Timothy J Donohoe

Timothy J Donohoe

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Timothy J Donohoe

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The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation.

Nat Chem 2018 Dec 17. Epub 2018 Dec 17.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK.

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http://dx.doi.org/10.1038/s41557-018-0178-5DOI Listing
December 2018

Stereoselective Synthesis of Cyclohexanes via an Iridium Catalyzed (5 + 1) Annulation Strategy.

J Am Chem Soc 2018 Sep 13;140(38):11916-11920. Epub 2018 Sep 13.

Department of Chemistry, Chemical Research Laboratory , University of Oxford , Oxford , OX1 3TA , United Kingdom.

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http://dx.doi.org/10.1021/jacs.8b07776DOI Listing
September 2018

OBO-Protected Pyruvates as Reagents for the Synthesis of Functionalized Heteroaromatic Compounds.

Org Lett 2018 07 15;20(13):4048-4051. Epub 2018 Jun 15.

Department of Chemistry , University of Oxford, Chemistry Research Laboratory , Mansfield Road , Oxford OX1 3TA , U.K.

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http://dx.doi.org/10.1021/acs.orglett.8b01614DOI Listing
July 2018

Asymmetric Total Synthesis of (-)-(3 R)-Inthomycin C.

Org Lett 2018 06 4;20(12):3583-3586. Epub 2018 Jun 4.

Department of Chemistry , University of Oxford , Chemistry Research Laboratory, Mansfield Road , Oxford OX1 3TA , U.K.

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http://dx.doi.org/10.1021/acs.orglett.8b01370DOI Listing
June 2018

Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4.

Angew Chem Int Ed Engl 2017 Nov 19;56(47):14883-14887. Epub 2017 Oct 19.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.201708278DOI Listing
November 2017

Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis.

Org Lett 2017 10 18;19(19):5248-5251. Epub 2017 Sep 18.

Department of Chemistry, University of Oxford , Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.

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http://dx.doi.org/10.1021/acs.orglett.7b02524DOI Listing
October 2017

Catalytic Enolate Arylation with 3-Bromoindoles Allows the Formation of β-Carbolines.

J Org Chem 2017 04 31;82(8):4435-4443. Epub 2017 Mar 31.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory , Mansfield Road, Oxford OX1 3TA, U.K.

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http://dx.doi.org/10.1021/acs.joc.7b00299DOI Listing
April 2017

Hydrogen Borrowing Catalysis with Secondary Alcohols: A New Route for the Generation of β-Branched Carbonyl Compounds.

J Am Chem Soc 2017 02 8;139(7):2577-2580. Epub 2017 Feb 8.

Department of Chemistry, Chemical Research Laboratory, University of Oxford , Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/jacs.6b12840DOI Listing
February 2017

Orthogonally Protected 1,2-Diols from Electron-Rich Alkenes Using Metal-Free Olefin syn-Dihydroxylation.

Org Lett 2016 11 9;18(22):5880-5883. Epub 2016 Nov 9.

Department of Chemistry, University of Oxford , Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.

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http://dx.doi.org/10.1021/acs.orglett.6b02959DOI Listing
November 2016

Dehydromicrosclerodermin B and Microsclerodermin J: Total Synthesis and Structural Revision.

Angew Chem Int Ed Engl 2016 08 15;55(33):9753-7. Epub 2016 Jul 15.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.201604764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5132153PMC
August 2016

Hydrogen Bonding to Hexafluoroisopropanol Controls the Oxidative Strength of Hypervalent Iodine Reagents.

J Am Chem Soc 2016 07 5;138(28):8855-61. Epub 2016 Jul 5.

Department of Chemistry, Physical and Theoretical Chemistry Laboratory, University of Oxford , South Parks Road, Oxford OX1 3QZ, United Kingdom.

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http://dx.doi.org/10.1021/jacs.6b04057DOI Listing
July 2016

Catalytic Hypervalent Iodine Promoters Lead to Styrene Dimerization and the Formation of Tri- and Tetrasubstituted Cyclobutanes.

Angew Chem Int Ed Engl 2016 Apr 7;55(15):4748-52. Epub 2016 Mar 7.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.201511683DOI Listing
April 2016

Palladium-catalyzed enolate arylation as a key C-C bond-forming reaction for the synthesis of isoquinolines.

