Publications by authors named "Sadik Etka Bayramoglu"

10 Publications

  • Page 1 of 1

Inter-eye comparison of retinal vascular growth rate and angiographic findings following unilateral bevacizumab treatment.

Eur J Ophthalmol 2021 Dec 1:11206721211064019. Epub 2021 Dec 1.

Departmant of Health Science University Kanuni Sultan Suleyman Training and Research Hospital, Tertiary ROP Center, Istanbul, Turkey.

Purpose: To compare retinal vascularization progression rate, final retinal vascularization, and fluorescein angiography (FA) findings in infants who received intravitreal bevacizumab (IVB) treatment in one eye and with spontaneous regression in the other eye.

Methods: Thirty eyes of 15 infants who underwent IVB in one eye due to asymmetric retinopathy of prematurity, and who had pre-treatment fundus photographs and fluorescein angiography images were included in the study. Horizontal disc diameter (DD), optic disc-to-fovea distance (FD), and the length of temporal retinal vascularization (LTRV) distance were measured by evaluating pre-treatment and FA images.

Results: The mean ages at the time of treatment and FA were 40.38  ±  3.35 and 68.72  ±  10.52 weeks postmenstrual age, respectively. The pre-treatment LTRV/FD ratio was 3.11  ±  0.41 in the treated eyes and 3.26  ±  0.43 in the non-treated eyes (p  =  0.053). The final LTRV/FD ratio was 4.23  ±  0.38 in the treated group and 4.33  ±  0.37 in the non-treated group (p  =  0.286). Staining of the vessels, hyperfluorescent focus, and irregular branching of the vessels were similar between the groups, respectively (p  =  1.000; p  =  0.250; p  =  0.625).

Conclusion: The progression rate of retinal vascularization and angiographic findings were similar between the treated eyes and the non-treated eyes. Our study suggests that incomplete retinal vascularization in eyes treated with anti-vascular endothelial growth factor (VEGF) is due to the nature of the disease, and anti-VEGF treatment was not to cause cessation in vascular progression.
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http://dx.doi.org/10.1177/11206721211064019DOI Listing
December 2021

The effect of intravitreal bevacizumab dose on retinal vascular progression in retinopathy of prematurity.

Ophthalmologica 2021 Nov 29. Epub 2021 Nov 29.

Introduction: In this study, we investigate the effect of drug dose on the progression of retinal vascularization in eyes treated with different doses of intravitreal bevacizumab (IVB).

Methods: The patient charts of 259 eyes of 142 patients who were administered 0.3125 mg or 0.625 mg IVB as primary therapy for type 1 ROP or aggressive ROP (A-ROP) were retrospectively evaluated. Eighty-four eyes of 42 infants met all study inclusion criteria and underwent further morphological evaluation. Eyes treated with 0.3125 mg and 0.625 mg bevacizumab were grouped as the low dose and standard dose groups, respectively. Horizontal disc diameter (DD), optic disc-to-fovea distance (FD), and the length of temporal retinal vascularization (LTRV) were measured on pre-treatment photographs (PP) and final fluorescein angiography (FA) images. LTRV, measured in pixels, was converted to DD and FD units and analyzed. All PPs and FA images were captured with 130° PanoCam Pro camera. The difference between final LTRV and pre-treatment LTRV was defined as the difference of LTRV. The ratio of difference of LTRV to pre-treatment LTRV was defined as the rate of increase of LTRV.

Results: Of the 255 eyes, re-treatment rate before 55 weeks postmenstrual age (PMA) was 23% in the eyes treated with 0.3125 mg IVB and 19% in the eyes treated with 0.625 mg IVB (p = 0.362). Of the 42 infants included for further morphological evaluation, the median age at the time of treatment was 36 (35-38) weeks PMA, and the median age at the time of FA imaging was 66 (62-75) weeks PMA. While the difference of LTRV by unit of DD was higher in the low dose group (p=0.017), this difference was similar between groups by unit of FD (p=0.412). The ratio of the increase of the LTRV was similar between groups by units of DD and FD (p=0.081, p=0.390; respectively). The FD/DD ratio was 4.13 ± 0.49 and 3.26 ± 0.33 at the pre-treatment and final sessions, respectively (p=0.000).

