Thomas Langmann

Thomas Langmann

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Phenotypic Differences in Primary Murine Microglia Treated with NOD1, NOD2, and NOD1/2 Agonists.

J Mol Neurosci 2020 Apr 7;70(4):600-609. Epub 2020 Jan 7.

Ophtha-Lab, Ophthalmic Center at St.Franziskus Hospital, Münster, Germany.

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http://dx.doi.org/10.1007/s12031-019-01466-xDOI Listing
April 2020

The role of lymphocytes and phagocytes in age-related macular degeneration (AMD).

Cell Mol Life Sci 2020 Mar 2;77(5):781-788. Epub 2020 Jan 2.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.

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http://dx.doi.org/10.1007/s00018-019-03419-4DOI Listing
March 2020

AMD-Associated HTRA1 Variants Do Not Influence TGF-β Signaling in Microglia.

Adv Exp Med Biol 2019 ;1185:3-7

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1007/978-3-030-27378-1_1DOI Listing
February 2020

ERG Alteration Due to the rd8 Mutation of the Crb1 Gene in Cln3 Mice.

Adv Exp Med Biol 2019 ;1185:395-400

Department of Ophthalmology, University Eye Clinic Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1007/978-3-030-27378-1_65DOI Listing
February 2020

Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration.

Exp Eye Res 2019 11 25;188:107816. Epub 2019 Sep 25.

Lab for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Schlieren, Switzerland; Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland; Neuroscience Center, University of Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2019.107816DOI Listing
November 2019

Microglia in Retinal Degeneration.

Front Immunol 2019 20;10:1975. Epub 2019 Aug 20.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.3389/fimmu.2019.01975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710350PMC
August 2019

Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3 Knock-In Mice.

Adv Exp Med Biol 2018 ;1074:403-411

Department of Ophthalmology, University Eye Clinic Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1007/978-3-319-75402-4_50DOI Listing
May 2019

Anti-VEGF-A/ANG2 combotherapy limits pathological angiogenesis in the eye: a replication study.

EMBO Mol Med 2019 05;11(5)

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.15252/emmm.201910362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505573PMC
May 2019

Testing for Known Retinal Degeneration Mutants in Mouse Strains.

Methods Mol Biol 2019 ;1834:45-58

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.

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http://link.springer.com/10.1007/978-1-4939-8669-9_3
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http://dx.doi.org/10.1007/978-1-4939-8669-9_3DOI Listing
April 2019

Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina.

J Neuroinflammation 2019 Feb 7;16(1):26. Epub 2019 Feb 7.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, 50931, Cologne, Germany.

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http://dx.doi.org/10.1186/s12974-019-1419-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366121PMC
February 2019

Microglia Analysis in Retinal Degeneration Mouse Models.

Methods Mol Biol 2018 ;1753:159-166

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7720-8_10DOI Listing
January 2019

Transcriptional regulation of Translocator protein (18 kDa) (TSPO) in microglia requires Pu.1, Ap1 and Sp factors.

Biochim Biophys Acta Gene Regul Mech 2018 12 6;1861(12):1119-1133. Epub 2018 Nov 6.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, D-50931 Cologne, Germany; Centre for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18749399183036
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http://dx.doi.org/10.1016/j.bbagrm.2018.10.018DOI Listing
December 2018

Modulation of three key innate immune pathways for the most common retinal degenerative diseases.

EMBO Mol Med 2018 10;10(10)

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany

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http://dx.doi.org/10.15252/emmm.201708259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180304PMC
October 2018

Immunomodulation with minocycline rescues retinal degeneration in juvenile neuronal ceroid lipofuscinosis mice highly susceptible to light damage.

Dis Model Mech 2018 09 5;11(9). Epub 2018 Sep 5.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, 50931 Cologne, Germany

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http://dx.doi.org/10.1242/dmm.033597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176999PMC
September 2018

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration.

Invest Ophthalmol Vis Sci 2018 09;59(11):4392-4403

Departamento de Oftalmología, Facultad de Medicina, Universidad de Murcia and Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain.

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http://dx.doi.org/10.1167/iovs.18-24621DOI Listing
September 2018

Resveratrol induces dynamic changes to the microglia transcriptome, inhibiting inflammatory pathways and protecting against microglia-mediated photoreceptor apoptosis.