Org Biomol Chem 2016 Jan 3;14(3):1065-90. Epub 2015 Dec 3.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c5ob02320cDOI Listing
January 2016

Strategic Application and Transformation of ortho-Disubstituted Phenyl and Cyclopropyl Ketones To Expand the Scope of Hydrogen Borrowing Catalysis.

J Am Chem Soc 2015 Dec 11;137(50):15664-7. Epub 2015 Dec 11.

Department of Chemistry, Chemistry Research Laboratory, University of Oxford , Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/jacs.5b11196DOI Listing
December 2015

Aziridine electrophiles in the functionalisation of peptide chains with amine nucleophiles.

Org Biomol Chem 2015 Aug;13(31):8545-9

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c5ob00856eDOI Listing
August 2015

Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation.

Org Lett 2015 Jul 18;17(13):3222-5. Epub 2015 Jun 18.

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, U.K.

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http://dx.doi.org/10.1021/acs.orglett.5b01312DOI Listing
July 2015

Palladium-catalyzed α-arylation of carbonyls in the de novo synthesis of aromatic heterocycles.

Org Biomol Chem 2015 Apr;13(15):4367-73

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1039/c5ob00055fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424829PMC
April 2015

Hydrogen-borrowing and interrupted-hydrogen-borrowing reactions of ketones and methanol catalyzed by iridium.

Angew Chem Int Ed Engl 2015 Jan 9;54(5):1642-5. Epub 2014 Dec 9.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA (UK).

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http://dx.doi.org/10.1002/anie.201410391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344817PMC
January 2015

Short and efficient syntheses of protoberberine alkaloids using palladium-catalyzed enolate arylation.

Angew Chem Int Ed Engl 2014 Dec 27;53(52):14555-8. Epub 2014 Oct 27.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA (UK).

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http://dx.doi.org/10.1002/anie.201409164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502971PMC
December 2014

New methods for the synthesis of naphthyl amines; application to the synthesis of dihydrosanguinarine, sanguinarine, oxysanguinarine and (±)-maclekarpines B and C.

Chem Commun (Camb) 2014 Oct;50(77):11314-6

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c4cc05209aDOI Listing
October 2014

Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction.

Bioorg Med Chem 2014 Oct 24;22(19):5476-86. Epub 2014 Jul 24.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896140054
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http://dx.doi.org/10.1016/j.bmc.2014.07.029DOI Listing
October 2014

De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.

Org Lett 2014 Apr 19;16(7):1920-3. Epub 2014 Mar 19.

Department of Chemistry, Chemistry Research Laboratory, University of Oxford , Mansfield Road, Oxford, OX1 3TA, U.K.

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http://dx.doi.org/10.1021/ol500441qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979090PMC
April 2014

Rhodium-catalyzed ketone methylation using methanol under mild conditions: formation of α-branched products.

Angew Chem Int Ed Engl 2014 Jan 29;53(3):761-5. Epub 2013 Nov 29.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA (UK).

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http://dx.doi.org/10.1002/anie.201307950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138999PMC
January 2014

Modular isoquinoline synthesis using catalytic enolate arylation and in situ functionalization.

Org Lett 2013 Dec 19;15(24):6190-3. Epub 2013 Nov 19.

Department of Chemistry, University of Oxford , Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K., and GlaxoSmithKline , Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, U.K.

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http://dx.doi.org/10.1021/ol4030309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880054PMC
December 2013

Tethered aminohydroxylation: synthesis of the β-amino acid of microsclerodermins A and B.

Org Lett 2013 Nov 16;15(21):5492-5. Epub 2013 Oct 16.

Department of Chemistry, University of Oxford , Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, U.K.

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http://dx.doi.org/10.1021/ol402638nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005371PMC
November 2013

Osmium-catalyzed oxidative cyclization of dienes and their derivatives.

J Org Chem 2013 Mar 31;78(6):2149-67. Epub 2013 Jan 31.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/jo302719yDOI Listing
March 2013

Interplay of cascade oxidative cyclization and hydride shifts in the synthesis of the ABC spiroketal ring system of pectenotoxin-4.

Angew Chem Int Ed Engl 2013 Feb 30;52(9):2491-4. Epub 2013 Jan 30.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.201208919DOI Listing
February 2013

Natural product synthesis as a challenging test of newly developed methodology.

