Publications by authors named "Sheila K Singh"

74Publications

Development of a peptide-based delivery platform for targeting malignant brain tumors.

Biomaterials 2020 Sep 7;252:120105. Epub 2020 May 7.

Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, T2N 4N1, Canada; Clark H. Smith Brain Tumour Centre, University of Calgary, Calgary, Alberta, T2N 4N1, Canada; Departments of Oncology, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2020.120105DOI Listing
September 2020

A CD133-AKT-Wnt signaling axis drives glioblastoma brain tumor-initiating cells.

Oncogene 2020 Feb 6;39(7):1590-1599. Epub 2019 Nov 6.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, L8S 4K1, Canada.

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http://dx.doi.org/10.1038/s41388-019-1086-xDOI Listing
February 2020

Analysis of factors that influence neurosurgical length of hospital stay among newly diagnosed pediatric brain tumor patients.

Pediatr Blood Cancer 2020 01 14;67(1):e28041. Epub 2019 Oct 14.

McMaster Pediatric Brain Tumor Study Group, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/pbc.28041DOI Listing
January 2020

Deciphering brain tumor heterogeneity, one cell at a time.

Nat Med 2019 10;25(10):1474-1476

Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1038/s41591-019-0605-1DOI Listing
October 2019

Predictive measures and outcomes of extent of resection in juvenile pilocytic astrocytoma.

J Clin Neurosci 2019 Dec 26;70:79-84. Epub 2019 Aug 26.

McMaster Pediatric Brain Tumor Study Group, McMaster University, Hamilton, Canada; Department of Surgery, Division of Neurosurgery, McMaster University, Hamilton, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2019.08.066DOI Listing
December 2019

A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

Cancer Cell 2019 07;36(1):51-67.e7

Arthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G0A4, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S1A8, Canada; Division of Hematology-Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON M5G1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.06.002DOI Listing
July 2019

Regulation of the proline regulatory axis and autophagy modulates stemness in TP73/p73 deficient cancer stem-like cells.

Autophagy 2019 05 8;15(5):934-936. Epub 2019 Mar 8.

a Department of Pathology , Dalhousie University , Halifax , Nova Scotia , Canada.

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http://dx.doi.org/10.1080/15548627.2019.1586321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6526861PMC
May 2019

In Vivo Murine Models of Brain Metastasis.

Methods Mol Biol 2019 ;1869:231-238

Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_19
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http://dx.doi.org/10.1007/978-1-4939-8805-1_19DOI Listing
May 2019

In Vitro Assays for Screening Small Molecules.

Methods Mol Biol 2019 ;1869:189-196

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_16
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http://dx.doi.org/10.1007/978-1-4939-8805-1_16DOI Listing
May 2019

EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF.

Methods Mol Biol 2019 ;1869:155-168

Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_14
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http://dx.doi.org/10.1007/978-1-4939-8805-1_14DOI Listing
May 2019

Differentiation of Brain Tumor Initiating Cells.

Methods Mol Biol 2019 ;1869:85-91

Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_8
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http://dx.doi.org/10.1007/978-1-4939-8805-1_8DOI Listing
May 2019

In Vitro Self-Renewal Assays for Brain Tumor Stem Cells.

Methods Mol Biol 2019 ;1869:79-84

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_7
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http://dx.doi.org/10.1007/978-1-4939-8805-1_7DOI Listing
May 2019

Flow Cytometric Analysis of Brain Tumor Stem Cells.

Methods Mol Biol 2019 ;1869:69-77

Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_6
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http://dx.doi.org/10.1007/978-1-4939-8805-1_6DOI Listing
May 2019

Detecting Stem Cell Marker Expression Using the NanoString nCounter System.

Methods Mol Biol 2019 ;1869:57-67

Division of Cell Biology, Hospital for Sick Children Research Center, Toronto, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_5
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http://dx.doi.org/10.1007/978-1-4939-8805-1_5DOI Listing
May 2019

Introduction to Brain Tumor Stem Cells.

Methods Mol Biol 2019 ;1869:1-9

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

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http://link.springer.com/10.1007/978-1-4939-8805-1_1
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http://dx.doi.org/10.1007/978-1-4939-8805-1_1DOI Listing
May 2019

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.

Nature 2018 01 20;553(7686):101-105. Epub 2017 Dec 20.

Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1038/nature25169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993422PMC
January 2018

Erratum to: Introduction to Cancer Stem Cells: Past, Present, and Future.

Methods Mol Biol 2018 ;1692:E1

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada, L8S 4K1.

