Rodolfo Gabriel Gatto, MD, PhD - University of Illinois at Chicago - Adjunct Research Assistant Professor

Rodolfo Gabriel Gatto

MD, PhD

University of Illinois at Chicago

Adjunct Research Assistant Professor

Chicago, IL | United States

Additional Specialties: Neuroimaging

ORCID logohttps://orcid.org/0000-0003-2170-6662

Rodolfo Gabriel Gatto, MD, PhD - University of Illinois at Chicago - Adjunct Research Assistant Professor

Rodolfo Gabriel Gatto

MD, PhD

Introduction

Research Scientist with solid experience in Neuroimaging and Experimental Animal Models of Neurodegenerative Diseases and Traumatic Brain Injury. Heavily trained in Signal & Imaging Data Processing with broad experience in Microscopy, Molecular Biology and Bioinstrumentation. Particularly interested in Translational Research subjects that integrate Biology, Medicine and Engineering fields.

Primary Affiliation: University of Illinois at Chicago - Chicago, IL , United States

Additional Specialties:

Education

Aug 2005 - Dec 2009
University of Illinois at Chicago
PhD
Biomedical Engineering
Mar 1991 - Dec 1999
Universidad de la República Uruguay
MD
College of Medicine

Experience

Jan 2009 - Jan 2011
Jesse Brown VA Medical Center
Research Scientist
Research & Development Division
Jan 2004 - Jan 2007
University of Illinois at Chicago
Visiting Research Specialist in Health Sciences
Department of Neurosurgery

Publications

43Publications

372Reads

211Profile Views

105PubMed Central Citations

Editorial for "Evaluating the Therapeutic Effect of Low-Intensity Transcranial Ultrasound on Traumatic Brain Injury With Diffusion Kurtosis Imaging".

Authors:
Rodolfo G Gatto

J Magn Reson Imaging 2020 Feb 7. Epub 2020 Feb 7.

Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/jmri.27082DOI Listing
February 2020
3.210 Impact Factor

Unveiling early cortical and subcortical neuronal degeneration in ALS mice by ultra-high field diffusion MRI.

Amyotroph Lateral Scler Frontotemporal Degener 2019 11 3;20(7-8):549-561. Epub 2019 Jun 3.

Department of Bioengineering, University of Illinois at Chicago , Chicago , IL , USA.

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http://dx.doi.org/10.1080/21678421.2019.1620285DOI Listing
November 2019
13 Reads
2.591 Impact Factor

Detection of axonal degeneration in a mouse model of Huntington's disease: comparison between diffusion tensor imaging and anomalous diffusion metrics.

MAGMA 2019 Aug 15;32(4):461-471. Epub 2019 Feb 15.

Department of Bioengineering, University of Illinois at Chicago, 851 S Morgan St, 218 SEO (MC 063), Chicago, IL, 60607, USA.

Objective: The goal of this work is to study the changes in white matter integrity in R6/2, a well-established animal model of Huntington's disease (HD) that are captured by ex vivo diffusion imaging (DTI) using a high field MRI (17.6 T).

Materials And Methods: DTI and continuous time random walk (CTRW) models were used to fit changes in the diffusion-weighted signal intensity in the corpus callosum of controls and in R6/2 mice.

Results: A significant 13% decrease in fractional anisotropy, a 7% increase in axial diffusion, and a 33% increase in radial diffusion were observed between R6/2 and control mice. No change was observed in the CTRW beta parameter, but a significant decrease in the alpha parameter (-?21%) was measured. Histological analysis of the corpus callosum showed a decrease in axonal organization, myelin alterations, and astrogliosis. Electron microscopy studies demonstrated ultrastructural changes in degenerating axons, such as an increase in tortuosity in the R6/2 mice.

Conclusions: DTI and CTRW diffusion models display quantitative changes associated with the microstructural alterations observed in the corpus callosum of the R6/2 mice. The observed increase in the diffusivity and decrease in the alpha CTRW parameter providing support for the use of these diffusion models for non-invasive detection of white matter alterations in HD.

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http://dx.doi.org/10.1007/s10334-019-00742-6DOI Listing
August 2019
10 Reads
1.353 Impact Factor

Neurite orientation dispersion and density imaging can detect presymptomatic axonal degeneration in the spinal cord of ALS mice.

Funct Neurol 2018 Jul/Sept;33(3):155-163

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February 2019
132 Reads
1.860 Impact Factor

Diffusion Tensor Imaging in Preclinical and Human Studies of Huntington's Disease: What Have we Learned so Far?

Curr Med Imaging Rev 2019 ;15(6):521-542

Insituto de Fisiología Biologia Molecular y Neurociencias-IFIBYNE-CONICET, University of Buenos Aires, Buenos Aires, Argentina.

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http://dx.doi.org/10.2174/1573405614666181115113400DOI Listing
January 2019
1.059 Impact Factor

Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice.

Transl Neurodegener 2018 8;7:20. Epub 2018 Aug 8.

5Department of Bioengineering, University of Illinois at Chicago, Chicago, IL USA.

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http://dx.doi.org/10.1186/s40035-018-0122-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097419PMC
August 2018
3 Reads

In vivo diffusion MRI detects early spinal cord axonal pathology in a mouse model of amyotrophic lateral sclerosis.

