Sarah J Tabrizi

Sarah J Tabrizi

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Sarah J Tabrizi

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Fluid and imaging biomarkers for Huntington's disease.

Mol Cell Neurosci 2019 Jun 23;97:67-80. Epub 2019 Feb 23.

Huntington's Disease Centre, University College London (UCL) Institute of Neurology, London WC1N 3BG, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2019.02.004DOI Listing
June 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

N Engl J Med 2019 06 6;380(24):2307-2316. Epub 2019 May 6.

From University College London (UCL) Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, and the U.K. Dementia Research Institute at UCL, London (S.J.T., E.J.W.), the Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge (R.A.B., N.F.B.), Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, and the Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester (D.C.), the University of Edinburgh and the U.K. Dementia Research Institute, Edinburgh (J.P.), the Institute of Clinical Sciences, College of Medical and Dental Sciences, University Hospital Birmingham, Birmingham (H.R.), and the Cardiff University Brain Repair Group, Brain Repair and Intracranial Neurotherapeutics Unit, Neuroscience and Mental Health Research Institute and School of Biosciences, Cardiff (A.R.) - all in the United Kingdom; the Centre for Huntington's Disease, Department of Medical Genetics, and the Division of Neurology, Department of Medicine, University of British Columbia, and the Centre for Molecular Medicine and Therapeutics, B.C. Children's Hospital, Vancouver, Canada (B.R.L.); the Department of Neurology, Ulm University, Huntington's Disease Centre, Ulm (G.B.L.), the Department of Neurology, Huntington Center North Rhine-Westphalia, Ruhr University Bochum, St. Josef-Hospital, Bochum (C.S.), and the Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin (J.P.) - all in Germany; Ionis Pharmaceuticals, Carlsbad, CA (H.B.K., E.E.S., D.A.N., T.B., E.P., A.V.S., C.F.B., R.M.L.); and F. Hoffmann-La Roche, Basel, Switzerland (C.C., I.G., S.A.S.).

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http://dx.doi.org/10.1056/NEJMoa1900907DOI Listing
June 2019

Apathy Associated With Impaired Recognition of Happy Facial Expressions in Huntington's Disease.

J Int Neuropsychol Soc 2019 May 15;25(5):453-461. Epub 2019 Feb 15.

2Monash Institute of Cognitive and Clinical Neurosciences,School of Psychological Sciences,Monash University,Melbourne,Australia.

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http://dx.doi.org/10.1017/S1355617718001224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542690PMC
May 2019

Inhibition of tumour necrosis factor alpha in the R6/2 mouse model of Huntington's disease by etanercept treatment.

Sci Rep 2019 May 10;9(1):7202. Epub 2019 May 10.

Huntington's Disease Centre, Department of Neurodegenerative Disease and UK Dementia Research Institute, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1038/s41598-019-43627-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510744PMC
May 2019

Defining pediatric huntington disease: Time to abandon the term Juvenile Huntington Disease?

Mov Disord 2019 04 20;34(4):584-585. Epub 2019 Feb 20.

Swiss HD Center, Neurozentrum Siloah and Department of Neurology, University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1002/mds.27640DOI Listing
April 2019

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Neuron 2019 03;101(5):801-819

UBC Centre for Huntington's Disease, Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.neuron.2019.01.039DOI Listing
March 2019

FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.

Hum Mol Genet 2019 02;28(4):650-661

UCL Huntington's Disease Centre,Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London,Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1093/hmg/ddy375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360275PMC
February 2019

Automated Segmentation of Cortical Grey Matter from T1-Weighted MRI Images.

J Vis Exp 2019 Jan 7(143). Epub 2019 Jan 7.

Huntington's Disease Research Centre, UCL Institute of Neurology;

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http://dx.doi.org/10.3791/58198DOI Listing
January 2019

Executive impairment is associated with unawareness of neuropsychiatric symptoms in premanifest and early Huntington's disease.

Neuropsychology 2018 Nov 13;32(8):958-965. Epub 2018 Sep 13.

Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University.

