Publications by authors named "Thomas Helleday"

100Publications

Ex vivo assessment of targeted therapies in a rare metastatic epithelial-myoepithelial carcinoma.

Neoplasia 2020 09 6;22(9):390-398. Epub 2020 Jul 6.

Misvik Biology Oy, Turku, Finland; University of Sheffield, Department of Oncology and Metabolism, South Yorkshire, Sheffield, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2020.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341452PMC
September 2020

High content drug screening for Fanconi anemia therapeutics.

Orphanet J Rare Dis 2020 06 30;15(1):170. Epub 2020 Jun 30.

Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1186/s13023-020-01437-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325660PMC
June 2020

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.

J Biol Chem 2020 Aug 22;295(33):11656-11668. Epub 2020 Jun 22.

Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

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http://dx.doi.org/10.1074/jbc.RA120.013695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450103PMC
August 2020

MetaCNV - a consensus approach to infer accurate copy numbers from low coverage data.

BMC Med Genomics 2020 06 1;13(1):76. Epub 2020 Jun 1.

Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Box 1031, 17121, Solna, Sweden.

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http://dx.doi.org/10.1186/s12920-020-00731-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268502PMC
June 2020

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.

Cancer Res 2020 Sep 20;80(17):3530-3541. Epub 2020 Apr 20.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-0883DOI Listing
September 2020

Correction: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

Oncotarget 2020 Feb 25;11(8):827. Epub 2020 Feb 25.

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.18632/oncotarget.27484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055542PMC
February 2020

TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.

EBioMedicine 2020 Mar 7;53:102704. Epub 2020 Mar 7.

Université de Nantes, INSERM, U1238, Sarcomes osseux et remodelage des tissus calcifiés, Team 3, Epistress, Rue Gaston Veil, 44035 Nantes cedex, France. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2020.102704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063190PMC
March 2020

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

J Biol Chem 2020 Apr 6;295(15):4761-4772. Epub 2020 Mar 6.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden

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http://dx.doi.org/10.1074/jbc.RA120.012636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152754PMC
April 2020

Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics.

Mol Cell Proteomics 2020 04 12;19(4):608-623. Epub 2020 Feb 12.

Science for Life Laboratory, Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

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http://dx.doi.org/10.1074/mcp.RA120.001938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124475PMC
April 2020

The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.

J Mol Biol 2020 02 15;432(4):1126-1142. Epub 2020 Jan 15.

Department of Experimental Medical Science, Lund University, Lund, 221 00, Sweden; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, S-106 91, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2020.01.005DOI Listing
February 2020

Karonudib is a promising anticancer therapy in hepatocellular carcinoma.

Ther Adv Med Oncol 2019 23;11:1758835919866960. Epub 2019 Aug 23.

Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet, Tomtebodav.23A, Stockholm, 171 21, Sweden.

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http://dx.doi.org/10.1177/1758835919866960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710815PMC
August 2019

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity.

Cell Death Differ 2020 02 8;27(2):773-789. Epub 2019 Jul 8.

Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41418-019-0387-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205879PMC
February 2020

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.

FEBS Lett 2019 07 10;593(14):1863-1873. Epub 2019 Jun 10.

Department of Biochemistry and Biophysics, Stockholm University, Sweden.

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http://dx.doi.org/10.1002/1873-3468.13455DOI Listing
July 2019

Restriction of AID activity and somatic hypermutation by PARP-1.

Nucleic Acids Res 2019 08;47(14):7418-7429

Department of Cell Biology, Institute of Biochemistry and Biophysics, School of Biology and Pharmacy, Friedrich Schiller University, 07745 Jena, Germany.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gkz466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698665PMC
August 2019

The DNA Damaging Revolution: PARP Inhibitors and Beyond.

Am Soc Clin Oncol Educ Book 2019 Jan 17;39:185-195. Epub 2019 May 17.

4 Weston Park Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.1200/EDBK_238473DOI Listing
January 2019

Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.