Biochem Biophys Res Commun 2018 06 4;501(1):239-245. Epub 2018 May 4.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, D-50931, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.04.223DOI Listing
June 2018

Microglia Activation and Immunomodulatory Therapies for Retinal Degenerations.

Front Cell Neurosci 2018 21;12:176. Epub 2018 Jun 21.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.3389/fncel.2018.00176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021747PMC
June 2018

Crocin, a plant-derived carotenoid, modulates microglial reactivity.

Biochem Biophys Rep 2017 Dec 2;12:245-250. Epub 2017 Oct 2.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, D-50931 Cologne, Germany.

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http://dx.doi.org/10.1016/j.bbrep.2017.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704034PMC
December 2017

Comprehensive analysis of mouse retinal mononuclear phagocytes.

Nat Protoc 2017 Jun 4;12(6):1136-1150. Epub 2017 May 4.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/nprot.2017.032DOI Listing
June 2017

Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy.

Eur J Pharm Sci 2017 May 20;103:27-35. Epub 2017 Feb 20.

Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium; Center for Nano-and Biophotonics (NB-Photonics), Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.02.027DOI Listing
May 2017

[Polysialic Acid for Immunomodulation in an Animal Model for Wet Age-Related Macular Degeneration (AMD)].

Klin Monbl Augenheilkd 2017 May 5;234(5):657-661. Epub 2017 Apr 5.

Lehrstuhl für Experimentelle Immunologie des Auges, Zentrum für Augenheilkunde, Uniklinik Köln.

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http://dx.doi.org/10.1055/s-0043-105138DOI Listing
May 2017

Activated microglia trigger inflammasome activation and lysosomal destabilization in human RPE cells.

Biochem Biophys Res Commun 2017 03 1;484(3):681-686. Epub 2017 Feb 1.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, D-50931, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.01.176DOI Listing
March 2017

Retinal expression and localization of Mef2c support its important role in photoreceptor gene expression.

Biochem Biophys Res Commun 2017 01 23;483(1):346-351. Epub 2016 Dec 23.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.12.141DOI Listing
January 2017

Gut flora connects obesity with pathological angiogenesis in the eye.

EMBO Mol Med 2016 12 1;8(12):1361-1363. Epub 2016 Dec 1.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.15252/emmm.201607165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167127PMC
December 2016

Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization.

EMBO Mol Med 2016 06 1;8(6):670-8. Epub 2016 Jun 1.

Retinal Immunology Laboratory (RIL), Department of Ophthalmology, University of Cologne, Cologne, Germany

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http://dx.doi.org/10.15252/emmm.201505994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888856PMC
June 2016

Norrin mediates angiogenic properties via the induction of insulin-like growth factor-1.

Exp Eye Res 2016 04 17;145:317-326. Epub 2015 Dec 17.

Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2015.12.001DOI Listing
April 2016