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http://dx.doi.org/10.1007/978-1-4939-7401-6_19DOI Listing
January 2018

Introduction to Cancer Stem Cells: Past, Present, and Future.

Methods Mol Biol 2018 ;1692:1-16

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada, L8S 4K1.

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http://link.springer.com/10.1007/978-1-4939-7401-6_1
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http://dx.doi.org/10.1007/978-1-4939-7401-6_1DOI Listing
June 2018

Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System.

Front Oncol 2017 19;7:220. Epub 2017 Sep 19.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://journal.frontiersin.org/article/10.3389/fonc.2017.002
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http://dx.doi.org/10.3389/fonc.2017.00220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609558PMC
September 2017

EMT: Mechanisms and therapeutic implications.

Pharmacol Ther 2018 02 20;182:80-94. Epub 2017 Aug 20.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, L8S 4K1, Canada; Department of Surgery, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258173021
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http://dx.doi.org/10.1016/j.pharmthera.2017.08.009DOI Listing
February 2018

Evaluating overweight and obesity prevalence in survivors of childhood brain tumors: a systematic review protocol.

Syst Rev 2017 03 3;6(1):43. Epub 2017 Mar 3.

Department of Pediatrics, McMaster University, 1280 Main Street West, HSC-3A57, Hamilton, Ontario, L8S 4K1, Canada.

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http://dx.doi.org/10.1186/s13643-017-0439-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335753PMC
March 2017

Progression of atypical extraventricular neurocytoma to anaplastic ganglioglioma.

Hum Pathol 2017 01 3;59:125-130. Epub 2016 Sep 3.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8S-4L8; Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada L8S-4L8; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8S-4L8; Department of Surgery, McMaster University, Hamilton, Ontario, Canada L8S-4L8. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.08.007DOI Listing
January 2017

Development of a Patient-Derived Xenograft Model Using Brain Tumor Stem Cell Systems to Study Cancer.

Methods Mol Biol 2016 ;1458:231-45

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-3801-8_17DOI Listing
January 2018

A novel stem cell culture model of recurrent glioblastoma.

J Neurooncol 2016 Jan;126(1):57-67

McMaster Stem Cell and Cancer Research Institute, McMaster University, MDCL 5027, 1200 Main Street West, Hamilton, ON, L8S 4K1, Canada.

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http://link.springer.com/content/pdf/10.1007%2Fs11060-015-19
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http://link.springer.com/10.1007/s11060-015-1951-6
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http://dx.doi.org/10.1007/s11060-015-1951-6DOI Listing
January 2016

Culture and Isolation of Brain Tumor Initiating Cells.

Curr Protoc Stem Cell Biol 2015 Aug 3;34:3.3.1-3.3.13. Epub 2015 Aug 3.

McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/9780470151808.sc0303s34DOI Listing
August 2015

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.

Clin Cancer Res 2015 Dec 7;21(23):5324-37. Epub 2015 Jul 7.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada. Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3147DOI Listing
December 2015

MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours.

Stem Cells Int 2015 3;2015:141793. Epub 2015 May 3.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada L8S 4K1 ; Department of Surgery, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5 ; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5 ; Michael G. DeGroote School of Medicine, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1155/2015/141793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433683PMC
June 2015

Temporal evolution of medulloblastoma subgroups.

J Neurosurg Pediatr 2015 Sep 29;16(3):349-50. Epub 2015 May 29.

McMaster Stem Cell and Cancer Research Institute.

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http://dx.doi.org/10.3171/2014.12.PEDS14717DOI Listing
September 2015

The role of stem cells in pediatric central nervous system malignancies.

Adv Exp Med Biol 2015 ;853:49-68

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada, L8S 4K1.

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http://link.springer.com/content/pdf/10.1007/978-3-319-16537
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http://link.springer.com/10.1007/978-3-319-16537-0_4
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http://dx.doi.org/10.1007/978-3-319-16537-0_4DOI Listing
August 2015

Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis.

Neuro Oncol 2015 Jun 3;17(6):868-81. Epub 2015 Jan 3.

Division of Neurosurgery, McMaster University, Hamilton, Ontario, Canada (S.A.A., A.A., E.K., A.C., P.K., T.G., O.A., K.R., S.K.S., N.K.M.); Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada (S.A.A., W.A., F.F.); Department of Medicine, McMaster University, Hamilton, Ontario, Canada (W.A.); Department of Oncology, McMaster University, Hamilton, Ontario, Canada (J.G.); Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada (S.K.S.); Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada (J.H.B.); Department of Radiation Oncology, Dalhousie University, Halifax, Nova Scotia, Canada (W.S.); Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas (B.Y.).

