Dr Shahab Uddin, Ph.D. - Hamad Medical Corp - Senior Scientist/ Head of the Molecular Pathophysiology core facility at ITRI

Dr Shahab Uddin

Ph.D.

Hamad Medical Corp

Senior Scientist/ Head of the Molecular Pathophysiology core facility at ITRI

Doha, Ad Dawhah | Qatar

Main Specialties: Biology, Biotechnology, Oncology

Additional Specialties: Translational Research

ORCID logohttps://orcid.org/0000-0003-1886-6710


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Dr Shahab Uddin, Ph.D. - Hamad Medical Corp - Senior Scientist/ Head of the Molecular Pathophysiology core facility at ITRI

Dr Shahab Uddin

Ph.D.

Introduction

Dr. Shahab Uddin is a Senior Scientist and Head of Molecular Pathophysiology, at Transnational Research Institute, Hamad Medical Corporation, Doha. He graduated with BSc. Degree in Chemistry from the Aligarh Muslim University, India in 1982. He then received his MSc, MPhil and Ph.D. degrees in Biochemistry from Aligarh Muslim University, India in 1984, 1986 and 1988 respectively. After completing his graduate degree, he joined the Ohio State University, Columbus, the USA for postdoctoral training for two years (1989-1991). He worked in the area molecular biology of DNA. He joined Loyola University of Chicago, Illinois, USA, and worked from April1991-1995 under Molecular Biology Training Program. He received extensive training in the molecular biology of brain hormone as well signaling mechanism of interferon in leukemia. In 1996, he joined the University of Illinois at Chicago initially as Instructor and then as Research Assistant Professor in the Department of Medicine. He continued working in the area of interferon signaling. He joined the University of Chicago as Research Associate Professor and worked till 2003. In 2003, he joined King Faisal Specialist Hospital & Research Centre, Riyadh, KSA, as a Scientist initially (2003-2005) and subsequently promoted to Senior Scientist (2005) and deputy director of Human Cancer Genomic Program. Dr. Shahab contributed to the establishment of Human Cancer Genomic Program at King Faisal Specialist Hospital & Research Centre for translational research. Currently, he is working as Senior Scientist and Head of Molecular Pathophysiology section in interim Translational Research Institute at Hamad Medical Corporation, Doha, Qatar.

The primary research interest of Dr. Shahab is to identify dysregulated signaling molecular that are involved in survival and proliferation of malignant cells. These molecular targets, once identified, will be helpful in the prognostic marker for detection of the onset of malignancy. On the other hand, these molecules will also serve as an attractive target for targeted therapy for the treatment and management of cancer cells

He is currently a member of several international scientific societies and an active member of the editorial board of various journals such Leukemia-Lymphoma, Plosone, Oncology and Target and Journal of some Immunology Research. Dr. Shahab Uddin has a lead research team of Scientist, Junior Scientist, Postdoctoral and Research Assistant for many years. He has supervised fellows, medical students as well as Ph.D. and Master students. He has obtained successfully many research grants from different organizations such as National Institute of Health (USA), Veteran Administration (USA), American Cancer Society, Illinois (USA), Wendy Will Foundation USA) KACST (Saudi Arabia), SANAD foundation ( Saudi Arabia), Medical Research Centre Hamad Medical Corporation and Qatar Foundation (Qatar).

Dr. Shahab Uddin published over 190 peer-reviewed articles in high impact factor journal such as Journal of Biological Chemistry, PNAS, Blood, Cancer Research, Journal of Immunology, Clinical Cancer Research. He has trained numerous postdoctoral fellows, Medical fellows, and graduate students. He has supervised numerous scientists, technicians, and students of different levels. He has served numerous scientific and administrative committees. He has been consciously reviewing manuscripts and grants proposals of international journal and agencies respectively.

Primary Affiliation: Hamad Medical Corp - Doha, Ad Dawhah , Qatar

Specialties:

Additional Specialties:

Research Interests:


View Dr Shahab Uddin’s Resume / CV

Education

Apr 1988
Aligarh Muslim University
Ph.D.
Biochemistry
Jul 1979 - May 1986
Aligarh Muslim University
M.Phil.
Biochemistry
Jul 1979 - May 1984
Aligarh Muslim University
MSc
Biochemistry
Jul 1983 - May 1982
Aligarh Muslim University
BSc (Hons)
Chemistry

Experience

Jan 2015 - Jan 2015
Hamad Medical Corp
Senior Scientist/ Head of the Molecular Pathophysiology core facility at ITRI
Hamad Medical Corporation Translational Research Institute
Aug 2003 - Jan 2015
King Faisal Specialist Hospital and Research Center
Deputy Director/Senior Scientist
Human Cancer Genomic Research
Jul 2001 - Jul 2003
University of Chicago
Research Associate Professor
Medicine
Mar 1995 - Jun 2001
University of Illinois at Chicago
Research Assistant Professor
Medicine
Apr 1991 - May 1995
Loyola University Medical Center
Postdoctoral Researcher
Medicine
Jul 1989 - Mar 1991
Ohio State University
Postdoctoral fellow
Radiology

Publications

191Publications

603Reads

20Profile Views

199PubMed Central Citations

Immunotherapeutic strategies in patients with advanced head and neck squamous cell carcinoma.