Conclusion: The ratio of FD to DD decreased significantly with increasing age. The additional treatment rate and progression of retinal vascularization by unit of FD were similar between the groups. The difference of LTRV by unit of DD was higher in the low dose group. The usage of different formulas and methods may affect the evaluation of the progression of retinal vascularization.
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http://dx.doi.org/10.1159/000521070DOI Listing
November 2021

Anterior Segment Analysis and Evaluation of Corneal Biomechanical Properties in Children with Joint Hypermobility.

Turk J Ophthalmol 2020 04;50(2):71-74

University of Health Sciences Şanlıurfa Training and Research Hospital, Clinic of Pediatric Rheumatology, Şanlıurfa, Turkey.

Objectives: To compare anterior segment parameters and biomechanical analysis of the cornea in children with joint hypermobility (JH) and healthy children.

Materials And Methods: Cross-sectional case-control study. Fifty eyes of 25 children with JH were compared with 74 eyes of 37 healthy age- and sex-matched controls in terms of refractive, anterior segment topographic, and corneal biomechanical measurements. Axial length (AL) was measured with a Nidek AL-Scan biometry device; corneal-compensated intraocular pressure (IOPcc), Goldmann-correlated IOP (IOPg), corneal hysteresis (CH), and corneal resistance factor (CRF) were measured with a Reichert ocular response analyzer (ORA). Central corneal thickness (CCT), anterior chamber depth (ACD), K1/K2 values, iris diameter, and anterior chamber volume (ACV) were measured with a Sirius topography device.

Results: Mean age in the JH group was 10.56±4.03 years, while that of the control group was 11.27±2.59 years (p=0.23). Spherical equivalent was -0.22±1.02 diopter (D) in the JH group and -0.12±1.12 D in the control group (p=0.60); CCT was 23.01±0.82 µm in the JH group and 23.17±0.82 µm in the control group (p=0.33). There were no significant differences between the two groups in terms of age, sex, IOP, IOPcc, IOPg, CH, CRF, AL, K1, K2, iris diameter, ACD, and ACV.

Conclusion: JH, which causes increased flexibility of the joints, was concluded not to cause a significant change in the corneal biomechanical markers of CRF and CH or in anterior segment topographic parameters.
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http://dx.doi.org/10.4274/tjo.galenos.2019.28000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204896PMC
April 2020

Comparison of two different treatment regimens' efficacy in neovascular age-related macular degeneration in Turkish population-based on real life data-Bosphorus RWE Study Group.

Int J Ophthalmol 2020 18;13(1):104-111. Epub 2020 Jan 18.

Ophthalmology Clinic, Bağcılar Training and Research Hospital, Istanbul 34200, Turkey.

Aim: To compare two different anti-vascular endothelial growth factor (anti-VEGF) treatment regimens'-a priori (PRN) and PRN regimen following the loading phase-anatomical and functional results in neovascular age-related macular degeneration (nAMD) patients.

Methods: Totally 544 nAMD patients followed and treated with aflibercept (=135) and ranibizumab (=409) at 9 different centers between 2013 and 2015 were enrolled into this retrospective multicenter study. Patients with initial best corrected visual acuity (BCVA) interval of 1.3-0.3 (logMAR) and a minimum follow-up of 12mo were included. Patients under two different regimens-a priori (1+PRN) or 3 consecutive intravitreal injections followed by a PRN regimen (3+PRN)-were compared in BCVA at 3, 6 and 12 months, and in central macular thickness (CMT) at 6 and 12 months. The total study group, intravitreal ranibizumab (IVR) and intravitreal aflibercept (IVA) groups were evaluated separately.

Results: The mean CMT decreased in the 1+PRN (=101) regimen from 407 to 358 and 340 µm and in the 3+PRN (=443) group from 398 to 318 and finally to 310 µm at months 6 and 12, respectively. Anatomically, the CMT reduction at 6 month (48.5 76.4; <0.05) was statistically significant in favor of 3+PRN group. BCVA changed in 1+PRN group from 0.77 to 0.78, 0.75 and 0.75; in 3+PRN group from 0.81 to 0.69, 0.72, and 0.76 at months 3, 6, and 12, respectively. Visual gain was statistically better in 3+PRN group at 3 month (-0.01 0.12; <0.001). In IVR group, CMT reduction was in greater in 3+PRN at 6 (44 72) and 12 month (61 84), but statistically insignificant. The 3+PRN group revealed statistically better visual results at 3 month (-0.02 0.11, <0.05). In IVA group, although statistically insignificant, CMT reduction (61 89, 6 month; 85 97, 12 month) and visual gain (0.02 0.16; 0.02 0.14; 0.05 0.11) was found in favor of 3+PRN group at all visits.

