Rongbin Zhou

Rongbin Zhou

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Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors.

Bioorg Med Chem Lett 2020 Apr 6;30(7):127021. Epub 2020 Feb 6.

State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2020.127021DOI Listing
April 2020

Loss of Annexin A5 expression attenuates the lipopolysaccharide-induced inflammatory response of rat alveolar macrophages.

Cell Biol Int 2020 Feb 26;44(2):391-401. Epub 2019 Sep 26.

Department of Emergency, The Seventh Medical Center, General Hospital of the Chinese PLA, Beijing, 100700, China.

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http://dx.doi.org/10.1002/cbin.11239DOI Listing
February 2020

DAMP-sensing receptors in sterile inflammation and inflammatory diseases.

Nat Rev Immunol 2020 Feb 26;20(2):95-112. Epub 2019 Sep 26.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1038/s41577-019-0215-7DOI Listing
February 2020

ApoC3: an 'alarmin' triggering sterile inflammation.

Nat Immunol 2020 Jan;21(1):9-11

Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1038/s41590-019-0562-3DOI Listing
January 2020

Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells.

Nat Commun 2020 Jan 23;11(1):438. Epub 2020 Jan 23.

Department of Oncology of The First Affiliated Hospital, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.

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http://dx.doi.org/10.1038/s41467-020-14332-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978340PMC
January 2020

Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling.

Nat Immunol 2019 12 21;20(12):1681-1691. Epub 2019 Oct 21.

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1038/s41590-019-0513-zDOI Listing
December 2019

The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases.

Adv Immunol 2020 9;145:55-93. Epub 2019 Dec 9.

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, China. Electronic address:

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http://dx.doi.org/10.1016/bs.ai.2019.11.003DOI Listing
December 2019

Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis.

Front Immunol 2018 17;9:2398. Epub 2018 Oct 17.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, China.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02398
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http://dx.doi.org/10.3389/fimmu.2018.02398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199378PMC
October 2019

Crystal structure and activation mechanism of DR3 death domain.

FEBS J 2019 Jul 11;286(13):2593-2610. Epub 2019 Apr 11.

Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui, China.

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http://dx.doi.org/10.1111/febs.14834DOI Listing
July 2019

The lncRNA Neat1 promotes activation of inflammasomes in macrophages.

Nat Commun 2019 04 2;10(1):1495. Epub 2019 Apr 2.

The Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Cell and Molecular Biology, School of Life Sciences, University of Science and Technology of China, 230026, Hefei, China.

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http://dx.doi.org/10.1038/s41467-019-09482-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445148PMC
April 2019

Immunometabolism regulates TCR recycling and iNKT cell functions.

Sci Signal 2019 02 26;12(570). Epub 2019 Feb 26.

Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.

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http://dx.doi.org/10.1126/scisignal.aau1788DOI Listing
February 2019

Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect.

ACS Nano 2018 10 8;12(10):9966-9973. Epub 2018 Oct 8.

Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry , University of Science and Technology of China , 96 Jinzhai Road , Hefei , Anhui 230026 , China.

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http://pubs.acs.org/doi/10.1021/acsnano.8b04143
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http://dx.doi.org/10.1021/acsnano.8b04143DOI Listing
October 2018

Control of Inflammasome Activation by Phosphorylation.

Trends Biochem Sci 2018 09 23;43(9):685-699. Epub 2018 Jul 23.

Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei 230027, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei 230027, China. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2018.06.008DOI Listing
September 2018

GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics.

Trends Pharmacol Sci 2018 09 24;39(9):798-811. Epub 2018 Jul 24.

Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei 230027, China; CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei 230027, China. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2018.07.002DOI Listing
September 2018

Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice.

J Autoimmun 2018 09 7;93:104-113. Epub 2018 Jul 7.

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, Anhui 230027, China; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183031
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http://dx.doi.org/10.1016/j.jaut.2018.07.003DOI Listing
September 2018

Functional and structural characterization of zebrafish ASC.

FEBS J 2018 07 14;285(14):2691-2707. Epub 2018 Jun 14.

Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1111/febs.14514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105367PMC
July 2018

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.

Nat Commun 2018 06 29;9(1):2550. Epub 2018 Jun 29.

Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.

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http://dx.doi.org/10.1038/s41467-018-04947-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026158PMC
June 2018

M2-specific reduction of CD1d switches NKT cell-mediated immune responses and triggers metaflammation in adipose tissue.

Cell Mol Immunol 2018 May 10;15(5):506-517. Epub 2017 Apr 10.

CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, School of Life Sciences and Medical Center, University of Science and Technology of China, 230027, Hefei, China.

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http://dx.doi.org/10.1038/cmi.2017.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068179PMC
May 2018

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes.

Trends Immunol 2018 05 13;39(5):393-406. Epub 2018 Feb 13.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, People's Republic of China; Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei 230027, People's Republic of China; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230027, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.it.2018.01.009DOI Listing
May 2018

Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.

