Dr Simon Waddington
BSc MSc PhD
University College London
Reader in Gene Transfer Technology
London, Greater London | United Kingdom
Main Specialties: Medical Genetics
Additional Specialties: Gene Therapy
Top Author
BSc MSc PhD
University College London
Reader in Gene Transfer Technology
London, Greater London | United Kingdom
Main Specialties: Medical Genetics
Additional Specialties: Gene Therapy
Top Author
I am Joint Acting Director of the Institute for Women’s Health and also lead a team which is focused upon preclinical models of gene and stem cell transfer, particularly for perinatal gene delivery for early onset, debilitating and often lethal diseases including neurodegenerative diseases, inherited epilepsy and metabolic diseases. For Dravet Syndrome we recently obtained funding from the UK Medical Research Council Developmental Pathway Funding Scheme. We have obtained project grant funding for neuronopathic Gaucher Disease and, led by Dr Ahad Rahim, Niemann Pick Type C at UCL School of Pharmacy.
In a parallel research stream, we have developed an application of gene transfer, with Prof Tristan McKay, whereby signalling pathways in diseased organs and tumours can be quantified continually and non-invasively. This was funded, primarily, through a European Research Council Starting Grant. From this work we filed two patents through University College London.
In collaboration with Professors Andy Baker and John McVey we elucidated one of the fundamental mechanisms by which adenovirus vectors transduce cells and published this work in Cell journal. My team and I have published more than one hundred peer reviewed publications and reviews in journals including Nature Immunology, Cell Metabolism and Blood.
The expertise of my team and I in mouse models of perinatal intervention has enabled us to maintain excellent collaborations in areas such as preterm labour and perinatal brain injury, with Professors Donald Peebles, Mark Johnson and Phil Bennet. We have several long-standing international collaborations. These include Drs Jerry Chan and Citra Mattar, Duke-NUS Graduate Medical School Singapore and Prof Patrick Arbuthnot, at the University of Witwatersrand, South Africa, where I hold an honorary position.
Primary Affiliation: University College London - London, Greater London , United Kingdom
Specialties:
Additional Specialties:
Publications
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82Publications
1076Reads
1755PubMed Central Citations
J Hepatol 2017 05 9;66(5):1001-1011. Epub 2017 Jan 9.
UCL Institute of Child Health, University College London, London WC1N 1EH, UK; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK; Inherited Metabolic Disease Unit, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK. Electronic address:
Biol Reprod 2016 12 19;95(6):125. Epub 2016 Oct 19.
Imperial College Parturition Research Group, Academic Department of Obstetrics & Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, United Kingdom
Curr Gene Ther 2016 Nov 2. Epub 2016 Nov 2.
Gene Expression and Therapy Group, King`s College London, Faculty of Life Sciences and Medicine, Department of Medical and Molecular Genetics, 8th Floor Tower Wing, Guy's Hospital, London SE1 9RT, UK.
Nat Commun 2016 07 20;7:12111. Epub 2016 Jul 20.
MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK.
BMC Med 2016 06 13;14(1):86. Epub 2016 Jun 13.
Imperial College Parturition Research Group, Institute of Reproduction and Developmental Biology, Imperial College London, Hammersmith Campus, London, United Kingdom.
Cell Rep 2016 Mar 18;14(8):1883-91. Epub 2016 Feb 18.
Stem Cell Group, Cardiovascular and Cell Sciences Research Institute, St. George's University of London, Cranmer Terrace, London SW17 0RE, UK; School of Healthcare Science, John Dalton Building, Manchester Metropolitan University, Chester Street, Manchester M1 5GD, UK. Electronic address:
Am J Respir Crit Care Med 2016 Feb;193(3):234-6
2 Gene Transfer Technology Group University College London London, United Kingdom.
Curr Stem Cell Rep 2016;2:9-20. Epub 2016 Feb 11.
Preimplantation Genetics and Embryology Group, Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX UK.
J Immunol Res 2015 31;2015:397879. Epub 2015 Jan 31.
Gene Transfer Technology Group, University College London, 86-96 Chenies Mews, London WC1E 6HXZ, UK ; Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Reproduction 2015 Oct 16;150(4):269-77. Epub 2015 Jul 16.
