Publications by authors named "Thomas Klockgether"

100Publications

Intermediate phenotype of ATP13A2 mutation in two Chilean siblings: Towards a continuum between parkinsonism and hereditary spastic paraplegia.

Parkinsonism Relat Disord 2020 Oct 6;81:45-47. Epub 2020 Oct 6.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2020.10.004DOI Listing
October 2020

How specific are non-motor symptoms in the prodrome of Parkinson's disease compared to other movement disorders?

Parkinsonism Relat Disord 2020 Oct 5. Epub 2020 Oct 5.

Department of Neurology, Christian-Albrechts University, Kiel, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2020.10.003DOI Listing
October 2020

Effects of Rivastigmine on Patients with Spinocerebellar Ataxia Type 3: A Case Series of Five Patients.

Neurodegener Dis 2020 Sep 29:1-6. Epub 2020 Sep 29.

Department of Neurology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1159/000510057DOI Listing
September 2020

A word of hope for ataxia trials in COVID-19 time and beyond.

J Neurol 2020 Sep 22. Epub 2020 Sep 22.

Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Reinier Postlaan 4, 6525 GC, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00415-020-10231-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508233PMC
September 2020

Poor blood pressure control following subarachnoid hemorrhage in patients with sleep apnea.

Sleep Breath 2020 Sep 14. Epub 2020 Sep 14.

Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.

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http://dx.doi.org/10.1007/s11325-020-02184-0DOI Listing
September 2020

Association of serum neurofilament light (sNfL) and disease severity in patients with spinocerebellar ataxia type 3.

Neurology 2020 Aug 14. Epub 2020 Aug 14.

From the Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.Institute of Chemical Biology and Nanomedicine (ICBN), Hunan University, Changsha, Hunan, P. R. China.Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.School of Computer Science and Engineering, Central South University, Changsha, Hunan, P. R. China.Department of Neurology, University of Bonn, Bonn, Germany.German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.Laboratory of Medical Genetics, Central South University, Changsha, Hunan, P. R. China.National Clinical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, P. R. China.

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http://dx.doi.org/10.1212/WNL.0000000000010671DOI Listing
August 2020

Investigation of Visual System Involvement in Spinocerebellar Ataxia Type 14.

Cerebellum 2020 Aug;19(4):469-482

Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1007/s12311-020-01130-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351844PMC
August 2020

Multiple system atrophy mimicry in MRI: Watch out for paraneoplastic rhombencephalitis.

J Clin Neurosci 2020 Jun 16;76:238-240. Epub 2020 Apr 16.

Department of Neurology, University Hospital of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Strasse 27, 53127 Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2020.04.052DOI Listing
June 2020

Natural history of most common spinocerebellar ataxia: a systematic review and meta-analysis.

J Neurol 2020 Apr 7. Epub 2020 Apr 7.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1007/s00415-020-09815-2DOI Listing
April 2020

Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.

J Neurochem 2020 03 21;152(6):710-726. Epub 2019 Oct 21.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1111/jnc.14870DOI Listing
March 2020

The art of making a clinical diagnosis of multiple system atrophy.

Brain 2019 09;142(9):2555-2557

Department of Neurology, University of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1093/brain/awz255DOI Listing
September 2019

Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3 (SCA3-tDCS): rationale and protocol of a randomized, double-blind, sham-controlled study.

BMC Neurol 2019 Jul 4;19(1):149. Epub 2019 Jul 4.

Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Reinier Postlaan 4, 6525, GC, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s12883-019-1379-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610834PMC
July 2019

Loss of paraplegin drives spasticity rather than ataxia in a cohort of 241 patients with .

Neurology 2019 06 8;92(23):e2679-e2690. Epub 2019 May 8.

