Thomas Hartung

Thomas Hartung

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Corrigendum to Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity Toxicol Appl Pharmacol, 354 (2018) 64-80.

Toxicol Appl Pharmacol 2019 Jun 16;372:70. Epub 2019 Apr 16.

In Vitro Toxicology and Biomedicine, Dept Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, 78457 Konstanz, Germany; CAAT-Europe, University of Konstanz, Konstanz 78457, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.04.010DOI Listing
June 2019

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across.

Environ Health Perspect 2019 Apr;127(4):47001

1 Center for Computational and Integrative Biology, Rutgers University , Camden, New Jersey, USA.

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http://dx.doi.org/10.1289/EHP3614DOI Listing
April 2019

Missing the Difference Between Big Data and Artificial Intelligence in RASAR Versus Traditional QSAR.

Toxicol Sci 2019 Jan;167(1):4-5

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205.

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https://academic.oup.com/toxsci/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/toxsci/kfy287DOI Listing
January 2019

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres.

Front Microbiol 2018 4;9:2766. Epub 2018 Dec 4.

Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fmicb.2018.02766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296317PMC
December 2018

Animal testing and its alternatives - the most important omics is economics.

ALTEX 2018 ;35(3):275-305

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1807041DOI Listing
November 2018

Regulatory acceptance of read-across.

ALTEX 2018;35(3):413-419

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1805081DOI Listing
November 2018

Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response.

Front Genet 2018 12;9:508. Epub 2018 Nov 12.

Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.

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http://dx.doi.org/10.3389/fgene.2018.00508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240694PMC
November 2018

3S - Systematic, systemic, and systems biology and toxicology.

ALTEX 2018 ;35(2):139-162

Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1804051DOI Listing
October 2018

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity.

Toxicol Appl Pharmacol 2018 09 24;354:64-80. Epub 2017 Dec 24.

In Vitro Toxicology and Biomedicine, Dept Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, 78457 Konstanz, Germany; CAAT-Europe, University of Konstanz, Konstanz 78457, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.12.013DOI Listing
September 2018

Rotenone exerts developmental neurotoxicity in a human brain spheroid model.

Toxicol Appl Pharmacol 2018 09 8;354:101-114. Epub 2018 Feb 8.

Center for Alternative to Animal Testing (CAAT), Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082736PMC
September 2018

Machine Learning of Toxicological Big Data Enables Read-Across Structure Activity Relationships (RASAR) Outperforming Animal Test Reproducibility.

Toxicol Sci 2018 09;165(1):198-212

Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, Maryland 21205.

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http://dx.doi.org/10.1093/toxsci/kfy152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135638PMC
September 2018

Big-data and machine learning to revamp computational toxicology and its use in risk assessment.

Toxicol Res (Camb) 2018 Sep 1;7(5):732-744. Epub 2018 May 1.

Center for Alternatives to Animal Testing at Johns Hopkins Bloomberg School of Public Health , 615 N. Wolfe Street , Baltimore , MD 21205 , USA . Email:

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http://dx.doi.org/10.1039/c8tx00051dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116175PMC
September 2018

Food for thought ... the first ten years.

Authors:
Thomas Hartung

ALTEX 2017 ;34(2):187-192

Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1703311DOI Listing
August 2018

Computational approaches to chemical hazard assessment.

ALTEX 2017 ;34(4):459-478

Johns Hopkins Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1710141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848496PMC
August 2018

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US.

Authors:
Thomas Hartung

ALTEX 2018 ;35(1):3-25

Johns Hopkins Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1712181DOI Listing
August 2018

Induction of IL-10-balanced immune profiles following exposure to LTA from Staphylococcus epidermidis.

Exp Dermatol 2018 04;27(4):318-326

Department of Dermatology and Allergology, Technical University Munich, Munich, Germany.

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http://dx.doi.org/10.1111/exd.13540DOI Listing
April 2018

Green Toxicology-Know Early About and Avoid Toxic Product Liabilities.

Toxicol Sci 2018 02;161(2):285-289

Center for Alternatives to Animal Testing (CAAT), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1093/toxsci/kfx243DOI Listing
February 2018

Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review.

Environ Int 2016 Jul-Aug;92-93:630-46. Epub 2016 Mar 31.

Johns Hopkins Center for Alternatives to Animal Testing, 615 N. Wolfe St., Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2016.03.010DOI Listing
January 2018

Good cell culture practices &in vitro toxicology.

Toxicol In Vitro 2017 Dec 25;45(Pt 3):272-277. Epub 2017 Apr 25.

CAAT-Europe, Konstanz University, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2017.04.022DOI Listing
December 2017

Opinion versus evidence for the need to move away from animal testing.

