Roger P Hollis

Roger P Hollis

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Roger P Hollis

Roger P Hollis

Publications by authors named "Roger P Hollis"

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Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

Cell Stem Cell 2019 Oct 5;25(4):542-557.e9. Epub 2019 Sep 5.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.004DOI Listing
October 2019

Improved Titer and Gene Transfer by Lentiviral Vectors Using Novel, Small β-Globin Locus Control Region Elements.

Mol Ther 2019 Sep 28. Epub 2019 Sep 28.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology & Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA; The Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.09.020DOI Listing
September 2019

Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates.

Mol Ther 2019 Aug 24;27(8):1389-1406. Epub 2019 May 24.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, USA; Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697408PMC
August 2019

PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector.

Mol Ther Methods Clin Dev 2019 Jun 4;13:390-398. Epub 2019 Apr 4.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.omtm.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477655PMC
June 2019

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.

Cell Stem Cell 2019 Feb 10;24(2):309-317.e7. Epub 2019 Jan 10.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183059
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http://dx.doi.org/10.1016/j.stem.2018.12.003DOI Listing
February 2019

Gene Therapy for Sickle Cell Disease: A Lentiviral Vector Comparison Study.

Hum Gene Ther 2018 10;29(10):1153-1166

1 Department of Microbiology, Immunology, and Molecular Genetics, University of California , Los Angeles, California; University of Modena and Reggio Emilia , Italy .

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https://www.liebertpub.com/doi/10.1089/hum.2018.061
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http://dx.doi.org/10.1089/hum.2018.061DOI Listing
October 2018

Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome.

Cell Rep 2018 05;23(9):2606-2616

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Division of Hematology & Oncology, Department of Pediatrics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.celrep.2018.04.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181643PMC
May 2018

Improving Gene Therapy Efficiency through the Enrichment of Human Hematopoietic Stem Cells.

Mol Ther 2017 09 27;25(9):2163-2175. Epub 2017 Jun 27.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular & Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589063PMC
September 2017

Preclinical studies for a phase 1 clinical trial of autologous hematopoietic stem cell gene therapy for sickle cell disease.

Cytotherapy 2017 09 18;19(9):1096-1112. Epub 2017 Jul 18.

Department of Microbiology, Immunology and Molecular Genetics and the Eli & Edythe Broad Stem Cell Research Center, University of California, Los Angeles, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2017.06.002DOI Listing
September 2017

Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases.

Mol Ther Nucleic Acids 2016 ;5:e351

Department of Microbiology, Immunology, & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA; Department of Pediatrics, University of California, Los Angeles, Los Angeles, California, USA. Electronic address:

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http://dx.doi.org/10.1038/mtna.2016.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023398PMC
January 2016

The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells.

Mol Ther Methods Clin Dev 2015 22;2:15012. Epub 2015 Apr 22.

Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California, USA ; Department of Pediatrics, UCLA Children's Discovery and Innovation Institute David Geffen School of Medicine, University of California , Los Angeles, California, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23290501163002
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http://dx.doi.org/10.1038/mtm.2015.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445009PMC
June 2015

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells.

Blood 2015 Apr 2;125(17):2597-604. Epub 2015 Mar 2.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA; Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, University of California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1182/blood-2014-12-615948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408287PMC
April 2015

Dissecting the mechanism of histone deacetylase inhibitors to enhance the activity of zinc finger nucleases delivered by integrase-defective lentiviral vectors.

Hum Gene Ther 2014 Jul 2;25(7):599-608. Epub 2014 Apr 2.

Department of Microbiology, Immunology, and Molecular Genetics; and Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research; University of California , Los Angeles, Los Angeles, CA 90095.

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http://dx.doi.org/10.1089/hum.2013.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098962PMC
July 2014

Integrase-defective lentiviral vectors as a delivery platform for targeted modification of adenosine deaminase locus.

Mol Ther 2013 Sep 16;21(9):1705-17. Epub 2013 Jul 16.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095, USA

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http://dx.doi.org/10.1038/mt.2013.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776625PMC
September 2013

A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors.

J Transl Med 2013 Jan 29;11:23. Epub 2013 Jan 29.

Department of Pediatrics, University of California, Los Angeles (UCLA), 10833 Le Conte Avenue, A2-410 MDCC, MC 175217, Los Angeles, CA 90095-1752, USA.

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http://dx.doi.org/10.1186/1479-5876-11-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623748PMC
January 2013

Highly efficient large-scale lentiviral vector concentration by tandem tangential flow filtration.

J Virol Methods 2011 Oct 18;177(1):1-9. Epub 2011 Jul 18.

Molecular Biology Institute, University of California, Los Angeles, USA.

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http://dx.doi.org/10.1016/j.jviromet.2011.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276401PMC
October 2011

Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells, using the Sleeping Beauty transposon system.

Hum Gene Ther 2009 Dec;20(12):1607-26

Division of Research Immunology/Bone Marrow Transplantation, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1089/hum.2009.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094131PMC
December 2009

Stable gene transfer to human CD34(+) hematopoietic cells using the Sleeping Beauty transposon.

Exp Hematol 2006 Oct;34(10):1333-43

Division of Research Immunology/Bone Marrow Transplant, The Saban Research Institute of Childrens Hospital Los Angeles, Departments of Pediatrics, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1016/j.exphem.2006.05.023DOI Listing
October 2006

Transient gene expression by nonintegrating lentiviral vectors.

Mol Ther 2006 Jun 23;13(6):1121-32. Epub 2006 Mar 23.

Division of Research Immunology/Bone Marrow Transplant, The Saban Research Institute of Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA.

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http://dx.doi.org/10.1016/j.ymthe.2006.01.008DOI Listing
June 2006

Phage integrases for the construction and manipulation of transgenic mammals.

Reprod Biol Endocrinol 2003 Nov 7;1:79. Epub 2003 Nov 7.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.

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http://dx.doi.org/10.1186/1477-7827-1-79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC280723PMC
November 2003

Site-specific genomic integration produces therapeutic Factor IX levels in mice.

Nat Biotechnol 2002 Nov 15;20(11):1124-8. Epub 2002 Oct 15.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1038/nbt753DOI Listing
November 2002