Ann Transl Med 2019 Mar;7(Suppl 1):S22

National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.21037/atm.2019.01.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462621PMC
March 2019
3 Reads

Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance.

Mol Cancer 2019 03 30;18(1):55. Epub 2019 Mar 30.

Division of Translational Medicine, Sidra Medicine, PO BOX 26999, Doha, Qatar.

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http://dx.doi.org/10.1186/s12943-019-0965-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441157PMC
March 2019
5 Reads
4.257 Impact Factor

Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia.

Leuk Lymphoma 2019 03 6;60(3):782-794. Epub 2018 Sep 6.

a Translational Research Institute , Academic Health System, Hamad Medical Corporation , Doha , Qatar.

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http://dx.doi.org/10.1080/10428194.2018.1494270DOI Listing
March 2019
15 Reads

RAS-mediated oncogenic signaling pathways in human malignancies.

Semin Cancer Biol 2019 02 7;54:1-13. Epub 2018 Mar 7.

Academic Health System, Translational Research Institute, Hamad Medical Corporation, Doha, Qatar. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2018.03.001DOI Listing
February 2019
21 Reads
9.330 Impact Factor

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.

Front Physiol 2018 23;9:1942. Epub 2019 Jan 23.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.3389/fphys.2018.01942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351700PMC
January 2019
23 Reads

Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer Cells

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3501-3509. Epub 2018 Dec 25.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar. Email:

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http://dx.doi.org/10.31557/APJCP.2018.19.12.3501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428541PMC
December 2018
6 Reads
1.500 Impact Factor

Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.

Cancer Lett 2018 08 17;430:133-147. Epub 2018 May 17.

Department of Physiology and Biophysics, Weill Cornell Medicine - Qatar, Education City, PO 24144, Doha, Qatar. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835183034
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http://dx.doi.org/10.1016/j.canlet.2018.05.017DOI Listing
August 2018
33 Reads
1 Citation
5.621 Impact Factor

Dysregulated expression of SKP2 and its role in hematological malignancies.

Leuk Lymphoma 2018 05 10;59(5):1051-1063. Epub 2017 Aug 10.

a Translational Research Institute, Academic Health System , Hamad Medical Corporation , Doha , Qatar.

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http://dx.doi.org/10.1080/10428194.2017.1359740DOI Listing
May 2018
31 Reads
1 Citation

Nucleic Acid – Structure and Functions; Quick Revision of Molecular Biology.

Research India Publications ; 2016

Nucleic Acid – Structure and Functions

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2017
11 Reads

An Overview of Proteomics Techniques and its Application as a Tool in Biomarker and Drug Discovery

Journal of Proteomics & Enzymology. 2016 October 15; 5(2)

Journal of Proteomics & Enzymology

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2016
13 Reads

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells.

Ahmed M, Hussain AR, Siraj AK, Uddin S, Al-Sanea N, Al-Dayel F, Al-Assiri M, Beg S, Al-Kuraya KS, Molecular cancer, 2015, vol. 14, pp. 131

http://europepmc.org/abstract/med/26159723

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2015
13 Reads

Role of X-Linked Inhibitor of Apoptosis as a Prognostic Marker and Therapeutic Target in Papillary Thyroid Carcinoma.

Hussain AR, Bu R, Ahmed M, Jehan Z, Beg S, Al-Sobhi S, Al-Dayel F, Siraj AK, Uddin S, Al-Kuraya KS, The Journal of clinical endocrinology and metabolism, 2015, vol. 100, no. 7, pp. E974-85

http://europepmc.org/abstract/med/25974735

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July 2015
13 Reads

Molecular markers and pathway analysis of colorectal carcinoma in the Middle East.

Beg S, Siraj AK, Prabhakaran S, Bu R, Al-Rasheed M, Sultana M, Qadri Z, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS, Cancer, 2015

http://europepmc.org/abstract/med/26218848

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July 2015
10 Reads

Role of Leptin and Leptin receptors in hematological malignancies.

Uddin S, Mohammad RM, Leukemia & lymphoma, 2015

 

http://europepmc.org/abstract/med/26077362

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July 2015

10 Citations

Impact Factor 3.010

9 Reads

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer.

