Shankar Balasubramanian

Shankar Balasubramanian

UNVERIFIED PROFILE

Are you Shankar Balasubramanian?   Register this Author

Register author
Shankar Balasubramanian

Shankar Balasubramanian

Publications by authors named "Shankar Balasubramanian"

Are you Shankar Balasubramanian?   Register this Author

100Publications

1756Reads

32Profile Views

An Activatable Cancer-Targeted Hydrogen Peroxide Probe for Photoacoustic and Fluorescence Imaging.

Cancer Res 2019 Oct 27;79(20):5407-5417. Epub 2019 Aug 27.

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-19-0691DOI Listing
October 2019

Unusual Activity of a TET/JBP Family Enzyme.

Biochemistry 2019 Sep 22;58(35):3627-3629. Epub 2019 Aug 22.

La Jolla Institute for Immunology and Sanford Consortium for Regenerative Medicine , La Jolla , California 92037 , United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.9b00609DOI Listing
September 2019

A Spontaneous Ring Opening Reaction Leads to a Repair-Resistant T Oxidation Product in Genomic DNA.

Chembiochem 2019 Aug 6. Epub 2019 Aug 6.

University of Cambridge, Department of Chemistry, Lensfield Road, CB2 1EW, Cambridge, UNITED KINGDOM.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201900484DOI Listing
August 2019

Sequencing abasic sites in DNA at single-nucleotide resolution.

Nat Chem 2019 07 17;11(7):629-637. Epub 2019 Jun 17.

Department of Chemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41557-019-0279-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589398PMC
July 2019

METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation.

Mol Cell 2019 Jun 25;74(6):1278-1290.e9. Epub 2019 Apr 25.

The Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2019.03.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591002PMC
June 2019

A Photo-responsive Small-Molecule Approach for the Opto-epigenetic Modulation of DNA Methylation.

Angew Chem Int Ed Engl 2019 May 12;58(20):6620-6624. Epub 2019 Apr 12.

Department of Chemistry, Institute for Structural and Molecular Biology, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/anie.201901139
Publisher Site
http://dx.doi.org/10.1002/anie.201901139DOI Listing
May 2019

Whole genome experimental maps of DNA G-quadruplexes in multiple species.

Nucleic Acids Res 2019 May;47(8):3862-3874

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486626PMC
May 2019

Detection, Structure and Function of Modified DNA Bases.

J Am Chem Soc 2019 Apr 28;141(16):6420-6429. Epub 2019 Mar 28.

Department of Chemistry , University of Cambridge , Cambridge CB2 1EW , United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.9b01915DOI Listing
April 2019

Publisher Correction: DNA sequencing at 40: past, present and future.

Nature 2019 Apr;568(7752):E11

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1120-8DOI Listing
April 2019

Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.

Nucleic Acids Res 2019 02;47(3):1564-1572

School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gky1179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379715PMC
February 2019

RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs.

Genome Biol 2018 12 27;19(1):229. Epub 2018 Dec 27.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-018-1602-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307142PMC
December 2018

Sequencing 5-Hydroxymethyluracil at Single-Base Resolution.

Angew Chem Int Ed Engl 2018 07 4;57(31):9694-9696. Epub 2018 Jul 4.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201804046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100112PMC
July 2018

Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome.

Cold Spring Harb Perspect Biol 2018 07 2;10(7). Epub 2018 Jul 2.

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a032284DOI Listing
July 2018

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.

Nature 2018 06 13;558(7710):465-469. Epub 2018 Jun 13.

Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41586-018-0209-9
Publisher Site
http://dx.doi.org/10.1038/s41586-018-0209-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261253PMC
June 2018

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing.

Nat Protoc 2018 03 22;13(3):551-564. Epub 2018 Feb 22.

Cancer Research UK, Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2017.150DOI Listing
March 2018

Synthesis and Multiple Incorporations of 2'-O-Methyl-5-hydroxymethylcytidine, 5-Hydroxymethylcytidine and 5-Formylcytidine Monomers into RNA Oligonucleotides.