Conclusion: The loading dose of anti-VEGF treatments in nAMD leads to significantly better anatomical and functional results, regardless of the agent, specially in early follow-up interval.
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http://dx.doi.org/10.18240/ijo.2020.01.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942941PMC
January 2020

Correction to: Assessment of vascular leakage and its development with FFA among patients treated with intravitreal anti-VEGF due to aggressive posterior ROP.

Int Ophthalmol 2019 12;39(12):2707

The Department of Anesthesiology, Istanbul Bakirköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.

In the original publication, the authors' affiliations were published incorrectly.
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http://dx.doi.org/10.1007/s10792-019-01220-7DOI Listing
December 2019

Assessment of vascular leakage and its development with FFA among patients treated with intravitreal anti-VEGF due to aggressive posterior ROP.

Int Ophthalmol 2019 Dec 4;39(12):2697-2705. Epub 2019 Mar 4.

Gazi Yaşargil Eğitim ve Araştırma Hastanesi, Diyarbakir, Turkey.

Objective: Evaluation of vascular leakage and retinal vascular development with fundus fluorescein angiography for infants diagnosed with aggressive posterior retinopathy of prematurity who underwent intravitreal anti-VEGF treatment.

Method: Medical recordings of 30 patients who received RetCam fluorescein angiography during follow-up and had been treated with anti-VEGF on diagnosis of aggressive posterior ROP in the zone I or zone II between the dates of April 2014-January 2017 were evaluated retrospectively.

Results: Fifty-nine eyes of 30 patients were included in the study. Mean birth weight was 1145 g; gestation week was 28.4. Recurrence occurred in 30.5% of the patients, and 10.1% of them were given a second dose of injection of anti-VEGF. Leakage was detected in 15.3% of the eyes during angiography, and all of these eyes were treated with laser photocoagulation. Evaluation of vascular development revealed that in the temporal, complete retinal vascular development was achieved in only 8% of the eyes. It was detected that complete retinal vascularization was not observed in any of the cases which were given second dose of injection due to recurrence. The patients were distributed into groups according to postmenstrual week taken to angiography as 32 eyes of 16 patients in group 1, 17 eyes of 9 patients in group 2 and 10 eyes of 5 patients in group 3. The vascular leakage rate of group 3 patients was statistically significantly higher (p < 0.05) and vascular development between groups was not statistically significant (p > 0.05).

Discussion: With the initiation of FFA usage in pediatric cases, especially treated with anti-VEGF due to retinopathy of prematurity (ROP), more findings (vascular arrest, leakage, and abnormalities, etc.) are obtained than those achieved via ophthalmoscopic examination. In the light of these findings, early intervention with laser photocoagulation in early stages becomes possible enabling prevention of possible blindness.
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http://dx.doi.org/10.1007/s10792-019-01088-7DOI Listing
December 2019

Evaluation of choroidal thickness measurements in patients with marked nasal septal deviation.

Braz J Otorhinolaryngol 2020 Mar - Apr;86(2):242-246. Epub 2018 Dec 31.

Istanbul Kanuni Sultan Süleyman Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, Turkey.

Introduction: Chronic upper airway obstruction due to marked nasal septal deviation may cause chronic hypoxia. It may change the balance of the sympathetic-parasympathetic system and may affect blood flow in the choroid.

Objective: To assess choroidal thickness measurements of patients with marked nasal septal deviation.

Methods: The patients who had nasal obstruction symptoms diagnosed with marked nasal septal deviation by anterior rhinoscopy and nasal endoscopy and scheduled for septoplasty were included in the study. The control group consisted of age, sex and body mass index-matched healthy individuals. The choroidal measurements at the central fovea and 1000μm away from the fovea in the nasal and temporal regions were performed using enhanced depth imaging optical coherence tomography.

Results: In the study group, 52 eyes of 26 patients with a mean age of 26.34±8.14 years were examined. In the control group, 52 eyes of 28 healthy individuals with a mean age of 26.69±7.84 years were examined. There was no statistically significant difference in terms of choroidal thickness measurements between the groups (p>0.05).

Conclusion: Our results suggest that marked nasal septal deviation may not lead to significant hypoxia and sympathetic activation, resulting in deterioration of the choroidal blood flow and consequent choroidal thickening.
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http://dx.doi.org/10.1016/j.bjorl.2018.11.009DOI Listing
May 2020

The Effect of Acute Hypovolemia on the Eye.