From Sorbonne Université (G.C., C.E., B.F., M.-L.M., F.M., M.P., C.-S.D., G.S., A.D.), Institut du Cerveau et de la Moelle épinière (ICM), AP-HP, INSERM, CNRS, University Hospital Pitié-Salpêtrière; Department of Genetics (G.C., C.E., M.-L.M., P.C., F.M., G.B., G.S., A.D.), Pitié-Salpêtrière Charles-Foix University Hospital, Assistance publique-Hôpitaux de Paris, Sorbonne Université, Paris, France; Center for Neurology and Hertie Institute for Clinical Brain Research (R.S., M.S., L.S.), University of Tübingen, German Center for Neurodegenerative Diseases; German Center for Neurodegenerative Diseases (R.S., M.S., L.S.), Tübingen; Department of Neurology (B.P.C.v.d.W., E.G.H.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Neurogenetics Group (P.D.J., J.B., T.D., P.M., J.D.B., M.D.), University of Antwerp; Laboratories of Neurogenetics and Neuromuscular Pathology (P.D.J., J.B., T.D., P.M., J.D.B., M.D.), Institute Born-Bunge, University of Antwerp; Department of Neurology (P.D.J., J.B., T.D., P.M., J.D.B., M.D.), Antwerp University Hospital, Belgium; Scientific Institute IRCCS "E. Medea" (A.M.), Conegliano, Italy; Department of Neurology (M.A.), Hôpital de Hautepierre, Strasbourg; Institut de Génétique et de Biologie Moléculaire et Cellulaire (M.A.), INSERM-U964/CNRS-UMR7104/Université de Strasbourg, Illkirch; Fédération de Médecine Translationnelle de Strasbourg (M.A.), Université de Strasbourg; Department of Neurology (B.F.), Pitié-Salpêtrière Charles-Foix University Hospital, Assistance publique-Hôpitaux de Paris, Sorbonne Université, France; Department of Neurology (T. Klockgether, D.K.), University of Bonn; German Center for Neurodegenerative Diseases (T. Klockgether, D.K.), Bonn; Scientific Institute IRCCS E. Medea Neurorehabilitation Unit (M.G.D.), Bosisio Parini, Lecco, Italy; ULB Center of Human Genetics (I.M.), Brussels, Belgium; Scientific Institute IRCCS E. Medea Laboratory of Molecular Biology (M.T.B.), Bosisio Parini, Lecco, Italy; Department of Neurology With Friedrich-Baur Institute (T. Klopstock), University Hospital of the Ludwig-Maximilians-Universität München; German Center for Neurodegenerative Diseases (T. Klopstock); Munich Cluster for Systems Neurology (T. Klopstock), Germany; Department of Genetics (E.O.-R.), Croix-Rousse University Hospital, Lyon, France; Department of Neurology (C.K.), University of Rostock, Germany; Ecole Pratique des Hautes Etudes (M.P., G.S.), PSL Research University; Sorbonne Université (S.T.d.M.), INSERM, Institut Pierre Louis de Santé Publique, Medical Information Unit, Pitié-Salpêtrière Charles-Foix University Hospital, Assistance publique-Hôpitaux de Paris; and Raymond Escourolle Neuropathology Department (D.S., C.D.), Pitié-Salpêtrière University Hospital, Assistance publique-Hôpitaux de Paris, Sorbonne Université, France.

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http://dx.doi.org/10.1212/WNL.0000000000007606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556095PMC
June 2019

Spinocerebellar ataxia.

Nat Rev Dis Primers 2019 04 11;5(1):24. Epub 2019 Apr 11.

Department of Neurology, University of Michigan, Ann Arbor, MI, USA.

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http://www.nature.com/articles/s41572-019-0074-3
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http://dx.doi.org/10.1038/s41572-019-0074-3DOI Listing
April 2019

Disentangling motor planning and motor execution in unmedicated de novo Parkinson's disease patients: An fMRI study.

Neuroimage Clin 2019 19;22:101784. Epub 2019 Mar 19.

Functional Neuroimaging Group, Department of Radiology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

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http://dx.doi.org/10.1016/j.nicl.2019.101784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438987PMC
January 2020

Patient-reported outcomes in Friedreich's ataxia after withdrawal from idebenone.