Chembiochem 2017 11 9;18(22):2236-2241. Epub 2017 Oct 9.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201700492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779611PMC
November 2017

Local epigenetic reprogramming induced by G-quadruplex ligands.

Nat Chem 2017 11 31;9(11):1110-1117. Epub 2017 Jul 31.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchem.2828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669467PMC
November 2017

Machine learning model for sequence-driven DNA G-quadruplex formation.

Sci Rep 2017 11 6;7(1):14535. Epub 2017 Nov 6.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-14017-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673958PMC
November 2017

DNA sequencing at 40: past, present and future.

Nature 2017 10 11;550(7676):345-353. Epub 2017 Oct 11.

Department of Genome Sciences, University of Washington, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature24286DOI Listing
October 2017

Therapeutics: Click and discover.

Nature 2017 08;548(7666):162-164

Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK, and in the Cancer Research UK Cambridge Institute.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/548162aDOI Listing
August 2017

The Profile and Dynamics of RNA Modifications in Animals.

Chembiochem 2017 06 27;18(11):979-984. Epub 2017 Apr 27.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201700093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784800PMC
June 2017

DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.

Nat Rev Mol Cell Biol 2017 05 22;18(5):279-284. Epub 2017 Feb 22.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrm.2017.3
Publisher Site
http://dx.doi.org/10.1038/nrm.2017.3DOI Listing
May 2017

G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.

Nat Struct Mol Biol 2017 03 30;24(3):243-247. Epub 2017 Jan 30.

Department of Chemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.3367DOI Listing
March 2017

2'-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA.

J Am Chem Soc 2017 02 25;139(5):1766-1769. Epub 2017 Jan 25.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.6b12180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504488PMC
February 2017

Single genome retrieval of context-dependent variability in mutation rates for human germline.

BMC Genomics 2017 01 13;18(1):81. Epub 2017 Jan 13.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12864-016-3440-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237266PMC
January 2017

Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania.

Genome Biol 2017 01 30;18(1):23. Epub 2017 Jan 30.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-017-1150-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282726PMC
January 2017

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

Cell Rep 2017 01;18(5):1079-1089

Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK; Centre for Trophoblast Research, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2017.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300890PMC
January 2017

Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing.

Org Biomol Chem 2016 Nov;14(43):10208-10216

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. and Cancer Research UK, Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c6ob01945eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433426PMC
November 2016

Accuracy of commercial blood gas analyzers for monitoring ionized calcium at low concentrations.

Clin Chim Acta 2016 Oct 19;461:34-40. Epub 2016 Jul 19.

Instrumentation Laboratory Company, 180 Hartwell Rd., Bedford, MA, United States.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00098981163031
Publisher Site
http://dx.doi.org/10.1016/j.cca.2016.07.010DOI Listing
October 2016

DSBCapture: in situ capture and sequencing of DNA breaks.

Nat Methods 2016 10 15;13(10):855-7. Epub 2016 Aug 15.

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045719PMC
http://dx.doi.org/10.1038/nmeth.3960DOI Listing
October 2016

rG4-seq reveals widespread formation of G-quadruplex structures in the human transcriptome.

Nat Methods 2016 10 29;13(10):841-4. Epub 2016 Aug 29.

Department of Chemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3965DOI Listing
October 2016

G-quadruplex structures mark human regulatory chromatin.

Nat Genet 2016 10 12;48(10):1267-72. Epub 2016 Sep 12.

Cancer Research UK, Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3662DOI Listing
October 2016

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

Proc Natl Acad Sci U S A 2016 10 11;113(43):12202-12207. Epub 2016 Oct 11.

Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1608679113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086989PMC
October 2016

An Epigenetics-Inspired DNA-Based Data Storage System.

Angew Chem Int Ed Engl 2016 09 21;55(37):11144-8. Epub 2016 Jul 21.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201605531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113786PMC
September 2016

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA.

