Siegfried Labeit

Siegfried Labeit

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Siegfried Labeit

Publications by authors named "Siegfried Labeit"

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Titin-based mechanosensing modulates muscle hypertrophy.

J Cachexia Sarcopenia Muscle 2018 10 5;9(5):947-961. Epub 2018 Jul 5.

Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.

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http://doi.wiley.com/10.1002/jcsm.12319
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http://dx.doi.org/10.1002/jcsm.12319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204599PMC
October 2018

The giant protein titin regulates the length of the striated muscle thick filament.

Nat Commun 2017 10 19;8(1):1041. Epub 2017 Oct 19.

Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, 85721, USA.

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http://dx.doi.org/10.1038/s41467-017-01144-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648799PMC
October 2017

FoxO3a suppression and VPS34 activity are essential to anti-atrophic effects of leucine in skeletal muscle.

Cell Tissue Res 2017 08 24;369(2):381-394. Epub 2017 Apr 24.

Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 2415, Butantã, CEP: 05508-000, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1007/s00441-017-2614-zDOI Listing
August 2017

The Binding Sites of miR-619-5p in the mRNAs of Human and Orthologous Genes.

BMC Genomics 2017 06 1;18(1):428. Epub 2017 Jun 1.

Institute for Anaesthesiology and Intensive Operative Care Medical Faculty Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1186/s12864-017-3811-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452331PMC
June 2017

Inhibition of miR-208b improves cardiac function in titin-based dilated cardiomyopathy.

Int J Cardiol 2017 Mar 28;230:634-641. Epub 2016 Dec 28.

Department of Cardiology and Cardiovascular Diseases, Eberhard Karls University, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.12.171DOI Listing
March 2017

Dysregulated IER3 Expression is Associated with Enhanced Apoptosis in Titin-Based Dilated Cardiomyopathy.

Int J Mol Sci 2017 Mar 29;18(4). Epub 2017 Mar 29.

Department of Cardiology and Cardiovascular Diseases, Eberhard Karls University, 72076 Tübingen, Germany.

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http://dx.doi.org/10.3390/ijms18040723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412309PMC
March 2017

Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury.

Int J Cardiol 2016 Jun 16;212:232-4. Epub 2016 Mar 16.

Department of Integrative Pathophysiology, Medical Faculty Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.03.045DOI Listing
June 2016

Screening for anti-titin antibodies in patients with various paraneoplastic neurological syndromes.

J Neuroimmunol 2016 06 13;295-296:18-20. Epub 2016 Apr 13.

Department of Neurology and Neurophysiology, University Hospital Freiburg, Breisacher Straße 64, D-79106 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.jneuroim.2016.04.004DOI Listing
June 2016

Sympathetic innervation controls homeostasis of neuromuscular junctions in health and disease.

Proc Natl Acad Sci U S A 2016 Jan 5;113(3):746-50. Epub 2016 Jan 5.

Interdisciplinary Center for Neurosciences, Universität Heidelberg, 69120 Heidelberg, Germany; Institute of Molecular and Cell Biology, Hochschule Mannheim, 68163 Mannheim, Germany; Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany;

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http://www.pnas.org/content/113/3/746.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1524272113
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http://dx.doi.org/10.1073/pnas.1524272113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725522PMC
January 2016

Molecular mechanisms behind progressing chronic inflammatory dilated cardiomyopathy.

BMC Cardiovasc Disord 2015 Mar 26;15:26. Epub 2015 Mar 26.

Department of Pathology, Forensic Medicine and Pharmacology, Vilnius University, Faculty of Medicine, Vilnius, Lithuania.

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http://dx.doi.org/10.1186/s12872-015-0017-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466865PMC
March 2015

Degeneration of neuromuscular junction in age and dystrophy.

Front Aging Neurosci 2014 22;6:99. Epub 2014 May 22.

Department of Kinesiology and Health Sciences, The College of William and Mary , Williamsburg, VA , USA.

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http://dx.doi.org/10.3389/fnagi.2014.00099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033055PMC
June 2014

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line.

