Scott W Lowe

Scott W Lowe

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MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.

Proc Natl Acad Sci U S A 2019 Feb 1. Epub 2019 Feb 1.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892;

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http://dx.doi.org/10.1073/pnas.1817494116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410784PMC
February 2019

MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.

Cell Mol Gastroenterol Hepatol 2019 11;7(4):803-817. Epub 2019 Feb 11.

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468197PMC
February 2019

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import.

Cell 2018 08 9;174(5):1200-1215.e20. Epub 2018 Aug 9.

Cancer Biology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA; Medical Oncology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA; Pathology Department, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150493PMC
August 2018

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy.

Immunity 2018 07 26;49(1):178-193.e7. Epub 2018 Jun 26.

Abramson Family Cancer Research Institute, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA; Department of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707727PMC
July 2018

Arid1a restrains Kras-dependent changes in acinar cell identity.

Elife 2018 07 17;7. Epub 2018 Jul 17.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, United States.

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http://dx.doi.org/10.7554/eLife.35216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050044PMC
July 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma.

Cancer Cell 2018 03 1;33(3):527-541.e8. Epub 2018 Mar 1.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881394PMC
March 2018

A Pipeline for Drug Target Identification and Validation.

Cold Spring Harb Symp Quant Biol 2016 5;81:257-267. Epub 2017 Jan 5.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York 10065.

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http://dx.doi.org/10.1101/sqb.2016.81.031096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469697PMC
February 2018

Differential Effector Engagement by Oncogenic KRAS.

Cell Rep 2018 02;22(7):1889-1902

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1450 3rd Street, San Francisco, CA 94158, USA; Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., P.O. Box B, Frederick, MD 21702, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.01.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343826PMC
February 2018

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.

Cell 2018 02;172(5):1007-1021.e17

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02210, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052445PMC
February 2018

Longitudinal Monitoring of Antibody Responses against Tumor Cells Using Magneto-nanosensors with a Nanoliter of Blood.

Nano Lett 2017 11 20;17(11):6644-6652. Epub 2017 Oct 20.

Department of Materials Science and Engineering, Stanford University , Stanford, California 94305, United States.

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http://dx.doi.org/10.1021/acs.nanolett.7b02591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851288PMC
November 2017

Putting p53 in Context.

Cell 2017 Sep;170(6):1062-1078

Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173095
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http://dx.doi.org/10.1016/j.cell.2017.08.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743327PMC
September 2017

USP39 Deubiquitinase Is Essential for Oncogene-driven Cancer.

J Biol Chem 2017 03 1;292(10):4164-4175. Epub 2017 Feb 1.

From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain,

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http://dx.doi.org/10.1074/jbc.M116.762757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354494PMC
March 2017

Using CRISPR/Cas to study gene function and model disease in vivo.

FEBS J 2016 09 16;283(17):3194-203. Epub 2016 Jun 16.

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1111/febs.13750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120361PMC
September 2016

Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.

J Cell Sci 2016 06 13;129(12):2307-15. Epub 2016 May 13.

Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 1L7, Canada Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, M5G 2M9, Canada Department of Medicine, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA 02215, USA

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http://dx.doi.org/10.1242/jcs.185413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920253PMC
June 2016

Coordinated Tumor Suppression by Chromosome 8p.

Cancer Cell 2016 05;29(5):617-619

Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120649PMC
May 2016

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas.

Proc Natl Acad Sci U S A 2016 Mar 29;113(11):3030-5. Epub 2016 Feb 29.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065; Howard Hughes Medical Institute, New York, NY 10065

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http://dx.doi.org/10.1073/pnas.1523693113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801318PMC
March 2016

Immunofluorescent Staining of Mouse Intestinal Stem Cells.

Bio Protoc 2016 Feb;6(4)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996654PMC
February 2016

Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells.

Bio Protoc 2016 Feb;6(4)

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996657PMC
February 2016

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma.

PLoS One 2015 4;10(3):e0118480. Epub 2015 Mar 4.

Cancer Genome Center, Cold Spring Harbor Laboratory, Woodbury, NY 11740, United States of America; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118480PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349704PMC
December 2015

Cancer: Mutant p53 and chromatin regulation.

Nature 2015 Sep 2;525(7568):199-200. Epub 2015 Sep 2.

Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature15212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683398PMC
September 2015

Direct and indirect targeting of MYC to treat acute myeloid leukemia.

Cancer Chemother Pharmacol 2015 Jul 9;76(1):35-46. Epub 2015 May 9.

