Theodore Nicolaides

Theodore Nicolaides

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Theodore Nicolaides

Theodore Nicolaides

Publications by authors named "Theodore Nicolaides"

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Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness.

Cell Rep 2019 Aug;28(8):2064-2079.e11

Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.071DOI Listing
August 2019

Surveillance Screening in Li-Fraumeni Syndrome: Raising Awareness of False Positives.

Cureus 2018 Apr 24;10(4):e2527. Epub 2018 Apr 24.

Pediatrics, NYU Langone Medical Center, New York, NEW YORK, USA.

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http://dx.doi.org/10.7759/cureus.2527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017131PMC
April 2018

Inhibiting 4EBP1 in Glioblastoma.

Clin Cancer Res 2018 01 10;24(1):14-21. Epub 2017 Jul 10.

Department of Neurology, University of California, San Francisco, California.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754225PMC
January 2018

Suprasellar Germinoma Presenting with Slipped Capital Femoral Epiphysis: Case Report.

Cureus 2017 Dec 16;9(12):e1954. Epub 2017 Dec 16.

Department of Pediatrics, Department of Neurosurgery, University of California - San Francisco.

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http://dx.doi.org/10.7759/cureus.1954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815654PMC
December 2017

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

J Clin Oncol 2017 Sep 20;35(25):2934-2941. Epub 2017 Jul 20.

Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, and Uri Tabori, The Hospital for Sick Children, Toronto; Adam Fleming, McMaster Children's Hospital, McMaster University, Hamilton; Shayna Zelcer, Children's Hospital of Western Ontario, London, Ontario; David Eisenstat and Bev Wilson, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta; Anne Sophie Carret, Hospital Sainte Justine; Nada Jabado, McGill University, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; Ofelia Cruz and Carmen de Torres, Hospital Sant Joan de Déu, Barcelona, Spain; Cheng-Ying Ho, University of Maryland School of Medicine, Baltimore, MD; Roger J. Packer, Children's National Health System, Washington, DC; Ruth Tatevossian, Ibrahim Qaddoumi, Julie H. Harreld, James D. Dalton, and David W. Ellison, St Jude Children's Research Hospital, Memphis, TN; Jean Mulcahy-Levy and Nicholas Foreman, Children's Hospital Colorado, Aurora, CO; Matthias A. Karajannis, Shiyang Wang, and Matija Snuderl, New York University Langone Medical Center, New York, NY; Amulya Nageswara Rao and Caterina Giannini, The Mayo Clinic, Rochester, MN; Mark Kieran and Keith L. Ligon, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA; Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, and Alessandro Raso, Istituto Giannina Gaslini, Genoa, Italy; Sabine Mueller and Theodore Nicolaides, University of California, San Francisco, San Francisco, CA; Karen Silva and Romain Perbet, Hospices Civils de Lyon; Alexandre Vasiljevic, Cécile Faure Conter, and Didier Frappaz, Institute of Pediatric Hematology and Oncology, Lyon, France; Sarah Leary and Courtney Crane, Seattle Children's Hospital, Seattle, WA; Aden Chan and Ho-Keung Ng, The Chinese University of Hong Kong, Hong Kong; Zhi-Feng Shi and Ying Mao, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Elizabeth Finch, University of North Carolina, School of Medicine, Chapel Hill, NC; Peter Hauser, Semmelweis University, Budapest, Hungary; and David Sumerauer and Lenka Krskova, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.

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http://dx.doi.org/10.1200/JCO.2016.71.8726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791837PMC
September 2017

A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study.

Neuro Oncol 2017 Aug;19(8):1135-1144

University of California San Francisco, San Francisco, California; Boston Children's Hospital, Boston, Massachusetts; Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania; St Jude Children's Research Hospital, Memphis, Tennessee; Lurie Children's Hospital, Chicago, Illinois; Children's National Medical Center, Washington, DC; Duke University Medical Center, Durham, North Carolina; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1093/neuonc/now282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570236PMC
August 2017

Precision knockdown of EGFR gene expression using radio frequency electromagnetic energy.

J Neurooncol 2017 Jun 22;133(2):257-264. Epub 2017 Apr 22.

Ben & Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, 550 17th Avenue, Seattle, WA, 98122, USA.