Chem Commun (Camb) 2012 Dec;48(98):11924-38

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c2cc36040cDOI Listing
December 2012

Asymmetric synthesis of the fully elaborated pyrrolidinone core of oxazolomycin A.

Org Lett 2012 Nov 12;14(21):5460-3. Epub 2012 Oct 12.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol302541jDOI Listing
November 2012

Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones.

Proc Natl Acad Sci U S A 2012 Jul 2;109(29):11605-8. Epub 2012 Jul 2.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1206532109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406859PMC
July 2012

Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes.

Org Biomol Chem 2012 Feb 12;10(5):1093-101. Epub 2011 Dec 12.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK OX1 3TA.

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http://xlink.rsc.org/?DOI=C1OB06587D
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http://dx.doi.org/10.1039/c1ob06587dDOI Listing
February 2012

Olefin cross-metathesis for the synthesis of heteroaromatic compounds.

Org Biomol Chem 2012 Feb 4;10(7):1322-8. Epub 2012 Jan 4.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c2ob06659aDOI Listing
February 2012

The influence of exocyclic stereochemistry on the tethered aminohydroxylation reaction.

Chem Asian J 2011 Dec 14;6(12):3214-22. Epub 2011 Sep 14.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/asia.201100497DOI Listing
December 2011

Amino acid-based reoxidants for aminohydroxylation: application to the construction of amino acid-amino alcohol conjugates.

Angew Chem Int Ed Engl 2011 Nov 23;50(46):10957-60. Epub 2011 Sep 23.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.201103293DOI Listing
November 2011

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.

Chem Commun (Camb) 2011 Oct 25;47(38):10611-3. Epub 2011 Aug 25.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c1cc14257gDOI Listing
October 2011

Total synthesis of (±)-streptonigrin: de novo construction of a pentasubstituted pyridine using ring-closing metathesis.

J Am Chem Soc 2011 Oct 23;133(41):16418-21. Epub 2011 Sep 23.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ja207835wDOI Listing
October 2011

A short and efficient synthesis of neodysiherbaine A by using catalytic oxidative cyclization.

Angew Chem Int Ed Engl 2011 Aug 27;50(33):7604-6. Epub 2011 Jun 27.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.201102525DOI Listing
August 2011

Dehydrogenation of cyclic thioethers bound to a [Rh(diphosphine)]+ fragment.

Dalton Trans 2011 Jul 25;40(25):6626-8. Epub 2011 May 25.

Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c1dt10503eDOI Listing
July 2011

Exerting control over the acyloin reaction.

Chem Commun (Camb) 2011 May 18;47(20):5849-51. Epub 2011 Apr 18.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c1cc11654aDOI Listing
May 2011

Intramolecular hydride addition to pyridinium salts: new routes to enantiopure dihydropyridones.

Org Lett 2011 Apr 18;13(8):2074-7. Epub 2011 Mar 18.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol200478pDOI Listing
April 2011

Heteroaromatic synthesis via olefin cross-metathesis: entry to polysubstituted pyridines.

Org Lett 2011 Mar 26;13(5):1036-9. Epub 2011 Jan 26.

Department of Chemistry, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1021/ol103088rDOI Listing
March 2011

Osmium-free direct syn-dihydroxylation of alkenes.

Chem Soc Rev 2011 Jan 3;40(1):114-28. Epub 2010 Nov 3.

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

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http://xlink.rsc.org/?DOI=B923880H
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http://dx.doi.org/10.1039/b923880hDOI Listing
January 2011

Recent developments in methodology for the direct oxyamination of olefins.

Chemistry 2011 Jan 16;17(1):58-76. Epub 2010 Dec 16.

Department of Chemistry, Chemical Research Laboratory, University of Oxford, UK.

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http://dx.doi.org/10.1002/chem.201002323DOI Listing
January 2011

Olefin cross-metathesis-based approaches to furans: procedures for the preparation of di- and trisubstituted variants.

Nat Protoc 2010 Dec 2;5(12):2005-10. Epub 2010 Dec 2.

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nprot.2010.147DOI Listing
December 2010

Identification of epigenetic DNA modifications with a protein nanopore.

Chem Commun (Camb) 2010 Nov 6;46(43):8195-7. Epub 2010 Oct 6.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK OX1 3TA.

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http://xlink.rsc.org/?DOI=c0cc02864a
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http://dx.doi.org/10.1039/c0cc02864aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147113PMC
November 2010

A novel oxidative cyclisation onto vinyl silanes.