Department of Laboratory Medicine and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Avenue, Room S-561, Box 0451, San Francisco, CA, 94143-0451, USA.

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http://dx.doi.org/10.1007/s00280-015-2766-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485702PMC
July 2015

Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Nat Genet 2015 May 30;47(5):539-43. Epub 2015 Mar 30.

1] Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. [2] Howard Hughes Medical Institute, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414804PMC
May 2015

Inducible in vivo genome editing with CRISPR-Cas9.

Nat Biotechnol 2015 Apr 18;33(4):390-394. Epub 2015 Feb 18.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1038/nbt.3155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390466PMC
April 2015

Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference.

PLoS One 2014 2;9(7):e101263. Epub 2014 Jul 2.

Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America; Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101263PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079684PMC
February 2015

Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.

Blood 2015 Feb 12;125(9):1444-51. Epub 2014 Dec 12.

Cancer Biology & Genetics Program, and Howard Hughes Medical Institute, and Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1182/blood-2014-09-601062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342356PMC
February 2015

Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging.

Sci Transl Med 2015 Jan;7(271):271ra7

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.3010633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414254PMC
January 2015

Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice.

PLoS One 2014 17;9(4):e95236. Epub 2014 Apr 17.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990578PMC
December 2014

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

Nature 2014 Dec 22;516(7531):423-7. Epub 2014 Oct 22.

Memorial Sloan Kettering Cancer Center, Cancer Biology and Genetics Program, 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature13902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270925PMC
December 2014

In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Nat Med 2014 Oct 14;20(10):1138-46. Epub 2014 Sep 14.

1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2] Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nm.3679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587571PMC
October 2014

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition.

Cell Rep 2014 Sep 18;8(6):1919-1929. Epub 2014 Sep 18.

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234106PMC
September 2014

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma.

Genes Dev 2014 Aug;28(16):1800-14

Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA; Cell and Developmental Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA;

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http://dx.doi.org/10.1101/gad.244368.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197965PMC
August 2014

p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.

Cell 2014 Jul;158(3):579-92

Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221237PMC
July 2014

PTEN action in leukaemia dictated by the tissue microenvironment.

Nature 2014 Jun 4;510(7505):402-6. Epub 2014 May 4.

1] Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [2] Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA [3] Howard Hughes Medical Institute, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature13239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165899PMC
June 2014

MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

Cancer Cell 2014 May 1;25(5):652-65. Epub 2014 May 1.

Cancer Biology and Genetics Program, Memorial-Sloan Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Memorial-Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206212PMC
May 2014

Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling.

Cell 2014 Apr;157(2):382-394

Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001090PMC
April 2014

Stable RNA interference rules for silencing.

Nat Cell Biol 2014 Jan;16(1):10-8

Howard Hughes Medical Institute and Memorial Sloan-Kettering Cancer Center, 415 East 68th Street, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb2895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001088PMC
January 2014

Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.

Proc Natl Acad Sci U S A 2013 Nov 23;110(48):19513-8. Epub 2013 Oct 23.

Cancer Biology and Genetics Program and Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1311707110
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http://dx.doi.org/10.1073/pnas.1311707110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845141PMC
November 2013

Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models.

Cold Spring Harb Protoc 2013 Nov 1;2013(11). Epub 2013 Nov 1.

Memorial Sloan-Kettering Cancer Center, New York, New York 10065;

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http://dx.doi.org/10.1101/pdb.top069856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102000PMC
November 2013

Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins.

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19519-24. Epub 2013 Nov 11.

Knight Cancer Institute, Howard Hughes Medical Institute, and Departments of Biochemistry and Molecular Biology and Cell and Developmental Biology, Oregon Health and Sciences University, Portland, OR 97239.

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http://dx.doi.org/10.1073/pnas.1319583110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845150PMC
November 2013

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.

BMC Pharmacol Toxicol 2013 Nov 13;14:58. Epub 2013 Nov 13.

Departments of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada.

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http://dx.doi.org/10.1186/2050-6511-14-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225821PMC
November 2013

A new development in senescence.

Cell 2013 Nov;155(5):977-8

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2013.10.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702512PMC
November 2013

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.

Genes Dev 2013 Sep;27(18):1974-85

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA;

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http://dx.doi.org/10.1101/gad.226613.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792474PMC
September 2013

Senescent cells spread the word: non-cell autonomous propagation of cellular senescence.

EMBO J 2013 Jul 18;32(14):1975-6. Epub 2013 Jun 18.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/emboj.2013.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715860PMC
July 2013