Biochemistry 2019 02 16;58(7):887-899. Epub 2019 Jan 16.

Department of Biochemistry and Biophysics , Stockholm University , Stockholm S-106 91 , Sweden.

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http://dx.doi.org/10.1021/acs.biochem.8b00950DOI Listing
February 2019

Targeting BER enzymes in cancer therapy.

DNA Repair (Amst) 2018 11 25;71:118-126. Epub 2018 Aug 25.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, S-171 76 Stockholm, Sweden; Sheffield Cancer Centre, Department of Oncology and Metabolism, University of Sheffield, Sheffield S10 2RX, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864183018
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http://dx.doi.org/10.1016/j.dnarep.2018.08.015DOI Listing
November 2018

Structure-metabolism-relationships in the microsomal clearance of piperazin-1-ylpyridazines.

Medchemcomm 2017 Jul 4;8(7):1553-1560. Epub 2017 Jul 4.

Division of Translational Medicine and Chemical Biology , Science for Life Laboratory , Department of Medical Biochemistry and Biophysics , Karolinska Institutet , Stockholm , Sweden . Email: ; Email:

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http://dx.doi.org/10.1039/c7md00230kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072423PMC
July 2017

Mechanisms for stalled replication fork stabilization: new targets for synthetic lethality strategies in cancer treatments.

EMBO Rep 2018 09 13;19(9). Epub 2018 Aug 13.

Department of Pharmacology & Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, Institute of Respiratory Diseases, Zhejiang University School of Medicine, Hangzhou, China

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http://embor.embopress.org/lookup/doi/10.15252/embr.20184626
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http://dx.doi.org/10.15252/embr.201846263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123652PMC
September 2018

STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions.

J Pharm Biomed Anal 2018 Oct 17;160:80-88. Epub 2018 Jul 17.

Karolinska Institute, Science for Life Laboratory, Department of Oncology and Pathology, 171 21, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2018.07.018DOI Listing
October 2018

A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate.

Medchemcomm 2018 Jul 4;9(7):1105-1113. Epub 2018 Jun 4.

Medicinal Chemistry and Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.

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http://dx.doi.org/10.1039/C8MD00149ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071853PMC
July 2018

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity.

Nat Commun 2018 06 20;9(1):2419. Epub 2018 Jun 20.

Department of Gene Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Science for Life Laboratory, Tomtebodavägen 23, Solna, 17165, Sweden.

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http://dx.doi.org/10.1038/s41467-018-04724-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010471PMC
June 2018

An orthotopic glioblastoma animal model suitable for high-throughput screenings.

Neuro Oncol 2018 10;20(11):1475-1484

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1093/neuonc/noy071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176805PMC
October 2018

Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.

Structure 2018 02;26(2):295-303.e6

Department of Biochemistry and Biophysics, Stockholm University, 106 91 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.01.004DOI Listing
February 2018

Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.

Biochemistry 2018 02 16;57(5):593-603. Epub 2018 Jan 16.

Department of Biochemistry and Biophysics, Stockholm University , S-106 91 Stockholm, Sweden.

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http://pubs.acs.org/doi/10.1021/acs.biochem.7b01163
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http://dx.doi.org/10.1021/acs.biochem.7b01163DOI Listing
February 2018

Glioblastoma and glioblastoma stem cells are dependent on functional MTH1.

Oncotarget 2017 Oct 20;8(49):84671-84684. Epub 2017 Jul 20.

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, Stockholm, Sweden.

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http://www.oncotarget.com/fulltext/19404
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http://dx.doi.org/10.18632/oncotarget.19404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689565PMC
October 2017

Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation.

Cell Cycle 2018 2;17(5):568-579. Epub 2018 Apr 2.

a Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics , Karolinska Institutet , Stockholm , Sweden.

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http://dx.doi.org/10.1080/15384101.2017.1387696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969565PMC
September 2019

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.

J Med Chem 2017 10 3;60(19):8160-8169. Epub 2017 Oct 3.