Open Biol 2014 May;4(5):140041

Institute of Integrative Biology, Biosciences Building, University of Liverpool, Crown St., Liverpool L69 7ZB, UK

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http://dx.doi.org/10.1098/rsob.140041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042850PMC
May 2014

Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness.

Intensive Care Med 2014 Apr 15;40(4):528-38. Epub 2014 Feb 15.

Anesthesiology and Operative Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Campus Virchow and Campus Mitte, Berlin, Germany.

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http://dx.doi.org/10.1007/s00134-014-3224-9DOI Listing
April 2014

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.

J Gen Physiol 2014 Feb;143(2):215-30

Department of Physiology and 2 Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721.

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http://dx.doi.org/10.1085/jgp.201311129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001778PMC
February 2014

Role of autophagy, SQSTM1, SH3GLB1, and TRIM63 in the turnover of nicotinic acetylcholine receptors.

Autophagy 2014 Jan 8;10(1):123-36. Epub 2013 Nov 8.

Institute of Toxicology and Genetics; Karlsruhe Institute of Technology; Eggenstein-Leopoldshafen, Germany; Institute of Molecular and Cell Biology; University of Applied Sciences Mannheim; Mannheim, Germany; Institute of Medical Technology; University of Heidelberg and University of Applied Sciences Mannheim; Mannheim, Germany.

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http://dx.doi.org/10.4161/auto.26841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389866PMC
January 2014

Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways.

Age (Dordr) 2013 Oct 6;35(5):1663-74. Epub 2012 Sep 6.

Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany,

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http://dx.doi.org/10.1007/s11357-012-9468-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776120PMC
October 2013

Alterations of cAMP-dependent signaling in dystrophic skeletal muscle.

Front Physiol 2013 Oct 17;4:290. Epub 2013 Oct 17.

Institute of Molecular and Cell Biology, University of Applied Sciences Mannheim , Mannheim, Germany ; Institute of Toxicology and Genetics, Karlsruhe Institute of Technology , Eggenstein-Leopoldshafen, Germany.

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http://dx.doi.org/10.3389/fphys.2013.00290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797997PMC
October 2013

MuRFs: specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism.

Adv Exp Med Biol 2012 ;770:119-29

School of Biological Sciences, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1007/978-1-4614-5398-7_9DOI Listing
June 2013

Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.

J Biol Chem 2013 Feb 6;288(8):5303-15. Epub 2013 Jan 6.

Department of Physics, University of Arizona, Tucson, Arizona 85724, USA.

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http://dx.doi.org/10.1074/jbc.M112.401372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581406PMC
February 2013

The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization.

Front Physiol 2012 27;3:37. Epub 2012 Feb 27.

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphys.2012.00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286824PMC
October 2012

Titin-actin interaction: PEVK-actin-based viscosity in a large animal.

J Biomed Biotechnol 2011 15;2011:310791. Epub 2011 Nov 15.

Molecular Cardiovascular Research Program, Sarver Heart Center, Department of Physiology, University of Arizona, Tucson, AZ 85724, USA.

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http://www.hindawi.com/journals/bmri/2011/310791/
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http://dx.doi.org/10.1155/2011/310791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227466PMC
April 2012

BAG3 in heart disease: novel clues for cardiomyocyte survival from the Z-disk?

Authors:
Siegfried Labeit

Hum Mutat 2011 Dec;32(12):iv

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http://dx.doi.org/10.1002/humu.21637DOI Listing
December 2011

Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.

Biophys J 2011 Sep 20;101(6):1385-92. Epub 2011 Sep 20.

Graduate Interdisciplinary Program in Biomedical Engineering, University of Arizona, Tucson, Arizona, USA.

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http://dx.doi.org/10.1016/j.bpj.2011.06.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177072PMC
September 2011

Nebulin, a major player in muscle health and disease.

FASEB J 2011 Mar 29;25(3):822-9. Epub 2010 Nov 29.

Department of Integrative Pathophysiology, Universitätsmedizin Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1096/fj.10-157412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042846PMC
March 2011

Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice.

J Biomed Biotechnol 2010 24;2010:693741. Epub 2010 Jun 24.