Imperial College Parturition Research GroupDepartment of Reproductive Biology, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UKGene Transfer Technology GroupInstitute for Women's Health, University College London, 86-96 Chenies Mews, London WC1E 6HX, UKProteostasis Therapeutics 200 Technology SquareSuite 402, Cambridge, Massachusetts 02139, USADepartment of Biomedical and Forensic SciencesAnglia Ruskin University, East Road, Cambridge CB1 1PT, UK.
Am J Pathol 2015 Sep 26;185(9):2390-401. Epub 2015 Jul 26.
Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom. Electronic address:
FASEB J 2015 Sep 10;29(9):3876-88. Epub 2015 Jun 10.
*Experimental Fetal Medicine Group, Department of Obstetrics and Gynaecology, National University of Singapore, Singapore; Pediatric Storage Disorders Laboratory, Institute of Psychiatry, King's College London, London, United Kingdom; University College London (UCL) Institute for Child Health, Gene Transfer Technology Group, Institute for Women's Health, and **Department of Pharmacology, UCL School of Pharmacy, University College London, London, United Kingdom; Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa; Department of Reproductive Medicine, KK Women's and Children's Tower, Singapore; and Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore.
Sci Rep 2015 Jul 3;5:11842. Epub 2015 Jul 3.
Stem Cell Group, Cardiovascular &Cell Sciences Research Institute, St. George's University of London, Cranmer Terrace, London SW17 0RE, UK.
Curr Gene Ther 2014 ;14(4):276-88
Dubowitz Neuromuscular Centre and MRC Centre for Neuromuscular Diseases, UCL Institute of Child Health, 30 Guilford Street, London WC1N1EH, UK.
PLoS One 2014 2;9(9):e105985. Epub 2014 Sep 2.
Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore; Experimental Fetal Medicine Group, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore.
Front Mol Neurosci 2014 14;7:89. Epub 2014 Nov 14.
Department of Pharmacology, UCL School of Pharmacy, University College London London, UK.
Mol Ther 2014 Sep 18;22(9):1614-24. Epub 2014 Jul 18.
1] Department of Gene Therapy and Regenerative Medicine, Free University of Brussels, Brussels, Belgium [2] Center for Molecular and Vascular Biology, Department of Cardiovascular Medicine, University of Leuven, Leuven, Belgium.
FASEB J 2014 May 4;28(5):2358-68. Epub 2014 Feb 4.
2Imperial College Parturition Research Group, Institute of Reproduction and Developmental Biology, Imperial College London, Hammersmith Campus, London, W12 0NN, UK.
Mol Ther 2014 Jan 28;22(1):59-68. Epub 2013 Aug 28.
Goldyne Savad Institute of Gene Therapy, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
J Inherit Metab Dis 2013 Sep 15;36(5):869-72. Epub 2012 Nov 15.
Clinical & Molecular Genetics Unit, UCL Institute of Child Health and Chemical Pathology, Great Ormond Street Hospital, London, UK.
J Biol Chem 2013 Sep 23;288(36):26052-66. Epub 2013 Jul 23.
Atlantic Research Centre, Departments of Pediatrics and Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Cell Metab 2013 Jun 23;17(6):941-53. Epub 2013 May 23.
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK.
Blood 2013 Apr 20;121(17):3335-44. Epub 2013 Feb 20.
University College London Cancer Institute, London, United Kingdom.
Mol Ther 2013 Mar 15;21(3):602-9. Epub 2013 Jan 15.
Institute for Liver and Digestive Health, UCL, London, UK.
Mol Ther 2013 Feb 13;21(2):324-37. Epub 2012 Nov 13.
National Centre for Tumorigenesis, Heidelberg Technology park TP4, Heidelberg, Germany.
Nat Immunol 2012 Dec 21;13(12):1213-21. Epub 2012 Oct 21.
Division of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London, UK.
Best Pract Res Clin Obstet Gynaecol 2012 Oct 20;26(5):697-709. Epub 2012 Jul 20.
Experimental Fetal Medicine Group, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Methods Mol Biol 2012 ;891:41-53
National Heart and Lung Institute, Molecular and Cellular Medicine Section, Imperial College London, London, UK.
Methods Mol Biol 2012 ;891:273-90
Gene Transfer Technology Group, Institute for Women's Health, University College London, London, UK.
Methods Mol Biol 2012 ;891:9-39
Prenatal Cell and Gene Therapy Group, EGA Institute for Women's Health, University College London, London, UK.
