Publications by authors named "Teresa Macarulla"

100Publications

Early dose reduction/delay and the efficacy of liposomal irinotecan with fluorouracil and leucovorin in metastatic pancreatic ductal adenocarcinoma (mPDAC): A post hoc analysis of NAPOLI-1.

Pancreatology 2020 Oct 10. Epub 2020 Oct 10.

German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany, West German Cancer Center, University Hospital of Essen, Essen, Germany.

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October 2020

A new targeted treatment for patients with a germline mutation: olaparib in pancreatic cancer.

Future Oncol 2020 Nov 17;16(33):2691-2700. Epub 2020 Aug 17.

Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, 08035, Spain.

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November 2020

Safety of Aflibercept in Metastatic Colorectal Cancer: A Literature Review and Expert Perspective on Clinical and Real-World Data.

Cancers (Basel) 2020 Mar 31;12(4). Epub 2020 Mar 31.

Gastrointestinal Tumors Service of the Medical Oncology Service, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, IOB, Barcelona 08035, Spain.

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March 2020

The role of PIGF blockade in the treatment of colorectal cancer: overcoming the pitfalls.

Expert Opin Biol Ther 2020 01 16;20(1):15-22. Epub 2019 Oct 16.

Vall d´Hebron University Hospital (HUVH) and Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.

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January 2020

Reply to I. Pecora et al.

J Clin Oncol 2019 08 12;37(22):1979. Epub 2019 Jun 12.

Teresa Macarulla, MD, PhD, Hospital Vall d'Hebron, Barcelona, Spain; and Manuel Hidalgo, MD, PhD, Beth Israel Deaconess Medical Center, Boston, MA.

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August 2019

Maintenance Olaparib for Germline -Mutated Metastatic Pancreatic Cancer.

N Engl J Med 2019 07 2;381(4):317-327. Epub 2019 Jun 2.

From the Oncology Institute, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel (T.G.); Hôpital Beaujon (Assistance Publique-Hôpitaux de Paris), Clichy, and University Paris VII, Paris (P.H.); IRCCS Ospedale San Raffaele Scientific Institute, Milan (M.R.), Azienda Ospedaliera Universitaria Integrata Verona, Verona (G.T.), and Fondazione Policlinico Universitario Gemelli IRCCS, Rome (G.T.) - all in Italy; University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium (E.V.C.); Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona (T.M.); Fox Chase Cancer Center, Philadelphia (M.J.H.); Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-O.P.), and Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine (D.-Y.O.) - both in Seoul, South Korea; University College London Cancer Institute, London (D.H.), and AstraZeneca, Cambridge (D.M.) - both in the United Kingdom; Asklepios Tumorzentrum Hamburg Asklepios Klinik Altona, Hamburg (D.A.), St. Josef-Hospital, Ruhr University Bochum, Bochum (A.R.-S.), and Klinikum rechts der Isar, Department of Internal Medicine II, Technische Universität München, Munich (H.A.) - all in Germany; Memorial Sloan Kettering Cancer Center, New York (E.M.O.); AstraZeneca, Gaithersburg, MD (K.Y.C., G.Y.L.); Merck, Kenilworth, NJ (K.S.); and the University of Chicago, Chicago (H.L.K.).

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July 2019

Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer.

Br J Cancer 2018 11 15;119(10):1208-1214. Epub 2018 Oct 15.

Vall d'Hebron University Hospital and Institute of Oncology (VHIO), CIBERONC, Universitat Autònoma de Barcelona, P. Vall d'Hebron 119-129, 08035, Barcelona, Spain.

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November 2018

From First Line to Sequential Treatment in the Management of Metastatic Pancreatic Cancer.

J Cancer 2018 30;9(11):1978-1988. Epub 2018 Apr 30.

Dpt. Medical Oncology, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERONC, Madrid, Spain.

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April 2018

Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma.

J Clin Oncol 2018 01 28;36(3):276-282. Epub 2017 Nov 28.

Milind Javle and Rachna T. Shroff, The University of Texas MD Anderson Cancer Center, Houston, TX; Maeve Lowery and Ghassan K. Abou-Alfa, Memorial Sloan Kettering Cancer Center, and Weill Cornell Medical College, New York, NY; Karl Heinz Weiss and Christoph Springfeld, Universitäts Klinikum Heidelberg, Heidelberg, Germany; Mitesh J. Borad, Ramesh K. Ramanathan, and Tanios Bekaii-Saab, Mayo Clinic, Phoenix, AZ; Lipika Goyal and Andrew X. Zhu, Massachusetts General Hospital Cancer Center, Boston, MA; Saeed Sadeghi and Richard S. Finn, David Geffen School of Medicine at UCLA; Anthony El-Khoueiry, USC Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles; Robin Kate Kelley, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; Teresa Macarulla, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain; Ivan Borbath, Cliniques Universitaires Saint-Luc, Brussels; Eric Van Cutsem, University Hospitals Gasthuisberg and KU Leuven, Leuven, Belgium; Su Pin Choo, National Cancer Centre of Singapore, Singapore; Do-Youn Oh, Seoul National University, Seoul, South Korea; Philip A. Philip, Karmanos Cancer Institute, Detroit, MI; Li-Tzong Chen, National Institute of Cancer Research and National Cheng Kung University Hospital, Tainan; Kun-Huei Yeh, National Taiwan University Hospital Cancer Center, and Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan; Thanyanan Reungwetwattana, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Kristen Ciombor, The Ohio State University Wexner Medical Center, Columbus, OH; and Anuradha Patel, Suman Sen, Dale Porter, and Randi Isaacs, Novartis Pharmaceuticals Corporation, East Hanover, NJ.