Department of Integrative Pathophysiology, Universitätsmedizin Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, Mannheim, Germany.

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http://dx.doi.org/10.1155/2010/693741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896721PMC
October 2010

The effects of PKCalpha phosphorylation on the extensibility of titin's PEVK element.

J Struct Biol 2010 May 10;170(2):270-7. Epub 2010 Feb 10.

Dept. of Physics, University of Arizona, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1016/j.jsb.2010.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856808PMC
May 2010

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance.

J Struct Biol 2010 May 10;170(2):344-53. Epub 2010 Feb 10.

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Lineu Prestes Av., 1524, 05508-900 Sao Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.jsb.2010.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856802PMC
May 2010

Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development.

J Struct Biol 2010 May 20;170(2):325-33. Epub 2010 Feb 20.

Depts of Physiology and Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85724, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104784771000061
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http://dx.doi.org/10.1016/j.jsb.2010.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856706PMC
May 2010

Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle.

J Cell Sci 2010 Feb 5;123(Pt 3):384-91. Epub 2010 Jan 5.

Department of Physiology, University of Arizona, Tucson, Arizona 85724-5217, USA.

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http://dx.doi.org/10.1242/jcs.042234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816184PMC
February 2010

Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.

Cardiovasc Res 2010 Jan 22;85(2):357-66. Epub 2009 Oct 22.

Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1093/cvr/cvp348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023316PMC
January 2010

Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost.

J Biol Chem 2009 Nov 7;284(45):30889-96. Epub 2009 Sep 7.

Department of Physiology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, Arizona 85724-5217, USA.

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http://dx.doi.org/10.1074/jbc.M109.049718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781488PMC
November 2009

PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness.

Circ Res 2009 Sep 13;105(7):631-8, 17 p following 638. Epub 2009 Aug 13.

Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.198465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764991PMC
September 2009

Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency.

Hum Mol Genet 2009 Jul 4;18(13):2359-69. Epub 2009 Apr 4.

Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1093/hmg/ddp168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694687PMC
July 2009

Single molecule force spectroscopy of the cardiac titin N2B element: effects of the molecular chaperone alphaB-crystallin with disease-causing mutations.

J Biol Chem 2009 May 12;284(20):13914-23. Epub 2009 Mar 12.

Department of Molecular and Cellular Biology, Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, Arizona 85724-5217, USA.

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http://dx.doi.org/10.1074/jbc.M809743200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679491PMC
May 2009

Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice.

J Mol Biol 2008 Dec 11;384(1):48-59. Epub 2008 Sep 11.

Heart Center Leipzig, University Leipzig, Strümpellstrasse 39, D-04289 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.jmb.2008.08.087DOI Listing
December 2008

Nuclear localization of the titin Z1Z2Zr domain and role in regulating cell proliferation.

Am J Physiol Cell Physiol 2008 Oct 6;295(4):C975-85. Epub 2008 Aug 6.

Flexcell International Corporation, Hillsborough, North Carolina 27278, USA.

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http://dx.doi.org/10.1152/ajpcell.90619.2007DOI Listing
October 2008

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold.

Biochemistry 2008 Oct 17;47(40):10722-30. Epub 2008 Sep 17.

Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1021/bi800733zDOI Listing
October 2008

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle.

FASEB J 2008 Aug 23;22(8):2912-9. Epub 2008 Apr 23.

Dept. of Molecular and Cellular Biology, University of Arizona, PO Box 245217, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1096/fj.07-104372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493448PMC
August 2008

Titin expression in human articular cartilage and cultured chondrocytes: a novel component in articular cartilage biomechanical sensing?

Biomed Pharmacother 2008 Jun 4;62(5):339-47. Epub 2007 Sep 4.

Laboratory for Biomechanics and Experimental Orthopedics, Department of Orthopedic Surgery and Traumatology, University Hospital, Mannheim, Medical Faculty of Mannheim University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1016/j.biopha.2007.08.003DOI Listing
June 2008

MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies.

J Mol Biol 2008 Jun 3;379(4):666-77. Epub 2008 Apr 3.