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

Authors:
Lars G Fritsche Wilmar Igl Jessica N Cooke Bailey Felix Grassmann Sebanti Sengupta Jennifer L Bragg-Gresham Kathryn P Burdon Scott J Hebbring Cindy Wen Mathias Gorski Ivana K Kim David Cho Donald Zack Eric Souied Hendrik P N Scholl Elisa Bala Kristine E Lee David J Hunter Rebecca J Sardell Paul Mitchell Joanna E Merriam Valentina Cipriani Joshua D Hoffman Tina Schick Yara T E Lechanteur Robyn H Guymer Matthew P Johnson Yingda Jiang Chloe M Stanton Gabriëlle H S Buitendijk Xiaowei Zhan Alan M Kwong Alexis Boleda Matthew Brooks Linn Gieser Rinki Ratnapriya Kari E Branham Johanna R Foerster John R Heckenlively Mohammad I Othman Brendan J Vote Helena Hai Liang Emmanuelle Souzeau Ian L McAllister Timothy Isaacs Janette Hall Stewart Lake David A Mackey Ian J Constable Jamie E Craig Terrie E Kitchner Zhenglin Yang Zhiguang Su Hongrong Luo Daniel Chen Hong Ouyang Ken Flagg Danni Lin Guanping Mao Henry Ferreyra Klaus Stark Claudia N von Strachwitz Armin Wolf Caroline Brandl Guenther Rudolph Matthias Olden Margaux A Morrison Denise J Morgan Matthew Schu Jeeyun Ahn Giuliana Silvestri Evangelia E Tsironi Kyu Hyung Park Lindsay A Farrer Anton Orlin Alexander Brucker Mingyao Li Christine A Curcio Saddek Mohand-Saïd José-Alain Sahel Isabelle Audo Mustapha Benchaboune Angela J Cree Christina A Rennie Srinivas V Goverdhan Michelle Grunin Shira Hagbi-Levi Peter Campochiaro Nicholas Katsanis Frank G Holz Frédéric Blond Hélène Blanché Jean-François Deleuze Robert P Igo Barbara Truitt Neal S Peachey Stacy M Meuer Chelsea E Myers Emily L Moore Ronald Klein Michael A Hauser Eric A Postel Monique D Courtenay Stephen G Schwartz Jaclyn L Kovach William K Scott Gerald Liew Ava G Tan Bamini Gopinath John C Merriam R Theodore Smith Jane C Khan Humma Shahid Anthony T Moore J Allie McGrath Reneé Laux Milam A Brantley Anita Agarwal Lebriz Ersoy Albert Caramoy Thomas Langmann Nicole T M Saksens Eiko K de Jong Carel B Hoyng Melinda S Cain Andrea J Richardson Tammy M Martin John Blangero Daniel E Weeks Bal Dhillon Cornelia M van Duijn Kimberly F Doheny Jane Romm Caroline C W Klaver Caroline Hayward Michael B Gorin Michael L Klein Paul N Baird Anneke I den Hollander Sascha Fauser John R W Yates Rando Allikmets Jie Jin Wang Debra A Schaumberg Barbara E K Klein Stephanie A Hagstrom Itay Chowers Andrew J Lotery Thierry Léveillard Kang Zhang Murray H Brilliant Alex W Hewitt Anand Swaroop Emily Y Chew Margaret A Pericak-Vance Margaret DeAngelis Dwight Stambolian Jonathan L Haines Sudha K Iyengar Bernhard H F Weber Gonçalo R Abecasis Iris M Heid

Nat Genet 2016 Feb 21;48(2):134-43. Epub 2015 Dec 21.

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1038/ng.3448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745342PMC
February 2016

Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.

J Neuroinflammation 2015 Nov 2;12:201. Epub 2015 Nov 2.

Department of Ophthalmology, Laboratory for Experimental Immunology of the Eye, University of Cologne, 50931, Cologne, Germany.

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http://dx.doi.org/10.1186/s12974-015-0422-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630900PMC
November 2015

Intracellular Toll-Like Receptors Help Retinal Microglia Sense Corneal Infections.

Authors:
Thomas Langmann

Invest Ophthalmol Vis Sci 2015 Nov;56(12):7387

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http://dx.doi.org/10.1167/iovs.15-18268DOI Listing
November 2015

Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration.

J Neuroinflammation 2015 Nov 17;12:209. Epub 2015 Nov 17.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, 50931, Cologne, Germany.

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http://dx.doi.org/10.1186/s12974-015-0431-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650866PMC
November 2015

Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function.

Biochem Biophys Res Commun 2015 Aug 27;464(2):434-40. Epub 2015 Jun 27.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.133DOI Listing
August 2015

Activated microglia/macrophage whey acidic protein (AMWAP) inhibits NFκB signaling and induces a neuroprotective phenotype in microglia.

J Neuroinflammation 2015 Apr 19;12:77. Epub 2015 Apr 19.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Kerpener Strasse 62, D-50931, Cologne, Germany.

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http://dx.doi.org/10.1186/s12974-015-0296-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417279PMC
April 2015

Retinal microglia: just bystander or target for therapy?

Prog Retin Eye Res 2015 Mar 2;45:30-57. Epub 2014 Dec 2.

Laboratory for Experimental Immunology of the Eye, Department of Ophthalmology, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.preteyeres.2014.11.004DOI Listing
March 2015

RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl).

Adv Exp Med Biol 2014 ;801:31-41

Department of Ophthalmology, University of Cologne, Joseph-Stelzmann-Str. 9, 50931, Cologne, Germany.

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http://dx.doi.org/10.1007/978-1-4614-3209-8_5DOI Listing
July 2014

Microglia in the aging retina.

Adv Exp Med Biol 2014 ;801:207-12

Department of Ophthalmology, University of Cologne, Kerpener Straße 62, D-50924, Cologne, Germany,

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http://link.springer.com/10.1007/978-1-4614-3209-8_27
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http://dx.doi.org/10.1007/978-1-4614-3209-8_27DOI Listing
July 2014

Retinal function in aging homozygous Cln3 (Δex7/8) knock-in mice.