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http://dx.doi.org/10.1007/s11060-017-2440-xDOI Listing
June 2017

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

Cancer Cell 2017 03;31(3):424-435

Department of Neurology, University of California, San Francisco, CA 94158, USA; Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, CA 94158, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386178PMC
March 2017

Combined BRAF and MEK blockade for BRAF-mutant gliomas.

J Neurooncol 2017 02 15;131(3):495-505. Epub 2016 Nov 15.

Department of Pediatrics, University of California San Francisco, 1450 3rd Street, San Francisco, CA, 94158, USA.

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http://link.springer.com/10.1007/s11060-016-2333-4
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http://dx.doi.org/10.1007/s11060-016-2333-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560871PMC
February 2017

Acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas.

Oncotarget 2017 Jan;8(1):583-595

Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.11882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352180PMC
January 2017

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System Tumors.

Cureus 2016 May 21;8(5):e620. Epub 2016 May 21.

Neurological Surgery and Pediatrics, University of California, San Francisco.

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http://dx.doi.org/10.7759/cureus.620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917374PMC
May 2016

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells.

Cancer Res 2015 Dec 16;75(24):5355-66. Epub 2015 Nov 16.

Department of Neurosurgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, California. Helen Diller Comprehensive Cancer Research Center, University of California San Francisco, San Francisco, California. Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-3689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698003PMC
December 2015

EGFR blockade prevents glioma escape from BRAFV600E targeted therapy.

Oncotarget 2015 Sep;6(26):21993-2005

Departments of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.4014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673141PMC
September 2015

Metastatic Diffuse Intrinsic Pontine Glioma to the Peritoneal Cavity Via Ventriculoperitoneal Shunt: Case Report and Literature Review.

J Neurol Surg Rep 2015 Jul 27;76(1):e91-6. Epub 2015 Apr 27.

Departments of Pediatrics, University of California San Francisco, San Francisco, California, United States ; Departments of Neurological Surgery, University of California San Francisco, San Francisco, California, United States.

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http://dx.doi.org/10.1055/s-0035-1547365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520967PMC
July 2015

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.

Lancet Oncol 2015 May 14;16(5):569-82. Epub 2015 Apr 14.

Division of Hematology-Oncology, University of Toronto, Toronto, ON, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)70114-2DOI Listing
May 2015

Pure germinomas of the central nervous system: treatment strategies and outcomes.

J Neurooncol 2014 Dec 5;120(3):643-9. Epub 2014 Sep 5.

School of Medicine, University of California San Francisco (UCSF), San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s11060-014-1599-7DOI Listing
December 2014

NT113, a pan-ERBB inhibitor with high brain penetrance, inhibits the growth of glioblastoma xenografts with EGFR amplification.

Mol Cancer Ther 2014 Dec 13;13(12):2919-29. Epub 2014 Oct 13.

Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Northwestern Medicine Developmental Therapeutics Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364529PMC
December 2014

Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children.

Childs Nerv Syst 2013 Aug 11;29(8):1313-9. Epub 2013 May 11.

Department of Neurological Surgery, Pediatric Neurosurgery, University of California, San Francisco, 505 Parnassus Ave, Room M779, San Francisco, CA 94143-0112, USA.

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http://dx.doi.org/10.1007/s00381-013-2101-0DOI Listing
August 2013

Sensitivity of glioblastomas to clinically available MEK inhibitors is defined by neurofibromin 1 deficiency.

Cancer Res 2012 Jul 9;72(13):3350-9. Epub 2012 May 9.

Department of Neurological Surgery, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128256PMC
July 2012

Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Sci Signal 2010 Nov 9;3(147):ra81. Epub 2010 Nov 9.

Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158-9001, USA.

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http://dx.doi.org/10.1126/scisignal.2001017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001107PMC
November 2010

High-dose chemotherapy and autologous stem cell rescue for atypical teratoid/rhabdoid tumor of the central nervous system.

J Neurooncol 2010 May 22;98(1):117-23. Epub 2009 Nov 22.

Department of Pediatrics, University of California San Francisco School of Medicine, 505 Parnassus Avenue, M649, Box 0106, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1007/s11060-009-0071-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880232PMC
May 2010

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.

Cancer Res 2007 Sep;67(17):7960-5

Department of Neurology and Brain Tumor Research Center, Comprehensive Cancer Center, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597547PMC
September 2007