Institute for Anaesthesiology and Intensive Operative Care, Medical Faculty Mannheim, Mannheim 68167, Germany.

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http://dx.doi.org/10.1016/j.jmb.2008.03.049DOI Listing
June 2008

Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle.

J Biol Chem 2008 May 29;283(21):14801-14. Epub 2008 Feb 29.

Department of Enzymatic Regulation for Cell Functions (Calpain Project), The Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo, Japan.

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http://dx.doi.org/10.1074/jbc.M708262200DOI Listing
May 2008

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis.

J Mol Biol 2008 Mar 22;376(5):1224-36. Epub 2007 Nov 22.

Department of Enzymatic Regulation for Cell Functions (Calpain Project), Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo 113-8613, Japan.

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http://dx.doi.org/10.1016/j.jmb.2007.11.049DOI Listing
March 2008

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

EMBO J 2008 Jan 20;27(2):350-60. Epub 2007 Dec 20.

Institute of Anesthesiology and Intensive Care, Universitätsklinikum Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7601952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168395PMC
January 2008

A regular pattern of Ig super-motifs defines segmental flexibility as the elastic mechanism of the titin chain.

Proc Natl Acad Sci U S A 2008 Jan 22;105(4):1186-91. Epub 2008 Jan 22.

Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.0707163105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234113PMC
January 2008

Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells.

Muscle Nerve 2007 Dec;36(6):740-55

Department of Veterinary and Comparative Anatomy, Pharmacology Physiology, and Physiology, Washington State University, Pullman, Washington, USA.

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http://dx.doi.org/10.1002/mus.20886DOI Listing
December 2007

Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle.

Am J Physiol Regul Integr Comp Physiol 2007 Aug 23;293(2):R557-67. Epub 2007 May 23.

Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Wegner Hall, Rm. 205, Pullman, WA 99164-6520, USA.

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http://dx.doi.org/10.1152/ajpregu.00001.2007DOI Listing
August 2007

The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles.

Structure 2007 Jul;15(7):813-24

Molecular Structure Division, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1016/j.str.2007.05.007DOI Listing
July 2007

Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin.

FASEB J 2007 May 10;21(7):1383-92. Epub 2007 Jan 10.

Division of Structural Biology, Biozentrum, University of Basel, Klingelbergstr. 70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1096/fj.06-7644comDOI Listing
May 2007

Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain.

J Biol Chem 2007 May 19;282(19):14493-504. Epub 2007 Mar 19.

Department of Enzymatic Regulation for Cell Functions, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1074/jbc.M610806200DOI Listing
May 2007

Modular proteins from the Drosophila sallimus (sls) gene and their expression in muscles with different extensibility.

J Mol Biol 2007 Apr 27;367(4):953-69. Epub 2007 Jan 27.

Institut für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Mannheim, D-68167 Mannheim, Germany.

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http://dx.doi.org/10.1016/j.jmb.2007.01.059DOI Listing
April 2007

Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region.

Circulation 2007 Feb 29;115(6):743-51. Epub 2007 Jan 29.

Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-6520, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.645499DOI Listing
February 2007

The function of elastic proteins in the oscillatory contraction of insect flight muscle.

J Muscle Res Cell Motil 2005 ;26(6-8):479-85

European Molecular Biology Laboratory, D-69117, Heidelberg, Germany.

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http://link.springer.com/10.1007/s10974-005-9032-7
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http://dx.doi.org/10.1007/s10974-005-9032-7DOI Listing
January 2007

Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling.

J Muscle Res Cell Motil 2005 ;26(6-8):401-8

Institut für Anaesthesiologie und Operative Intensivmedizin, Universitätsklinikum Mannheim, 68167, Mannheim, Germany.

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http://dx.doi.org/10.1007/s10974-005-9022-9DOI Listing
January 2007

Restoring force development by titin/connectin and assessment of Ig domain unfolding.

J Muscle Res Cell Motil 2005 ;26(6-8):307-17

Department VCAPP, Washington State University, Pullman, WA 99164-6520, USA.

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http://dx.doi.org/10.1007/s10974-005-9037-2DOI Listing
January 2007

Cardiac titin: structure, functions and role in disease.