Acta Neurol Scand 2019 Jun 8;139(6):533-539. Epub 2019 Apr 8.

Department of Molecular Neuroscience, Ataxia Centre, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1111/ane.13088DOI Listing
June 2019

Increased risk for subarachnoid hemorrhage in patients with sleep apnea.

J Neurol 2019 Jun 5;266(6):1351-1357. Epub 2019 Mar 5.

Department of Neurosurgery, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.

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http://dx.doi.org/10.1007/s00415-019-09265-5DOI Listing
June 2019

Mirror movements and blepharoclonus as novel phenomena in hereditary diffuse leukoencephalopathy with spheroids.

Parkinsonism Relat Disord 2019 01 2;58:83-84. Epub 2018 Jul 2.

University Hospital of Bonn, Department of Neurology, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.07.001DOI Listing
January 2019

Teaching NeuroImages: Distinct visual anosognosia after serial lesions of Meyer loop and the lateral geniculate body.

Neurology 2018 07;91(1):e94-e95

From the Departments of Neurology (A.T., T.K.) and Neuroradiology (E.H.), University Hospital of Bonn; and German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000005744DOI Listing
July 2018

Sporadic adult-onset ataxia.

Handb Clin Neurol 2018 ;155:217-225

Department of Neurology, University Hospital Bonn, and German Center for Neurodegenerative Diseases, Bonn, Germany. Electronic address:

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http://dx.doi.org/10.1016/B978-0-444-64189-2.00014-7DOI Listing
October 2018

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Neurology 2018 01 13;90(2):74-82. Epub 2017 Dec 13.

From Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (F.K., G.K.W., W.P., K.S., N.S.), Medical University Innsbruck, Austria; National Institute of Neurological Disorders and Stroke (W.R.G., W.J.K.), NIH, Bethesda, MD; Department of Neurology (P.A.L.), Mayo Clinic, Rochester, MN; Brain and Mind Centre (G.H.), Sydney Medical School, the University of Sydney; UNSW Medicine & Neuroscience Research Australia (G.H.), Sydney; Queen Square Brain Bank (J.H.), UCL Institute of Neurology (N.P.Q.), London, UK; UPS, INSERM, and CHU de Toulouse (O.R.), University de Toulouse; Centre de Référence Maladie Rare contre l'AMS (O.R.), Centre d'Investigation Clinique CIC1436, Départments de Pharmacologie Clinique et de Neurosciences, NeuroToul/COEN Center of Excellence in Neurodegeneration, Toulouse, France; Department of Pathology & Laboratory Medicine (L.M.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Neurosciences (D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; The Multiple System Atrophy (MSA) Coalition, Inc. (P. B., J.B., P.F., L.K., C.L., C.R., S.S.), Charlotte, NC; Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Medical Affairs (V.A.), Teva Pharmaceuticals, Frazer, PA; Department of Neurology (G.B.), David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles; Institute of Neurology (D.J.B.), University of Newcastle upon Tyne, UK; Van Andel Research Institute (P. Brundin), Center for Neurodegenerative Science, Grand Rapids, MI; Center for Neurological Restoration (H.F.), Cleveland Clinic, OH; Defeat MSA (P.F.); MSA Shoe Charity (P.F., C.R.), Saint Clair Shores, MI; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Neurodegenerative Diseases (T.G.), Hertie Institute of Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.), Tübingen, Germany; Lundbeck LLC (A.H.), Deerfield, IL; German Center for Neurodegenerative Diseases (DZNE) (G.U.H.), Munich; Department of Neurology (G.U.H.), Technical University of Munich, Germany; Neurogenomics Division (M.J.H.), The Translational Genomics Research Institute, Phoenix, AZ; Dandrite & Department of Biomedicine (P.H.J.), Aarhus University, Denmark; Quanterix (A.J.), Lexington, MA; Department of Neurology (U.J.K.), Columbia University Medical Center; Department of Neurology (H.K.), New York University School of Medicine, New York; Whitehead Institute for Biomedical Research (V.K.), Cambridge; Ann Romney Center for Neurologic Disease (V.K.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston; Harvard Stem Cell Institute (V.K.), Cambridge, MA; Department of Neurology (T.K.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany; Brain and Mind Centre (W.S.K.), Sydney Medical School, University of Sydney, Australia; Department of Neurology (P.L.), Henry Ford Hospital; Department of Neurology (P.L.), Wayne State University School of Medicine, Detroit, MI; Division of Neurosciences (E.M.), National Institute on Aging/NIH, Bethesda, MD; Centre de Référence Maladie Rare AMS (W.M.), Hôpital Pellegrin, CHU de Bordeaux; Université de Bordeaux (W.M.), Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux; Paris Saclay Institute of Neuroscience (R.M.), CNRS, Gif-sur-Yvette, France; Genentech Inc. (S.O.), South San Francisco; Cedars-Sinai Medical Center (S.P.), Los Angeles, CA; Department of Neurology (D.R.), Vanderbilt University Medical Center, Nashville, TN; MSA NJ (C.R.), Howell, NJ; Prothena Biosciences (D.S.), South San Francisco, CA; Division of Neurology (M.S.), Department of Medicine, The Ottawa Hospital, Canada; Department of Neurology (J.D.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Cure MSA Foundation (L.S.), Fremont, CA; Avid Radiopharmaceuticals (A.S.), Philadelphia, PA; Department of Neurological Sciences (G.T.S.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.), Graduate School of Medicine, Tokyo University, Tokyo, Japan; and University of Washington (J.Z.), Seattle. W.R.G. is currently affiliated with Janssen Research and Development, Titusville, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000004798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772155PMC
January 2018