Science for Life Laboratory, Department of Cell and Molecular Biology, BMC, Uppsala University , Box 596, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01006DOI Listing
October 2017

Novel spirocyclic systems via multicomponent aza-Diels-Alder reaction.

Org Biomol Chem 2017 Sep;15(37):7758-7764

Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1039/c7ob02069dDOI Listing
September 2017

Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm.

Bioorg Med Chem Lett 2017 09 5;27(18):4462-4466. Epub 2017 Aug 5.

Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 65, Sweden.

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http://dx.doi.org/10.1016/j.bmcl.2017.08.006DOI Listing
September 2017

Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination.

DNA Repair (Amst) 2017 09 12;57:116-124. Epub 2017 Jul 12.

Department of Cell Biology, University of Seville, Avda. Reina Mercedes 6, 41012 Seville, Spain,. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.07.002DOI Listing
September 2017

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 1: Triazoles, triazolopyrimidines, triazinoindoles, quinoline hydrazones and arylpiperazines.

Bioorg Med Chem Lett 2017 08 16;27(16):3897-3904. Epub 2017 Jun 16.

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, 17121 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.06.038DOI Listing
August 2017

Mutations in Cancer Cause Gain of Cysteine, Histidine, and Tryptophan at the Expense of a Net Loss of Arginine on the Proteome Level.

Biomolecules 2017 07 3;7(3). Epub 2017 Jul 3.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, S171 21, Sweden.

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http://www.mdpi.com/2218-273X/7/3/49
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http://dx.doi.org/10.3390/biom7030049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618230PMC
July 2017

Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.

Bioorg Med Chem Lett 2017 08 15;27(15):3219-3225. Epub 2017 Jun 15.

Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Karolinska Institutet, 17121 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.06.039DOI Listing
August 2017

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.

Exp Hematol 2017 08 11;52:32-39. Epub 2017 May 11.

Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.05.001DOI Listing
August 2017

SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.

Cell Cycle 2017 Jun 24;16(11):1029-1038. Epub 2017 Apr 24.

d Department of Infectious Diseases, Virology , University Hospital Heidelberg , Heidelberg , Germany.

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http://dx.doi.org/10.1080/15384101.2017.1314407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499833PMC
June 2017

dUTPase inhibition augments replication defects of 5-Fluorouracil.

Oncotarget 2017 Apr;8(14):23713-23726

Division of Translational Medicine and Chemical Biology, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.18632/oncotarget.15785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410339PMC
April 2017

A novel method for crosstalk analysis of biological networks: improving accuracy of pathway annotation.

Nucleic Acids Res 2017 01 22;45(2):e8. Epub 2016 Sep 22.

Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, 17121 Solna, Sweden.

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http://dx.doi.org/10.1093/nar/gkw849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314790PMC
January 2017

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.

Cancer Res 2016 09 16;76(18):5501-11. Epub 2016 Aug 16.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847052PMC
September 2016

Pathways controlling dNTP pools to maintain genome stability.

DNA Repair (Amst) 2016 08 28;44:193-204. Epub 2016 May 28.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2016.05.032DOI Listing
August 2016

DNA REPAIR. Drugging DNA repair.

Science 2016 Jun;352(6290):1178-9

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.aab0958DOI Listing
June 2016

PathwAX: a web server for network crosstalk based pathway annotation.

Nucleic Acids Res 2016 07 5;44(W1):W105-9. Epub 2016 May 5.

Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Box 1031, 17121 Solna, Sweden

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http://dx.doi.org/10.1093/nar/gkw356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987909PMC
July 2016

Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.

Methods Enzymol 2016 26;566:305-32. Epub 2015 Jul 26.

Biochemical Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2015.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888786PMC
October 2016

Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair.

Sci Transl Med 2015 Nov;7(312):312re11

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 65 Stockholm, Sweden.

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aac5671DOI Listing
November 2015

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies.

FEBS J 2016 Jan 18;283(2):232-45. Epub 2015 Nov 18.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://doi.wiley.com/10.1111/febs.13574
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http://dx.doi.org/10.1111/febs.13574DOI Listing
January 2016

Poisoning Cancer Cells with Oxidized Nucleosides.

