Rudolph L Leibel

Rudolph L Leibel

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Rudolph L Leibel

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Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Naomi Berrie Diabetes Center & Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1172/jci.insight.123337DOI Listing
February 2019

DMSO increases efficiency of genome editing at two non-coding loci.

PLoS One 2018 4;13(6):e0198637. Epub 2018 Jun 4.

Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198637PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986138PMC
January 2019

ILDR2 has a negligible role in hepatic steatosis.

PLoS One 2018 30;13(5):e0197548. Epub 2018 May 30.

Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197548PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976177PMC
December 2018

Triiodothyronine and leptin repletion in humans similarly reverse weight-loss-induced changes in skeletal muscle.

Am J Physiol Endocrinol Metab 2018 Nov 19;315(5):E771-E779. Epub 2018 Jun 19.

Departments of Pediatrics and Medicine, Columbia University College of Physicians and Surgeons, New York, New York.

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https://www.physiology.org/doi/10.1152/ajpendo.00116.2018
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http://dx.doi.org/10.1152/ajpendo.00116.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293163PMC
November 2018

Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells.

Curr Protoc Hum Genet 2018 10 7;99(1):e68. Epub 2018 Sep 7.

Naomi Berrie Diabetes Center & Department of Pediatrics, College of Physicians and Surgeons, Columbia University Medical Center, New York.

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http://doi.wiley.com/10.1002/cphg.68
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http://dx.doi.org/10.1002/cphg.68DOI Listing
October 2018

Resistance Training Reduces Skeletal Muscle Work Efficiency in Weight-Reduced and Non-Weight-Reduced Subjects.

Obesity (Silver Spring) 2018 Oct 27;26(10):1576-1583. Epub 2018 Sep 27.

Division of Endocrinology, Diabetes, & Metabolism, New York Weill Cornell Medical Center Comprehensive Weight Control Center, New York, New York, USA.

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http://doi.wiley.com/10.1002/oby.22274
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http://dx.doi.org/10.1002/oby.22274DOI Listing
October 2018

The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function.

FASEB J 2018 07 21;32(7):3946-3956. Epub 2018 Feb 21.

Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1096/fj.201701216RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998974PMC
July 2018

FTO genotype impacts food intake and corticolimbic activation.

Am J Clin Nutr 2018 Feb;107(2):145-154

Departments of Medicine and Radiology, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1093/ajcn/nqx029DOI Listing
February 2018

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells.

Diabetes 2018 01 20;67(1):26-35. Epub 2017 Sep 20.

Naomi Berrie Diabetes Center and Department of Pediatrics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY

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http://dx.doi.org/10.2337/db17-0120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741143PMC
January 2018

Energy homeostasis in leptin deficient Lepob/ob mice.

PLoS One 2017 20;12(12):e0189784. Epub 2017 Dec 20.

Department of Pediatrics, Columbia University, New York City, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189784PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738099PMC
January 2018

Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain.

PLoS One 2017 20;12(1):e0168226. Epub 2017 Jan 20.

Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249166PMC
August 2017

Obesity Pathogenesis: An Endocrine Society Scientific Statement.

Endocr Rev 2017 08;38(4):267-296

Naomi Berrie Diabetes Center and Department of Pathology and Cell Biology, Columbia University, New York, New York 10032.

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http://academic.oup.com/edrv/article/38/4/267/3892397/Obesit
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http://dx.doi.org/10.1210/er.2017-00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546881PMC
August 2017

PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons.

Stem Cell Reports 2017 02 26;8(2):264-277. Epub 2017 Jan 26.

Division of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, 1150 St. Nicholas Avenue, Room 620A, New York, NY 10032, USA; Department of Medicine and Naomi Berrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312251PMC
February 2017

Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS.

Stem Cell Res 2016 11 16;17(3):526-530. Epub 2016 Aug 16.

Columbia University, Department of Pediatrics, Division of Molecular Genetics, United States; Naomi Berrie Diabetes Center, United States; New York Obesity Research Center, United States. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.08.008DOI Listing
November 2016

Reply to DS Ludwig and CB Ebbeling.