Clinical and genetic characteristics of sporadic adult-onset degenerative ataxia.

Neurology 2017 Sep 9;89(10):1043-1049. Epub 2017 Aug 9.

From the Department of Neurology (I.G., T.K.), University Hospital of Bonn; German Center for Neurodegenerative Diseases (DZNE) (I.G., H.J., B.P., T.K.), Bonn; Institute of Medical Genetics and Applied Genomics (F.H., M.S.) and Department of Neurodegenerative Diseases (L.S., M.S.), Hertie-Institute for Clinical Brain Research, University of Tübingen; Department of Neurology (H.J.), Heidelberg University Hospital; Department of Neurology (S.V.), Otto-von-Guericke University Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (S.V., J.M.), Magdeburg; German Center for Neurodegenerative Diseases (DZNE) (L.S., M.S.), Tübingen, Germany; Department of Neurology (C.T., I.M.W.), Oslo University Hospital; Faculty of Medicine (C.T.), Institute of Clinical Medicine, University of Oslo, Norway; Department of Neurology (S.B., A.E.), Medical University Innsbruck, Austria; Department of Neurology (B.v.d.W., J.v.G.), Radboud University Medical Center, Nijmegen, Netherlands; Department of Neurology (C.K., A.D.), University of Rostock; German Center for Neurodegenerative Diseases (DZNE) (C.K., A.D.), Rostock; Department of Neurology (J.-S.K.), University of Frankfurt; Department of Neurology (D.T.), Essen University Hospital, University of Duisburg-Essen, Germany; Institute of Neurology (G.S.), Catholic University of Sacred Heart; SPInal REhabilitation Lab (SPIRE) (M.M.), Fondazione Santa Lucia, IRCCS, Rome, Italy; Department of Neurology (T.K., C.N.), Friedrich-Baur-Institute, Ludwig-Maximilians-University, Munich; German Center for Neurodegenerative Diseases (DZNE) (T.K., C.N.), Munich; Munich Cluster for Systems Neurology (SyNergy) (T.K.), Munich; Department of Neurology (C.G.), University Medical Center Hamburg-Eppendorf (UKE), Germany; Department of Neuroscience and Reproductive and Odontostomatological Sciences (A.F.), Federico II University, Naples, Italy; Centogene AG (P.B.), Rostock, Germany; Pierre Louis Institute of Epidemiology and Public Health (S.T.d.M.), Pierre and Marie Curie University (UPMC); and AP-HP (S.T.d.M.), Biostatistics Unit, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1212/WNL.0000000000004311DOI Listing
September 2017

