Thomas W Kensler

Thomas W Kensler

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Thomas W Kensler

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Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway.

Curr Pharm Des 2019 ;25(16):1828-1846

Service of Endocrinology, Diabetology and Metabolism, University of Lausanne, Lausanne, Switzerland.

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http://www.eurekaselect.com/173143/article
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http://dx.doi.org/10.2174/1381612825666190701165821DOI Listing
March 2020

Nrf2 in liver toxicology.

Arch Pharm Res 2020 Mar 28;43(3):337-349. Epub 2019 Nov 28.

Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, Seattle, WA, 98109, USA.

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http://dx.doi.org/10.1007/s12272-019-01192-3DOI Listing
March 2020

Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction.

Antioxid Redox Signal 2020 Feb 16. Epub 2020 Feb 16.

University of Alabama at Birmingham, Pathology, 901 19th St South, BMR2-RM#533, Cardiac Aging and Redox Signaling Laboratory, Birmingham, Alabama, United States, 35294.

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http://dx.doi.org/10.1089/ars.2019.7808DOI Listing
February 2020

Serum miR-182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats.

Mol Carcinog 2019 11 2;58(11):2017-2025. Epub 2019 Aug 2.

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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http://dx.doi.org/10.1002/mc.23093DOI Listing
November 2019

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Molecules 2019 Oct 6;24(19). Epub 2019 Oct 6.

Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.3390/molecules24193593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804255PMC
October 2019

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.

Nat Rev Drug Discov 2019 04;18(4):295-317

Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1038/s41573-018-0008-xDOI Listing
April 2019

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Food Chem Toxicol 2019 Apr 5;126:1-6. Epub 2019 Feb 5.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422739PMC
April 2019

Evaluation of 2-Thiothiazolidine-4-Carboxylic Acid, a Common Metabolite of Isothiocyanates, as a Potential Biomarker of Cruciferous Vegetable Intake.

Mol Nutr Food Res 2019 02 22;63(3):e1801029. Epub 2018 Nov 22.

Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

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http://doi.wiley.com/10.1002/mnfr.201801029
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http://dx.doi.org/10.1002/mnfr.201801029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488352PMC
February 2019

Qidong: a crucible for studies on liver cancer etiology and prevention.

Cancer Biol Med 2019 Feb;16(1):24-37

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore 21205, MD, USA.

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http://www.cancerbiomed.org/index.php/cocr/article/view/1371
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http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528445PMC
February 2019

NRF2 as an Emerging Therapeutic Target.

Oxid Med Cell Longev 2017;2017:8165458. Epub 2017 Jan 31.

Reata Pharmaceuticals Inc., 2801 Gateway Drive, Irving, TX 75063, USA.

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http://dx.doi.org/10.1155/2017/8165458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306997PMC
January 2019

Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice.

J Endocrinol 2019 Jan 1. Epub 2019 Jan 1.

M Yamamoto, Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.

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https://joe.bioscientifica.com/view/journals/joe/aop/joe-18-
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http://dx.doi.org/10.1530/JOE-18-0355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602871PMC
January 2019

Isothiocyanates: Translating the Power of Plants to People.

Mol Nutr Food Res 2018 09 26;62(18):e1700965. Epub 2018 Mar 26.

Departments of Medicine, Pharmacology and Molecular Sciences, International Health and Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/mnfr.201700965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226005PMC
September 2018

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.

Physiol Rev 2018 07;98(3):1169-1203

Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University , Sendai , Japan ; Department of Pharmacology & Chemical Biology, University of Pittsburgh , Pittsburgh, Pennsylvania ; and Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University , Sendai , Japan.

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http://dx.doi.org/10.1152/physrev.00023.2017DOI Listing
July 2018

Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.

Mol Pharmacol 2018 04 24;93(4):297-308. Epub 2018 Jan 24.

Departments of Chemistry (R.S.W., T.R.S.) and Biological Sciences (C.H.S., T.R.S.,) and the W. Harry Feinstone Center for Genomic Research (R.S.W., S.F., T.R.S.), University of Memphis, Memphis, Tennessee; Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee (Q.T.T.); Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (T.W.K.); and Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania (T.W.K.)