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http://dx.doi.org/10.1093/neuonc/nou349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483123PMC
June 2015

Revealed: The spy who regulates neuroblastoma stem cells.

Oncotarget 2014 Nov;5(22):11014-6

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada. Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, Canada. Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294329PMC
http://dx.doi.org/10.18632/oncotarget.2839DOI Listing
November 2014

Generation of murine xenograft models of brain tumors from primary human tissue for in vivo analysis of the brain tumor-initiating cell.

Methods Mol Biol 2014 ;1210:37-49

McMaster Children's Hospital, McMaster University, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1.

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http://dx.doi.org/10.1007/978-1-4939-1435-7_4DOI Listing
May 2015

Brain metastasis-initiating cells: survival of the fittest.

Int J Mol Sci 2014 May 22;15(5):9117-33. Epub 2014 May 22.

McMaster Stem Cell and Cancer Research Institute, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada.

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http://dx.doi.org/10.3390/ijms15059117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057778PMC
May 2014

Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.

Cancer Res 2013 Nov 9;73(22):6734-44. Epub 2013 Sep 9.

Authors' Affiliations: Department of Pediatrics; Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine; Division of Pediatric Neurosurgery, Department of Surgery, BC Children's Hospital, University of British Columbia; Department of Pathology and Laboratory Medicine, Centre for Applied Genomics, British Columbia Cancer Agency, Vancouver, British Columbia; Division of Neurosurgery, Department of Surgery, Faculty of Health Sciences, McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton; The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario; Pediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC) Laboratory for Pre-Clinical and Drug Discovery Studies, Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, Alberta, Canada; and Division of Pediatric Neuro-Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4331DOI Listing
November 2013

A cancer stem cell model for studying brain metastases from primary lung cancer.

J Natl Cancer Inst 2013 Apr 15;105(8):551-62. Epub 2013 Feb 15.

Department of Biochemistry and Biomedical Sciences, Faculty of HealthSciences, McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Canada.

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http://jnci.oxfordjournals.org/content/early/2013/02/15/jnci
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djt022
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http://dx.doi.org/10.1093/jnci/djt022DOI Listing
April 2013

Processing of primary brain tumor tissue for stem cell assays and flow sorting.

J Vis Exp 2012 Sep 25(67). Epub 2012 Sep 25.

Stem Cell and Cancer Research Institute, McMaster University.

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http://dx.doi.org/10.3791/4111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490257PMC
September 2012

Medulloblastoma stem cells: modeling tumor heterogeneity.

Cancer Lett 2013 Sep 14;338(1):23-31. Epub 2012 Jul 14.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada L8S 4K1.

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http://dx.doi.org/10.1016/j.canlet.2012.07.010DOI Listing
September 2013

GBM secretome induces transient transformation of human neural precursor cells.

J Neurooncol 2012 Sep 1;109(3):457-66. Epub 2012 Jul 1.

Faculty of Health Sciences, McMaster University Stem Cell and Cancer Research Institute, McMaster University, 1280 Main Street West, MDCL 5027, Hamilton, ON, L8S 4K1, Canada.

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http://dx.doi.org/10.1007/s11060-012-0917-1DOI Listing
September 2012

Medulloblastoma stem cells: where development and cancer cross pathways.

Pediatr Res 2012 Apr 8;71(4 Pt 2):516-22. Epub 2012 Feb 8.

McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/pr.2011.62DOI Listing
April 2012

Endoscopic transnasal drainage of frontal epidural abscesses.

J Otolaryngol Head Neck Surg 2011 Oct;40(5):401-6

Department of Surgery, McMaster University Medical Centre, Hamilton, ON.

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October 2011

Culture and isolation of brain tumor initiating cells.

Curr Protoc Stem Cell Biol 2009 Oct;Chapter 3:Unit3.3

McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1002/9780470151808.sc0303s11DOI Listing
October 2009

Identification of human brain tumour initiating cells.

Nature 2004 Nov;432(7015):396-401

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada.

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http://dx.doi.org/10.1038/nature03128DOI Listing
November 2004

Cancer stem cells in nervous system tumors.

Oncogene 2004 Sep;23(43):7267-73

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Canada.

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http://www.nature.com/articles/1207946
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http://dx.doi.org/10.1038/sj.onc.1207946DOI Listing
September 2004

Identification of a cancer stem cell in human brain tumors.

Cancer Res 2003 Sep;63(18):5821-8

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

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September 2003