[On the fast track to diagnosis : Recommendations for patients without a diagnosis].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2017 May;60(5):517-522

Zentrum für seltene Erkrankungen Bonn (ZSEB), Universitätsklinikum Bonn, Biomedizinisches Zentrum (BMZ), Sigmund-Freud-Straße 25, 53127, Bonn, Deutschland.

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http://dx.doi.org/10.1007/s00103-017-2535-8DOI Listing
May 2017

F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor.

Oncol Lett 2016 Dec 10;12(6):4705-4707. Epub 2016 Oct 10.

Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, 53127 Bonn, Germany; Stem Cell Pathologies Group, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, 53127 Bonn, Germany; Clinical Cooperation Unit Neurooncology, MediClin Robert Janker Klinik, 53129 Bonn, Germany.

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http://dx.doi.org/10.3892/ol.2016.5234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228534PMC
December 2016

Progression characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS): a 2 year cohort study.

Lancet Neurol 2016 Dec;15(13):1346-1354

Department of Neurology, RWTH Aachen University, Aachen, Germany; JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(16)30287-3DOI Listing
December 2016

Linkage and Association Analysis Identifies TRAF1 Influencing Common Carotid Intima-Media Thickness.

Stroke 2016 12 8;47(12):2904-2909. Epub 2016 Nov 8.

From the Institute of Medical Biometry and Statistics (IMBS), University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany (N.H., M.V., A.Z.); Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Germany (M.H.G., A.S.); Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University of Duisburg-Essen, Germany (M.H.G., R.E., K.-H.J., S.M.); Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Austria (S.C., F.K.); Institute of Human Genetics (S.H.) and Department of Epileptology (S.M.-H.), University of Bonn, Germany; Department of Genomics, Life & Brain Research Center, Bonn, Germany (S.H.); Institute of Occupational, Social and Environmental Medicine, Center for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany (F.H., B.H.); Department of Neurology, University Hospital Bonn, Germany (S.M.-H., T.K.); Cologne Center of Genomics, University of Cologne, Germany (G.N., P.N.); Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Germany (M.V.); Center for Clinical Trials, University of Lübeck, Germany (A.Z.); and School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa (A.Z.).

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http://dx.doi.org/10.1161/STROKEAHA.116.013943DOI Listing
December 2016

Wernicke encephalopathy: SWI detects petechial hemorrhages in mammillary bodies in vivo.

Neurology 2016 11;87(18):1956-1957

From the University Hospital of Bonn (E.H., A.B., A.M., T.K., C.K.) and the German Center for Neurodegenerative Diseases (T.K.), Bonn, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000003294DOI Listing
November 2016

Cognition in Friedreich's ataxia: a behavioral and multimodal imaging study.

Ann Clin Transl Neurol 2016 08 21;3(8):572-87. Epub 2016 Jun 21.

Department of Neurology RWTH Aachen University Aachen Germany; JARA - Translational Brain Medicine Aachen and Jülich Germany; JARA BRAIN Institute IIInstitute of Neuroscience and Medicine (INM-1)Research Center Jülich GmbH Jülich Germany.

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http://dx.doi.org/10.1002/acn3.315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999591PMC
August 2016

Elevated in vivo [18F]-AV-1451 uptake in a patient with progressive supranuclear palsy.

Mov Disord 2017 01 1;32(1):170-171. Epub 2016 Aug 1.

Multimodal Neuroimaging Group, Department of Nuclear Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/mds.26727DOI Listing
January 2017

Multisystemic SYNE1 ataxia: confirming the high frequency and extending the mutational and phenotypic spectrum.