Am J Clin Nutr 2016 11;104(5):1488-1490

From the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD (KDH, e-mail: KYC; JG; MLR); Columbia University, New York, NY (RLL, LESM, MR, BTW); Pennington Biomedical Research Center, Baton Rouge, LA (ER); and The Translational Research Institute for Metabolism and Diabetes, Orlando, FL (SRS).

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http://dx.doi.org/10.3945/ajcn.116.143628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081725PMC
November 2016

ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.

Biochem Biophys Res Commun 2016 09 25;477(4):712-716. Epub 2016 Jun 25.

Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2016.06.124DOI Listing
September 2016

Models of energy homeostasis in response to maintenance of reduced body weight.

Obesity (Silver Spring) 2016 08;24(8):1620-9

Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1002/oby.21559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965234PMC
August 2016

Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells.

Curr Protoc Hum Genet 2016 07 1;90:21.5.1-21.5.14. Epub 2016 Jul 1.

Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York.

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http://dx.doi.org/10.1002/cphg.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963463PMC
July 2016

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Authors:
Tuomas O Kilpeläinen Jayne F Martin Carli Alicja A Skowronski Qi Sun Jennifer Kriebel Mary F Feitosa Åsa K Hedman Alexander W Drong James E Hayes Jinghua Zhao Tune H Pers Ursula Schick Niels Grarup Zoltán Kutalik Stella Trompet Massimo Mangino Kati Kristiansson Marian Beekman Leo-Pekka Lyytikäinen Joel Eriksson Peter Henneman Jari Lahti Toshiko Tanaka Jian'an Luan Fabiola Del Greco M Dorota Pasko Frida Renström Sara M Willems Anubha Mahajan Lynda M Rose Xiuqing Guo Yongmei Liu Marcus E Kleber Louis Pérusse Tom Gaunt Tarunveer S Ahluwalia Yun Ju Sung Yolande F Ramos Najaf Amin Antoinette Amuzu Inês Barroso Claire Bellis John Blangero Brendan M Buckley Stefan Böhringer Yii-Der I Chen Anton J N de Craen David R Crosslin Caroline E Dale Zari Dastani Felix R Day Joris Deelen Graciela E Delgado Ayse Demirkan Francis M Finucane Ian Ford Melissa E Garcia Christian Gieger Stefan Gustafsson Göran Hallmans Susan E Hankinson Aki S Havulinna Christian Herder Dena Hernandez Andrew A Hicks David J Hunter Thomas Illig Erik Ingelsson Andreea Ioan-Facsinay John-Olov Jansson Nancy S Jenny Marit E Jørgensen Torben Jørgensen Magnus Karlsson Wolfgang Koenig Peter Kraft Joanneke Kwekkeboom Tiina Laatikainen Karl-Heinz Ladwig Charles A LeDuc Gordon Lowe Yingchang Lu Pedro Marques-Vidal Christa Meisinger Cristina Menni Andrew P Morris Richard H Myers Satu Männistö Mike A Nalls Lavinia Paternoster Annette Peters Aruna D Pradhan Tuomo Rankinen Laura J Rasmussen-Torvik Wolfgang Rathmann Treva K Rice J Brent Richards Paul M Ridker Naveed Sattar David B Savage Stefan Söderberg Nicholas J Timpson Liesbeth Vandenput Diana van Heemst Hae-Won Uh Marie-Claude Vohl Mark Walker Heinz-Erich Wichmann Elisabeth Widén Andrew R Wood Jie Yao Tanja Zeller Yiying Zhang Ingrid Meulenbelt Margreet Kloppenburg Arne Astrup Thorkild I A Sørensen Mark A Sarzynski D C Rao Pekka Jousilahti Erkki Vartiainen Albert Hofman Fernando Rivadeneira André G Uitterlinden Eero Kajantie Clive Osmond Aarno Palotie Johan G Eriksson Markku Heliövaara Paul B Knekt Seppo Koskinen Antti Jula Markus Perola Risto K Huupponen Jorma S Viikari Mika Kähönen Terho Lehtimäki Olli T Raitakari Dan Mellström Mattias Lorentzon Juan P Casas Stefanie Bandinelli Winfried März Aaron Isaacs Ko W van Dijk Cornelia M van Duijn Tamara B Harris Claude Bouchard Matthew A Allison Daniel I Chasman Claes Ohlsson Lars Lind Robert A Scott Claudia Langenberg Nicholas J Wareham Luigi Ferrucci Timothy M Frayling Peter P Pramstaller Ingrid B Borecki Dawn M Waterworth Sven Bergmann Gérard Waeber Peter Vollenweider Henrik Vestergaard Torben Hansen Oluf Pedersen Frank B Hu P Eline Slagboom Harald Grallert Tim D Spector J W Jukema Robert J Klein Erik E Schadt Paul W Franks Cecilia M Lindgren Rudolph L Leibel Ruth J F Loos

