Publications by authors named "Shawn S-C Li"

77Publications

Single-Cell Analysis of Signaling Proteins Provides Insights into Proapoptotic Properties of Anticancer Drugs.

Anal Chem 2020 Sep 27;92(18):12498-12508. Epub 2020 Aug 27.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

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http://dx.doi.org/10.1021/acs.analchem.0c02344DOI Listing
September 2020

MMS2plot: An R Package for Visualizing Multiple MS/MS Spectra for Groups of Modified and Non-Modified Peptides.

Proteomics 2020 Jul 8:e2000061. Epub 2020 Jul 8.

School of Basic Medicine, Qingdao University, Qingdao, 266021, China.

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http://dx.doi.org/10.1002/pmic.202000061DOI Listing
July 2020

DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA.

J Biol Chem 2020 01 5;295(2):645-656. Epub 2019 Dec 5.

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada

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http://dx.doi.org/10.1074/jbc.RA119.011929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956525PMC
January 2020

Single-Layer β Sheets as Versatile Protein-Binding Modules.

Structure 2019 09;27(9):1352-1354

Department of Biochemistry, Western University, London, ON N6G 2V4, Canada; Department of Chemistry, Western University, London, ON N6G 2V4, Canada; Department of Oncology, Western University, London, ON N6G 2V4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.str.2019.08.007DOI Listing
September 2019

Hybrid CuCoO-GO enables ultrasensitive detection of antibiotics with enhanced laser desorption/ionization at nano-interfaces.

Chem Sci 2019 Jan 8;10(1):257-267. Epub 2018 Oct 8.

Institute of Functional Nano and Soft Materials (FUNSOM) , Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices , Joint International Research Laboratory of Carbon-based Functional Materials and Devices , Soochow University , Suzhou , Jiangsu Province 215123 , China . Email: ; Email:

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http://dx.doi.org/10.1039/c8sc03692fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333240PMC
January 2019

N-acetylcysteine decreases malignant characteristics of glioblastoma cells by inhibiting Notch2 signaling.

J Exp Clin Cancer Res 2019 Jan 3;38(1). Epub 2019 Jan 3.

School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

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http://dx.doi.org/10.1186/s13046-018-1016-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319015PMC
January 2019

Surface Loops in a Single SH2 Domain Are Capable of Encoding the Spectrum of Specificity of the SH2 Family.

Mol Cell Proteomics 2019 02 27;18(2):372-382. Epub 2018 Nov 27.

§Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1;

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http://dx.doi.org/10.1074/mcp.RA118.001123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356082PMC
February 2019

Affinity Purification of Methyllysine Proteome by Site-Specific Covalent Conjugation.

Anal Chem 2018 12 16;90(23):13876-13881. Epub 2018 Nov 16.

Department of Biochemistry and Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry , Western University , London , Ontario N6A 5C1 , Canada.

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http://dx.doi.org/10.1021/acs.analchem.8b02796DOI Listing
December 2018

Phosphorylation-Dependent Inhibition of Akt1.

Genes (Basel) 2018 Sep 7;9(9). Epub 2018 Sep 7.

Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.3390/genes9090450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162393PMC
September 2018

Reverse Binding Mode of Phosphotyrosine Peptides with SH2 Protein.

Biochemistry 2018 09 22;57(35):5257-5269. Epub 2018 Aug 22.

Department of Biochemistry and Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry , Western University , London , Ontario N6A 5C1 , Canada.

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http://dx.doi.org/10.1021/acs.biochem.8b00677DOI Listing
September 2018

(Arg)-SH2 superbinder: a novel promising anticancer therapy to melanoma by blocking phosphotyrosine signaling.

J Exp Clin Cancer Res 2018 Jul 5;37(1):138. Epub 2018 Jul 5.

Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

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http://dx.doi.org/10.1186/s13046-018-0812-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034221PMC
July 2018

Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.

Cell Rep 2017 12;21(13):3781-3793

Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.107DOI Listing
December 2017

SnapShot: Lysine Methylation beyond Histones.

Mol Cell 2017 Dec;68(5):1016-1016.e1

Department of Biochemistry, Western University, London, ON, Canada.

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http://dx.doi.org/10.1016/j.molcel.2017.11.018DOI Listing
December 2017

Interactome Mapping Uncovers a General Role for Numb in Protein Kinase Regulation.