Brain 2016 08 19;139(Pt 8):e46. Epub 2016 May 19.

10 Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen, Germany 11 German Research Centre for Neurodegenerative Diseases (DZNE), Tübingen, Germany

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http://dx.doi.org/10.1093/brain/aww115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958896PMC
August 2016

(CAG)n loci as genetic modifiers of age-at-onset in patients with Machado-Joseph disease from mainland China.

Brain 2016 08 16;139(Pt 8):e41. Epub 2016 Apr 16.

1 Department of Neurology Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P. R. China 8 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078, P. R. China 12 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, P. R. China 13 Xinjiang Medical University, Xinjiang, 830011, P.R. China

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http://brain.oxfordjournals.org/content/early/2016/04/15/bra
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http://dx.doi.org/10.1093/brain/aww087DOI Listing
August 2016

Does degeneration of the subthalamic nucleus prevent parkinsonism in spinocerebellar ataxia type 2 and type 3?

Brain 2015 Nov;138(Pt 11):3139-40

Department of Neurology, University of Bonn, and German Center for Neruodegenerative Diseases (DZNE), Bonn, Germany

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http://dx.doi.org/10.1093/brain/awv253DOI Listing
November 2015

Feature Binding Deficits in Subjective Cognitive Decline and in Mild Cognitive Impairment.

J Alzheimers Dis 2015 Sep;48 Suppl 1:S161-70

Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University Bonn, Bonn, Germany.

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http://dx.doi.org/10.3233/JAD-150105DOI Listing
September 2015

Dual task effect on postural control in patients with degenerative cerebellar disorders.

Cerebellum Ataxias 2015 8;2. Epub 2015 May 8.

Department of Neurology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1186/s40673-015-0025-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552271PMC
September 2015

The preclinical stage of spinocerebellar ataxias.

Neurology 2015 Jul 10;85(1):96-103. Epub 2015 Jun 10.

From the Department of Neurology & Donders Institute for Brain, Cognition, and Behaviour (R.P.P.W.M.M., J.v.G., B.P.C.v.d.W.), Radboud University Medical Center, Nijmegen, the Netherlands; and the Department of Neurology & German Center for Neurodegenerative Diseases (T.K.), University Hospital Bonn, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000001711DOI Listing
July 2015

High Serum GFAP Levels in SCA3/MJD May Not Correlate with Disease Progression.

Cerebellum 2015 Dec;14(6):677-81

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People's Republic of China.

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http://dx.doi.org/10.1007/s12311-015-0667-7DOI Listing
December 2015

Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data.

Lancet Neurol 2015 Feb 5;14(2):174-82. Epub 2015 Jan 5.

Department of Neurology, University Hospital Rheinisch-Westfälische Technische Hochschule [RWTH], Aachen, Aachen, Germany; Centre for Rare Diseases, University Hospital Rheinisch-Westfälische Technische Hochschule [RWTH], Aachen, Aachen, Germany; Clinical Trial Centre, University Hospital Rheinisch-Westfälische Technische Hochschule [RWTH], Aachen, Aachen, Germany; JARA-Translational Brain Medicine, Jülich and Aachen, Germany. Electronic address:

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February 2015

Modulation of the age at onset in spinocerebellar ataxia by CAG tracts in various genes.

Brain 2014 Sep 26;137(Pt 9):2444-55. Epub 2014 Jun 26.

4 AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Genetics and Cytogenetics, F-75013, Paris, France5 Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, F-75013, Paris, France27 Ecole Pratique des Hautes Etudes, heSam Université, laboratoire de neurogénétique, ICM, Groupe Hospitalier Pitié-Salpêtrière, F-75013 Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132646PMC
September 2014

Spinocerebellar ataxia type 2: progression before diagnosis.

Lancet Neurol 2014 May 20;13(5):445-6. Epub 2014 Mar 20.

