Publications by authors named "Tobias Rumpf"

20Publications

Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases.

J Med Chem 2019 03 6;62(5):2582-2597. Epub 2019 Mar 6.

Institute of Pharmaceutical Sciences , University of Freiburg , Albertstraße 25 , 79104 Freiburg im Breisgau , Germany.

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March 2019

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions.

Chem Rec 2018 Dec 21;18(12):1701-1707. Epub 2018 Jun 21.

Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.

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December 2018

New chemical tools for probing activity and inhibition of the NAD-dependent lysine deacylase sirtuin 2.

Philos Trans R Soc Lond B Biol Sci 2018 06;373(1748)

Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 19, 79104 Freiburg im Breisgau, Germany

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June 2018

The Current State of NAD -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.

Med Res Rev 2018 01 17;38(1):147-200. Epub 2017 Jan 17.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

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January 2018

Structure-Based Development of an Affinity Probe for Sirtuin 2.

Angew Chem Int Ed Engl 2016 Feb 8;55(6):2252-6. Epub 2016 Jan 8.

Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstrasse 25, 79104, Freiburg im Breisgau, Germany.

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February 2016

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.

J Med Chem 2016 Feb 7;59(4):1599-612. Epub 2016 Jan 7.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg , Albertstraße 25, 79104 Freiburg im Breisgau, Germany.

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February 2016

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.

Acta Crystallogr F Struct Biol Commun 2015 Dec 18;71(Pt 12):1498-510. Epub 2015 Nov 18.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Albertstrasse 25, 79104 Freiburg, Baden-Württemberg, Germany.

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December 2015

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.

ACS Med Chem Lett 2012 Dec 6;3(12):1050-3. Epub 2012 Oct 6.

Institute of Pharmaceutical Sciences, Albert-Ludwigs Universität , Albertstrasse 25, 79104 Freiburg, Germany.

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December 2012

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.

PLoS One 2012 20;7(4):e34973. Epub 2012 Apr 20.

Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse, Freiburg, Germany.

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August 2012

Steroid boost for sirtuin research.

Aging (Albany NY) 2011 Sep;3(9):818

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September 2011

Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).

Bioorg Med Chem 2011 Jun 22;19(12):3669-77. Epub 2011 Jan 22.

Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany.

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June 2011

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

Biochim Biophys Acta 2010 Oct-Dec;1799(10-12):726-39. Epub 2010 Jun 23.

Department of Pharmaceutical Chemistry, Martin-Luther Universität Halle-Wittenberg, Wolfgang-Langenbeckstr. 4, 06120 Halle/Saale, Germany.

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February 2011

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

J Med Chem 2010 Feb;53(3):1383-6

Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany.

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February 2010