Publications by authors named "Robert L Martuza"

81Publications

Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma.

Authors:
Ming Li Guoping Li Juri Kiyokawa Zain Tirmizi Leland G Richardson Jianfang Ning Saumya Das Robert L Martuza Anat Stemmer-Rachamimov Samuel D Rabkin Hiroaki Wakimoto

Acta Neuropathol Commun 2020 12 11;8(1):221. Epub 2020 Dec 11.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.

View Article and Find Full Text PDF
December 2020

Modification of Extracellular Matrix Enhances Oncolytic Adenovirus Immunotherapy in Glioblastoma.

Authors:
Juri Kiyokawa Yoichiro Kawamura Shanawaz M Ghouse Simge Acar Erinç Barçın Jordi Martínez-Quintanilla Robert L Martuza Ramon Alemany Samuel D Rabkin Khalid Shah Hiroaki Wakimoto

Clin Cancer Res 2021 Feb 30;27(3):889-902. Epub 2020 Nov 30.

Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Boston, Massachusetts.

View Article and Find Full Text PDF
February 2021

Adjuvant Radiation Therapy Versus Surveillance After Surgical Resection of Atypical Meningiomas.

Authors:
Grace Lee Nayan Lamba Andrzej Niemierko Daniel W Kim Paul H Chapman Jay S Loeffler William T Curry Robert L Martuza Kevin S Oh Fred G Barker Helen A Shih

Int J Radiat Oncol Biol Phys 2021 Jan 8;109(1):252-266. Epub 2020 Aug 8.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF
January 2021

Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma.

Authors:
Dipongkor Saha Samuel D Rabkin Robert L Martuza

J Immunother Cancer 2020 05;8(1)

Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
May 2020

Atypical Histopathological Features and the Risk of Treatment Failure in Nonmalignant Meningiomas: A Multi-Institutional Analysis.

Authors:
Nayan Lamba William L Hwang Daniel W Kim Andrzej Niemierko Ariel E Marciscano William A Mehan Marc D Benayoun William T Curry Fred G Barker Robert L Martuza Ian F Dunn Elizabeth Claus Wenya Linda Bi Ayal A Aizer Brian M Alexander Kevin S Oh Jay S Loeffler Helen A Shih

World Neurosurg 2020 Jan 9;133:e804-e812. Epub 2019 Oct 9.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

View Article and Find Full Text PDF
January 2020

A Monoclonal Antibody Against β1 Integrin Inhibits Proliferation and Increases Survival in an Orthotopic Model of High-Grade Meningioma.

Authors:
Fares Nigim Juri Kiyokawa Alessandra Gurtner Yoichiro Kawamura Lingyang Hua Ekkehard M Kasper Priscilla K Brastianos Daniel P Cahill Samuel D Rabkin Robert L Martuza W Shawn Carbonell Hiroaki Wakimoto

Target Oncol 2019 08;14(4):479-489

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
August 2019

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma.

Authors:
Jian-Fang Ning Monica Stanciu Melissa R Humphrey Joshua Gorham Hiroko Wakimoto Reiko Nishihara Jacqueline Lees Lee Zou Robert L Martuza Hiroaki Wakimoto Samuel D Rabkin

Nat Commun 2019 07 2;10(1):2910. Epub 2019 Jul 2.

Molecular Neurosurgery Laboratory and the Brain Tumor Research Center and Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.

View Article and Find Full Text PDF
July 2019

Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells.

Authors:
Lei Wang Jianfang Ning Hiroaki Wakimoto Shulin Wu Chin-Lee Wu Melissa R Humphrey Samuel D Rabkin Robert L Martuza

Mol Ther Oncolytics 2019 Jun 29;13:58-66. Epub 2019 Mar 29.

Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

View Article and Find Full Text PDF
June 2019

Performance of a Hospital Pathway for Patients With a New Single Brain Mass.

Authors:
Isabel Arrillaga-Romany William T Curry Justin T Jordan Daniel P Cahill Brian V Nahed Robert L Martuza Jay S Loeffler Susann J Järhult Alona Muzikansky Adam B Cohen Aneesh B Singhal Joshua N Goldstein Tracy T Batchelor

J Oncol Pract 2019 Mar 25;15(3):e211-e218. Epub 2019 Jan 25.

1 Massachusetts General Hospital and Harvard Medical School, Boston, MA.

View Article and Find Full Text PDF
March 2019

Author Correction: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.

Authors:
Pakawat Chongsathidkiet Christina Jackson Shohei Koyama Franziska Loebel Xiuyu Cui S Harrison Farber Karolina Woroniecka Aladine A Elsamadicy Cosette A Dechant Hanna R Kemeny Luis Sanchez-Perez Tooba A Cheema Nicholas C Souders James E Herndon Jean-Valery Coumans Jeffrey I Everitt Brian V Nahed John H Sampson Michael D Gunn Robert L Martuza Glenn Dranoff William T Curry Peter E Fecci

Nat Med 2019 Mar;25(3):529

Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.