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http://dx.doi.org/10.1037/neu0000479DOI Listing
November 2018

Altered Intracortical T-Weighted/T-Weighted Ratio Signal in Huntington's Disease.

Front Neurosci 2018 5;12:805. Epub 2018 Nov 5.

Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.3389/fnins.2018.00805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230564PMC
November 2018

In vivo characterization of white matter pathology in premanifest huntington's disease.

Ann Neurol 2018 10 15;84(4):497-504. Epub 2018 Sep 15.

Department of Computer Science and Centre for Medical Image Computing, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/ana.25309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221120PMC
October 2018

Huntington disease.

Handb Clin Neurol 2018 ;147:255-278

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/B97804446323330
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http://dx.doi.org/10.1016/B978-0-444-63233-3.00017-8DOI Listing
July 2018

Clinical Features of Huntington's Disease.

Adv Exp Med Biol 2018 ;1049:1-28

UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1007/978-3-319-71779-1_1DOI Listing
July 2018

In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington's disease.

Sci Rep 2018 Jul 30;8(1):11447. Epub 2018 Jul 30.

Huntington's Disease Centre, Department of Neurodegenerative Disease and Dementia Research Institute, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1038/s41598-018-29792-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065433PMC
July 2018

Overlap between age-at-onset and disease-progression determinants in Huntington disease.

Neurology 2018 06 9;90(24):e2099-e2106. Epub 2018 May 9.

From the Department of Neurodegenerative Disease (N.A.A., S.J.T.), UCL Huntington's Disease Centre, University College London Institute of Neurology, UK; Departments of Neurology (N.A.A.) and Public Health and Primary Care (J.M.M.v.d.B.), Leiden University Medical Centre, the Netherlands; Department of Population Health Sciences (N.A.A.), German Center for Neurodegenerative Diseases (DZNE), Bonn; and Department of Neurology (G.B.L.), Ulm University Hospital, Germany.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996832PMC
June 2018

Working Memory-Related Effective Connectivity in Huntington's Disease Patients.

Front Neurol 2018 4;9:370. Epub 2018 Jun 4.

Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.3389/fneur.2018.00370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994408PMC
June 2018

An image-based model of brain volume biomarker changes in Huntington's disease.

Ann Clin Transl Neurol 2018 May 2;5(5):570-582. Epub 2018 Apr 2.

Department of Computer Science Centre for Medical Image Computing University College London Gower Street London WC1E 6BT United Kingdom.

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http://dx.doi.org/10.1002/acn3.558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945962PMC
May 2018

Structural imaging in premanifest and manifest Huntington disease.

Handb Clin Neurol 2017 ;144:247-261

Center for Integrative Brain Research, Seattle Children's Research Institute, University of Washington, Seattle, WA, United States.

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http://dx.doi.org/10.1016/B978-0-12-801893-4.00020-1DOI Listing
March 2018

Brain Regions Showing White Matter Loss in Huntington's Disease Are Enriched for Synaptic and Metabolic Genes.

Biol Psychiatry 2018 03 26;83(5):456-465. Epub 2017 Oct 26.

Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square, London, United Kingdom; National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803509PMC
March 2018

Stimulating neural plasticity with real-time fMRI neurofeedback in Huntington's disease: A proof of concept study.

Hum Brain Mapp 2018 03 13;39(3):1339-1353. Epub 2017 Dec 13.

UCL Huntington's Disease Centre, Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/hbm.23921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838530PMC
March 2018

Motor cortex synchronization influences the rhythm of motor performance in premanifest huntington's disease.

Mov Disord 2018 03 22;33(3):440-448. Epub 2018 Jan 22.

Department of Neurology, Ulm University Hospital, Ulm, Germany.

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http://dx.doi.org/10.1002/mds.27285DOI Listing
March 2018

Predicting clinical diagnosis in Huntington's disease: An imaging polymarker.

Ann Neurol 2018 03 13;83(3):532-543. Epub 2018 Mar 13.

The Computational, Cognitive & Clinical Neuroimaging Laboratory (CNL), Division of Brain Sciences, Imperial College London, United Kingdom.