Department of Neurology, University Hospital Bonn, D-53105 Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), D-53175 Bonn, Germany. Electronic address:

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May 2014

Reply to: Cognitive dysfunction in spinocerebellar ataxia type 3: variable topographies and patterns.

Mov Disord 2014 Jan 11;29(1):157-8. Epub 2013 Dec 11.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, University Hospital of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/mds.25755DOI Listing
January 2014

Abnormal movement preparation in task-specific focal hand dystonia.

PLoS One 2013 22;8(10):e78234. Epub 2013 Oct 22.

FE Funktionelle Neurobildgebung, Radiologische Universitätsklinik, Universität Bonn, Bonn, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805688PMC
May 2014

Progressive cognitive dysfunction in spinocerebellar ataxia type 3.

Mov Disord 2013 Sep 4;28(10):1435-8. Epub 2013 Jun 4.

German Center for Neurodegenerative Diseases, Bonn, Germany; Department of Neurology, University Hospital of Bonn, Bonn, Germany.

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http://dx.doi.org/10.1002/mds.25512DOI Listing
September 2013

Never neglect inspecting the leg in movement disorders.

Arch Neurol 2012 Jun;69(6):782-3

Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D52425 Jülich, Germany.

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June 2012

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.

Nature 2011 Nov 23;480(7378):543-6. Epub 2011 Nov 23.

Institute of Reconstructive Neurobiology, Life and Brain Center, University of Bonn and Hertie Foundation, 53127 Bonn, Germany.

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November 2011

Instability of syllable repetition in patients with spinocerebellar ataxia and Parkinson's disease.

Mov Disord 2012 Feb 22;27(2):316-9. Epub 2011 Nov 22.

Department of Neurology, University Clinic Bonn, Bonn, Germany.

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February 2012

[Natural history studies and the EUROSCA clinical research network].

Rinsho Shinkeigaku 2010 Nov;50(11):926

Department of Neurology, University Hospital Bonn, Germany.

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November 2010

Sporadic adult-onset ataxia of unknown etiology.

Handb Clin Neurol 2012 ;103:253-62

Department of Neurology, University Hospital Bonn, Germany.

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http://dx.doi.org/10.1016/B978-0-444-51892-7.00015-2DOI Listing
December 2011

Update on degenerative ataxias.

Curr Opin Neurol 2011 Aug;24(4):339-45

Department of Neurology, University Hospital Bonn and German Center for Neurodegenerative Disorders, Bonn, Germany.

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August 2011

Milestones in ataxia.

Mov Disord 2011 May;26(6):1134-41

Department of Neurology, University Hospital Bonn, Bonn, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105349PMC
May 2011

Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: a controlled study.

J Neurol 2011 Oct 16;258(10):1835-40. Epub 2011 Apr 16.

Department of Neurology, University of Bonn, Sigmund-Freud-Straße 25, 53127, Bonn, Germany.

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http://dx.doi.org/10.1007/s00415-011-6029-6DOI Listing
October 2011

Cost-of-illness in multiple system atrophy and progressive supranuclear palsy.

J Neurol 2011 Oct 10;258(10):1827-34. Epub 2011 Apr 10.

Department of Neurology, Philipps-University Marburg, Baldingerstrasse, 35043, Marburg, Germany.

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http://dx.doi.org/10.1007/s00415-011-6028-7DOI Listing
October 2011

Cost of illness in subarachnoid hemorrhage: a German longitudinal study.

Stroke 2010 Dec 11;41(12):2918-23. Epub 2010 Nov 11.

Department of Neurology, Philipps-University Marburg, Marburg, Germany.

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December 2010

Health-related quality of life in patients with subarachnoid haemorrhage.

Cerebrovasc Dis 2010 18;30(4):423-31. Epub 2010 Aug 18.

Department of Neurosurgery, Klinikum rechts der Isar, Technical University Munich, Rudolf-Bultmannstrasse 8, Munich, Germany.

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January 2011