Publications by authors named "Steven Sheriff"

47Publications

Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.

Bioorg Med Chem Lett 2020 02 7;30(4):126949. Epub 2020 Jan 7.

Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.

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http://dx.doi.org/10.1016/j.bmcl.2020.126949DOI Listing
February 2020

Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.

Bioorg Med Chem Lett 2018 04 27;28(6):987-992. Epub 2018 Feb 27.

Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540, United States.

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http://dx.doi.org/10.1016/j.bmcl.2018.02.049DOI Listing
April 2018

Macrocyclic factor XIa inhibitors.

Bioorg Med Chem Lett 2017 09 25;27(17):4056-4060. Epub 2017 Jul 25.

Bristol-Myers Squibb Company, Research and Development, 350 Carter Road, Hopewell, NJ 08540 United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.07.048DOI Listing
September 2017

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase.

Bioorg Med Chem Lett 2017 01 22;27(2):295-298. Epub 2016 Nov 22.

Bristol-Myers Squibb, Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.

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http://dx.doi.org/10.1016/j.bmcl.2016.11.054DOI Listing
January 2017

Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.

J Mol Biol 2016 07 21;428(14):2860-79. Epub 2016 May 21.

Department of Molecular Discovery Technologies, Bristol-Myers Squibb, Princeton, NJ 08543, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.05.014DOI Listing
July 2016

Crystal structures of apo and inhibitor-bound TGFβR2 kinase domain: insights into TGFβR isoform selectivity.

Acta Crystallogr D Struct Biol 2016 05 26;72(Pt 5):658-74. Epub 2016 Apr 26.

Molecular Structure and Design, Bristol-Myers Squibb R & D, PO Box 4000, Princeton, NJ 08543-4000, USA.

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http://dx.doi.org/10.1107/S2059798316003624DOI Listing
May 2016

The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

Acta Crystallogr F Struct Biol Commun 2015 Oct 23;71(Pt 10):1273-81. Epub 2015 Sep 23.

Molecular Structure and Design, Bristol-Myers Squibb R&D, PO Box 4000, Princeton, NJ 08543-4000, USA.

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http://dx.doi.org/10.1107/S2053230X15016416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601591PMC
October 2015

Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1).

ACS Med Chem Lett 2014 Jul 22;5(7):803-8. Epub 2014 May 22.

Department of Medicinal Chemistry, Department of Biology, Lead Evaluation, CADD, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb , Bldg 13, Princeton, New Jersey 08543-5400, United States.

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http://dx.doi.org/10.1021/ml500144hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094253PMC
July 2014

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

J Med Chem 2014 Mar 7;57(5):1855-79. Epub 2014 Jan 7.

Discovery Chemistry, ‡Molecular Discovery Technologies, Molecular Structure & Design, §Molecular Discovery Technologies, Protein Science, ∥Pharmaceutical Candidate Optimization, ⊥Discovery Virology, Disease Sciences and Biologics, #Leads Discovery and Optimization, ▽Materials Science, Drug Product Science and Technology, Bristol-Myers Squibb Research and Development , 5 Research Parkway, Wallingford, Connecticut 06492, United States.

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http://pubs.acs.org/doi/10.1021/jm4016894
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http://dx.doi.org/10.1021/jm4016894DOI Listing
March 2014

Conserved core substructures in the overlay of protein-ligand complexes.

J Chem Inf Model 2011 Aug 22;51(8):1931-41. Epub 2011 Jul 22.

Department of Medicinal Chemistry, University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1021/ci100475yDOI Listing
August 2011

Phenyltriazolinones as potent factor Xa inhibitors.

Bioorg Med Chem Lett 2010 Feb 11;20(4):1373-7. Epub 2010 Jan 11.

Research and Development, Bristol-Myers Squibb, PO Box 5400, Princeton, NJ 08543-5400, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.011DOI Listing
February 2010

Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

Bioorg Med Chem Lett 2007 Jun 21;17(12):3511-5. Epub 2006 Dec 21.

Department of Metabolic Disease Chemistry, Bristol Myers-Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.12.044DOI Listing
June 2007

Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold.

Bioorg Med Chem Lett 2007 Apr 24;17(7):1908-11. Epub 2007 Jan 24.

Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, NJ 08543-4000, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.01.036DOI Listing
April 2007