Authors:
Thomas Hartung

ALTEX 2017 ;34(2):193-200

Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1703291DOI Listing
October 2017

Thresholds of Toxicological Concern - Setting a threshold for testing below which there is little concern.

Authors:
Thomas Hartung

ALTEX 2017 ;34(3):331-351

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1707011DOI Listing
October 2017

A Novel Selective Inverse Agonist of the CB Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies.

Mol Pharmacol 2017 10 26;92(4):389-400. Epub 2017 Jul 26.

Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (A.M., H.S., A.P.I., L.H.H.), and Department of Molecular Physiology, Leiden Institute of Chemistry (A.M., M.S.), Leiden University, Leiden, The Netherlands; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland (A.M., A.C.R., U.G., C.U., T.H.); and Natural and Medical Sciences Institute, University of Tübingen, Reutlingen, Germany (J.F.)

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http://dx.doi.org/10.1124/mol.117.108605DOI Listing
October 2017

3D Differentiation of LUHMES Cell Line to Study Recovery and Delayed Neurotoxic Effects.

Curr Protoc Toxicol 2017 Aug 4;73:11.23.1-11.23.28. Epub 2017 Aug 4.

Center for Alternatives to Animal Testing (CAAT), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1002/cptx.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674809PMC
August 2017

A primer on systematic reviews in toxicology.

Arch Toxicol 2017 Jul 13;91(7):2551-2575. Epub 2017 May 13.

Evidence-Based Toxicology Collaboration at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00204-017-1980-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489636PMC
July 2017

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance.

Cell Rep 2017 07;20(3):655-667

Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.06.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546239PMC
July 2017

Evidence-Based Toxicology.

Adv Exp Med Biol 2016;856:231-241

Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-3-319-33826-2_9DOI Listing
June 2017

The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency.

Cell Chem Biol 2017 Jun 4;24(6):673-684.e4. Epub 2017 May 4.

Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482780PMC
June 2017

Systems Toxicology: Real World Applications and Opportunities.

Chem Res Toxicol 2017 04 31;30(4):870-882. Epub 2017 Mar 31.

Department of Health Sciences and Technology, ETH Zurich , 8092 Zurich, Switzerland.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396025PMC
April 2017

Systems Toxicology II: A Special Issue.

Chem Res Toxicol 2017 04;30(4):869

Department of Health Sciences and Technology, ETH Zürich , Zürich 8092, Switzerland.

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http://dx.doi.org/10.1021/acs.chemrestox.7b00038DOI Listing
April 2017

Green Toxicology: a strategy for sustainable chemical and material development.

Environ Sci Eur 2017 4;29(1):16. Epub 2017 Apr 4.

Empa, Materials Science and Technology, Lerchenfeld-straße 5, 9014 St. Gallen, Switzerland.

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http://dx.doi.org/10.1186/s12302-017-0115-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380705PMC
April 2017

Joint Bounding of Peaks Across Samples Improves Differential Analysis in Mass Spectrometry-Based Metabolomics.

Anal Chem 2017 03 7;89(6):3517-3523. Epub 2017 Mar 7.

Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b04719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362739PMC
March 2017

From somatic pain to psychic pain: The body in the psychoanalytic field.

Int J Psychoanal 2017 Mar 24. Epub 2017 Mar 24.

Gyrhofstr. 2, 50931, Köln, Germany.

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http://dx.doi.org/10.1111/1745-8315.12651DOI Listing
March 2017

Whole Blood Cytokine Response to Local Traffic-Related Particulate Matter in Peruvian Children With and Without Asthma.

Front Pharmacol 2017 30;8:157. Epub 2017 Mar 30.

Department of Environmental Health Sciences, Bloomberg School of Public Health, The Johns Hopkins University, BaltimoreMD, USA.

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http://dx.doi.org/10.3389/fphar.2017.00157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371665PMC
March 2017

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening.

J Appl Toxicol 2017 02 3;37(2):167-180. Epub 2016 May 3.

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA.

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http://doi.wiley.com/10.1002/jat.3334
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http://dx.doi.org/10.1002/jat.3334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094908PMC
February 2017

The need for strategic development of safety sciences.

ALTEX 2017 ;34(1):3-21

Center for Alternatives to Animal Testing, CAAT-Europe, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1701031DOI Listing
February 2017

Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of overrepresentation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis.

Arch Toxicol 2017 Jan 2;91(1):217-230. Epub 2016 Apr 2.