Angew Chem Int Ed Engl 2016 07 29;55(31):8958-61. Epub 2016 Jun 29.

The University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201603562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680278PMC
July 2016

Long genes and genes with multiple splice variants are enriched in pathways linked to cancer and other multigenic diseases.

BMC Genomics 2016 Mar 12;17:225. Epub 2016 Mar 12.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://www.biomedcentral.com/1471-2164/17/225
Publisher Site
http://dx.doi.org/10.1186/s12864-016-2582-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788956PMC
March 2016

Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.

J Am Chem Soc 2016 Jan 12;138(3):718-21. Epub 2016 Jan 12.

Medical Research Council Laboratory of Molecular Biology , Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.5b07627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821487PMC
January 2016

Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues.

PLoS One 2014 17;9(7):e102711. Epub 2014 Jul 17.

Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom; Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102711PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102534PMC
November 2015

Accurate measurement of 5-methylcytosine and 5-hydroxymethylcytosine in human cerebellum DNA by oxidative bisulfite on an array (OxBS-array).

PLoS One 2015 23;10(2):e0118202. Epub 2015 Feb 23.

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom; Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118202PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338296PMC
November 2015

5-Formylcytosine can be a stable DNA modification in mammals.

Nat Chem Biol 2015 Aug 22;11(8):555-7. Epub 2015 Jun 22.

1] Department of Chemistry, University of Cambridge, Cambridge, UK. [2] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486442PMC
August 2015

High-throughput sequencing of DNA G-quadruplex structures in the human genome.

Nat Biotechnol 2015 Aug 20;33(8):877-81. Epub 2015 Jul 20.

1] Department of Chemistry, University of Cambridge, Cambridge, UK. [2] Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK. [3] School of Clinical Medicine, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.3295DOI Listing
August 2015

Selective Chemical Labeling of Natural T Modifications in DNA.

J Am Chem Soc 2015 Jul 12;137(29):9270-2. Epub 2015 May 12.

†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jacs.5b03730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521287PMC
July 2015

Targeted Detection of G-Quadruplexes in Cellular RNAs.

Angew Chem Int Ed Engl 2015 Jun 23;54(23):6751-4. Epub 2015 Apr 23.

The University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW (UK).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201500891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510783PMC
June 2015

FOXM1 binds directly to non-consensus sequences in the human genome.

Genome Biol 2015 Jun 23;16:130. Epub 2015 Jun 23.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Center, Robinson Way, Cambridge, CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-015-0696-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492089PMC
June 2015

Chemical methods for decoding cytosine modifications in DNA.

Chem Rev 2015 Mar 5;115(6):2240-54. Epub 2014 Aug 5.

†Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/cr5002904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378238PMC
March 2015

Formation and abundance of 5-hydroxymethylcytosine in RNA.

Chembiochem 2015 Mar 12;16(5):752-5. Epub 2015 Feb 12.

University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW (UK).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201500013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471624PMC
March 2015

Decoding genomes.

Biochem Soc Trans 2015 Feb;43(1):1-5

*Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20140254DOI Listing
February 2015

Insights into the mechanism of a G-quadruplex-unwinding DEAH-box helicase.

Nucleic Acids Res 2015 Feb 4;43(4):2223-31. Epub 2015 Feb 4.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkv051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344499PMC
February 2015

oxBS-450K: a method for analysing hydroxymethylation using 450K BeadChips.

Methods 2015 Jan 28;72:9-15. Epub 2014 Aug 28.

Department of Cancer Biology, UCL Cancer Institute, University College London, London WC1E 6BT, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2014.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304834PMC
January 2015

Solexa sequencing: decoding genomes on a population scale.

Clin Chem 2015 Jan 20;61(1):21-4. Epub 2014 Oct 20.

Professor, Department of Chemistry, University of Cambridge; CRUK Cambridge Institute, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2014.221747DOI Listing
January 2015

Dual binding of an antibody and a small molecule increases the stability of TERRA G-quadruplex.