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http://dx.doi.org/10.1124/mol.117.110262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832324PMC
April 2018

Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.

Hepatoma Res 2018 26;4. Epub 2018 Jan 26.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200032, China.

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http://dx.doi.org/10.20517/2394-5079.2017.50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824723PMC
January 2018

KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane.

Trends Food Sci Technol 2017 Nov 16;69(Pt B):257-269. Epub 2017 Feb 16.

Lewis B. and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.tifs.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725197PMC
November 2017

NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction.

Cancer Res 2017 06 17;77(11):2881-2892. Epub 2017 Apr 17.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey and Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464605PMC
June 2017

Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms.

Free Radic Biol Med 2016 12 4;101:116-128. Epub 2016 Oct 4.

Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154810PMC
December 2016

Keap1 hypomorphism protects against ischemic and obstructive kidney disease.

Sci Rep 2016 11 2;6:36185. Epub 2016 Nov 2.

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1038/srep36185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090361PMC
November 2016

Lung Cancer in a Rural Area of China: Rapid Rise in Incidence and Poor Improvement in Survival.

Asian Pac J Cancer Prev 2015 ;16(16):7295-302

Qidong Liver Cancer Institute / Qidong People's Hospital, Qidong, China E-mail :

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http://dx.doi.org/10.7314/apjcp.2015.16.16.7295DOI Listing
September 2016

Generation of a New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity.

Toxicol Sci 2016 07 12;152(1):40-52. Epub 2016 Apr 12.

*Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Aoba, Sendai 980-8575, Japan;

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http://dx.doi.org/10.1093/toxsci/kfw065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922541PMC
July 2016

Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane.

Cancer Prev Res (Phila) 2016 Jul 23;9(7):547-57. Epub 2016 Jun 23.

Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930727PMC
July 2016

Withania somnifera: From prevention to treatment of cancer.

Mol Nutr Food Res 2016 06 29;60(6):1342-53. Epub 2016 Jan 29.

Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1002/mnfr.201500756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899165PMC
June 2016

Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle.

FASEB J 2016 05 2;30(5):1865-79. Epub 2016 Feb 2.

Cardiac Aging and Redox Signaling Laboratory, Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Division of Cardiovascular Medicine/Pulmonary Medicine, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA; Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA;

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http://dx.doi.org/10.1096/fj.201500153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836373PMC
May 2016

Cancer Prevention: Obstacles, Challenges and the Road Ahead.

J Natl Cancer Inst 2016 Feb 7;108(2). Epub 2015 Nov 7.

Biological Chemistry, Public Health, and Epidemiology, Chao Family Comprehensive Cancer Center, School of Medicine - University of California, Irvine, Irvine, CA (FLMJr); Arizona Board of Regents Professor of Medicine, Pharmacology, Public Health, Nutritional Sciences & BIO5, University of Arizona Cancer Center, Skin Cancer Institute, Tucson, AZ (DSA); Wolfson Institute of Preventive Medicine and Head, Centre for Cancer Prevention; Centre for Cancer Prevention, Queen Mary University of London, Mile End Road, London, UK (JC); Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA (TWK); Moores Cancer Center (SML) and Department of Family Medicine and Public Health, Cancer Prevention and Control Program (CLR), UC San Diego, San Diego, CA (SML); Dermatology Research Laboratories, University of Wisconsin; Madison, WI (HM); Hutchinson Institute for Cancer Outcomes Research, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA (SDR); Center for Cancer Prevention Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ (CSY).

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http://dx.doi.org/10.1093/jnci/djv309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907357PMC
February 2016

Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet.

Arch Biochem Biophys 2016 Feb 14;591:57-65. Epub 2015 Dec 14.

Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2015.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747866PMC
February 2016

Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane.

Semin Oncol 2016 Feb 8;43(1):146-153. Epub 2015 Sep 8.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261. Electronic address:

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http://dx.doi.org/10.1053/j.seminoncol.2015.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789124PMC
February 2016

Aflatoxin regulations and global pistachio trade: insights from social network analysis.

PLoS One 2014 26;9(3):e92149. Epub 2014 Mar 26.

Department of Food Science and Human Nutrition and Department of Agricultural, Food and Resource Economics, Michigan State University, East Lansing, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092149PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966772PMC
December 2015

Crosstalk between Nrf2 and Notch signaling.

