Publications by authors named "Tobias Rumpf"

20Publications

Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases.

Authors:
Roman P Simon Tobias Rumpf Vaida Linkuviene Daumantas Matulis Asifa Akhtar Manfred Jung

J Med Chem 2019 03 6;62(5):2582-2597. Epub 2019 Mar 6.

Institute of Pharmaceutical Sciences , University of Freiburg , Albertstraße 25 , 79104 Freiburg im Breisgau , Germany.

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March 2019

De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation.

Authors:
M Felicia Basilicata Ange-Line Bruel Giuseppe Semplicio Claudia Isabelle Keller Valsecchi Tuğçe Aktaş Yannis Duffourd Tobias Rumpf Jenny Morton Iben Bache Witold G Szymanski Christian Gilissen Olivier Vanakker Katrin Õunap Gerhard Mittler Ineke van der Burgt Salima El Chehadeh Megan T Cho Rolph Pfundt Tiong Yang Tan Maria Kirchhoff Björn Menten Sarah Vergult Kristin Lindstrom André Reis Diana S Johnson Alan Fryer Victoria McKay Richard B Fisher Christel Thauvin-Robinet David Francis Tony Roscioli Sander Pajusalu Kelly Radtke Jaya Ganesh Han G Brunner Meredith Wilson Laurence Faivre Vera M Kalscheuer Julien Thevenon Asifa Akhtar

Nat Genet 2018 10 17;50(10):1442-1451. Epub 2018 Sep 17.

Max Planck Institute of Immunobiology and Epigenetics, Freiburg im Breisgau, Germany.

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October 2018

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions.

Authors:
Dina Robaa Daria Monaldi Nathalie Wössner Norio Kudo Tobias Rumpf Matthias Schiedel Minoru Yoshida Manfred Jung

Chem Rec 2018 Dec 21;18(12):1701-1707. Epub 2018 Jun 21.

Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr. 25, 79104, Freiburg, Germany.

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December 2018

New chemical tools for probing activity and inhibition of the NAD-dependent lysine deacylase sirtuin 2.

Authors:
Sören Swyter Matthias Schiedel Daria Monaldi Sándor Szunyogh Attila Lehotzky Tobias Rumpf Judit Ovádi Wolfgang Sippl Manfred Jung

Philos Trans R Soc Lond B Biol Sci 2018 06;373(1748)

Institute of Pharmaceutical Sciences, University of Freiburg, Albertstraße 19, 79104 Freiburg im Breisgau, Germany

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June 2018

The Current State of NAD -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.

Authors:
Matthias Schiedel Dina Robaa Tobias Rumpf Wolfgang Sippl Manfred Jung

Med Res Rev 2018 01 17;38(1):147-200. Epub 2017 Jan 17.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.

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January 2018

Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).

Authors:
Dmytro Ostrovskyi Tobias Rumpf Julia Eib Alexandre Lumbroso Inna Slynko Susan Klaeger Stephanie Heinzlmeir Michael Forster Matthias Gehringer Ellen Pfaffenrot Silke Mona Bauer Karin Schmidtkunz Sandra Wenzler Eric Metzger Bernhard Kuster Stefan Laufer Roland Schüle Wolfgang Sippl Bernhard Breit Manfred Jung

Future Med Chem 2016 09 30;8(13):1537-51. Epub 2016 Aug 30.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Albertstraße 25, 79104 Freiburg im Breisgau, Germany.

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September 2016

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing.

Authors:
Inna Slynko Karin Schmidtkunz Tobias Rumpf Susan Klaeger Stephanie Heinzlmeir Abdulkarim Najar Eric Metzger Bernhard Kuster Roland Schüle Manfred Jung Wolfgang Sippl

ChemMedChem 2016 09 29;11(18):2084-94. Epub 2016 Jul 29.

Institute of Pharmacy, Martin Luther University of Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle/Saale, Germany.

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September 2016

Structure-Based Development of an Affinity Probe for Sirtuin 2.

Authors:
Matthias Schiedel Tobias Rumpf Berin Karaman Attila Lehotzky Stefan Gerhardt Judit Ovádi Wolfgang Sippl Oliver Einsle Manfred Jung

Angew Chem Int Ed Engl 2016 Feb 8;55(6):2252-6. Epub 2016 Jan 8.

Institut für Pharmazeutische Wissenschaften, Albert-Ludwigs-Universität Freiburg, Albertstrasse 25, 79104, Freiburg im Breisgau, Germany.

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February 2016

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study.

Authors:
Matthias Schiedel Tobias Rumpf Berin Karaman Attila Lehotzky Judit Oláh Stefan Gerhardt Judit Ovádi Wolfgang Sippl Oliver Einsle Manfred Jung

J Med Chem 2016 Feb 7;59(4):1599-612. Epub 2016 Jan 7.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg , Albertstraße 25, 79104 Freiburg im Breisgau, Germany.