Clin Chim Acta 2007 Jan 7;375(1-2):1-9. Epub 2006 Jul 7.

Department of Medicine and Cardiology Unit, University of Vermont, Burlington, VT, United States.

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http://dx.doi.org/10.1016/j.cca.2006.06.035DOI Listing
January 2007

Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance.

J Mol Cell Cardiol 2007 Jan 27;42(1):186-95. Epub 2006 Oct 27.

Department VCAPP, Washington State University, Pullman, WA 99164-6520, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2006.09.017DOI Listing
January 2007

Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo.

EMBO J 2006 Aug 10;25(16):3843-55. Epub 2006 Aug 10.

Institute for Anaesthesiology and Intensive Care, University Hospital Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7601242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1553189PMC
August 2006

Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.

J Biol Chem 2006 Jul 20;281(27):18519-31. Epub 2006 Apr 20.

Department of Enzymatic Regulation for Cell Functions, Tokyo Metropolitan Institute of Medical Science (Rinshoken), Tokyo 113-8613, Japan.

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http://dx.doi.org/10.1074/jbc.M601029200DOI Listing
July 2006

Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy.

J Mol Med (Berl) 2006 Jun 6;84(6):478-83. Epub 2006 May 6.

Max-Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, 13092, Berlin-Buch, Germany.

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http://dx.doi.org/10.1007/s00109-006-0060-6DOI Listing
June 2006

The giant muscle protein titin is an adjustable molecular spring.

Exerc Sport Sci Rev 2006 Apr;34(2):50-3

Department of Veterinary and Comparative Anatomy, Wegner Hall 205, Washington State University, Pullman, WA 99164-6520, USA.

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http://dx.doi.org/10.1249/00003677-200604000-00002DOI Listing
April 2006

Titin and diaphragm dysfunction in chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2006 Mar 9;173(5):527-34. Epub 2005 Dec 9.

Department of Pulmonary Diseases, 454 Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1164/rccm.200507-1056OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662936PMC
March 2006

Titin and its associated proteins: the third myofilament system of the sarcomere.

Adv Protein Chem 2005 ;71:89-119

Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington, USA.

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http://dx.doi.org/10.1016/S0065-3233(04)71003-7DOI Listing
December 2005

Titin: physiological function and role in cardiomyopathy and failure.

Heart Fail Rev 2005 Sep;10(3):211-23

Department of Veterinary and Comparative Anatomy, Washington State University, Pullman, WA 99164-6520, USA.

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http://dx.doi.org/10.1007/s10741-005-5251-7DOI Listing
September 2005

MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.

J Mol Biol 2005 Jul;350(4):713-22

Institut für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Mannheim, Mannheim 68167, Germany.

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http://dx.doi.org/10.1016/j.jmb.2005.05.021DOI Listing
July 2005

Titin isoform-dependent effect of calcium on passive myocardial tension.

Am J Physiol Heart Circ Physiol 2004 Dec;287(6):H2528-34

Dept. of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State Univ., Pullman, WA 99164, USA.

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http://dx.doi.org/10.1152/ajpheart.00553.2004DOI Listing
December 2004

Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development.

J Cell Sci 2004 Jul 15;117(Pt 15):3175-88. Epub 2004 Jun 15.

Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA.

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http://dx.doi.org/10.1242/jcs.01158DOI Listing
July 2004

Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy.

Circulation 2004 Jul 6;110(2):155-62. Epub 2004 Jul 6.

Section of Cardiology, Department of Medicine, Baylor College of Medicine, 6550 Fannin, SM-1256, Houston, TX 77030-2717, USA.

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http://dx.doi.org/10.1161/01.CIR.0000135591.37759.AFDOI Listing
July 2004

Adaptations in titin's spring elements in normal and cardiomyopathic hearts.

Adv Exp Med Biol 2003 ;538:517-30; discussion 530-1

VCAPP, Washington State University, Pullman, WA 99164-6520, USA.

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http://dx.doi.org/10.1007/978-1-4419-9029-7_46DOI Listing
May 2004