Free Radic Biol Med 2015 Nov 21;88(Pt B):158-167. Epub 2015 May 21.

Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Environmental Health Science, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628857PMC
November 2015

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism.

Biochem Soc Trans 2015 Aug 3;43(4):639-44. Epub 2015 Aug 3.

Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, U.S.A.

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http://dx.doi.org/10.1042/BST20150049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613493PMC
August 2015

Chemoprevention targets for tobacco-related head and neck cancer: past lessons and future directions.

Oral Oncol 2015 Jun 11;51(6):557-64. Epub 2015 Apr 11.

Department of Medicine, University of Pittsburgh, United States. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2015.02.101DOI Listing
June 2015

NRF2/long noncoding RNA ROR signaling regulates mammary stem cell expansion and protects against estrogen genotoxicity.

J Biol Chem 2014 Nov 17;289(45):31310-8. Epub 2014 Sep 17.

From the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201 and

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http://www.jbc.org/content/289/45/31310.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M114.604868
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http://dx.doi.org/10.1074/jbc.M114.604868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223331PMC
November 2014

Reduced foodborne toxin exposure is a benefit of improving dietary diversity.

Toxicol Sci 2014 Oct 11;141(2):329-34. Epub 2014 Jul 11.

Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205 Environmental and Occupational Health, Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.

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http://academic.oup.com/toxsci/article/141/2/329/2511220/Red
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http://dx.doi.org/10.1093/toxsci/kfu137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271042PMC
October 2014

Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity.

Toxicol Sci 2014 Sep 12;141(1):112-9. Epub 2014 Jun 12.

Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205

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http://dx.doi.org/10.1093/toxsci/kfu109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271119PMC
September 2014

Changing rates for liver and lung cancers in Qidong, China.

Chem Res Toxicol 2014 Jan 20;27(1):3-6. Epub 2013 Nov 20.

Department of Epidemiology, Qidong Liver Cancer Institute , Qidong, 226200, Jiangsu, China.

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http://dx.doi.org/10.1021/tx400313jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946948PMC
January 2014

Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells.

Carcinogenesis 2013 Nov 10;34(11):2587-92. Epub 2013 Jul 10.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1093/carcin/bgt246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888356PMC
November 2013

Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.

Cardiovasc Res 2013 Oct 12;100(1):63-73. Epub 2013 Jun 12.

Cardiac Aging and Redox Signaling Laboratory, RM # 4A100, Division of Cardiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1093/cvr/cvt150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778956PMC
October 2013

Global risk assessment of aflatoxins in maize and peanuts: are regulatory standards adequately protective?

Toxicol Sci 2013 Sep 12;135(1):251-9. Epub 2013 Jun 12.

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan 48824, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kft132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748761PMC
September 2013

The Keap1-Nrf2 system prevents onset of diabetes mellitus.

Mol Cell Biol 2013 Aug 28;33(15):2996-3010. Epub 2013 May 28.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

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http://dx.doi.org/10.1128/MCB.00225-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719683PMC
August 2013

Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.

Mol Biol Cell 2013 Jun 1;24(12):1852-62. Epub 2013 May 1.

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1091/mbc.E12-09-0666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681691PMC
June 2013

Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo.

Am J Physiol Lung Cell Mol Physiol 2013 May 8;304(10):L646-56. Epub 2013 Mar 8.

Division of Cardiothoracic Transplantation, Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00164.2012
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http://dx.doi.org/10.1152/ajplung.00164.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652058PMC
May 2013

Health span extension through green chemoprevention.

Virtual Mentor 2013 Apr 1;15(4):311-8. Epub 2013 Apr 1.

Department of Pharmacology and Molecular Sciences at the Johns Hopkins School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1001/virtualmentor.2013.15.4.stas1-1304DOI Listing
April 2013

Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.

Top Curr Chem 2013 ;329:163-77

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/128_2012_339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553557PMC
March 2013

New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome.

Curr Diabetes Rev 2013 Mar;9(2):137-45

Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, PA 15261, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601410PMC
http://dx.doi.org/10.2174/1573399811309020005DOI Listing
March 2013

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.

