Richard Wade-Martins

Richard Wade-Martins

UNVERIFIED PROFILE

Are you Richard Wade-Martins?   Register this Author

Register author
Richard Wade-Martins

Richard Wade-Martins

Publications by authors named "Richard Wade-Martins"

Are you Richard Wade-Martins?   Register this Author

100Publications

2144Reads

29Profile Views

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.

Neurobiol Dis 2019 Sep 11;129:56-66. Epub 2019 May 11.

Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.05.006DOI Listing
September 2019

LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function.

Hum Mol Genet 2019 Aug;28(16):2696-2710

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
Publisher Site
http://dx.doi.org/10.1093/hmg/ddz088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687951PMC
August 2019

Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation.

Neurobiol Dis 2019 Aug 21;132:104581. Epub 2019 Aug 21.

Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloews Vej 21, st, DK5000 Odense C, Denmark; BRIDGE, Brain Research - Inter-Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, J.B. Winsloews Vej 19, DK5000 Odense C, Denmark. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.104581DOI Listing
August 2019

The A30P α-synuclein mutation decreases subventricular zone proliferation.

Hum Mol Genet 2019 Jul;28(14):2283-2294

Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddz057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606853PMC
July 2019

Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase.

Mol Neurobiol 2019 Mar 15;56(3):1558-1577. Epub 2018 Jun 15.

Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-018-1174-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368252PMC
March 2019

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.

Cell Stem Cell 2019 Jan 29;24(1):93-106.e6. Epub 2018 Nov 29.

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327112PMC
January 2019

Are rodent models of Parkinson's disease behaving as they should?

Behav Brain Res 2018 10 24;352:133-141. Epub 2017 Oct 24.

Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbr.2017.10.021DOI Listing
October 2018

Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD.

Neurology 2018 10 19;91(16):e1528-e1538. Epub 2018 Sep 19.

From the Oxford Parkinson's Disease Centre (OPDC) (S.A., F.B., C.L., T.R.B., M.R., C.R., J.C.K., J.R., A.L., R.W.-M, M.T.H.), University of Oxford, UK; Engineering and Applied Science (S.A., M.A.L.), Aston University, Birmingham, UK; Somerville College (S.A.), University of Oxford, UK; Nuffield Department of Clinical Neurosciences (F.B., C.L., T.R.B., M.A.L., M.T.H.), University of Oxford, UK; Population Health Sciences (M.A.L.), University of Bristol, UK; andDepartment of Computer Science (A.Z.), Johns Hopkins University, Baltimore; Department of Neurology and Neurophysiology (Z.Z., G.L., M.T.H.), Oxford University Hospitals NHS Trust, UK; Respiratory Support and Sleep Centre (T.Q.), Papworth Hospital, Cambridge, UK; Department of Neurology (G.D.), Royal Hallamshire Hospital, Sheffield, UK; and Media Lab (M.A.L.), Massachusetts Institute of Technology, Cambridge, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202945PMC
October 2018

Potential Metabolomic Linkage in Blood between Parkinson's Disease and Traumatic Brain Injury.

Metabolites 2018 Sep 7;8(3). Epub 2018 Sep 7.

Translational Laboratory and Biorepository, Department of Neurology, University of California Irvine School of Medicine, Irvine, CA 92697-3910, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/metabo8030050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161135PMC
September 2018

Convergent pathways in Parkinson's disease.

Cell Tissue Res 2018 Jul 23;373(1):79-90. Epub 2017 Oct 23.

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00441-017-2700-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015598PMC
July 2018

Alpha-synuclein oligomers: a new hope.

Acta Neuropathol 2017 12 12;134(6):819-838. Epub 2017 Aug 12.

Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-017-1755-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663814PMC
December 2017

Preclinical development of a vaccine against oligomeric alpha-synuclein based on virus-like particles.

PLoS One 2017 10;12(8):e0181844. Epub 2017 Aug 10.

The Jenner Institute, Nuffield Department of Medicine, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Roosevelt Drive, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181844PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552317PMC
October 2017

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.

Stem Cell Reports 2017 08 6;9(2):587-599. Epub 2017 Jul 6.

Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549835PMC
August 2017

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

Sci Rep 2017 08 21;7(1):9003. Epub 2017 Aug 21.

James Martin Stem Cell Facility, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-09362-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567139PMC
August 2017

A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor.