Methods Mol Biol 2012 ;891:201-18
Department of Surgery, Children's Center for Fetal Research and Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Methods Mol Biol 2012 ;891:1-7
National Heart and Lung Institute, Molecular and Cellular Medicine Section, Imperial College London, London, UK.
Methods Mol Biol 2012 ;891:291-328
Prenatal Cell and Gene Therapy Group, EGA Institute for Women's Health, University College London, London, UK.
Curr Pharm Des 2011 ;17(24):2528-41
William Harvey Research Institute, Queen Mary University of London, London, UK.
Blood 2012 Jan 1;119(4):957-66. Epub 2011 Dec 1.
University College London Cancer Institute, London, UK.
Mol Ther 2011 Nov 31;19(11):1950-60. Epub 2011 May 31.
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
FASEB J 2011 Oct 11;25(10):3505-18. Epub 2011 Jul 11.
Gene Transfer Technology Group, Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WC1E 6HX, UK.
Expert Opin Biol Ther 2011 Oct 31;11(10):1257-71. Epub 2011 May 31.
Yong Loo Lin School of Medicine, National University of Singapore, Department of Obstetrics and Gynaecology, Experimental Fetal Medicine Group, NUHS Tower Block, Level 12, 1E Kent Ridge Road, 119228 Singapore.
Prenat Diagn 2011 Jul 25;31(7):720-34. Epub 2011 May 25.
Prenatal Cell and Gene Therapy Group, Institute for Women's Health, University College London, London, UK.
Mol Ther 2011 May 18;19(5):876-85. Epub 2011 Jan 18.
Department of Hematology, University College London Cancer Institute, London, UK.
J Mol Med (Berl) 2011 May 8;89(5):515-29. Epub 2011 Feb 8.
Gene Therapy Research Group, Section of Molecular Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Hum Gene Ther 2011 Apr 2;22(4):419-26. Epub 2011 Feb 2.
Institute for Women's Health, University College London, London WC1E 6HX, United Kingdom.
Ther Deliv 2011 Apr;2(4):483-91
Institute for Women's Health, University College London, 86-96 Chenies Mews, London, WCIE 6HX, UK.
Blood 2011 Jan 1;117(3):798-807. Epub 2010 Nov 1.
Molecular Immunology Unit, Institute of Child Health, University College London, London, UK.
Biochem Soc Trans 2010 Dec;38(6):1489-93
Institute for Women's Health, University College London, 86-96 Chenies Mews, London WC1E 6HX, UK.
Mol Ther 2010 Dec 24;18(12):2104-11. Epub 2010 Aug 24.
Institute for Women's Health, University College London, London, UK.
Biochem Soc Trans 2010 Dec;38(6):1484-8
Pediatric Storage Disorders Laboratory, Department of Neuroscience and Centre for the Cellular Basis of Behaviour, MRC Centre for Neurodegeneration Research, James Black Centre, Institute of Psychiatry, King's College London, 125 Coldharbour Lane, London SE5 9NU, UK.
Int Arch Med 2010 Dec 13;3:36. Epub 2010 Dec 13.
Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Al-Abedia Campus, P, O, Box 715, Makkah 21955, Saudi Arabia.
Blood 2010 Nov 9;116(18):3645-52. Epub 2010 Aug 9.
Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada.
Blood 2010 Oct 7;116(15):2656-64. Epub 2010 Jul 7.
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Mol Ther 2010 Sep 22;18(9):1592-8. Epub 2010 Jun 22.
Goldyne Savad Institute of Gene Therapy, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Arterioscler Thromb Vasc Biol 2010 Jul 6;30(7):1333-9. Epub 2010 May 6.
Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Ducane Road, London W12 0NN, England.
Mol Ther 2010 Mar 24;18(3):601-8. Epub 2009 Nov 24.
King's College London School of Medicine, Nuclear Biology Group, Department of Medical and Molecular Genetics, Guy's Hospital, London, UK.
Analyst 2010 Jan 13;135(1):157-64. Epub 2009 Nov 13.
Wolfson Centre for Gene Therapy, Molecular Immunology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK.
Glia 2010 Jan;58(1):11-28
Department of Obstetrics and Gynecology, EGA Institute of Women's Health, University College London, London, United Kingdom.
Mol Ther 2009 Oct 14;17(10):1683-91. Epub 2009 Jul 14.
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK.
Blood 2009 Jul 8;114(5):965-71. Epub 2009 May 8.