NMR Biomed 2018 08 26;31(8):e3954. Epub 2018 Jun 26.

University of Illinois at Chicago, Bioengineering, Chicago, IL, USA.

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http://dx.doi.org/10.1002/nbm.3954DOI Listing
August 2018
3 Reads
3.044 Impact Factor

Diffusion tensor imaging as a tool to detect presymptomatic axonal degeneration in a preclinical spinal cord model of amyotrophic lateral sclerosis.

Neural Regen Res 2018 Mar;13(3):425-426

Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.

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http://www.nrronline.org/text.asp?2018/13/3/425/228723
Publisher Site
http://dx.doi.org/10.4103/1673-5374.228723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900503PMC
March 2018
2 Reads
0.234 Impact Factor

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation.

Sci Rep 2017 03 8;7(1):115. Epub 2017 Mar 8.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.1038/s41598-017-00091-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428330PMC
March 2017
11 Reads
2 Citations
5.080 Impact Factor

Anti-edema effects of rhEpo in experimental traumatic brain injury.

Restor Neurol Neurosci 2015 ;33(6):927-41

Neuroscience Research, R&D, Jesse Brown VA Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.3233/RNN-150577DOI Listing
August 2016
2 Reads
3 Citations
2.490 Impact Factor

Restoration of cognitive deficits after statin feeding in TBI.

Restor Neurol Neurosci 2011 ;29(1):23-34

Neuroscience Research, Research & Development, Jesse Brown VA Medical Center Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.3233/RNN-2011-0573DOI Listing
January 2012
2 Reads
7 Citations
2.490 Impact Factor

A novel method for extracting respiration rate and relative tidal volume from infrared thermography.

Psychophysiology 2011 Jul 7;48(7):877-87. Epub 2011 Jan 7.

Department of Psychiatry, Brain-Body Center, University of Illinois at Chicago, Chicago, Illinois 60608, USA.

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http://dx.doi.org/10.1111/j.1469-8986.2010.01167.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107393PMC
July 2011
17 Reads
10 Citations
2.990 Impact Factor

Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury.

Brain Res 2010 Nov 15;1360:177-92. Epub 2010 Sep 15.

Jesse Brown VA Medical Center, University of Illinois, Chicago, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.09.010DOI Listing
November 2010
3 Reads
14 Citations
2.843 Impact Factor

Neuroanatomical correlation of behavioral deficits in the CCI model of TBI.

J Neurosci Methods 2010 Jun 10;190(1):1-9. Epub 2010 Apr 10.

Research & Development, Jesse Brown VA Medical Center Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2010.04.004DOI Listing
June 2010
5 Reads
10 Citations
2.025 Impact Factor

The utility of intraoperative blood flow measurement during aneurysm surgery using an ultrasonic perivascular flow probe.

Neurosurgery 2008 Jun;62(6 Suppl 3):1346-53

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois 60612-5970, USA.

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http://dx.doi.org/10.1227/01.neu.0000333799.44338.19DOI Listing
June 2008
15 Reads
4 Citations
3.620 Impact Factor

Age effects on brain oxygenation during hypercapnia.

J Biomed Opt 2007 Nov-Dec;12(6):062113

University of Illinois at Chicago, Department of Neurosurgery, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1117/1.2804705DOI Listing
March 2008
4 Reads
7 Citations
2.860 Impact Factor

Effect of age on brain oxygenation regulation during changes in position.

J Neurosci Methods 2007 Aug 5;164(2):308-11. Epub 2007 May 5.

Department of Neurosurgery, University of Illinois at Chicago, 912 South Wood Street 4th FL, NPI building, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2007.04.020DOI Listing
August 2007
5 Reads
2.025 Impact Factor

Frequency domain near-infrared spectroscopy technique in the assessment of brain oxygenation: a validation study in live subjects and cadavers.

J Neurosci Methods 2006 Oct 24;157(2):274-7. Epub 2006 May 24.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2006.04.013DOI Listing
October 2006
11 Reads
8 Citations
2.025 Impact Factor

The utility of intraoperative blood flow measurement during aneurysm surgery using an ultrasonic perivascular flow probe.

Neurosurgery 2006 Apr;58(4 Suppl 2):ONS-305-12; discussion ONS-312

Neuropsychiatric Institute (MC 799), Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois 60612-5970, USA.

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http://dx.doi.org/10.1227/01.NEU.0000209339.47929.34DOI Listing
April 2006
26 Reads
1 Citation
3.620 Impact Factor

Top co-authors

Richard L Magin
Richard L Magin

University of Illinois at Chicago

5
Fady T Charbel
Fady T Charbel

University of Illinois at Chicago

4
Scott T Brady
Scott T Brady

University of Illinois at Chicago

4
Neelima B Chauhan
Neelima B Chauhan

Jesse Brown VA Medical Center Chicago

3
Thomas H Mareci
Thomas H Mareci

University of Florida

3
Andrew Bauer
Andrew Bauer

Uniformed Services University of the Health Sciences

2
Gerardo A Morfini
Gerardo A Morfini

University of Illinois at Chicago

2
Sepideh Amin-Hanjani
Sepideh Amin-Hanjani

University of Illinois at Chicago

2
Daryl A Bosco
Daryl A Bosco

University of Massachusetts Medical School

2