J Pharmacol Exp Ther 2017 06 30;361(3):417-428. Epub 2017 Mar 30.

Departments of Physiology, Anatomy, and Genetics (A.G.K., L.C.S.T., M.C., S.A., O.H., J.H.-M., R.W.-M.) and Pharmacology (A.J.R.), University of Oxford, Oxford, United Kingdom; Division of Cardiovascular Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom (A.B.H., G.D., K.M.C.); and Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, United Kingdom (J.M., C.J.R.B., G.M.W., A.J.R.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.116.239574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443320PMC
June 2017

The Role of Astrocyte Dysfunction in Parkinson's Disease Pathogenesis.

Trends Neurosci 2017 06 17;40(6):358-370. Epub 2017 May 17.

Oxford Parkinson's Disease Centre, University of Oxford, Oxford, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2017.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462417PMC
June 2017

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.

Stem Cell Reports 2017 06;8(6):1727-1742

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK; Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470330PMC
June 2017

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance.

Free Radic Biol Med 2017 03 17;104:214-225. Epub 2017 Jan 17.

BHF Centre of Research Excellence, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2017.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338462PMC
March 2017

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.

Front Neurosci 2016 23;10:578. Epub 2016 Dec 23.

Department of Physiology, Anatomy and Genetics, Oxford Parkinson's Disease Centre, University of Oxford Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2016.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179548PMC
December 2016

Episomal Nonviral Gene Therapy Vectors Slow Progression of Atherosclerosis in a Model of Familial Hypercholesterolemia.

Mol Ther Nucleic Acids 2016 Nov 8;5(11):e383. Epub 2016 Nov 8.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mtna.2016.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155321PMC
November 2016

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies.

Ann Clin Transl Neurol 2016 10 28;3(10):812-818. Epub 2016 Aug 28.

The National CJD Research & Surveillance Unit Western General Hospital University of Edinburgh Edinburgh EH4 2XU United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048391PMC
October 2016

The infectious BAC genomic DNA expression library: a high capacity vector system for functional genomics.

Sci Rep 2016 06 29;6:28644. Epub 2016 Jun 29.

Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep28644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926088PMC
June 2016

Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism.

Proc Natl Acad Sci U S A 2016 Apr 21;113(15):E2180-8. Epub 2016 Mar 21.

Medical Research Council Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom; Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3QX, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1515941113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839395PMC
April 2016

Improving the physiological realism of experimental models.

Interface Focus 2016 Apr;6(2):20150076

Neuroimaging Centre, Division of Neuroscience, University Medical Center Groningen, Groningen, The Netherlands; Department of Radiology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rsfs.2015.0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759746PMC
April 2016

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Stem Cell Reports 2016 Mar 18;6(3):342-56. Epub 2016 Feb 18.

Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2016.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788783PMC
March 2016

Can pathological oligomeric proteins make good biomarkers? (Commentary on Williams et al.).

Eur J Neurosci 2016 Jan 10;43(1):1-2. Epub 2015 Dec 10.

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejn.13115DOI Listing
January 2016

Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson's disease.

Sci Rep 2015 Nov 26;5:17004. Epub 2015 Nov 26.

Oxford Parkinson's Disease Centre, Anatomy and Genetics, University of Oxford, OX1 3QX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep17004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660280PMC
November 2015

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain.

Brain 2015 Jun 1;138(Pt 6):1642-57. Epub 2015 Mar 1.

1 Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK 2 Oxford Parkinson's Disease Centre, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford, OX1 3QX, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awv040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614141PMC
June 2015

Expanded GAA repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells.

Hum Mol Genet 2015 Jun 26;24(12):3457-71. Epub 2015 Mar 26.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddv096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498154PMC
June 2015

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.

Brain 2015 May 14;138(Pt 5):e348. Epub 2014 Nov 14.

1 Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awu308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963397PMC
May 2015

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease.

Trends Biochem Sci 2015 Apr 8;40(4):200-10. Epub 2015 Mar 8.

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2015.02.003DOI Listing
April 2015

Identification of distinct circulating exosomes in Parkinson's disease.

Ann Clin Transl Neurol 2015 Apr 6;2(4):353-61. Epub 2015 Feb 6.