Curr Eye Res 2018 07 4;43(7):949-954. Epub 2018 Apr 4.

e Department of Ophthalmology , Gaziantep University Faculty of Medicine , Gaziantep , Turkey.

Introduction: To investigate the effects of acute hypovolemia induced by blood donation on the eye. Methods or Study Design: This prospective, observational study included a single eye from each of 48 healthy men between 20 and 40 years of age who had donated 500 ml of blood and 28 eyes of 28 healthy, age- and gender-matched control subjects. The ocular parameters including ocular perfusion pressure (OPP), intraocular pressure (IOP), axial length (AL), central corneal thickness (CCT), choroidal and retinal thicknesses, and retinal nerve fiber layer (RNFL) were measured before blood donation and at 10 min and 1, 2, 3, and 4 h after blood donation.

Results: The mean OPP was significantly reduced following blood donation (baseline, 43.4 ± 4.9 vs. 40.8 ± 4.6 mmHg; p = 0.003). The mean subfoveal choroidal thickness (SFCT) was measured as 322.96 ± 76.23, 291.63 ± 77.85, 309.77 ± 75.72, 312.31 ± 75.98, 315.73 ± 75.43, and 317.75 ± 75.73 µm before blood donation, at baseline, 10 min, and 1, 2, 3, and 4 h following donation, respectively [F(2.462, 115.731) = 22.618, p < 0.001]. In the control group, the SFCT was measured as 302.04 ± 32.04, 301.43 ± 35.16, 298.07 ± 37.33, 298.96 ± 39.17, 302.54 ± 39.24, and 301.61 ± 40.41 µm at baseline, 10 min, and 1, 2, 3, and 4 h following donation, respectively [F(2.124, 57.340) = 0.592, p = 0.566]. There was no difference in AL, CCT, RNFL, retinal thicknesses, and IOP measurements performed before and after blood donation (p > 0.05).

Conclusions: Acute hypovolemia caused a significant reduction in SFCT which persisted for 3 h. This study may pave way for better understanding of choroidal thickness changes in disease states.
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http://dx.doi.org/10.1080/02713683.2018.1453077DOI Listing
July 2018

Delayed diagnosis of an intraorbital wooden foreign body.

Orbit 2018 Dec 22;37(6):468-471. Epub 2018 Feb 22.

c Istanbul Medicine Faculty, Radiology Department , Istanbul University , Istanbul , Turkey.

A 35-year-old male patient was presented with pain on his right upper eyelid. A piece of wood injured his orbital and supraorbital regions while working at a furniture factory 10 days prior to our hospital admission. It was learned that the patient was discharged following the primary would closure procedure. Subsequent to the craniofacial computed tomography, primary wound closure was performed in the emergency room of previous hospital. In our clinic, a skin suturing on the nasal side of the right eyebrow was inspected and a foreign body (FB) was palpated on the superonasal contiguity of the patients' right globe. A hyperdense FB measuring 30 × 10 × 5 mm in size with smooth margins on superonasal contour of the globe was detected. Superonasal orbitotomy was performed and the FB was completely removed. Finally, visual acuity was 20/20 and a mild residual ptosis was observed.
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http://dx.doi.org/10.1080/01676830.2018.1440606DOI Listing
December 2018

Evaluation of choroidal thickness in children with adenoid hypertrophy.

Eur Arch Otorhinolaryngol 2018 Feb 8;275(2):439-442. Epub 2018 Jan 8.

Otolaryngology Clinic, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

Objective: To assess choroidal thickness in children with adenoid hypertrophy versus normal controls using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: Twenty-six children (left and right eyes, total 52 eyes), which were scheduled to adenoidectomy with severe adenoid hypertrophy and 26 age, sex and body mass index-matched healthy subjects (left and right eyes, total 52 eyes) were included in the study. Choroidal thicknesses (CT) were evaluated using enhanced depth imaging optical coherence tomography. The CT measurement was taken at the fovea and 1000 μ away from the fovea in the nasal and temporal regions. The macular retinal thickness was also measured.

Results: There was no statistically significant difference in the CT of all regions between the groups (p > 0.05). No statistically significant difference was found between two groups in terms of macular choroidal thickness (p > 0.05).

Conclusion: These results revealed that severe adenoid hypertrophy did not cause a significant effect on choroidal thickness. Short-term exposure to obstructive symptoms in children and preserved sympathetic-parasympathetic balance may explain this result.
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http://dx.doi.org/10.1007/s00405-017-4846-7DOI Listing
February 2018
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