152/ajprenal.00532.2014
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00532.2014DOI Listing
May 2015

Guideline treatment results in regression of atherosclerosis in type 2 diabetes mellitus.

Diab Vasc Dis Res 2015 Mar 14;12(2):126-32. Epub 2015 Jan 14.

Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1177/1479164114559511DOI Listing
March 2015

Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients.

BMC Nephrol 2014 Dec 11;15:197. Epub 2014 Dec 11.

Department of Nephrology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2369-15-197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293085PMC
December 2014