Nat Commun 2016 Feb 1;7:10494. Epub 2016 Feb 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms10494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740377PMC
February 2016

Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity.

Am J Physiol Endocrinol Metab 2015 Sep 7;309(5):E458-65. Epub 2015 Jul 7.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York;

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http://dx.doi.org/10.1152/ajpendo.00206.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556883PMC
September 2015

The gut microbiota in human energy homeostasis and obesity.

Trends Endocrinol Metab 2015 Sep 7;26(9):493-501. Epub 2015 Aug 7.

Columbia University, Department of Pediatrics, Division of Molecular Genetics, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.tem.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862197PMC
September 2015

Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.

FASEB J 2015 Feb 11;29(2):671-83. Epub 2014 Nov 11.

Departments of *Medicine and Pediatrics and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY USA; Department of Medicine, The University of Kansas Medical Center, Kansas City, KS, USA; Research Foundation Itsuu Laboratory, Tokyo, Japan; and Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan

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http://dx.doi.org/10.1096/fj.14-256743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314234PMC
February 2015

Molecular pathophysiology of metabolic effects of antipsychotic medications.

Trends Endocrinol Metab 2014 Nov 2;25(11):593-600. Epub 2014 Sep 2.

Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA; Division of Experimental Therapeutics, New York State Psychiatric Institute, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.07.004DOI Listing
November 2014

20 years of leptin: role of leptin in energy homeostasis in humans.

J Endocrinol 2014 Oct 25;223(1):T83-96. Epub 2014 Jul 25.

Division of Molecular GeneticsDepartments of Pediatrics and Medicine, College of Physicians and Surgeons, Columbia University, Russ Berrie Medical Science Pavilion, 6th Floor, 1150 St Nicholas Avenue, New York, New York 10032, USA.

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http://dx.doi.org/10.1530/JOE-14-0358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454393PMC
October 2014

The threshold shift paradigm of obesity: evidence from surgically induced weight loss.

Am J Clin Nutr 2014 Oct 6;100(4):996-1002. Epub 2014 Aug 6.

From the Department of Clinical & Experimental Medicine, University of Pisa School of Medicine, Pisa, Italy (EF), and the Department of Pediatrics, Division of Molecular Genetics, Columbia University College of Physicians and Surgeons, New York, NY (MR and RLL).

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http://dx.doi.org/10.3945/ajcn.114.090167DOI Listing
October 2014

A missing link in body weight homeostasis: the catabolic signal of the overfed state.

Cell Metab 2014 Oct;20(4):565-72

Department of Medicine, Columbia University, 1150 St. Nicholas Ave, New York, NY 10032, USA; Naomi Berrie Diabetes Center, Columbia University, 1150 St. Nicholas Ave, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191848PMC
October 2014

FOXO1 inhibition yields functional insulin-producing cells in human gut organoid cultures.

Nat Commun 2014 Jun 30;5:4242. Epub 2014 Jun 30.

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ncomms5242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083475PMC
June 2014

Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice.

Obesity (Silver Spring) 2014 May 9;22(5):1287-95. Epub 2014 Jan 9.

Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1002/oby.20678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008720PMC
May 2014

Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.