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January 2018

Predictive and prognostic biomarkers in personalized gastrointestinal cancer treatment.

J Gastrointest Oncol 2017 Jun;8(3):405-417

Vall d'Hebrón University Hospital (HUVH) and Vall d'Hebrón Institute of Oncology (VHIO), Barcelona, Spain.

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June 2017

A combination of resveratrol and quercetin induces browning in white adipose tissue of rats fed an obesogenic diet.

Obesity (Silver Spring) 2017 01 22;25(1):111-121. Epub 2016 Nov 22.

Department of Nutrition and Food Science, Nutrition and Obesity Group, University of the Basque Country (UPV/EHU), Lucio Lascaray Center and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Vitoria, Spain.

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January 2017

Dose modification and efficacy of nab-paclitaxel plus gemcitabine vs. gemcitabine for patients with metastatic pancreatic cancer: phase III MPACT trial.

J Gastrointest Oncol 2016 Jun;7(3):469-78

1 Medizinische Universität Wien, Wien, Austria ; 2 Division of Hematology/Oncology, Mayo Clinic, Scottsdale, Arizona, USA ; 3 BC Cancer Agency, Vancouver, British Columbia, Canada ; 4 Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona, Spain ; 5 Prince of Wales Hospital, Sydney, NSW, Australia ; 6 Hôpital Beaujon, Clichy, France ; 7 Universitätsklinikum Würzburg, Würzburg, Germany ; 8 Celgene Corporation, Summit, New Jersey, USA ; 9 Celgene Corporation, Boudry, Switzerland ; 10 Translational Genomics Research Institute and Honor Health, Scottsdale, Arizona, USA.

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June 2016

Ramucirumab in metastatic colorectal cancer: evidence to date and place in therapy.

Ther Adv Med Oncol 2016 May 11;8(3):230-42. Epub 2016 Mar 11.

Hospital Universitari Vall Hebrón, Passeig Vall Hebrón 119-129, Edificio Modular 2ª Planta, 08035, Barcelona, Spain.

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May 2016

Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.

Lancet 2016 Feb 29;387(10018):545-557. Epub 2015 Nov 29.

National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. Electronic address:

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February 2016

Pharmacokinetic and pharmacodynamic evaluation of aflibercept for the treatment of colorectal cancer.

Expert Opin Drug Metab Toxicol 2015 Jun;11(6):995-1004

Universitat Autònoma de Barcelona, Vall d'Hebron University Hospital, Department of Medical Oncology , P. Vall d'Hebron 119-129, 08035 Barcelona , Spain +34 93 274 6085 ; +34 93 274 6059 ;

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June 2015

Liver delipidating effect of a combination of resveratrol and quercetin in rats fed an obesogenic diet.

J Physiol Biochem 2015 Sep 1;71(3):569-76. Epub 2015 Apr 1.

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria, Spain.

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September 2015

The combination of resveratrol and quercetin enhances the individual effects of these molecules on triacylglycerol metabolism in white adipose tissue.

Eur J Nutr 2016 Feb 11;55(1):341-8. Epub 2015 Feb 11.

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Paseo de la Universidad 7, 01006, Vitoria, Spain.

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February 2016

Circulating pEGFR is a candidate response biomarker of cetuximab therapy in colorectal cancer.

Clin Cancer Res 2014 Dec 16;20(24):6346-56. Epub 2014 Oct 16.

Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

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December 2014

Evaluation of aflibercept in the treatment of metastatic colorectal cancer.

Expert Opin Biol Ther 2014 Oct 25;14(10):1493-505. Epub 2014 Aug 25.

Vall d'Hebron University Hospital , Barcelona , Spain

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October 2014

First-in-human phase I study of Lurbinectedin (PM01183) in patients with advanced solid tumors.

Clin Cancer Res 2014 Apr 21;20(8):2205-14. Epub 2014 Feb 21.

Authors' Affiliations: Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona; PharmaMar, S.A., Colmenar Viejo, Madrid, Spain; and Department of Medicine, The University of Chicago, Chicago, Illinois.

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April 2014

Resveratrol does not increase body fat loss induced by energy restriction.

J Physiol Biochem 2014 Jun 1;70(2):639-46. Epub 2014 Feb 1.

Nutrition and Obesity Group, Department of Nutrition and Food Sciences and Research Institute Lucio Lascaray, University of the Basque Country (UPV/EHU), Paseo de la Universidad, 7, 01006, Vitoria, Spain.

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June 2014

Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats.