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, G12 8TA, UK.
Cell Cycle 2009 Apr 9;8(7):1069-79. Epub 2009 Apr 9.
Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London, UK.
Endocrinology 2009 Feb 9;150(2):699-706. Epub 2008 Oct 9.
Imperial College Parturition Research Group, Department of Reproductive Biology, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK.
J Virol 2009 Jan 22;83(1):479-83. Epub 2008 Oct 22.
British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, 126 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom.
Hum Gene Ther 2008 Oct;19(10):1050-6
Department of Haematology, Haemophilia Centre and Haemostasis Unit, Royal Free and University College Medical School, London NW3 2PF, UK.
Cell 2008 Feb;132(3):397-409
Department of Haematology, Haemophilia Centre and Haemostasis Unit, Royal Free and University College Medical School, London NW3 2PF, UK.
Mol Ther 2007 Nov 14;15(11):1947-54. Epub 2007 Aug 14.
Molecular Immunology Unit, Institute of Child Health, London, UK.
Curr Opin Mol Ther 2007 Oct;9(5):432-8
University College London, Department of Haematology, Haemophilia Centre and Haemostasis Unit, Royal Free and University College London Medical School, Rowland Hill Street, London, NW3 2PF, UK.
J Virol 2007 Sep 6;81(17):9568-71. Epub 2007 Jun 6.
Department of Haematology, Haemophilia Centre and Haemostasis Unit, Royal Free and University College Medical School, London NW3 2PF, United Kingdom.
Mol Ther 2007 Aug 15;15(8):1410-6. Epub 2007 May 15.
British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
J Gene Med 2007 Jun;9(6):488-97
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, UK.
J Virol 2007 Apr 24;81(7):3627-31. Epub 2007 Jan 24.
British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom.
Stem Cells 2007 Apr 21;25(4):875-84. Epub 2006 Dec 21.
Experimental Fetal Medicine Group, Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London, United Kingdom.
Blood 2006 Oct 20;108(8):2554-61. Epub 2006 Jun 20.
British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, 126 University Place, University of Glasgow, G12 8TA, United Kingdom.
Blood 2006 Apr 1;107(7):2653-61. Epub 2005 Dec 1.
Department of Haematology, University College London, 98 Chenies Mews, London, United Kingdom, WC1E 6HX.
Mol Ther 2005 Oct;12(4):763-71
Gene Therapy Research Group, Section of Cell and Molecular Biology, Imperial College London, UK.
Am J Obstet Gynecol 2005 Sep;193(3 Pt 2):1105-9
Department of Obstetrics and Gynaecology, University College London, United Kingdom.
J Gene Med 2005 May;7(5):630-7
Department of Experimental Medicine I, Nikolaus Fiebiger Centre of Molecular Medicine, University of Erlangen-Nuernberg, Germany.
Mol Ther 2005 May;11(5):661-76
Gene Therapy Research Group, Sir Alexander Fleming Building, Imperial College, South Kensington, London SW7 2AZ, UK.
J Gene Med 2005 Mar;7(3):325-33
Division of Medicine, Faculty of Medicine, Imperial College London, St Mary's Campus, South Wharf Road, London W2 1NY, UK.
Blood 2004 Nov 1;104(9):2714-21. Epub 2004 Jul 1.
Imperial College London, Gene Therapy Research Group, Section of Cell and Molecular Biology, Sir Alexander Fleming Bldg, Imperial College Road, London, SW7 2AZ, United Kingdom.
Hum Gene Ther 2003 Mar;14(4):353-64
Department of Obstetrics and Gynaecology, Royal Free and University College Medical School, 86-96 Chenies Mews, London, WC1E 6HX, United Kingdom.
Blood 2003 Feb 3;101(4):1359-66. Epub 2002 Oct 3.
Gene Therapy, Section of Cell and Molecular Biology, Imperial College School of Science, Technology and Medicine, London, United Kingdom.
J Gene Med 2002 Jan-Feb;4(1):46-53
Children's Hospital, University of Erlangen-Nuernberg, Germany.
Kidney Int 2002 Mar;61(3):876-81
Gene Therapy Group, Section of Cell and Molecular Biology, Faculty of Medicine, Imperial College School of Science Technology and Medicine, Sir Alexander Fleming Building, Imperial College Road, London, England SW7 2AZ, UK.