Authors:
Thomas Helleday

N Engl J Med 2015 Oct;373(16):1570-1

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http://www.nejm.org/doi/10.1056/NEJMcibr1510335
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http://dx.doi.org/10.1056/NEJMcibr1510335DOI Listing
October 2015

Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.

Oncotarget 2015 Nov;6(35):37638-46

Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.18632/oncotarget.5497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741954PMC
November 2015

Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.

Mol Cell 2015 Oct 3;60(1):163-76. Epub 2015 Sep 3.

School of Biomedical Sciences, The University of Hong Kong, Hong Kong. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765150058
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http://dx.doi.org/10.1016/j.molcel.2015.07.031DOI Listing
October 2015

Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry.

DNA Repair (Amst) 2015 Sep 23;33:101-10. Epub 2015 Jun 23.

Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.05.008DOI Listing
September 2015

Vinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles.

Chemistry 2015 May 25;21(20):7394-8. Epub 2015 Mar 25.

Science for Life Laboratory, Division of Translational, Medicine & Chemical Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Stockholm, 171 21 (Sweden) http://www.helleday.org.

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http://dx.doi.org/10.1002/chem.201406549DOI Listing
May 2015

Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox.

Prog Lipid Res 2015 Apr 20;58:51-75. Epub 2015 Feb 20.

Science for Life Laboratory, Division of Translational Medicine & Chemical Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet, Stockholm S-171 21, Sweden.

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http://dx.doi.org/10.1016/j.plipres.2015.01.004DOI Listing
April 2015

A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.

Cell Discov 2015 1;1:15034. Epub 2015 Dec 1.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm, Sweden.

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http://dx.doi.org/10.1038/celldisc.2015.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860774PMC
July 2016

Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma.

J Pharm Biomed Anal 2015 Feb 15;104:1-11. Epub 2014 Nov 15.

Department of Analytical Chemistry, Stockholm University, S-106 91 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jpba.2014.11.009DOI Listing
February 2015

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2'-deoxycytidine lesions.

Nucleic Acids Res 2014 Aug 29;42(14):9108-20. Epub 2014 Jul 29.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 21 Stockholm, Sweden

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http://dx.doi.org/10.1093/nar/gku638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132747PMC
August 2014

Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative Stress.

Proteomes 2014 Jul 10;2(3):341-362. Epub 2014 Jul 10.

Center for Radiation Protections Research, Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, Stockholm S-106 91, Sweden.

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http://www.mdpi.com/2227-7382/2/3/341
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http://dx.doi.org/10.3390/proteomes2030341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302754PMC
July 2014

Mechanisms underlying mutational signatures in human cancers.

Nat Rev Genet 2014 Sep 1;15(9):585-98. Epub 2014 Jul 1.

1] Wellcome Trust Sanger Institute, Hinxton Genome Campus, Cambridge CB10 1SA, UK. [2] East Anglian Medical Genetics Service, Cambridge University Hospitals NHS Trust, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1038/nrg3729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044419PMC
September 2014

Rational design and validation of a Tip60 histone acetyltransferase inhibitor.

Sci Rep 2014 Jun 20;4:5372. Epub 2014 Jun 20.

1] Genome Stability Laboratory, Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland [2] [3].

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http://dx.doi.org/10.1038/srep05372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064327PMC
June 2014

Chemical strategies for development of ATR inhibitors.

Expert Rev Mol Med 2014 May 9;16:e10. Epub 2014 May 9.

Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden.

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http://dx.doi.org/10.1017/erm.2014.10DOI Listing
May 2014

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

Nucleic Acids Res 2014 Jun 20;42(10):6326-36. Epub 2014 Apr 20.

Genome Stability Laboratory, Cancer and Ageing Research Program, Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Woolloongabba, Queensland, 4102, Australia

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http://dx.doi.org/10.1093/nar/gku276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041449PMC
June 2014