Mol Cell Proteomics 2018 11 7;17(11):2216-2228. Epub 2017 Dec 7.

From the ‡Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada;

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http://dx.doi.org/10.1074/mcp.RA117.000114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210222PMC
November 2018

Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2β, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay.

Am J Pathol 2018 01 14;188(1):111-124. Epub 2017 Oct 14.

Department of Biochemistry, University of Western Ontario, London, Ontario, Canada; Department of Pediatrics, University of Western Ontario, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745526PMC
January 2018

Biphasic Affinity Chromatographic Approach for Deep Tyrosine Phosphoproteome Analysis.

Anal Chem 2017 02 1;89(4):2405-2410. Epub 2017 Feb 1.

Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.

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http://dx.doi.org/10.1021/acs.analchem.6b04288DOI Listing
February 2017

Using Reciprocal Protein-Peptide Array Screening to Unravel Protein Interaction Networks.

Methods Mol Biol 2017 ;1555:429-436

Department of Biochemistry, Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, N6A 5C1, Canada.

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http://dx.doi.org/10.1007/978-1-4939-6762-9_25DOI Listing
February 2018

Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain.

Methods Mol Biol 2017 ;1555:225-254

Department of Biochemistry and Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, N6A 5C1.

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http://dx.doi.org/10.1007/978-1-4939-6762-9_13DOI Listing
February 2018

SH2 Ligand Prediction-Guidance for In-Silico Screening.

Authors:
Shawn S C Li Lei Li

Methods Mol Biol 2017 ;1555:77-81

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5C1, Canada.

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http://dx.doi.org/10.1007/978-1-4939-6762-9_5DOI Listing
February 2018

TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1.

Sci Adv 2016 04 1;2(4):e1501290. Epub 2016 Apr 1.

Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/sciadv.1501290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065225PMC
April 2016

Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.

Nat Chem Biol 2016 Nov 19;12(11):959-966. Epub 2016 Sep 19.

Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian, China.

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http://dx.doi.org/10.1038/nchembio.2178DOI Listing
November 2016

Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands.

Mol Cell Proteomics 2016 10 20;15(10):3270-3281. Epub 2016 Jul 20.

From the ‡Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;

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http://dx.doi.org/10.1074/mcp.M116.060483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054349PMC
October 2016

A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration.

Nat Commun 2015 Jul 13;6:7721. Epub 2015 Jul 13.

1] Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada N6A 5C1 [2] Children's Health Research Institute, 800 Commissioners Road East, London, Ontario, Canada N6C 2V5.

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http://dx.doi.org/10.1038/ncomms8721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510974PMC
July 2015

Cell regulation by phosphotyrosine-targeted ubiquitin ligases.

Mol Cell Biol 2015 Jun 16;35(11):1886-97. Epub 2015 Mar 16.

Department of Biochemistry, Western University, London, Ontario, Canada.

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http://dx.doi.org/10.1128/MCB.00098-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420928PMC
June 2015

Non-histone protein methylation as a regulator of cellular signalling and function.

Nat Rev Mol Cell Biol 2015 Jan 10;16(1):5-17. Epub 2014 Dec 10.

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1038/nrm3915DOI Listing
January 2015

Systematic investigation of hierarchical phosphorylation by protein kinase CK2.

J Proteomics 2015 Apr 5;118:49-62. Epub 2014 Nov 5.

Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada; Department of Oncology, Schulich School of Medicine & Dentistry, Western University, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.10.020DOI Listing
April 2015

Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.

J Biol Chem 2014 Dec 7;289(52):36048-58. Epub 2014 Nov 7.

From the Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel,

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http://dx.doi.org/10.1074/jbc.M114.603548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276870PMC
December 2014

An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation.

Mol Cell Proteomics 2014 May 20;13(5):1184-97. Epub 2014 Feb 20.

Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5C1, Canada;

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http://dx.doi.org/10.1074/mcp.M113.037374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014278PMC
May 2014

Systematic characterization of the specificity of the SH2 domains of cytoplasmic tyrosine kinases.

J Proteomics 2013 Apr 9;81:56-69. Epub 2013 Jan 9.

Department of Biochemistry and Siebens-Drake Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada N6A 5C1.