EMBO Mol Med 2018 04;10(4)

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, China

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
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http://dx.doi.org/10.15252/emmm.201708689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887903PMC
April 2018

Smart Dual Quenching Strategy Enhances the Detection Sensitivity of Intracellular Furin.

Anal Chem 2018 02 17;90(3):1520-1524. Epub 2018 Jan 17.

CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.

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http://dx.doi.org/10.1021/acs.analchem.7b05251DOI Listing
February 2018

NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis.

EMBO Rep 2017 12 2;18(12):2160-2171. Epub 2017 Nov 2.

Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China

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http://dx.doi.org/10.15252/embr.201744480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709773PMC
December 2017

Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis.

Nat Commun 2017 12 1;8(1):1896. Epub 2017 Dec 1.

Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai, 200031, China.

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http://dx.doi.org/10.1038/s41467-017-01917-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711854PMC
December 2017

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.

J Exp Med 2017 Nov 11;214(11):3219-3238. Epub 2017 Oct 11.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China

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http://www.jem.org/lookup/doi/10.1084/jem.20171419
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http://dx.doi.org/10.1084/jem.20171419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679172PMC
November 2017

Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine.

CNS Neurol Disord Drug Targets 2016 ;15(7):857-65

Department of Pharmacology, Medical School of Southeast University, Nanjing, Jiangsu 210009, China.

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http://dx.doi.org/10.2174/1871527315666160518122816DOI Listing
October 2017

Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.

Autophagy 2017 Oct 8;13(10):1722-1741. Epub 2017 Aug 8.

a Department of Pharmacology, School of Medicine , Southeast University , Nanjing, Jiangsu , China.

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http://dx.doi.org/10.1080/15548627.2017.1356975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640207PMC
October 2017

Molecular mechanisms underlying the involvement of the sigma-1 receptor in methamphetamine-mediated microglial polarization.

Sci Rep 2017 09 14;7(1):11540. Epub 2017 Sep 14.

Department of Pharmacology, Medical School of Southeast University, Southeast University, Nanjing, China.

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http://dx.doi.org/10.1038/s41598-017-11065-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599501PMC
September 2017

CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells.

Cell Mol Immunol 2017 Aug 4;14(8):675-684. Epub 2016 Apr 4.

Institute of Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China.

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http://dx.doi.org/10.1038/cmi.2015.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549602PMC
August 2017

CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation.

Nat Commun 2017 08 4;8(1):202. Epub 2017 Aug 4.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, 230027, China.

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http://dx.doi.org/10.1038/s41467-017-00227-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544706PMC
August 2017

The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation.

Nat Commun 2017 08 15;8(1):244. Epub 2017 Aug 15.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://www.nature.com/articles/s41467-017-00279-z
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http://dx.doi.org/10.1038/s41467-017-00279-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557760PMC
August 2017

TLR9 Regulates the NF-κB-NLRP3-IL-1β Pathway Negatively in -Induced NKG2D-Mediated Intestinal Inflammation.

J Immunol 2017 07 2;199(2):761-773. Epub 2017 Jun 2.

Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China; and

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http://dx.doi.org/10.4049/jimmunol.1601416DOI Listing
July 2017

Perfluorodecanoic acid stimulates NLRP3 inflammasome assembly in gastric cells.

Sci Rep 2017 04 3;7:45468. Epub 2017 Apr 3.

Department of medical microbiology, School of basic medical science, Shandong University, Jinan, Shandong, 250012, China.

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http://dx.doi.org/10.1038/srep45468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377303PMC
April 2017

Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders.

J Immunol 2017 03 13;198(5):2082-2092. Epub 2017 Jan 13.

Institute of Immunology and the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China;

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http://dx.doi.org/10.4049/jimmunol.1600145DOI Listing
March 2017

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity.

J Exp Med 2017 02 28;214(2):459-473. Epub 2016 Dec 28.

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China

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http://dx.doi.org/10.1084/jem.20160592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294850PMC
February 2017

Corrigendum to "Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-κB signaling pathway" [Eur. J. Pharmacol. 791 (2016) 229-234].

Eur J Pharmacol 2016 12;792:78

Department of Dermatology in The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2016.11.021DOI Listing
December 2016

Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-κB signaling pathway.

Eur J Pharmacol 2016 11 18;791:229-234. Epub 2016 Aug 18.

Department of Dermatology in The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2016.08.013DOI Listing
November 2016

Invariant NKT cells promote alcohol-induced steatohepatitis through interleukin-1β in mice.

J Hepatol 2015 Jun 10;62(6):1311-8. Epub 2015 Jan 10.

Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science & Technology of China, Hefei, Anhui 230027, China; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui 230027, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2014.12.027DOI Listing
June 2015

RIP1/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice.

Cell Host Microbe 2015 Feb;17(2):229-42

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2015.01.002DOI Listing
February 2015

Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome.

Cell 2015 Jan;160(1-2):62-73

Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China; Innovation Center for Cell Biology, Hefei National Laboratory for Physical Sciences at Microscale, Hefei 230027, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.047DOI Listing
January 2015

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.