Adv Exp Med Biol 2014 ;801:495-501

Department of Ophthalmology, University Eye Clinic Regensburg, Franz-Josef-Strauß Allee 11, 93053, Regensburg, Germany,

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http://link.springer.com/10.1007/978-1-4614-3209-8_63
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http://dx.doi.org/10.1007/978-1-4614-3209-8_63DOI Listing
July 2014

Genetic and environmental risk factors for age-related macular degeneration in persons 90 years and older.

Invest Ophthalmol Vis Sci 2014 Mar 25;55(3):1842-7. Epub 2014 Mar 25.

Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1167/iovs.13-13420DOI Listing
March 2014

Class A scavenger receptors shed light on immune cell recruitment and CNV.

Authors:
Thomas Langmann

Invest Ophthalmol Vis Sci 2013 Sep 5;54(9):5971. Epub 2013 Sep 5.

Department of Ophthalmology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1167/iovs.13-13037DOI Listing
September 2013

Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus.

Atherosclerosis 2013 Apr 17;227(2):244-9. Epub 2013 Jan 17.

Department of Internal Medicine II, Regensburg University Medical Center, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.atherosclerosis.2012.12.030DOI Listing
April 2013

Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis.

Brain 2013 Apr 12;136(Pt 4):1083-101. Epub 2013 Mar 12.

Department of Neurology, Developmental Neurobiology, Josef-Schneider-Str. 11, D-97080 Wuerzburg, Germany.

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http://dx.doi.org/10.1093/brain/awt020DOI Listing
April 2013

The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association.

Hum Mol Genet 2012 Nov 12;21(21):4573-86. Epub 2012 Jul 12.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1093/hmg/dds268DOI Listing
November 2012

Microglial activation and transcriptomic changes in the blue light-exposed mouse retina.

Adv Exp Med Biol 2012 ;723:619-32

Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, 93055, Regensburg, Germany.

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http://dx.doi.org/10.1007/978-1-4614-0631-0_79DOI Listing
April 2012

Curcumin is a potent modulator of microglial gene expression and migration.

J Neuroinflammation 2011 Sep 29;8:125. Epub 2011 Sep 29.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1186/1742-2094-8-125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192695PMC
September 2011

Microglia in the healthy and degenerating retina: insights from novel mouse models.

Immunobiology 2010 Sep-Oct;215(9-10):685-91. Epub 2010 Jun 4.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.imbio.2010.05.010DOI Listing
March 2011

Immunobiology. Editorial.

Immunobiology 2010 Sep-Oct;215(9-10):673

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http://dx.doi.org/10.1016/j.imbio.2010.07.001DOI Listing
March 2011

The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.

Hum Mol Genet 2011 Mar 31;20(6):1132-42. Epub 2010 Dec 31.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1093/hmg/ddq557DOI Listing
March 2011

CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors.

Genome Res 2010 Nov 6;20(11):1512-25. Epub 2010 Aug 6.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110-1024, USA.

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http://dx.doi.org/10.1101/gr.109405.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963815PMC
November 2010

The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response.

J Immunol 2010 Sep 13;185(6):3379-90. Epub 2010 Aug 13.

Institute of Human Genetics, University of Regensburg, Regensburg, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.0903300DOI Listing
September 2010

HIF-1beta determines ABCA1 expression under hypoxia in human macrophages.

Int J Biochem Cell Biol 2010 Feb 12;42(2):241-52. Epub 2009 Oct 12.

Institute for Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.biocel.2009.10.002DOI Listing
February 2010

Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays.

Methods Mol Biol 2009 ;580:187-201

Synlab Medical Care Service, Medical Care Center, Weiden, Germany.

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http://dx.doi.org/10.1007/978-1-60761-325-1_10DOI Listing
January 2010

Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo.

Neuromolecular Med 2009 14;11(2):87-96. Epub 2009 Apr 14.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany.

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http://dx.doi.org/10.1007/s12017-009-8061-6DOI Listing
October 2009

Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.

J Neurochem 2009 Sep 17;110(6):1863-75. Epub 2009 Jul 17.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06286.xDOI Listing
September 2009

Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line.

Mol Cell Biochem 2009 Aug 6;328(1-2):85-92. Epub 2009 Mar 6.

Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

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http://www.springerlink.com/index/l350458t727u1185.pdf
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http://link.springer.com/10.1007/s11010-009-0077-6
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http://dx.doi.org/10.1007/s11010-009-0077-6DOI Listing
August 2009

Transcriptomic profiling identifies a PU.1 regulatory network in macrophages.

Biochem Biophys Res Commun 2009 Mar 22;380(2):308-12. Epub 2009 Jan 22.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2009.01.067DOI Listing
March 2009

High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages.

Exp Mol Med 2009 Feb;41(2):126-32

Synlab Medical Care Service, Medical Care Centre Weiden, Zur Kesselschmiede 4, 92637 Weiden, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679329PMC
http://dx.doi.org/10.3858/emm.2009.41.2.015DOI Listing
February 2009

Induction of STAP-1 promotes neurotoxic activation of microglia.

Biochem Biophys Res Commun 2009 Jan 17;379(1):121-6. Epub 2008 Dec 17.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2008.12.021DOI Listing
January 2009

Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesis.

Lab Invest 2008 Dec 20;88(12):1303-15. Epub 2008 Oct 20.

Institut für Laboratoriums-und Transfusionsmedizin, Herz-und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

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http://dx.doi.org/10.1038/labinvest.2008.96DOI Listing
December 2008

CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene.

Nucleic Acids Res 2008 Nov 16;36(20):6523-34. Epub 2008 Oct 16.

Institute of Human Genetics, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1093/nar/gkn737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582616PMC
November 2008

Chondroitin sulfate disaccharide stimulates microglia to adopt a novel regulatory phenotype.

J Leukoc Biol 2008 Sep 12;84(3):736-40. Epub 2008 Jun 12.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1189/jlb.0208138DOI Listing
September 2008

Murine Müller cells are progenitor cells for neuronal cells and fibrous tissue cells.

Biochem Biophys Res Commun 2008 Sep 9;374(2):187-91. Epub 2008 Jul 9.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2008.06.119DOI Listing
September 2008

An integrated workflow for analysis of ChIP-chip data.

Biotechniques 2008 Aug;45(2):131-2, 134, 136 passim

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.2144/000112819DOI Listing
August 2008

Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation.

J Leukoc Biol 2007 Dec 7;82(6):1564-74. Epub 2007 Sep 7.

Institute of Human Genetics, University of Regensburg, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://dx.doi.org/10.1189/jlb.0707447DOI Listing
December 2007

Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR.

World J Gastroenterol 2007 Aug;13(31):4230-5

Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg 93053, Germany.

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http://dx.doi.org/10.3748/wjg.v13.i31.4230DOI Listing
August 2007

ApoA-I induces a preferential efflux of monounsaturated phosphatidylcholine and medium chain sphingomyelin species from a cellular pool distinct from HDL(3) mediated phospholipid efflux.

Biochim Biophys Acta 2007 Jul 24;1771(7):853-63. Epub 2007 Apr 24.

Institute of Clinical Chemistry, University of Regensburg, 93042 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bbalip.2007.04.011DOI Listing
July 2007

Microglia activation in retinal degeneration.

Authors:
Thomas Langmann

J Leukoc Biol 2007 Jun 3;81(6):1345-51. Epub 2007 Apr 3.

Institute of Human Genetics, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany.

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http://doi.wiley.com/10.1189/jlb.0207114
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June 2007

Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis.

World J Gastroenterol 2007 Mar;13(11):1687-95

Department of Gastroenterology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146947PMC
http://dx.doi.org/10.3748/wjg.v13.i11.1687DOI Listing
March 2007

High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes.

Biochem Biophys Res Commun 2007 Jan 20;352(2):543-8. Epub 2006 Nov 20.

Department of Internal Medicine I, Regensburg University Medical Center, D-93042 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2006.11.058DOI Listing
January 2007

Isomer specific effects of Conjugated Linoleic Acid on macrophage ABCG1 transcription by a SREBP-1c dependent mechanism.

Biochem Biophys Res Commun 2007 Jan 27;352(3):805-11. Epub 2006 Nov 27.

Institute of Clinical Chemistry, University of Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2006.11.087DOI Listing
January 2007

Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease.

J Mol Med (Berl) 2006 Dec 21;84(12):1055-66. Epub 2006 Oct 21.

Institut für Klinische Chemie und Laboratoriumsmedizin, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93042, Regensburg, Germany.

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http://link.springer.com/10.1007/s00109-006-0100-2
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December 2006