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http://dx.doi.org/10.1016/j.jprot.2012.12.021DOI Listing
April 2013

Superbinder SH2 domains act as antagonists of cell signaling.

Sci Signal 2012 Sep 25;5(243):ra68. Epub 2012 Sep 25.

Department of Biochemistry and Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2003021
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http://dx.doi.org/10.1126/scisignal.2003021DOI Listing
September 2012

Reactive oxygen species and the neuronal fate.

Cell Mol Life Sci 2012 Jan 23;69(2):215-21. Epub 2011 Sep 23.

Department of Biochemistry, Medical Sciences Building, The University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1007/s00018-011-0807-2DOI Listing
January 2012

Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration.

Biochim Biophys Acta 2011 Jun 21;1812(6):703-10. Epub 2011 Mar 21.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.

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http://dx.doi.org/10.1016/j.bbadis.2011.03.004DOI Listing
June 2011

Evolving specificity from variability for protein interaction domains.

Trends Biochem Sci 2011 Apr 10;36(4):183-90. Epub 2011 Jan 10.

Department of Biochemistry and the Siebens-Drake Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada.

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http://dx.doi.org/10.1016/j.tibs.2010.12.001DOI Listing
April 2011

Systematic identification of methyllysine-driven interactions for histone and nonhistone targets.

J Proteome Res 2010 Nov 1;9(11):5827-36. Epub 2010 Oct 1.

Department of Biochemistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada.

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http://dx.doi.org/10.1021/pr100597bDOI Listing
November 2010

NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response.

Int J Biol Sci 2010 May 11;6(3):252-67. Epub 2010 May 11.

Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878171PMC
http://dx.doi.org/10.7150/ijbs.6.252DOI Listing
May 2010

Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.

J Biol Chem 2010 Jun 16;285(23):17974-85. Epub 2010 Mar 16.

Department of Biochemistry, Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1074/jbc.M109.084616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878559PMC
June 2010

Insulin-like growth factor binding protein-6 (IGFBP-6) interacts with DNA-end binding protein Ku80 to regulate cell fate.

Cell Signal 2010 Jul 24;22(7):1033-43. Epub 2010 Feb 24.

Department of Pediatrics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cellsig.2010.02.006DOI Listing
July 2010

Numb: A new player in EMT.

Cell Adh Migr 2010 Apr-Jun;4(2):176-9. Epub 2010 Apr 16.

Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900608PMC
http://dx.doi.org/10.4161/cam.4.2.10690DOI Listing
November 2010

Regulation of cell proliferation and survival: convergence of protein kinases and caspases.

Biochim Biophys Acta 2010 Mar 10;1804(3):505-10. Epub 2009 Nov 10.

Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario. Canada N6A 5C1.

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http://dx.doi.org/10.1016/j.bbapap.2009.11.001DOI Listing
March 2010

CelluSpots: a reproducible means of making peptide arrays for the determination of SH2 domain binding specificity.

Methods Mol Biol 2009 ;570:197-202

Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

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http://link.springer.com/10.1007/978-1-60327-394-7_8
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http://dx.doi.org/10.1007/978-1-60327-394-7_8DOI Listing
January 2010

Using peptide array to identify binding motifs and interaction networks for modular domains.

Methods Mol Biol 2009 ;570:67-76

Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

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http://dx.doi.org/10.1007/978-1-60327-394-7_3DOI Listing
January 2010

NIP1/DUOXA1 expression in epithelial breast cancer cells: regulation of cell adhesion and actin dynamics.

Breast Cancer Res Treat 2010 Feb 26;119(3):773-86. Epub 2009 Mar 26.

Department of Biochemistry and Siebens Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.1007/s10549-009-0372-7DOI Listing
February 2010

SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux.

Cell Signal 2009 Apr 24;21(4):540-50. Epub 2008 Dec 24.

Department of Biochemistry and the Siebens-Drake Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.

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http://dx.doi.org/10.1016/j.cellsig.2008.12.006DOI Listing
April 2009

Molecular characterization of propionyllysines in non-histone proteins.

Mol Cell Proteomics 2009 Jan 26;8(1):45-52. Epub 2008 Aug 26.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M800224-MCP2
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http://dx.doi.org/10.1074/mcp.M800224-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621001PMC
January 2009

Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells.