Nuffield Department of Clinical Neurosciences, University of Oxford Oxford, United Kingdom ; Oxford Parkinson's Disease Centre, University of Oxford Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402081PMC
April 2015

Impaired intracellular trafficking defines early Parkinson's disease.

Trends Neurosci 2015 Mar 29;38(3):178-88. Epub 2015 Jan 29.

Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2014.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740565PMC
March 2015

Physiological characterisation of human iPS-derived dopaminergic neurons.

PLoS One 2014 21;9(2):e87388. Epub 2014 Feb 21.

Oxford Parkinson's Disease Centre, University of Oxford, Oxford, United Kingdom ; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087388PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931621PMC
January 2015

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

PLoS Genet 2014 May 1;10(5):e1004318. Epub 2014 May 1.

Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006715PMC
May 2014

Familial Alzheimer's disease coding mutations reduce Presenilin-1 expression in a novel genomic locus reporter model.

Neurobiol Aging 2014 Feb 4;35(2):443.e5-443.e16. Epub 2013 Sep 4.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2013.07.026DOI Listing
February 2014

α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease.

Free Radic Biol Med 2014 Feb 19;67:58-68. Epub 2013 Oct 19.

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2013.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238936PMC
February 2014

The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort.

Parkinsonism Relat Disord 2014 Jan 12;20(1):99-105. Epub 2013 Oct 12.

Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, United Kingdom; Oxford Parkinson Disease Centre, University of Oxford, Oxford, United Kingdom; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.parkreldis.2013.09.025DOI Listing
January 2014

Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease.

Biochem Soc Trans 2013 Dec;41(6):1503-8

*Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20130194DOI Listing
December 2013

Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

Proc Natl Acad Sci U S A 2013 Oct 30;110(42):E4016-25. Epub 2013 Sep 30.

Oxford Parkinson's Disease Centre Department of Physiology, Anatomy and Genetics, Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, and Department of Experimental Psychology, University of Oxford, Oxford OX1 3QX, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1309143110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801069PMC
October 2013

RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum.

Brain 2013 May 9;136(Pt 5):1345-60. Epub 2013 Mar 9.

Department of Physiology, Anatomy and Genetics University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awt030DOI Listing
May 2013

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models.

Biochem Soc Trans 2012 Oct;40(5):1080-5

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20120151DOI Listing
October 2012

Cellular reprogramming: a new approach to modelling Parkinson's disease.

Biochem Soc Trans 2012 Oct;40(5):1152-7

Oxford Parkinson's Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20120159DOI Listing
October 2012

The role of MAPT sequence variation in mechanisms of disease susceptibility.

Biochem Soc Trans 2012 Aug;40(4):687-92

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://biochemsoctrans.org/lookup/doi/10.1042/BST20120063
Publisher Site
http://dx.doi.org/10.1042/BST20120063DOI Listing
August 2012

A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.

Autophagy 2012 Apr 1;8(4):677-89. Epub 2012 Apr 1.

BRC Translational Immunology Laboratory, National Institute for Health Research, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford UK.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/abs/10.4161/auto.18935
Publisher Site
http://dx.doi.org/10.4161/auto.18935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405842PMC
April 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://www.dwalab.ca/common/pdf/cdd200944a.pdf
Web Search
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404883PMC
http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

Combining M-FISH and Quantum Dot technology for fast chromosomal assignment of transgenic insertions.

BMC Biotechnol 2011 Dec 13;11:121. Epub 2011 Dec 13.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1472-6750-11-121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266222PMC
December 2011

Episomal transgene expression in pluripotent stem cells.

Methods Mol Biol 2011 ;767:369-87

Molecular Neurodegeneration and Gene Therapy Research Group, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-61779-201-4_27
Publisher Site
http://dx.doi.org/10.1007/978-1-61779-201-4_27DOI Listing
November 2011

A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.

Biochem Soc Trans 2011 Aug;39(4):862-7

Department of Physiology, Anatomy and Genetics and Oxford Parkinson's Disease Centre, University of Oxford, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST0390862DOI Listing
August 2011

Developing extrachromosomal gene expression vector technologies: an overview.

Methods Mol Biol 2011 ;738:1-17

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-099-7_1DOI Listing
July 2011

High capacity extrachromosomal gene expression vectors.

Methods Mol Biol 2011 ;738:19-40

Department of Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-099-7_2DOI Listing
July 2011

α-Synuclein and dopamine at the crossroads of Parkinson's disease.