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February 2016

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.

Authors:
Tobias Rumpf Stefan Gerhardt Oliver Einsle Manfred Jung

Acta Crystallogr F Struct Biol Commun 2015 Dec 18;71(Pt 12):1498-510. Epub 2015 Nov 18.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Albertstrasse 25, 79104 Freiburg, Baden-Württemberg, Germany.

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December 2015

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Authors:
Tobias Rumpf Matthias Schiedel Berin Karaman Claudia Roessler Brian J North Attila Lehotzky Judit Oláh Kathrin I Ladwein Karin Schmidtkunz Markus Gajer Martin Pannek Clemens Steegborn David A Sinclair Stefan Gerhardt Judit Ovádi Mike Schutkowski Wolfgang Sippl Oliver Einsle Manfred Jung

Nat Commun 2015 Feb 12;6:6263. Epub 2015 Feb 12.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-University Freiburg, Albertstraße 25, 79104 Freiburg im Breisgau, Germany.

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February 2015

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni.

Authors:
Diana A Stolfa Martin Marek Julien Lancelot Alexander-Thomas Hauser Alexandra Walter Emeline Leproult Jelena Melesina Tobias Rumpf Jean-Marie Wurtz Jean Cavarelli Wolfgang Sippl Raymond J Pierce Christophe Romier Manfred Jung

J Mol Biol 2014 Oct 20;426(20):3442-53. Epub 2014 Mar 20.

Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg, Germany. Electronic address:

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October 2014

Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development.

Authors:
Inna Slynko Michael Scharfe Tobias Rumpf Julia Eib Eric Metzger Roland Schüle Manfred Jung Wolfgang Sippl

J Chem Inf Model 2014 Jan 8;54(1):138-50. Epub 2014 Jan 8.

Institute of Pharmacy, MLU Halle-Wittenberg , 06120 Halle (Saale), Germany.

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January 2014

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5.

Authors:
Benjamin Maurer Tobias Rumpf Michael Scharfe Diana A Stolfa Martin L Schmitt Wenjuan He Eric Verdin Wolfgang Sippl Manfred Jung

ACS Med Chem Lett 2012 Dec 6;3(12):1050-3. Epub 2012 Oct 6.

Institute of Pharmaceutical Sciences, Albert-Ludwigs Universität , Albertstrasse 25, 79104 Freiburg, Germany.

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December 2012

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells.

Authors:
Jens Köhler German Erlenkamp Adrien Eberlin Tobias Rumpf Inna Slynko Eric Metzger Roland Schüle Wolfgang Sippl Manfred Jung

PLoS One 2012 20;7(4):e34973. Epub 2012 Apr 20.

Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse, Freiburg, Germany.

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August 2012

Steroid boost for sirtuin research.

Authors:
Tobias Rumpf Manfred Jung

Aging (Albany NY) 2011 Sep;3(9):818

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September 2011

Two-step synthesis of novel, bioactive derivatives of the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD).

Authors:
Thomas Pesnot Julia Kempter Jörg Schemies Giulia Pergolizzi Urszula Uciechowska Tobias Rumpf Wolfgang Sippl Manfred Jung Gerd K Wagner

J Med Chem 2011 May 29;54(10):3492-9. Epub 2011 Apr 29.

School of Pharmacy, University of East Anglia, Norwich, NR4 7TJ, UK.

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May 2011

Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).

Authors:
Marcus Freitag Jörg Schemies Tim Larsen Khattab El Gaghlab Felix Schulz Tobias Rumpf Manfred Jung Andreas Link

Bioorg Med Chem 2011 Jun 22;19(12):3669-77. Epub 2011 Jan 22.

Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Friedrich-Ludwig-Jahn-Str. 17, 17489 Greifswald, Germany.

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June 2011

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

Authors:
Michael Lawson Urszula Uciechowska Jörg Schemies Tobias Rumpf Manfred Jung Wolfgang Sippl

Biochim Biophys Acta 2010 Oct-Dec;1799(10-12):726-39. Epub 2010 Jun 23.

Department of Pharmaceutical Chemistry, Martin-Luther Universität Halle-Wittenberg, Wolfgang-Langenbeckstr. 4, 06120 Halle/Saale, Germany.

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February 2011

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

Authors:
Kilian Huber Jörg Schemies Urszula Uciechowska Julia M Wagner Tobias Rumpf Felicitas Lewrick Regine Süss Wolfgang Sippl Manfred Jung Franz Bracher

J Med Chem 2010 Feb;53(3):1383-6

Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany.

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February 2010