Chem Commun (Camb) 2010 Oct 6;46(39):7310-2. Epub 2010 Sep 6.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/c0cc01342kDOI Listing
October 2010

Substituted pyrroles via olefin cross-metathesis.

Org Lett 2010 Sep;12(18):4094-7

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol101681rDOI Listing
September 2010

New modes for the osmium-catalyzed oxidative cyclization.

Org Lett 2010 Mar;12(5):1060-3

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol100046aDOI Listing
March 2010

An expedient route to substituted furans via olefin cross-metathesis.

Proc Natl Acad Sci U S A 2010 Feb 8;107(8):3373-6. Epub 2010 Feb 8.

Department of Chemistry, University of Oxford, Oxford, OX1 3TA UK.

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http://dx.doi.org/10.1073/pnas.0913466107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840463PMC
February 2010

Regioselective nucleophilic addition to pyridinium salts: a new route to substituted dihydropyridones.

Org Lett 2009 Dec;11(23):5562-5

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol902402vDOI Listing
December 2009

Synthesis and phytotoxic activity of new pyridones derived from 4-hydroxy-6-methylpyridin-2(1H)-one.

Molecules 2009 Dec 1;14(12):4973-86. Epub 2009 Dec 1.

Department of Chemistry, Federal University of Vicosa, Av. P. H. Rolfs, s/n, 36570-000, Vicosa, MG, Brazil.

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http://dx.doi.org/10.3390/molecules14124973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255104PMC
December 2009

Synthesis of (-)-hygromycin A: application of Mitsunobu glycosylation and tethered aminohydroxylation.

Angew Chem Int Ed Engl 2009 ;48(35):6507-10

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.200902840DOI Listing
November 2009

Concise syntheses of the natural products (+)-sylvaticin and (+)-cis-sylvaticin.

J Am Chem Soc 2009 Sep;131(35):12854-61

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/ja9049959DOI Listing
September 2009

Osmium-mediated oxidative cyclizations: a study into the range of initiators that facilitate cyclization.

Chem Asian J 2009 Aug;4(8):1237-47

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/asia.200900168DOI Listing
August 2009

A Lewis acid promoted oxidative cyclization.

J Org Chem 2009 Aug;74(16):6394-7

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/jo901243yDOI Listing
August 2009

Tethered aminohydroxylation (TA) reaction of amides.

Org Lett 2009 Jun;11(11):2305-7

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol900631yDOI Listing
June 2009

Synthesis of substituted pyridines and pyridazines via ring closing metathesis.

Chem Commun (Camb) 2009 Jun 6(21):3008-10. Epub 2009 Apr 6.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Oxford, UK OX1 3TA.

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http://dx.doi.org/10.1039/b904363bDOI Listing
June 2009

Ruthenium-catalyzed isomerization of terminal olefins: applications to synthesis.

Angew Chem Int Ed Engl 2009 ;48(6):1014-7

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.200804617DOI Listing
March 2009

Synthesis of (+)-DGDP and (-)-7-epialexine.

Org Biomol Chem 2008 Nov 19;6(21):3896-8. Epub 2008 Sep 19.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1039/b815332aDOI Listing
November 2008

Synthesis of (-)-(Z)-deoxypukalide.

Angew Chem Int Ed Engl 2008 ;47(38):7314-6

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.200802703DOI Listing
October 2008

Ring-closing metathesis: novel routes to aromatic heterocycles.

Chemistry 2008 ;14(19):5716-26

Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA UK.

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http://dx.doi.org/10.1002/chem.200800130DOI Listing
September 2008

Alkali metal reductions of organic molecules: why mediated electron transfer from lithium is faster than direct reduction.

J Am Chem Soc 2008 Sep 21;130(37):12256-7. Epub 2008 Aug 21.

Department of Chemistry, Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, OX1 3QZ, UK.

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http://pubs.acs.org/doi/abs/10.1021/ja805086w
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http://dx.doi.org/10.1021/ja805086wDOI Listing
September 2008

Flexible strategy for the synthesis of pyrrolizidine alkaloids.

Org Lett 2008 Aug 18;10(16):3615-8. Epub 2008 Jul 18.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol801415dDOI Listing
August 2008

Hydride shift generated oxonium ions: evidence for mechanism and intramolecular trapping experiments to form trans THF derivatives.