Trends Neurosci 2010 Dec 18;33(12):559-68. Epub 2010 Oct 18.

Department of Physiology, Anatomy and Genetics; Oxford Parkinson's Disease Centre, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2010.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631137PMC
December 2010

Parkinson disease, LRRK2 and the endocytic-autophagic pathway.

Autophagy 2009 Nov 24;5(8):1208-10. Epub 2009 Nov 24.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/auto.5.8.9894DOI Listing
November 2009

Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons.

Mol Ther 2009 Sep 7;17(9):1517-26. Epub 2009 Apr 7.

Department of Neurological Surgery, Dardinger Laboratory for Neuro-oncology and Neurosciences, The Ohio State University Medical School, Columbus, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2009.64DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835262PMC
September 2009

Quantitative characterization of cell transduction by HSV-1 amplicons using flow cytometry and real-time PCR.

J Virol Methods 2009 Aug 26;159(2):160-6. Epub 2009 Mar 26.

Department of Clinical Pharmacology, Old Road Campus Research Building, University of Oxford, Oxford OX3 7DQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jviromet.2009.03.018DOI Listing
August 2009

Knock-out and transgenic mouse models of tauopathies.

Neurobiol Aging 2009 Jan 22;30(1):1-13. Epub 2007 Jun 22.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2007.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806682PMC
January 2009

Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus.

Neurobiol Aging 2008 Dec 28;29(12):1923-9. Epub 2007 Jun 28.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S019745800700205
Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2007.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801070PMC
December 2008

The effect of alpha-synuclein knockdown on MPP+ toxicity in models of human neurons.

Eur J Neurosci 2008 Dec 21;28(12):2459-73. Epub 2008 Nov 21.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1460-9568.2008.06527.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132457PMC
December 2008

Advances in high-capacity extrachromosomal vector technology: episomal maintenance, vector delivery, and transgene expression.

Mol Ther 2008 Sep 15;16(9):1525-38. Epub 2008 Jul 15.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2008.156DOI Listing
September 2008

An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency.

Nucleic Acids Res 2007 2;35(15):e98. Epub 2007 Aug 2.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkm570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976449PMC
October 2007

Functional MAPT haplotypes: bridging the gap between genotype and neuropathology.

Neurobiol Dis 2007 Jul 5;27(1):1-10. Epub 2007 May 5.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S096999610700094
Publisher Site
http://dx.doi.org/10.1016/j.nbd.2007.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801069PMC
July 2007

RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport.

J Neurosci Res 2007 Feb;85(2):351-63

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jnr.21125DOI Listing
February 2007

Infectious Delivery and Expression of a 135 kb Human FRDA Genomic DNA Locus Complements Friedreich's Ataxia Deficiency in Human Cells.

Mol Ther 2007 Feb 8;15(2):248-254. Epub 2016 Dec 8.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.mt.6300021DOI Listing
February 2007

Haplotype-specific expression of exon 10 at the human MAPT locus.

Hum Mol Genet 2006 Dec 3;15(24):3529-37. Epub 2006 Nov 3.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://academic.oup.com/hmg/article/15/24/3529/597842/Haplot
Publisher Site
http://dx.doi.org/10.1093/hmg/ddl429DOI Listing
December 2006

A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors.

EMBO Rep 2006 Sep 11;7(9):911-8. Epub 2006 Aug 11.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.embor.7400768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559671PMC
September 2006

Delivery of large genomic DNA inserts >100 kb using HSV-1 amplicons.

Curr Gene Ther 2006 Jun;6(3):325-36

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

View Article

Download full-text PDF

Source
June 2006

Delivering RNA interference to the mammalian brain.

Curr Gene Ther 2005 Aug;5(4):399-410

The Wellcome Trust Centre For Human Genetics, University of Oxford, UK.

View Article

Download full-text PDF

Source
August 2005

Herpes simplex virus type 1 amplicon vectors for the infectious delivery and expression of genomic DNA loci.

Curr Opin Mol Ther 2005 Aug;7(4):337-45

Wellcome Trust Centre For Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX37BN, UK.

View Article

Download full-text PDF

Source
August 2005

Functional delivery of large genomic DNA to human cells with a peptide-lipid vector.

J Gene Med 2003 Oct;5(10):883-892

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jgm.420DOI Listing
October 2003