Cell Signal 2008 Nov 6;20(11):1942-51. Epub 2008 Jul 6.

Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.

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http://dx.doi.org/10.1016/j.cellsig.2008.07.002DOI Listing
November 2008

The SH3 domain--a family of versatile peptide- and protein-recognition module.

Front Biosci 2008 May 1;13:4938-52. Epub 2008 May 1.

Department of Biochemistry and the Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.2741/3053DOI Listing
May 2008

Prediction of phosphotyrosine signaling networks using a scoring matrix-assisted ligand identification approach.

Nucleic Acids Res 2008 Jun 19;36(10):3263-73. Epub 2008 Apr 19.

Department of Biochemistry and the Siebens-Drake Medical Research Institute, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1093/nar/gkn161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2425477PMC
June 2008

Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.

Mol Cell Biol 2008 Mar 22;28(6):2035-46. Epub 2008 Jan 22.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 1084-600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1128/MCB.01770-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268406PMC
March 2008

The hypothetical protein Atu4866 from Agrobacterium tumefaciens adopts a streptavidin-like fold.

Protein Sci 2008 Jan 27;17(1):154-8. Epub 2007 Nov 27.

Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1110/ps.073167408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2144585PMC
January 2008

A functional nuclear localization signal in insulin-like growth factor binding protein-6 mediates its nuclear import.

Endocrinology 2008 Mar 26;149(3):1214-26. Epub 2007 Nov 26.

Department of Biochemistry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada N6A 5C1.

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http://dx.doi.org/10.1210/en.2007-0959DOI Listing
March 2008

Defining the specificity space of the human SRC homology 2 domain.

Mol Cell Proteomics 2008 Apr 22;7(4):768-84. Epub 2007 Oct 22.

Department of Biochemistry, Siebens-Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1074/mcp.M700312-MCP200DOI Listing
April 2008

Hypothetical protein AF2241 from Archaeoglobus fulgidus adopts a cyclophilin-like fold.

J Biomol NMR 2007 Aug 4;38(4):353-8. Epub 2007 Jul 4.

Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1007/s10858-007-9172-8DOI Listing
August 2007

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

Proteomics 2007 Jun;7(11):1775-85

Department of Biochemistry and the Siebens-Drake Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1002/pmic.200601006DOI Listing
June 2007

The role of SLAM family receptors in immune cell signaling.

Biochem Cell Biol 2006 Dec;84(6):832-43

Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.

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http://dx.doi.org/10.1139/o06-191DOI Listing
December 2006

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.

Nature 2006 Apr 8;440(7085):818-23. Epub 2006 Mar 8.

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.

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http://dx.doi.org/10.1038/nature04662DOI Listing
April 2006

Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction.

Authors:
Shawn S-C Li

Biochem J 2005 Sep;390(Pt 3):641-53

Department of Biochemistry, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada N6A 5C1.

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http://biochemj.org/lookup/doi/10.1042/BJ20050411
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http://dx.doi.org/10.1042/BJ20050411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199657PMC
September 2005

Novel Src homology 3 domain-binding motifs identified from proteomic screen of a Pro-rich region.

Mol Cell Proteomics 2005 Aug 31;4(8):1155-66. Epub 2005 May 31.

Department of Biochemistry, Schulich School of Medicine, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1074/mcp.M500108-MCP200DOI Listing
August 2005

A novel PTB-PDZ domain interaction mediates isoform-specific ubiquitylation of mammalian Numb.

J Biol Chem 2004 May 27;279(20):20807-15. Epub 2004 Feb 27.

The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children and Department of Medical Biophysics, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.

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http://www.jbc.org/content/279/20/20807.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M311396200
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http://dx.doi.org/10.1074/jbc.M311396200DOI Listing
May 2004

An oriented peptide array library (OPAL) strategy to study protein-protein interactions.

J Biol Chem 2004 Mar 16;279(10):8802-7. Epub 2003 Dec 16.

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M311886200DOI Listing
March 2004

A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.

J Biol Chem 2004 Mar 11;279(12):11304-12. Epub 2003 Dec 11.

Department of Biochemistry and Biology, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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http://dx.doi.org/10.1074/jbc.M311733200DOI Listing
March 2004