Siraj AK, Prabhakaran S, Bavi P, Bu R, Beg S, Hazmi MA, Al-Rasheed M, Al-Assiri M, Sairafi R, Al-Dayel F, Al-Sanea N, Uddin S, Al-Kuraya KS, Cancer, 2015, vol. 121, no. 11, pp. 1762-1771

http://europepmc.org/abstract/med/25712738

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July 2015
6 Reads

Dual Targeting of mTOR Activity with Torin2 Potentiates Anti-Cancer Effects of Cisplatin in Epithelial Ovarian Cancer.

Hussain AR, Al-Romaizan M, Ahmed M, Thangavel S, Al-Dayel F, Beg S, Uddin S, Siraj AK, Al-Kuraya KS, Molecular medicine (Cambridge, Mass.), 2015

http://europepmc.org/abstract/med/26023849

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May 2015
11 Reads

Notch signaling in colon cancer: Road less traveled.

2015 January 10; 2(1):1-3

Oncobiology and Targets

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January 2015
13 Reads

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.

Authors:

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

http://europepmc.org/abstract/med/24014051

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March 2014
9 Reads

Colorectal cancer risk is not associated with increased levels of homozygosity in Saudi Arabia.

Authors:

Genetics in medicine : official journal of the American College of Medical Genetics

http://europepmc.org/abstract/med/22481135

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May 2012
11 Reads

Role of leptin and its receptors in the pathogenesis of thyroid cancer.

Authors:

International journal of clinical and experimental pathology

http://europepmc.org/abstract/med/22076163

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2011
11 Reads

MMP7 Polymorphisms - A new tool in molecular pathology to understand esophageal cancer.

Authors:

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

http://europepmc.org/abstract/med/21912054

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2011
4 Reads

Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways.

Saudi Med J 2008 Jan;29(1):75-80

Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.

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January 2008
84 Reads
2 Citations
0.554 Impact Factor

p38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity.

Authors:

American journal of physiology. Lung cellular and molecular physiology

http://europepmc.org/abstract/med/16891390

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January 2007
13 Reads

JAK Family of Tyrosine Kinases: Its Functions and Alterations in Human Cancer

Uddin S, Hussain A, Alk-Kuraya KS. Vol 3; 163-171

Current Enzyme Inhibition

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2006
13 Reads

Molecular Mechanisms of curcumin-induced apoptosis in lymphoid malignant cells

2006; 24:37-45.

Emirates Medical Journal

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December 2006
11 Reads

Prevalence of fragile histidine triad expression in tumors from saudi arabia: a tissue microarray analysis.

Authors:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

http://europepmc.org/abstract/med/16985034

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October 2006
4 Reads

Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis.

Saudi Med J 2006 Mar;27(3):323-8

Research Research Centre, King Faisal Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.

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March 2006
55 Reads
3 Citations
0.554 Impact Factor

The PI3' kinase pathway in interferon signaling.

Authors:

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

http://europepmc.org/abstract/med/16375606

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2005
10 Reads

Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells.

Authors:

Clinical cancer research : an official journal of the American Association for Cancer Research

http://europepmc.org/abstract/med/15837766

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May 2005
11 Reads

Mechanisms of type-I interferon signal transduction.

Authors:

Journal of biochemistry and molecular biology

http://europepmc.org/abstract/med/15607020

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December 2004
8 Reads

Activation of protein kinase C delta by IFN-gamma.

Authors:

Journal of immunology (Baltimore, Md. : 1950)

http://europepmc.org/abstract/med/12817007

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July 2003
14 Reads

Poxvirus infection rapidly activates tyrosine kinase signal transduction.

J Biol Chem 2001 Dec 8;276(51):48371-5. Epub 2001 Oct 8.

Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Canadian Blood Services Building, Toronto, Ontario M5G 2M1, Canada.

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http://dx.doi.org/10.1074/jbc.M108019200DOI Listing
December 2001
10 Reads
10 Citations
4.573 Impact Factor

The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins.

J Biol Chem 2000 Sep;275(36):27634-40

Section of Hematology-Oncology, University of Illinois and West Side Veterans Administration Hospital, Chicago, Illinois 60607, USA.

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http://dx.doi.org/10.1074/jbc.M003170200DOI Listing
September 2000
7 Reads
48 Citations
4.573 Impact Factor

IFN-gamma activates the C3G/Rap1 signaling pathway.

Authors:

Journal of immunology (Baltimore, Md. : 1950)

http://europepmc.org/abstract/med/10657627

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March 2000
10 Reads

Activation of the Jak-Stat pathway in cells that exhibit selective sensitivity to the antiviral effects of IFN-beta compared with IFN-alpha.

Authors:

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

http://europepmc.org/abstract/med/10454351

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July 1999
13 Reads

Growth inhibition of a human myeloma cell line by all-trans retinoic acid is not mediated through downregulation of interleukin-6 receptors but through upregulation of p21(WAF1).