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http://dx.doi.org/10.1002/ana.25171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900832PMC
March 2018

Neurofilament light protein in blood predicts regional atrophy in Huntington disease.

Neurology 2018 02 24;90(8):e717-e723. Epub 2018 Jan 24.

From the Huntington's Disease Research Centre (E.B.J., L.M.B., S.G., F.B.R., S.J.T., R.I.S., E.J.W.), UCL Institute of Neurology, London, UK; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Institut du Cerveau et de la Moelle épinière (A.D.), Sorbonne Universités, UPMC University Paris 06, UMRS 1127, INSERM, U 1127, CNRS, UMR 7225; APHP (A.D.), Genetics Department, Pitié-Salpêtrière University Hospital, Paris, France; Centre for Molecular Medicine and Therapeutics (B.R.L.), University of British Columbia, Vancouver, BC, Canada; Department of Neurology (R.A.R.), Leiden University, the Netherlands; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; and UK Dementia Research Institute (H.Z.), London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000005005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818166PMC
February 2018

Test-Retest Reliability of Measures Commonly Used to Measure Striatal Dysfunction across Multiple Testing Sessions: A Longitudinal Study.

Front Psychol 2017 12;8:2363. Epub 2018 Jan 12.

Huntington's Disease Centre, Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fpsyg.2017.02363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770367PMC
January 2018

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

Neurology 2017 Dec 15;89(24):2495-2502. Epub 2017 Nov 15.

From F. Hoffman-La Roche, Ltd (S.A.S., G.P., O.S.K., D.T., J.J.S.), Roche Innovation Center, Basel, Switzerland; University of Rochester (P.A., S.M., E.R.D., K.D.K.), NY; University of Iowa (J.D.L., D.R.L.), Iowa City; Massachusetts General Hospital and Harvard Medical School (M.C., S.H.), Boston; CHDI Management/Foundation (C.S.), Princeton, NJ; University of British Columbia, Vancouver, Canada (B.R.L.); and University College London (S.J.T.), UK.

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http://dx.doi.org/10.1212/WNL.0000000000004743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729794PMC
December 2017

Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis.

JAMA Neurol 2017 11;74(11):1352-1360

Huntington's Disease Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, England.

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http://dx.doi.org/10.1001/jamaneurol.2017.2107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710578PMC
November 2017

Therapies targeting DNA and RNA in Huntington's disease.

Lancet Neurol 2017 10 12;16(10):837-847. Epub 2017 Sep 12.

Huntington's Disease Centre, University College London Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(17)30280-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604739PMC
October 2017

Gene suppression approaches to neurodegeneration.

Alzheimers Res Ther 2017 Oct 5;9(1):82. Epub 2017 Oct 5.

UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1186/s13195-017-0307-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629803PMC
October 2017

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington's Disease.

Front Neurol 2017 10;8:519. Epub 2017 Oct 10.

Huntington's Disease Centre, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fneur.2017.00519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641297PMC
October 2017

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.

Lancet Neurol 2017 09 20;16(9):701-711. Epub 2017 Jun 20.

UCL Huntington's Disease Centre, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30161-8DOI Listing
September 2017

Measuring compensation in neurodegeneration using MRI.

Curr Opin Neurol 2017 08;30(4):380-387

aHuntington's Disease Research Centre, UCL Institute of Neurology, London, UK bDepartments of Psychiatry and Biostatistics, University of Iowa, Iowa City, Iowa, USA cWellcome Trust Centre for Neuroimaging dInstitute of Cognitive Neuroscience, University College London, London, UK.

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http://dx.doi.org/10.1097/WCO.0000000000000469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837021PMC
August 2017

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.

Sci Rep 2017 05 2;7(1):1307. Epub 2017 May 2.

UCL Huntington's Disease Centre, Sobell Department of Motor Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-01510-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431000PMC
May 2017

Allele-Selective Suppression of Mutant Huntingtin in Primary Human Blood Cells.

Sci Rep 2017 04 24;7:46740. Epub 2017 Apr 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1038/srep46740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402279PMC
April 2017

Validation of a prognostic index for Huntington's disease.