Nat Immunol 2014 Dec 19;15(12):1126-33. Epub 2014 Oct 19.

1] Institute of Immunology and CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China. [2] Innovation Center for Cell Biology, Hefei National Laboratory for Physical Sciences at Microscale, Hefei, China.

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http://dx.doi.org/10.1038/ni.3015DOI Listing
December 2014

Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition.

Carcinogenesis 2014 Jul 17;35(7):1661-70. Epub 2014 Apr 17.

Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China, Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA and Department of Biology, Georgia State University, Atlanta, GA 30303, USA

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http://dx.doi.org/10.1093/carcin/bgu090DOI Listing
July 2014

Inhibitory effect of co-administration of atorvastatin and endothelin-1 receptor antagonist on the progression of atherosclerosis in rabbit.

APMIS 2014 Jun 29;122(6):556-64. Epub 2013 Oct 29.

Department of Cardiology, Chinese PLA General Hospital, Beijing, China; Department of Emergency, The Military General Hospital of Beijing PLA, Beijing, China.

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http://dx.doi.org/10.1111/apm.12185DOI Listing
June 2014

Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.

J Exp Med 2013 Oct 23;210(11):2465-76. Epub 2013 Sep 23.

the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.

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http://dx.doi.org/10.1084/jem.20122490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804938PMC
October 2013

Fibronectin extra domain A (EDA) sustains CD133(+)/CD44(+) subpopulation of colorectal cancer cells.

Stem Cell Res 2013 Sep 4;11(2):820-33. Epub 2013 Jun 4.

Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China.

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http://dx.doi.org/10.1016/j.scr.2013.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917514PMC
September 2013

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

Immunity 2013 Jun;38(6):1154-63

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Anhui 230027, China.

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http://dx.doi.org/10.1016/j.immuni.2013.05.015DOI Listing
June 2013

Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses.

J Immunol 2013 Apr 20;190(7):3517-24. Epub 2013 Feb 20.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, 361005 Xiamen, Fujian, China.

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http://dx.doi.org/10.4049/jimmunol.1202628DOI Listing
April 2013

Detection of p16INK4a promoter methylation status in non-small cell lung cancer by a fluorescence polarization assay.

Diagn Mol Pathol 2011 Sep;20(3):138-42

Department of Emergency, The 309th Hospital of Chinese People's Liberation Army, Beijing, China.

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http://dx.doi.org/10.1097/PDM.0b013e318205c0e0DOI Listing
September 2011

A role for mitochondria in NLRP3 inflammasome activation.

Nature 2011 Jan 1;469(7329):221-5. Epub 2010 Dec 1.

Department of Biochemistry, Center of Immunity and Infection, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

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http://immuno.grad.uiowa.edu/sites/immuno.grad.uiowa.edu/fil
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http://www.nature.com/doifinder/10.1038/nature09663
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http://dx.doi.org/10.1038/nature09663DOI Listing
January 2011

Thioredoxin-interacting protein links oxidative stress to inflammasome activation.

Nat Immunol 2010 Feb 20;11(2):136-40. Epub 2009 Dec 20.

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

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http://www.nature.com/articles/ni.1831
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http://dx.doi.org/10.1038/ni.1831DOI Listing
February 2010

The NLRP3 inflammasome: a sensor for metabolic danger?

Science 2010 Jan;327(5963):296-300

Department of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland.

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http://dx.doi.org/10.1126/science.1184003DOI Listing
January 2010

NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis.

Hepatology 2009 Mar;49(3):940-9

Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.1002/hep.22725DOI Listing
March 2009

TLR-9 activation aggravates concanavalin A-induced hepatitis via promoting accumulation and activation of liver CD4+ NKT cells.

J Immunol 2009 Mar;182(6):3768-74

Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.4049/jimmunol.0800973DOI Listing
March 2009

NKG2D recognition mediates Toll-like receptor 3 signaling-induced breakdown of epithelial homeostasis in the small intestines of mice.

Proc Natl Acad Sci U S A 2007 May 26;104(18):7512-5. Epub 2007 Apr 26.

Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230027, China.

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http://dx.doi.org/10.1073/pnas.0700822104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863471PMC
May 2007

Recognition of double-stranded RNA by TLR3 induces severe small intestinal injury in mice.

J Immunol 2007 Apr;178(7):4548-56

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, 443 Huang-shan Road, Hefei, China.

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http://dx.doi.org/10.4049/jimmunol.178.7.4548DOI Listing
April 2007

NK3-like NK cells are involved in protective effect of polyinosinic-polycytidylic acid on type 1 diabetes in nonobese diabetic mice.

J Immunol 2007 Feb;178(4):2141-7

Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China.

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http://dx.doi.org/10.4049/jimmunol.178.4.2141DOI Listing
February 2007

Isolation of lymphocytes and their innate immune characterizations from liver, intestine, lung and uterus.

Cell Mol Immunol 2005 Aug;2(4):271-80

Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.

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August 2005