View Article and Find Full Text PDF
March 2019

Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy.

Authors:
Shota Tanaka Samantha Luk Juri Kiyokawa Maristela L Onozato A John Iafrate Khalid Shah Robert L Martuza Samuel D Rabkin Tracy T Batchelor Daniel P Cahill Andrew S Chi Hiroaki Wakimoto

Sci Rep 2019 01 15;9(1):139. Epub 2019 Jan 15.

Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA.

View Article and Find Full Text PDF
January 2019

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.

Authors:
Pakawat Chongsathidkiet Christina Jackson Shohei Koyama Franziska Loebel Xiuyu Cui S Harrison Farber Karolina Woroniecka Aladine A Elsamadicy Cosette A Dechant Hanna R Kemeny Luis Sanchez-Perez Tooba A Cheema Nicholas C Souders James E Herndon Jean-Valery Coumans Jeffrey I Everitt Brian V Nahed John H Sampson Michael D Gunn Robert L Martuza Glenn Dranoff William T Curry Peter E Fecci

Nat Med 2018 09 13;24(9):1459-1468. Epub 2018 Aug 13.

Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.

View Article and Find Full Text PDF
September 2018

Oncolytic herpes simplex virus immunovirotherapy in combination with immune checkpoint blockade to treat glioblastoma.

Authors:
Dipongkor Saha Robert L Martuza Samuel D Rabkin

Immunotherapy 2018 07;10(9):779-786

Department of Neurosurgery, Molecular Neurosurgery Laboratory & Brain Tumor Research Center, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.

View Article and Find Full Text PDF
July 2018

Restriction of Replication of Oncolytic Herpes Simplex Virus with a Deletion of γ34.5 in Glioblastoma Stem-Like Cells.

Authors:
Cole Peters Max Paget Kizito-Tshitoko Tshilenge Dipongkor Saha Slawomir Antoszczyk Anouk Baars Thomas Frost Robert L Martuza Hiroaki Wakimoto Samuel D Rabkin

J Virol 2018 08 17;92(15). Epub 2018 Jul 17.

Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA

View Article and Find Full Text PDF
August 2018

Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models.

Authors:
Dipongkor Saha Hiroaki Wakimoto Cole W Peters Slawomir J Antoszczyk Samuel D Rabkin Robert L Martuza

Clin Cancer Res 2018 07 29;24(14):3409-3422. Epub 2018 Mar 29.

Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts.

View Article and Find Full Text PDF
July 2018

Curing glioblastoma: oncolytic HSV-IL12 and checkpoint blockade.

Authors:
Dipongkor Saha Robert L Martuza Samuel D Rabkin

Oncoscience 2017 Jul 20;4(7-8):67-69. Epub 2017 Sep 20.

Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

View Article and Find Full Text PDF
July 2017

Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.

Authors:
Dipongkor Saha Robert L Martuza Samuel D Rabkin

Cancer Cell 2017 08;32(2):253-267.e5

Molecular Neurosurgery Laboratory and the Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Department of Neurosurgery, Harvard Medical School, Boston, MA, USA. Electronic address:

View Article and Find Full Text PDF
August 2017

Blockade of transforming growth factor-β signaling enhances oncolytic herpes simplex virus efficacy in patient-derived recurrent glioblastoma models.

Authors:
Shinichi Esaki Fares Nigim Esther Moon Samantha Luk Juri Kiyokawa William Curry Daniel P Cahill Andrew S Chi A John Iafrate Robert L Martuza Samuel D Rabkin Hiroaki Wakimoto

Int J Cancer 2017 12 26;141(11):2348-2358. Epub 2017 Aug 26.

Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

View Article and Find Full Text PDF
December 2017

Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas.

Authors:
Daniel Kim Andrzej Niemierko William L Hwang Anat O Stemmer-Rachamimov William T Curry Fred G Barker Robert L Martuza Kevin S Oh Jay S Loeffler Helen A Shih

J Neurosurg 2018 04 16;128(4):1123-1132. Epub 2017 Jun 16.

Departments of2Radiation Oncology.

View Article and Find Full Text PDF
April 2018

Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.

Authors:
Jianfang Ning Hiroaki Wakimoto Cole Peters Robert L Martuza Samuel D Rabkin

J Natl Cancer Inst 2017 03;109(3):1-13

Molecular Neurosurgery Laboratory, Brain Tumor Research Center, Massachusetts General Hospital, Boston, MA, USA.

View Article and Find Full Text PDF
March 2017