Mov Disord 2017 02 28;32(2):256-263. Epub 2016 Nov 28.

CHDI Management/CHDI Foundation, Princeton, New Jersey, USA.

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http://dx.doi.org/10.1002/mds.26838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318276PMC
February 2017

DNA repair in the trinucleotide repeat disorders.

Lancet Neurol 2017 Jan;16(1):88-96

UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(16)30350-7DOI Listing
January 2017

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington's Disease.

J Huntingtons Dis 2015 ;4(4):371-82

Brain Disease Biomarker unit, Department of Experimental Medical Science, Wallenberg Neuroscience Centre, Lund University, Lund, Sweden.

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http://dx.doi.org/10.3233/JHD-150172DOI Listing
October 2016

The Prevalence of Huntington's Disease.

Neuroepidemiology 2016 30;46(2):144-53. Epub 2016 Jan 30.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1159/000443738DOI Listing
October 2016

Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease.

J Neurochem 2016 10 20;139(1):22-5. Epub 2016 Sep 20.

Huntington's Disease Centre, Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1111/jnc.13719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053298PMC
October 2016

Loss of extra-striatal phosphodiesterase 10A expression in early premanifest Huntington's disease gene carriers.

J Neurol Sci 2016 Sep 15;368:243-8. Epub 2016 Jul 15.

Neurodegeneration Imaging Group, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.07.033DOI Listing
September 2016

George Huntington: a legacy of inquiry, empathy and hope.

Brain 2016 08 14;139(Pt 8):2326-33. Epub 2016 Jul 14.

2 Huntington's Disease Centre, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1093/brain/aww165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958906PMC
August 2016

Neuropsychiatry and White Matter Microstructure in Huntington's Disease.

J Huntingtons Dis 2015 ;4(3):239-49

Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.3233/JHD-150160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684097PMC
July 2016

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes.

PLoS One 2015 3;10(11):e0141793. Epub 2015 Nov 3.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0141793PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631523PMC
June 2016

Laquinimod dampens hyperactive cytokine production in Huntington's disease patient myeloid cells.

J Neurochem 2016 06 5;137(5):782-94. Epub 2016 Apr 5.

Department of Neurodegenerative Diseases, University College London, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.

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http://dx.doi.org/10.1111/jnc.13553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982105PMC
June 2016

Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system.

Acta Neuropathol 2016 Mar 8;131(3):411-25. Epub 2015 Dec 8.

Department of Neurodegenerative Disease, University College London, Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

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http://link.springer.com/10.1007/s00401-015-1508-y
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http://dx.doi.org/10.1007/s00401-015-1508-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752964PMC
March 2016

Disruption of immune cell function by mutant huntingtin in Huntington's disease pathogenesis.

Curr Opin Pharmacol 2016 Feb 19;26:33-8. Epub 2015 Oct 19.

UCL Institute of Neurology, Department of Neurodegenerative Disease, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2015.09.008DOI Listing
February 2016

Incidence of adult Huntington's disease in the UK: a UK-based primary care study and a systematic review.

BMJ Open 2016 Feb 23;6(2):e009070. Epub 2016 Feb 23.

Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.1136/bmjopen-2015-009070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769413PMC
February 2016

Large-scale brain network abnormalities in Huntington's disease revealed by structural covariance.

Hum Brain Mapp 2016 Jan 10;37(1):67-80. Epub 2015 Oct 10.

Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/hbm.23014DOI Listing
January 2016

Short-interval observational data to inform clinical trial design in Huntington's disease.

J Neurol Neurosurg Psychiatry 2015 Dec 10;86(12):1291-8. Epub 2015 Feb 10.

Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1136/jnnp-2014-309768DOI Listing
December 2015

Detection of Motor Changes in Huntington's Disease Using Dynamic Causal Modeling.

Front Hum Neurosci 2015 25;9:634. Epub 2015 Nov 25.

Department of Psychiatry and Psychotherapy, University Medical Center Freiburg Freiburg, Germany ; Freiburg Brain Imaging Center, University Medical Center Freiburg Freiburg, Germany ; Department of Neurology, University Medical Center Freiburg Freiburg, Germany.