Department of Environmental Health Sciences, Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047848PMC
http://dx.doi.org/10.1007/s00204-016-1695-xDOI Listing
January 2017

E-cigarettes and the need and opportunities for alternatives to animal testing.

Authors:
Thomas Hartung

ALTEX 2016 ;33(3):211-24

Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, USA.

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http://dx.doi.org/10.14573/altex.1606291DOI Listing
January 2017

Utility of the adverse outcome pathway concept in drug development.

Authors:
Thomas Hartung

Expert Opin Drug Metab Toxicol 2017 Jan 21;13(1):1-3. Epub 2016 Oct 21.

a Center for Alternatives to Animal Testing (CAAT) , Johns Hopkins Bloomberg School of Public Health , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/17425255.2017.1246535DOI Listing
January 2017

Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods.

ALTEX 2016 ;33(4):343-358

Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, USA.

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http://dx.doi.org/10.14573/altex.1610101DOI Listing
January 2017

21st Century Cell Culture for 21st Century Toxicology.

Chem Res Toxicol 2017 01 5;30(1):43-52. Epub 2016 Dec 5.

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland 21205, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578455PMC
January 2017

Corrigendum to "The need for strategic development of safety sciences".

ALTEX 2017 ;34(2):361

Center for Alternatives to Animal Testing, CAAT-Europe, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1703281DOI Listing
January 2017

Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014.

ALTEX 2016 11;33(2):95-109. Epub 2016 Feb 11.

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Environmental Health Sciences, Baltimore, MD, USA.

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http://www.altex.ch/resources/epub_Luechtefeld_of_160211_1.p
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http://www.altex.ch/Online-first.95.html
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http://dx.doi.org/10.14573/altex.1510052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408747PMC
December 2016

Analysis of public oral toxicity data from REACH registrations 2008-2014.

ALTEX 2016 11;33(2):111-22. Epub 2016 Feb 11.

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Environmental Health Sciences, Baltimore, MD, USA.

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http://www.altex.ch/resources/epub_Luechtefeld_of_160211_2.p
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http://www.altex.ch/Online-first.95.html
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http://dx.doi.org/10.14573/altex.1510054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461469PMC
December 2016

Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data.

ALTEX 2016 11;33(2):123-34. Epub 2016 Feb 11.

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Environmental Health Sciences, Baltimore, MD, USA.

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http://www.altex.ch/resources/epub_Luechtefeld_of_160211_3.p
Web Search
http://www.altex.ch/Online-first.95.html
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http://dx.doi.org/10.14573/altex.1510053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461467PMC
December 2016

Analysis of publically available skin sensitization data from REACH registrations 2008-2014.

ALTEX 2016 11;33(2):135-48. Epub 2016 Feb 11.

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Environmental Health Sciences, Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1510055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546098PMC
December 2016

Supporting read-across using biological data.

ALTEX 2016 11;33(2):167-82. Epub 2016 Feb 11.

Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1601252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834201PMC
December 2016

Making big sense from big data in toxicology by read-across.

Authors:
Thomas Hartung

ALTEX 2016 ;33(2):83-93

Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, USA.

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http://www.altex.ch/resources/altex_2016_2_083_093_FFT_Hartu
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http://www.altex.ch/All-issues/Issue.50.html?iid=157&aid
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http://dx.doi.org/10.14573/altex.1603091DOI Listing
December 2016

Synthesis of enantiomerically pure [ C]-labelled morpholine derivatives for a class of trace amine-associate receptor 1 agonists.

J Labelled Comp Radiopharm 2016 12 15;59(14):635-639. Epub 2016 May 15.

Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070, Basel, Switzerland.

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http://doi.wiley.com/10.1002/jlcr.3403
Publisher Site
http://dx.doi.org/10.1002/jlcr.3403DOI Listing
December 2016

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment.

Chem Res Toxicol 2016 11;29(11):1789-1790

The U.S. Environmental Protection Agency , Research Triangle Park, Durham, North Carolina 27711, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00321DOI Listing
November 2016

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment.

Environ Sci Technol 2016 10;50(19):10295-10296

U.S. EPA National Center for Computational Toxicology, Research Triangle Park, North Carolina 27711, United States.

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http://dx.doi.org/10.1021/acs.est.6b04425DOI Listing
October 2016

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis.

Lab Chip 2016 10;16(21):4152-4162

Department of Biomedical Engineering and Yale Systems Biology Institute, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1039/c6lc00946hDOI Listing
October 2016

Staphylococcus aureus-derived lipoteichoic acid induces temporary T-cell paralysis independent of Toll-like receptor 2.

J Allergy Clin Immunol 2016 09 3;138(3):780-790.e6. Epub 2016 Mar 3.