Angew Chem Int Ed Engl 2015 Jan 24;54(3):910-3. Epub 2014 Nov 24.

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 (USA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201408113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506565PMC
January 2015

5-Formylcytosine alters the structure of the DNA double helix.

Nat Struct Mol Biol 2015 Jan 15;22(1):44-49. Epub 2014 Dec 15.

Department of Chemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb.2936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287393PMC
January 2015

Dual Binding of an Antibody and a Small Molecule Increases the Stability of TERRA G-Quadruplex.

Angew Chem Weinheim Bergstr Ger 2015 Jan 24;127(3):924-927. Epub 2014 Nov 24.

Department of Chemistry and Biochemistry, Kent State University Kent, OH 44242 (USA) E-mail:

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ange.201408113
Publisher Site
http://dx.doi.org/10.1002/ange.201408113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535663PMC
January 2015

5-Hydroxymethylcytosine is a predominantly stable DNA modification.

Nat Chem 2014 Dec 21;6(12):1049-55. Epub 2014 Sep 21.

1] Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK [2] Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nchem.2064
Publisher Site
http://dx.doi.org/10.1038/nchem.2064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382525PMC
December 2014

Targeting DNA G-quadruplexes with helical small molecules.

Chembiochem 2014 Nov 26;15(17):2563-70. Epub 2014 Sep 26.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK); Cambridge Institute, Cancer Research UK, Li Ka Shing Center, Cambridge CB2 0RE (UK).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201402439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284101PMC
November 2014

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.

Nat Commun 2014 Nov 12;5:5165. Epub 2014 Nov 12.

1] University Chemical Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK [2] Cancer Research UK, Li Ka Shing Centre, Cambridge Institute, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms6165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258842PMC
November 2014

Chemical biology of genomic DNA: minimizing PCR bias.

Chem Commun (Camb) 2014 Oct;50(81):12047-9

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C4CC05107F
Publisher Site
http://dx.doi.org/10.1039/c4cc05107fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759930PMC
October 2014

Nucleotide contributions to the structural integrity and DNA replication initiation activity of noncoding y RNA.

Biochemistry 2014 Sep 5;53(37):5848-63. Epub 2014 Sep 5.

Institute of Biological Chemistry, Academia Sinica , 128, Section 2, Academia Road, Taipei 11529, Taiwan.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/bi500470b
Publisher Site
http://dx.doi.org/10.1021/bi500470bDOI Listing
September 2014

Chemical biology on the genome.

Bioorg Med Chem 2014 Aug 15;22(16):4356-70. Epub 2014 May 15.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2014.05.016DOI Listing
August 2014

G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation.

Nat Chem Biol 2014 May 16;10(5):358-64. Epub 2014 Mar 16.

1] Tumour Immunology, Department of Immunology, Clive Berghofer Cancer Research Centre, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. [2] QIMR Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.1479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188979PMC
May 2014

Quantitative sequencing of 5-formylcytosine in DNA at single-base resolution.

Nat Chem 2014 May 23;6(5):435-40. Epub 2014 Mar 23.

1] Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK [2] Cancer Research UK, Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchem.1893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188980PMC
May 2014

Existence and consequences of G-quadruplex structures in DNA.

Curr Opin Genet Dev 2014 Apr 31;25:22-9. Epub 2013 Dec 31.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK; Cambridge Institute, Cancer Research UK, Li Ka Shing Center, Cambridge CB2 0RE, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0959437X130014
Publisher Site
http://dx.doi.org/10.1016/j.gde.2013.10.012DOI Listing
April 2014

Reprogramming the mechanism of action of chlorambucil by coupling to a G-quadruplex ligand.

J Am Chem Soc 2014 Apr 8;136(16):5860-3. Epub 2014 Apr 8.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja5014344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132976PMC
April 2014

Targeting a c-MYC G-quadruplex DNA with a fragment library.