Food Chem 2013 Nov 13;141(2):1530-5. Epub 2013 Apr 13.

Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU), Paseo de la Universidad, 7, 01006 Vitoria, Spain.

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November 2013

Effects of pomegranate seed oil on glucose and lipid metabolism-related organs in rats fed an obesogenic diet.

J Agric Food Chem 2013 May 17;61(21):5089-96. Epub 2013 May 17.

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Paseo de la Universidad , 7. 01006 Vitoria, Spain.

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May 2013

Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet.

Nutrition 2013 Mar 28;29(3):562-7. Epub 2012 Dec 28.

Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country-UPV/EHU, Vitoria, Spain.

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March 2013

Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

Mol Cancer Ther 2012 Sep 21;11(9):2062-71. Epub 2012 Jun 21.

Molecular Therapeutics Research Unit, Medical Oncology Department, Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain.

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September 2012

Distribution of resveratrol metabolites in liver, adipose tissue, and skeletal muscle in rats fed different doses of this polyphenol.

J Agric Food Chem 2012 May 7;60(19):4833-40. Epub 2012 May 7.

Department of Nutrition and Food Science, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain.

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May 2012

Successful treatment with GEMOX in patient with metastatic pancreatic adenosquamous carcinoma.

Tumori 2011 Mar-Apr;97(2):239-42

European Institute of Oncology, Medical Care Unit, Department of Medical Oncology, Milan, Italy.

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July 2011

New approaches and targets in advanced colorectal cancer.

Eur J Cancer 2009 Sep;45 Suppl 1:79-88

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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September 2009

Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment.

Cancer Treat Rev 2009 Jun 6;35(4):354-63. Epub 2009 Mar 6.

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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June 2009

Understanding the predictive role of K-ras for epidermal growth factor receptor-targeted therapies in colorectal cancer.

Clin Colorectal Cancer 2008 Dec;7 Suppl 2:S52-7

Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain.

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December 2008

The role of salvage treatment in advanced colorectal cancer.

Crit Rev Oncol Hematol 2009 Jul 1;71(1):53-61. Epub 2008 Nov 1.

Medical Oncology Department, Vall d'Hebron University Hospital, P. Vall d'Hebron 119-129, 08035 Barcelona, Spain.

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July 2009

Update on novel strategies to optimize cetuximab therapy in patients with metastatic colorectal cancer.

Clin Colorectal Cancer 2008 Sep;7(5):300-8

Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain.

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September 2008

Oxaliplatin-based chemotherapy in the management of colorectal cancer.

Expert Rev Anticancer Ther 2008 Aug;8(8):1223-36

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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August 2008

Aurora kinase family: a new target for anticancer drug.

Recent Pat Anticancer Drug Discov 2008 Jun;3(2):114-22

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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June 2008

New approaches in systemic treatment of advanced colorectal cancer: the molecular targets era.

Expert Rev Anticancer Ther 2007 Jul;7(7):1027-41

Vall d'Hebron University Hospital, Medical Oncology Department, Barcelona, Spain.

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July 2007

Effects of trans-10,cis-12 conjugated linoleic acid on cholesterol metabolism in hypercholesterolaemic hamsters.

Eur J Nutr 2007 Jun 3;46(4):213-9. Epub 2007 May 3.

Dept. of Nutrition and Food Science, Faculty of Pharmacy, University of País Vasco, Paseo de la Universidad 7, 01006 Vitoria, Spain.

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June 2007

Effects of trans-10, cis-12 conjugated linoleic acid on the expression of uncoupling proteins in hamsters fed an atherogenic diet.

Br J Nutr 2007 Jun 7;97(6):1074-82. Epub 2007 Mar 7.

Bioquímica, Biología Molecular, Nutrición y Biotecnología (Nutrigenómica), Universitat de les Illes Balears (UIB), Cra. Valldemossa, km 7.5, 07122 Palma de Mallorca, Spain.

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June 2007

Novel targets for anticancer treatment development in colorectal cancer.

Clin Colorectal Cancer 2006 Nov;6(4):265-72

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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November 2006

Novel targets in gastric and esophageal cancer.

Crit Rev Oncol Hematol 2006 Aug 10;59(2):128-38. Epub 2006 Jul 10.

Medical Oncology Department, Vall d'Hebron University Hospital, P Vall d'Hebron, Barcelona, Spain.

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August 2006

Epidermal growth factor receptor (EGFR) inhibitors in gastrointestinal cancer.

Onkologie 2006 Mar 3;29(3):99-105. Epub 2006 Mar 3.

Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

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March 2006

Effects of conjugated linoleic acid on skeletal muscle triacylglycerol metabolism in hamsters.

Nutrition 2006 May 3;22(5):528-33. Epub 2006 Feb 3.

Department of Nutrition and Food Science, Faculty of Pharmacy, University of País Vasco, Vitoria, Spain.

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May 2006

trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters.

J Nutr Biochem 2006 Feb 27;17(2):126-31. Epub 2005 Jun 27.

Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country, Paseo de la Univrsidad, 7, 01006 Vitoria, Spain.

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February 2006