Angew Chem Int Ed Engl 2008 ;47(15):2869-71

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.200705340DOI Listing
April 2008

Pyridine-N-oxide as a mild reoxidant which transforms osmium-catalyzed oxidative cyclization.

Angew Chem Int Ed Engl 2008 ;47(15):2872-5

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.200705425DOI Listing
April 2008

A metathesis-based approach to the synthesis of 2-pyridones and pyridines.

Org Lett 2008 Jan 23;10(2):285-8. Epub 2007 Dec 23.

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1021/ol702684dDOI Listing
January 2008

The partial reduction of electron-deficient pyrroles: procedures describing both Birch (Li/NH3) and ammonia-free (Li/DBB) conditions.

Nat Protoc 2007 ;2(8):1888-95

Chemistry Research Laboratory, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/nprot.2007.245DOI Listing
December 2007

A concise and efficient synthesis of (-)-allosamizoline.

Org Lett 2007 Dec 16;9(26):5509-11. Epub 2007 Nov 16.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol702449mDOI Listing
December 2007

Partial reduction of pyrroles: application to natural product synthesis.

Chem Rec 2007 ;7(3):180-90

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1002/tcr.20115DOI Listing
September 2007

Electrosynthetic reduction of 1-iodoadamantane forming 1,1'-biadamantane and adamantane in aprotic solvents: insonation switches the mechanism from dimerisation to exclusive monomer formation.

Ultrason Sonochem 2007 Jul 16;14(5):502-8. Epub 2007 Jan 16.

Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QZ, United Kingdom.

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http://dx.doi.org/10.1016/j.ultsonch.2006.11.007DOI Listing
July 2007

Tethered aminohydroxylation: dramatic improvements to the process.

Org Lett 2007 Apr 28;9(9):1725-8. Epub 2007 Mar 28.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol070430vDOI Listing
April 2007

A metathesis-based approach to the synthesis of furans.

Org Lett 2007 Mar 23;9(6):953-6. Epub 2007 Feb 23.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.

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http://dx.doi.org/10.1021/ol062933rDOI Listing
March 2007

Synthesis of the pyrrolidinone core of KSM-2690 B.

Org Lett 2007 Feb;9(3):421-4

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K.

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http://dx.doi.org/10.1021/ol062705xDOI Listing
February 2007

Stereoselective synthesis of pyrrolidines: catalytic oxidative cyclizations mediated by osmium.

Angew Chem Int Ed Engl 2006 Dec;45(47):8025-8

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.200603240DOI Listing
December 2006

Total synthesis of (+)-cis-sylvaticin: double oxidative cyclization reactions catalyzed by osmium.

J Am Chem Soc 2006 Oct;128(42):13704-5

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, UK.

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http://dx.doi.org/10.1021/ja0660148DOI Listing
October 2006

An enzymatic approach to the desymmetrization of disubstituted pyrrolines.

J Org Chem 2006 Aug;71(16):6298-301

Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/jo060926aDOI Listing
August 2006

Cryovoltammetrically probing functional group reductive cleavage: alkyl-sulfur versus aryl-sulfur bond cleavage in an alkyl naphthyl thioether under single electron-transfer is temperature switchable.

Chem Commun (Camb) 2006 Aug 10(32):3402-4. Epub 2006 Jul 10.

Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, UK.

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http://dx.doi.org/10.1039/b606638kDOI Listing
August 2006

New osmium-based reagent for the dihydroxylation of alkenes.

J Org Chem 2006 Jun;71(12):4481-9

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1021/jo060301cDOI Listing
June 2006

Ring-closing metathesis as a basis for the construction of aromatic compounds.

Angew Chem Int Ed Engl 2006 Apr;45(17):2664-70

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://doi.wiley.com/10.1002/anie.200503512
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April 2006

N-sulfonyloxy carbamates as reoxidants for the tethered aminohydroxylation reaction.

J Am Chem Soc 2006 Mar;128(8):2514-5

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, UK.

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http://dx.doi.org/10.1021/ja057389gDOI Listing
March 2006

The ammonia-free partial reduction of substituted pyridinium salts.

Org Biomol Chem 2006 Mar 16;4(6):1071-84. Epub 2006 Feb 16.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UKOX1 3TA.