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http://dx.doi.org/10.3389/fnhum.2015.00634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658414PMC
December 2015

Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies.

J Neuropsychiatry Clin Neurosci 2015 ;27(1):59-64

From the Cardiff University, School of Biosciences, Cardiff, United Kingdom (JC). Institute of Human Development, Faculty of Medicine and Human Sciences, University of Manchester and Manchester Academic Health Science Centre, Manchester, United Kingdom (CS, NA, DC); Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom (CS, DC); Dept. of Neuropsychology, Salford Royal Hospital NHS Foundation Trust, Salford, United Kingdom (NA); Centre de Référence National pour la Maladie de Huntington, AP-HP, Groupe Henri Mondor-Albert Chenevier, Créteil, France (M-FB, A-CB-L, CB); University of British Columbia, The Centre for Huntington's disease, Vancouver, Canada (AC, RDS); Leiden University Medical Centre, Department of Neurology, Leiden, The Netherlands (EMD, EPH, RACR); UPMC UnivParis06, UMR_S975 and Inserm, UMR_S975, CRICM and CNRS UMR7225, F-75013, Paris, France (DJ, AD); University College London, Institute of Neurology, London, United Kingdom (GO, JR, MJS, SJT); Brain and Spine Institute (ICM), F-75013, Paris, France (AD); AP-HP Pitie-Salpetriere Hospital, Dept. of Genetics and Cytogenetics, F-75013, Paris, France (AD); University of British Columbia, Centre for Molecular Medicine and Therapeutics, Vancouver, Canada (BRL); Service de Psychiatrie, 93G18, EPSVE, 93330 Neuilly-sur-Marne, France (CB); and Dept. of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands (EvD).

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http://dx.doi.org/10.1176/appi.neuropsych.13070169DOI Listing
November 2015

Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers.

Neurobiol Dis 2015 Nov 18;83:115-21. Epub 2015 Aug 18.

Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.08.011DOI Listing
November 2015

Treating the whole body in Huntington's disease.

Lancet Neurol 2015 Nov;14(11):1135-42

Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(15)00177-5DOI Listing
November 2015

Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.

Brain 2015 Oct 21;138(Pt 10):3016-29. Epub 2015 Jul 21.

1 Neurodegeneration Imaging Group, Department of Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK 2 Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK

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http://dx.doi.org/10.1093/brain/awv214DOI Listing
October 2015

Prion degradation pathways: Potential for therapeutic intervention.

Mol Cell Neurosci 2015 May 10;66(Pt A):12-20. Epub 2015 Jan 10.

Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2014.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503822PMC
May 2015

Basal ganglia-cortical structural connectivity in Huntington's disease.

Hum Brain Mapp 2015 May 30;36(5):1728-40. Epub 2015 Jan 30.

Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.

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http://dx.doi.org/10.1002/hbm.22733DOI Listing
May 2015

Huntington disease.

Nat Rev Dis Primers 2015 04 23;1:15005. Epub 2015 Apr 23.

Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1038/nrdp.2015.5DOI Listing
April 2015

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.

Mov Disord 2015 Mar 18;30(3):393-401. Epub 2015 Feb 18.

Centre for Molecular Medicine & Therapeutics, Vancouver, Canada; Centre for Huntington Disease, University of British Columbia (UBC) Hospital, Vancouver, Canada.

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http://dx.doi.org/10.1002/mds.26118DOI Listing
March 2015

Inconsistent emotion recognition deficits across stimulus modalities in Huntington׳s disease.

Neuropsychologia 2014 11 22;64:99-104. Epub 2014 Sep 22.

University College London, Institute of Neurology, Queen Square, c/o Box 104, London WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuropsychologia.2014.09.023DOI Listing
November 2014

Targets for future clinical trials in Huntington's disease: what's in the pipeline?

Mov Disord 2014 Sep 25;29(11):1434-45. Epub 2014 Aug 25.

Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology & Neurosurgery, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1002/mds.26007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265300PMC
September 2014