Blood 1999 Jul;94(1):251-9

Department of Medicine, University of Illinois College of Medicine and VA West Side Medical Center, Chicago, IL 60612, USA.

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July 1999
6 Reads
10 Citations
10.452 Impact Factor

Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression.

Blood 1998 Jan;91(2):570-6

Department of Pediatrics, Northwestern University Medical School, Chicago, IL, USA.

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January 1998
7 Reads
31 Citations
10.452 Impact Factor

Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis.

J Immunol 1998 Jan;160(2):929-35

Department of Physiology, Burn and Shock Trauma Institute, Loyola University Chicago Medical Center, Maywood, IL 60153, USA.

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January 1998
8 Reads
7 Citations
4.922 Impact Factor

The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors.

Blood 1997 Oct;90(7):2574-82

Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Hospital, 60607-7173, USA.

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October 1997
9 Reads
14 Citations
10.452 Impact Factor

Interaction of p59fyn with interferon-activated Jak kinases.

Authors:

Biochemical and biophysical research communications

http://europepmc.org/abstract/med/9196040

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July 1997
12 Reads

Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha.

J Immunol 1997 Mar;158(5):2390-7

Department of Medicine, University of Illinois at Chicago, 60607, USA.

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March 1997
53 Reads
22 Citations
4.922 Impact Factor

Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product.

Exp Hematol 1996 Apr;24(5):622-7

Department of Medicine, Loyola University Chicago, Maywood, IL, USA.

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April 1996
7 Reads
6 Citations
2.480 Impact Factor

Dietary antioxidants protection against oxidative stress.

Biochemical education.1995 January; 23(1):2-7

Biochemical education.

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1995
13 Reads

Quercetin, a bioflavonoid, inhibits the DNA synthesis of human leukemia cells.

Biochem Mol Biol Int 1995 Jul;36(3):545-50

Division of Hematology-Oncology, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153, USA.

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July 1995
7 Reads
3 Citations

Antioxidants protection against cancer and other human diseases.

Authors:
S Uddin S Ahmad

Compr Ther 1995 ;21(1):41-5

Department of Medicine, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois, USA.

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May 1995
7 Reads
4 Citations

Reactions of furfural and methylfurfural with DNA.

Authors:
S Uddin S M Hadi

Biochem Mol Biol Int 1995 Jan;35(1):185-95

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, U.P., India.

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January 1995
23 Reads
2 Citations

The effects of ethanol on pituitary function.

Compr Ther 1994 ;20(6):326-30

Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL 60153.

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September 1994
5 Reads

Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.

J Biol Chem 1994 Jul;269(27):17761-4

Department of Medicine, Loyola University of Chicago, Illinois.

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July 1994
7 Reads
25 Citations
4.573 Impact Factor

Repair of quercetin-induced single-strand breaks by a cell free system.

Authors:
S Uddin

Biochem Mol Biol Int 1994 Feb;32(2):341-7

Department of Radiology, Ohio State University, Columbus 43210.

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February 1994
7 Reads

The reproductive neuroendocrinology of aging and drug abuse.

CRC Press; 1993. Chapter Chap. 13

Alcohol and drug abuse

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1993
13 Reads

In vitro effects of methylfurfural on the secondary structure of DNA

Medical Science Research. 1993; 21(22):825-826

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1993
13 Reads

Effect of furfural on the secondary structure of DNA

1993; 21:545-546

Medical Science Research

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1993
12 Reads

The effects of alcohol on the neuroendocrine control of reproduction.

National Institutes of Health Monograph 23. 1993

National Institutes of Health Monograph 23. 1993

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1993
13 Reads

Reaction of furfural and methylfurfural with DNA: use of single-strand-specific nucleases.

Authors:

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

http://europepmc.org/abstract/med/1959826

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October 1991
11 Reads

Dietary mutagens and Carcinogens.

JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH . 1987; 46(2):54-60.

JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH

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1987
10 Reads

Top co-authors

Said Dermime
Said Dermime

Dasman Diabetes Institute

12
Kirti S Prabhu
Kirti S Prabhu

Translational Research Institute

9
Maysaloun Merhi
Maysaloun Merhi

National Center for Cancer Care and Research

8
Kodappully S Siveen
Kodappully S Siveen

Department of Immunology

8
Afsheen Raza
Afsheen Raza

Hamad Medical Corporation

7
Abdul Q Khan
Abdul Q Khan

Uniformed Services University of the Health Sciences

5
Martin Steinhoff
Martin Steinhoff

University of California

4
Mohammad Haris
Mohammad Haris

University of Pennsylvania

4
Ahmad Iskandarani
Ahmad Iskandarani

American University of Beirut

3