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http://dx.doi.org/10.1039/b517462gDOI Listing
March 2006

A noncarbohydrate based approach to polyhydroxylated pyrrolidizines: total syntheses of the natural products hyacinthacine A1 and 1-epiaustraline.

J Org Chem 2005 Sep;70(18):7297-304

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/jo050977s
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September 2005

Oxidative cyclization of diols derived from 1,5-dienes: formation of enantiopure cis-tetrahydrofurans by using catalytic osmium tetroxide; formal synthesis of (+)-cis-solamin.

Angew Chem Int Ed Engl 2005 Jul;44(30):4766-8

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK.

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http://dx.doi.org/10.1002/anie.200500513DOI Listing
July 2005

Concise and enantioselective synthesis of the aminocyclitol core of hygromycin A.

Org Lett 2005 Mar;7(7):1275-7

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.

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http://pubs.acs.org/doi/abs/10.1021/ol0473750
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March 2005

Partial reduction of pyridinium salts as a versatile route to dihydropyridones.

Org Lett 2005 Feb;7(3):435-7

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol0476624DOI Listing
February 2005

Enantioselective partial reduction of 2,5-disubstituted pyrroles via a chiral protonation approach.

Org Lett 2004 Sep;6(18):3055-8

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol049014qDOI Listing
September 2004

Efficient acyclic stereocontrol using the tethered aminohydroxylation reaction.

Org Lett 2004 Jul;6(15):2583-5

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://pubs.acs.org/doi/abs/10.1021/ol049136i
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July 2004

A concise total synthesis of (+/-)-1-epiaustraline.

Org Lett 2004 Jun;6(12):2003-6

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.

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http://dx.doi.org/10.1021/ol049397sDOI Listing
June 2004

Rearrangement of pyrrolines derived from the Birch reduction of electron-deficient pyrroles: radical ring-expansion to substituted tetrahydropyridines.

Chem Commun (Camb) 2004 Jun 18(12):1422-3. Epub 2004 May 18.

Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UKOX1 3TA.

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http://dx.doi.org/10.1039/b404002cDOI Listing
June 2004

An efficient synthesis of lactacystin beta-lactone.

Angew Chem Int Ed Engl 2004 Apr;43(17):2293-6

Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.

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http://dx.doi.org/10.1002/anie.200453843DOI Listing
April 2004

Enantiopure oxazolidinones as chiral acids in the asymmetric protonation of N-Boc pyrrole derived enolates.

Chem Commun (Camb) 2004 Mar 16(6):722-3. Epub 2004 Feb 16.

Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY.

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http://dx.doi.org/10.1039/b316719dDOI Listing
March 2004

Synthesis of (+/-)-secosyrin 1 and a formal synthesis of (-)-secosyrin 1.

Org Lett 2004 Feb;6(4):465-7

Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK.

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http://dx.doi.org/10.1021/ol0362313DOI Listing
February 2004

Trichloro-oxazolines as activated donors for aminosugar coupling.

Org Lett 2003 Dec;5(26):4995-8

Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, UK.

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http://dx.doi.org/10.1021/ol0359620DOI Listing
December 2003

Scope of the reductive aldol reaction: application to aromatic carbocycles and heterocycles.

Org Biomol Chem 2003 Nov;1(21):3749-57

Dyson Perrins Laboratory, South Parks Road, Oxford, UK OX1 3QY.

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November 2003

The tethered aminohydroxylation (TA) reaction.

Org Biomol Chem 2003 Jun;1(12):2025-8

The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY.

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June 2003

Scope of the directed dihydroxylation: application to cyclic homoallylic alcohols and trihaloacetamides.

Org Biomol Chem 2003 Jun;1(12):2173-86

Dyson Perrins Laboratory, South Parks Road, Oxford, UK OX1 3QY.

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June 2003

Flexibility in the partial reduction of 2,5-disubstituted pyrroles: application to the synthesis of DMDP.

Org Lett 2003 Apr;5(7):999-1002

Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, OX1 3QY, United Kingdom.

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http://pubs.acs.org/doi/abs/10.1021/ol027504h
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April 2003

A general oxidative cyclization of 1,5-dienes using catalytic osmium tetroxide.

Angew Chem Int Ed Engl 2003 Feb;42(8):948-51

Dyson Perrins Laboratory, South Parks Road, Oxford, UK.

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http://dx.doi.org/10.1002/anie.200390253DOI Listing
February 2003