Steven Xanthoudakis

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Authors:

Elise Isabel Renee Aspiotis W Cameron Black John Colucci Réjean Fortin André Giroux Erich L Grimm Yongxin Han Christophe Mellon Donald W Nicholson Dita M Rasper Johanne Renaud Sophie Roy John Tam Paul Tawa John P Vaillancourt Steven Xanthoudakis Robert J Zamboni

Bioorg Med Chem Lett 2007 Mar 11;17(6):1671-4. Epub 2007 Jan 11.

Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., PO Box 1005, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8.

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March 2007

Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.

Authors:

Paul Tawa Andre Giroux Erich Grimm Yongxin Han Donald W Nicholson Steven Xanthoudakis

Anal Biochem 2006 Mar 21;350(1):32-40. Epub 2005 Dec 21.

Department of Biochemistry and Molecular Biology/Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Que., Canada.

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March 2006

Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.

Authors:

Christophe Mellon Reneé Aspiotis Cameron W Black Christopher I Bayly Erich L Grimm André Giroux Yongxin Han Elise Isabel Daniel J McKay Donald W Nicholson Dita M Rasper Sophie Roy John Tam Nancy A Thornberry John P Vaillancourt Steven Xanthoudakis Robert Zamboni

Bioorg Med Chem Lett 2005 Sep;15(17):3886-90

Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., P.O. Box 1005, Pointe-Claire-Dorval, Que., Canada H9R 4P8.

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September 2005

Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma.

Authors:

Annette Robichaud Stephanie A Tuck Stacia Kargman John Tam Elizabeth Wong Mark Abramovitz James R Mortimer James Mortimer Helen E Burston Paul Masson Jeremy Hirota Deborah Slipetz Brian Kennedy Gary O'Neill Steven Xanthoudakis

Am J Respir Cell Mol Biol 2005 Sep 9;33(3):303-14. Epub 2005 Jun 9.

Department of Biochemistry and Molecular Biology, Merck Centre for Therapeutic Research, P.O. Box 1005, Pointe-Claire-Dorval, PQ, H9R 4P8 Canada.

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September 2005

Solid phase synthesis of selective caspase-3 peptide inhibitors.

Authors:

Erich L Grimm Bruno Roy Renee Aspiotis Christopher I Bayly Donald W Nicholson Dita M Rasper Johanne Renaud Sophie Roy John Tam Paul Tawa John P Vaillancourt Steven Xanthoudakis Robert J Zamboni

Bioorg Med Chem 2004 Mar;12(5):845-51

Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co. PO Box 1005, Pointe-Claire-Dorval, Québec, Canada H9R 4P8.

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March 2004

Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease.

Br J Pharmacol 2004 Feb 26;141(4):689-97. Epub 2004 Jan 26.

Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec, H9H 3L1, Canada.

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February 2004

Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics.

Authors:

Nathalie Méthot JingQi Huang Nathalie Coulombe John P Vaillancourt Dita Rasper John Tam Yongxin Han John Colucci Robert Zamboni Steven Xanthoudakis Sylvie Toulmond Donald W Nicholson Sophie Roy

J Exp Med 2004 Jan 12;199(2):199-207. Epub 2004 Jan 12.

Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Montreal, Quebec, Canada H9H 3L1.

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January 2004

Nicotinyl aspartyl ketones as inhibitors of caspase-3.

Authors:

Elise Isabel W Cameron Black Christopher I Bayly Erich L Grimm Marc K Janes Daniel J McKay Donald W Nicholson Dita M Rasper Johanne Renaud Sophie Roy John Tam Nancy A Thornberry John P Vaillancourt Steven Xanthoudakis Robert Zamboni

Bioorg Med Chem Lett 2003 Jul;13(13):2137-40

Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., Pointe-Claire-Dorval, H9R 4P8, Quebec, Canada.

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July 2003

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

Authors:

Amir H Salehi Steven Xanthoudakis Philip A Barker

J Biol Chem 2002 Dec 9;277(50):48043-50. Epub 2002 Oct 9.

Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec H3A 2B4, Canada.

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December 2002

Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury.

Authors:

Byung Hee Han Daigen Xu Junjeong Choi Yongxin Han Steven Xanthoudakis Sophie Roy John Tam John Vaillancourt John Colucci Robert Siman Andre Giroux George S Robertson Robert Zamboni Donald W Nicholson David M Holtzman

J Biol Chem 2002 Aug 10;277(33):30128-36. Epub 2002 Jun 10.

Department of Neurology, Washington University, St. Louis, Missouri 63110, USA.

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August 2002

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

Authors:

François G Gervais Roshni Singaraja Steven Xanthoudakis Claire-Anne Gutekunst Blair R Leavitt Martina Metzler Abigail S Hackam John Tam John P Vaillancourt Vicky Houtzager Dita M Rasper Sophie Roy Michael R Hayden Donald W Nicholson

Nat Cell Biol 2002 Feb;4(2):95-105

Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Pointe-Claire-Dorval, Quebec, Canada H9R 4P8.

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February 2002

Publications by authors named "Steven Xanthoudakis"

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