Department of Dermatology, Eberhard Karls University, Liebermeisterstr, Tubingen, Germany; Department of Dermatology and Allergology, Technische Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.11.043DOI Listing
September 2016

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.

Proc Natl Acad Sci U S A 2016 09 24;113(36):E5328-36. Epub 2016 Aug 24.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

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http://dx.doi.org/10.1073/pnas.1611406113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018752PMC
September 2016

Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.

Mol Cell Biol 2016 08 14;36(15):2089-104. Epub 2016 Jul 14.

Department of Biological Chemistry and Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/MCB.00166-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946427PMC
August 2016

The Lesser Evil of E-Cigarettes.

Authors:
Thomas Hartung

Sci Am 2016 Aug;315(2)

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http://dx.doi.org/10.1038/scientificamerican0816-9DOI Listing
August 2016

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.

Sci Rep 2016 07 26;6:28994. Epub 2016 Jul 26.

Center for Alternatives to Animal Testing (CAAT), Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University Baltimore, MD, USA.

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http://dx.doi.org/10.1038/srep28994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960662PMC
July 2016

Systems Toxicology: The Future of Risk Assessment.

Int J Toxicol 2015 Jul-Aug;34(4):346-8. Epub 2015 Mar 23.

Harvard University, Cambridge, MA, USA University of Massachusetts School of Public Health, Amherst, MA, USA

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http://dx.doi.org/10.1177/1091581815576551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778743PMC
June 2016

Cellular resilience.

ALTEX 2015 ;32(4):247-60

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;

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http://dx.doi.org/10.14573/altex.1509271DOI Listing
June 2016

Animal use for science in Europe.

ALTEX 2015 ;32(4):261-74

Center for Alternatives to Animal Testing - Europe, University of Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1509081DOI Listing
June 2016

Can TTIP Improve Laboratory Animal Welfare in Safety Testing and 3Rs?

ILAR J 2016 May;57(3):358-367

CAAT Europe, Brussels, Belgium. Evidence-Based Toxicology, and Molecular Microbiology and Immunology at Johns Hopkins Bloomberg School of Public Health, Baltimore MD, and Pharmacology and Toxicology, University of Konstanz, Germany. Center for Alternatives to Animal Testing, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health.

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http://dx.doi.org/10.1093/ilar/ilw022DOI Listing
May 2016

Arsenic Exposure and Immunotoxicity: a Review Including the Possible Influence of Age and Sex.

Curr Environ Health Rep 2016 Mar;3(1):1-12

CAAT, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s40572-016-0082-3DOI Listing
March 2016

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.

Proc Natl Acad Sci U S A 2015 Dec 10;112(52):E7276-85. Epub 2015 Dec 10.

Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205

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http://dx.doi.org/10.1073/pnas.1512867112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4703001PMC
December 2015

The human whole blood pyrogen test - lessons learned in twenty years.

Authors:
Thomas Hartung

ALTEX 2015 ;32(2):79-100

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.

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http://dx.doi.org/10.14573/altex.1503241DOI Listing
November 2015

Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships.

J Appl Toxicol 2015 Nov 5;35(11):1361-1371. Epub 2015 Jun 5.

Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/jat.3172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805435PMC
November 2015

Metabonomics and toxicology.

Methods Mol Biol 2015 ;1277:209-31

Center for Alternatives to Animal Testing, Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/978-1-4939-2377-9_15DOI Listing
October 2015

MPTP's pathway of toxicity indicates central role of transcription factor SP1.

Arch Toxicol 2015 May 8;89(5):743-55. Epub 2015 Apr 8.

Center for Alternatives to Animal Testing, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/s00204-015-1509-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415653PMC
May 2015

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

J Pharmacol Exp Ther 2015 Apr 9;353(1):213-33. Epub 2015 Feb 9.

Roche Pharmaceutical Research and Early Development, Discovery Neuroscience, Neuroscience, Ophthalmology, and Rare Diseases (L.L., S.H.S., B.K., A.B., M.v.K., M.H., E.B., E.P., W.S., J.G.W.), Discovery Chemistry (E.V., S.K., J.W., G.J.), Operations for Neuroscience, Ophthalmology, and Rare Diseases (R.H.P., J.-L.M.), Pharmaceutical Sciences (A.C.H., A.P., C.F., A.G., M.S., N.J.P., L.P., U.N.), and Small Molecules Process Research and Synthesis (T.H.), Roche Innovation Center Basel, Basel, Switzerland; and Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, California (S.R.M., T.S.K.).

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http://dx.doi.org/10.1124/jpet.114.222463DOI Listing
April 2015