Chem Commun (Camb) 2014 Feb;50(14):1704-7

Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C3CC48390H
Publisher Site
http://dx.doi.org/10.1039/c3cc48390hDOI Listing
February 2014

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells.

Nat Chem 2014 Jan 24;6(1):75-80. Epub 2013 Nov 24.

1] Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK [2] Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchem.1805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081541PMC
January 2014

Binding interactions between long noncoding RNA HOTAIR and PRC2 proteins.

Biochemistry 2013 Dec 17;52(52):9519-27. Epub 2013 Dec 17.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi401085hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964825PMC
December 2013

Targeting RNA-protein interactions within the human immunodeficiency virus type 1 lifecycle.

Biochemistry 2013 Dec 10;52(51):9269-74. Epub 2013 Dec 10.

Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge, CB2 1EW, U.K.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/bi401270d
Publisher Site
http://dx.doi.org/10.1021/bi401270dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928988PMC
December 2013

G-quadruplex structures are stable and detectable in human genomic DNA.

Nat Commun 2013 ;4:1796

Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms2792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736099PMC
November 2013

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.

Chem Commun (Camb) 2013 Oct;49(76):8453-5

Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=c3cc44737e
Publisher Site
http://dx.doi.org/10.1039/c3cc44737eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155816PMC
October 2013

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine.

Nat Protoc 2013 Oct 5;8(10):1841-51. Epub 2013 Sep 5.

Department of Chemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2013.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919000PMC
October 2013

Mechanochemical properties of individual human telomeric RNA (TERRA) G-quadruplexes.

Chembiochem 2013 Oct 26;14(15):1931-5. Epub 2013 Aug 26.

Department of Chemistry & Biochemistry, Kent State University, Williams Hall, Kent, OH 44242 (USA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.201300350DOI Listing
October 2013

G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells.

J Am Chem Soc 2013 Jul 25;135(26):9640-3. Epub 2013 Jun 25.

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja404868tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964824PMC
July 2013

High-performance bioassisted nanophotocatalyst for hydrogen production.

Nano Lett 2013 Jul 28;13(7):3365-71. Epub 2013 Jun 28.

Center for Nanoscale Materials, Argonne National Laboratory , Argonne, Illinois 60439, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/nl4016655DOI Listing
July 2013

Stimuli-responsive magnetic nanomicelles as multifunctional heat and cargo delivery vehicles.

Langmuir 2013 Jun 22;29(24):7425-32. Epub 2013 Feb 22.

Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/la3044158DOI Listing
June 2013

An interview with Shankar Balasubramanian.

Trends Biochem Sci 2013 Apr;38(4):170-1

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2013.02.006DOI Listing
April 2013

Quantitative visualization of DNA G-quadruplex structures in human cells.

Nat Chem 2013 Mar 20;5(3):182-6. Epub 2013 Jan 20.

Cancer Research UK, Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchem.1548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622242PMC
March 2013

An acetylene-bridged 6,8-purine dimer as a fluorescent switch-on probe for parallel G-quadruplexes.

Angew Chem Int Ed Engl 2013 Jan 13;52(5):1428-31. Epub 2012 Dec 13.

Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201207075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652027PMC
January 2013

An RNA hairpin to G-quadruplex conformational transition.

J Am Chem Soc 2012 Dec 29;134(49):19953-6. Epub 2012 Nov 29.

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja308665gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536296PMC
December 2012

The kinetics and folding pathways of intramolecular G-quadruplex nucleic acids.

J Am Chem Soc 2012 Nov 12;134(46):19297-308. Epub 2012 Nov 12.

Department of Chemistry, University of Cambridge, Lensfield Rd, Cambridge CB2 1EW, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja309851tDOI Listing
November 2012

Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

Angew Chem Int Ed Engl 2012 Oct 4;51(44):11073-8. Epub 2012 Oct 4.

University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201206281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652031PMC
October 2012