Neurobiol Dis 2014 May 14;65:188-92. Epub 2014 Jan 14.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians & Surgeons, New York, NY, USA; Department of Neurology, Columbia University, College of Physicians & Surgeons, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235335PMC
May 2014

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Cell Metab 2014 May;19(5):767-79

Naomi Berrie Diabetes Center and Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131684PMC
May 2014

Fat cell size and adipokine expression in relation to gender, depot, and metabolic risk factors in morbidly obese adolescents.

Obesity (Silver Spring) 2014 Mar 2;22(3):691-7. Epub 2013 Dec 2.

Division of Molecular Genetics, Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, USA; Naomi Berrie Diabetes Center, Columbia University, College of Physicians and Surgeons, New York, USA.

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http://dx.doi.org/10.1002/oby.20528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823663PMC
March 2014

Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity.

Obesity (Silver Spring) 2014 Feb 15;22(2):576-84. Epub 2013 Oct 15.

Division of Molecular Genetics Department of Pediatrics, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1002/oby.20492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791145PMC
February 2014

ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.

PLoS One 2013 24;8(6):e67234. Epub 2013 Jun 24.

Naomi Berrie Diabetes Center and Department of Pediatrics, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067234PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691114PMC
February 2014

Does diet composition have structural consequences in the hypothalamus?

Mol Metab 2013 31;2(2):58-9. Epub 2013 Jan 31.

Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.molmet.2013.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817386PMC
November 2013

The long-term stability of the human gut microbiota.

Science 2013 Jul;341(6141):1237439

Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

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http://dx.doi.org/10.1126/science.1237439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791589PMC
July 2013

Brain reorganization following weight loss.

Nestle Nutr Inst Workshop Ser 2012 29;73:1-20. Epub 2012 Oct 29.

Division of Molecular Genetics, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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https://www.karger.com/Article/FullText/341282
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http://dx.doi.org/10.1159/000341282DOI Listing
April 2013

TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.

Endocrinology 2012 Dec 15;153(12):5821-33. Epub 2012 Oct 15.

Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1210/en.2012-1510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512064PMC
December 2012

Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.

Mol Endocrinol 2012 Oct 21;26(10):1757-72. Epub 2012 Aug 21.

Division of Endocrinology, Department of Medicine, Columbia University Medical College, 650 West 168th Street, BB 2006, New York, New York 10032, USA.

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https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
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http://dx.doi.org/10.1210/me.2012-1101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458225PMC
October 2012

Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice.

Am J Physiol Regul Integr Comp Physiol 2012 Aug 3;303(4):R438-48. Epub 2012 Jul 3.

Department of Pediatrics, Division of Molecular Genetics, Columbia University, College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1152/ajpregu.00092.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423991PMC
August 2012

Responses of gut microbiota to diet composition and weight loss in lean and obese mice.

Obesity (Silver Spring) 2012 Apr 19;20(4):738-47. Epub 2011 May 19.

Division of Molecular Genetics and Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1038/oby.2011.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871199PMC
April 2012

Leptin reverses declines in satiation in weight-reduced obese humans.

Am J Clin Nutr 2012 Feb 11;95(2):309-17. Epub 2012 Jan 11.

St Luke's/Roosevelt Hospital Medical Center, New York, NY, USA.

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http://dx.doi.org/10.3945/ajcn.111.012385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260066PMC
February 2012

Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss.

Metabolism 2011 Sep 12;60(9):1222-6. Epub 2011 Apr 12.

Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.metabol.2011.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139754PMC
September 2011

Roles of the placenta in fetal brain development.

Proc Natl Acad Sci U S A 2011 Sep 2;108(38):15667-8. Epub 2011 Sep 2.

Naomi Berrie Diabetes Center, Division of Molecular Genetics, and Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.1112239108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179106PMC
September 2011

Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.

J Biol Chem 2011 May 1;286(21):18914-29. Epub 2011 Apr 1.

Division of Molecular Genetics, Department of Pediatrics, Naomi Berrie Diabetes Center and the Institute of Human Nutrition, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M111.224592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099707PMC
May 2011

Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny.