Free Radic Biol Med 2012 Aug 23;53(4):817-27. Epub 2012 Jun 23.

Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539416PMC
August 2012

Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2012 1;29(2):249-57. Epub 2011 Jun 1.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.tandfonline.com/doi/abs/10.1080/19440049.2011.563
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http://dx.doi.org/10.1080/19440049.2011.563370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659374PMC
June 2012

Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora.

Cancer Prev Res (Phila) 2012 Apr 7;5(4):603-11. Epub 2012 Feb 7.

Lewis B. and Dorothy Cullman Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe Street (WBSB 406), Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618677PMC
April 2012

Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.

Breast Cancer Res Treat 2012 Feb 20;132(1):175-87. Epub 2011 May 20.

Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/s10549-011-1536-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564494PMC
February 2012

"MAPping" the course of chemoprevention in breast cancer.

N Engl J Med 2011 Jun 4;364(25):2463-4. Epub 2011 Jun 4.

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http://www.nejm.org/doi/abs/10.1056/NEJMe1106052
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http://dx.doi.org/10.1056/NEJMe1106052DOI Listing
June 2011

Nrf2: control of sensitivity to carcinogens.

Arch Toxicol 2011 Apr 3;85(4):273-84. Epub 2011 Mar 3.

Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/s00204-011-0675-4DOI Listing
April 2011

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.

Toxicol Sci 2011 Mar 29;120 Suppl 1:S28-48. Epub 2010 Sep 29.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfq283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043084PMC
March 2011

Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2.

Arch Biochem Biophys 2011 Mar 4;507(2):356-64. Epub 2011 Jan 4.

College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749, South Korea.

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http://dx.doi.org/10.1016/j.abb.2010.12.034DOI Listing
March 2011

When NRF2 talks, who's listening?

Antioxid Redox Signal 2010 Dec 9;13(11):1649-63. Epub 2010 Jul 9.

Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1089/ars.2010.3216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966480PMC
December 2010

The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.

J Cereb Blood Flow Metab 2010 Dec 5;30(12):1951-61. Epub 2010 May 5.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/jcbfm.2010.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002885PMC
December 2010

Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.

Breast Cancer Res Treat 2010 Nov 10;124(2):585-91. Epub 2010 Jul 10.

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1007/s10549-010-1023-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417311PMC
November 2010

Regulation of notch1 signaling by nrf2: implications for tissue regeneration.

Sci Signal 2010 Jul 13;3(130):ra52. Epub 2010 Jul 13.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1126/scisignal.2000762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932745PMC
July 2010

Targeting NRF2 signaling for cancer chemoprevention.

Toxicol Appl Pharmacol 2010 Apr 2;244(1):66-76. Epub 2009 Sep 2.

College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan-si, Gyeongsangbuk-do 712-749, South Korea.

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http://dx.doi.org/10.1016/j.taap.2009.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584341PMC
April 2010

Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells.

Proteomics 2010 Mar;10(5):1029-39

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/pmic.200900602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337220PMC
March 2010

Nrf2: friend or foe for chemoprevention?

Carcinogenesis 2010 Jan 30;31(1):90-9. Epub 2009 Sep 30.

Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/carcin/bgp231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802668PMC
January 2010

Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials?

Cancer Prev Res (Phila) 2009 Dec 1;2(12):1003-7. Epub 2009 Dec 1.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-09-0232DOI Listing
December 2009

The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.

Am J Respir Crit Care Med 2009 Nov 13;180(9):867-74. Epub 2009 Aug 13.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200905-0670O
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http://dx.doi.org/10.1164/rccm.200905-0670OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773914PMC
November 2009

Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice.

J Immunol 2009 Oct 4;183(7):4601-8. Epub 2009 Sep 4.

Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room. E7610, 615 North Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.4049/jimmunol.0901754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820249PMC
October 2009

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice.

J Cell Biol 2009 Sep 14;186(6):805-16. Epub 2009 Sep 14.

Department of Cell Biology, School of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1083/jcb.200903065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753156PMC
September 2009

Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.

Chem Res Toxicol 2009 Aug;22(8):1427-34

Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA. CA91032

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http://dx.doi.org/10.1021/tx900110nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755628PMC
August 2009