Obesity (Silver Spring) 2011 Mar 14;19(3):492-9. Epub 2010 Oct 14.

Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/oby.2010.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234171PMC
March 2011

Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling.

J Biol Chem 2011 Jan 31;286(3):2155-70. Epub 2010 Oct 31.

Division of Molecular Genetics, Department of Pediatrics and Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1074/jbc.M110.188482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023512PMC
January 2011

FTO gains function.

Nat Genet 2010 Dec;42(12):1038-9

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http://dx.doi.org/10.1038/ng1210-1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818900PMC
December 2010

Obesity and leptin resistance: distinguishing cause from effect.

Trends Endocrinol Metab 2010 Nov 16;21(11):643-51. Epub 2010 Sep 16.

Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.tem.2010.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967652PMC
November 2010

Energy intake in weight-reduced humans.

Brain Res 2010 Sep 2;1350:95-102. Epub 2010 Jun 2.

Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.05.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2926239PMC
September 2010

Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome.

Proc Natl Acad Sci U S A 2010 Jun 24;107(23):10602-7. Epub 2010 May 24.

McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1073/pnas.1000219107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890780PMC
June 2010

In silico mutagenesis: a case study of the melanocortin 4 receptor.

FASEB J 2009 Sep 5;23(9):3059-69. Epub 2009 May 5.

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1096/fj.08-127530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735358PMC
September 2009

Generation of pluripotent stem cells from patients with type 1 diabetes.

Proc Natl Acad Sci U S A 2009 Sep 31;106(37):15768-73. Epub 2009 Aug 31.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1073/pnas.0906894106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735559PMC
September 2009

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2.

Neurobiol Dis 2009 Mar 25;33(3):499-508. Epub 2008 Dec 25.

Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Columbia University Medical College, Russell Berrie Medical Science Pavilion, Room 620, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.nbd.2008.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643333PMC
March 2009

Functional consequences of the human leptin receptor (LEPR) Q223R transversion.

Obesity (Silver Spring) 2009 Jan 6;17(1):126-35. Epub 2008 Nov 6.

Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/oby.2008.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808713PMC
January 2009

Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance.

Int J Body Compos Res 2009 ;7(4):147-154

Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169293PMC
January 2009

Considerations regarding the genetics of obesity.

Obesity (Silver Spring) 2008 Dec;16 Suppl 3:S33-9

Division of Molecular Genetics, Department of Pediatrics, Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1038/oby.2008.514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682366PMC
December 2008

Energy in, energy out, and the effects of obesity-related genes.

Authors:
Rudolph L Leibel

N Engl J Med 2008 Dec;359(24):2603-4

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http://dx.doi.org/10.1056/NEJMe0808660DOI Listing
December 2008

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.

Am J Clin Nutr 2008 Oct;88(4):906-12

Columbia University College of Physicians & Surgeons, New York Presbyterian Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1093/ajcn/88.4.906DOI Listing
October 2008

Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.

J Clin Invest 2008 Jul;118(7):2583-91

Department of Pediatrics, Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University Medical Center/New York Presbyterian Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI35055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430499PMC
July 2008

Location, location, location...

Cell Metab 2008 May;7(5):359-61

Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA.

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http://dx.doi.org/10.1016/j.cmet.2008.04.007DOI Listing
May 2008

Regulation of Fto/Ftm gene expression in mice and humans.

Am J Physiol Regul Integr Comp Physiol 2008 Apr 6;294(4):R1185-96. Epub 2008 Feb 6.

Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1152/ajpregu.00839.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808712PMC
April 2008

An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data.

Diabetes 2008 Jan;57(1):1-2

Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.2337/db07-1592DOI Listing
January 2008

The links between obesity, leptin, and prostate cancer.

Cancer J 2006 May-Jun;12(3):178-81

Division of Molecular Genetics and the Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, Russ Berrie Medical Science Pavilion, New York, New York 10032, USA.

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October 2006

The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity.

Am J Physiol Endocrinol Metab 2006 Sep 25;291(3):E611-20. Epub 2006 Apr 25.

Department of Pediatrics, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1152/ajpendo.00034.2006DOI Listing
September 2006