Richard A Padgett

Richard A Padgett

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Richard A Padgett

Richard A Padgett

Publications by authors named "Richard A Padgett"

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Clinical interpretation of variants identified in RNU4ATAC, a non-coding spliceosomal gene.

PLoS One 2020 6;15(7):e0235655. Epub 2020 Jul 6.

Equipe GENDEV, Centre de Recherche en Neurosciences de Lyon, Inserm U1028, CNRS UMR5292, Université Lyon 1, Université St Etienne, Lyon, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235655PLOS
July 2020

Comprehensive database and evolutionary dynamics of U12-type introns.

Nucleic Acids Res 2020 Jun 2. Epub 2020 Jun 2.

Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic and Department of Molecular Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1093/nar/gkaa464DOI Listing
June 2020

New roles for old RNA cap flavors.

Nat Chem Biol 2019 04;15(4):317-318

Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1038/s41589-019-0252-3DOI Listing
April 2019

The hnRNP RALY regulates transcription and cell proliferation by modulating the expression of specific factors including the proliferation marker E2F1.

J Biol Chem 2017 12 27;292(48):19674-19692. Epub 2017 Sep 27.

From the Laboratory of Molecular and Cellular Neurobiology, Centre for Integrative Biology, University of Trento, via Sommarive 9, 38123 Trento, Italy,

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http://dx.doi.org/10.1074/jbc.M117.795591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712610PMC
December 2017

DDX41-related myeloid neoplasia.

Semin Hematol 2017 04 21;54(2):94-97. Epub 2017 Apr 21.

Medizinische Klinik V, Hämatologie, Onkologie und Rheumatologie, Universitätsklinikum Heidelberg, Germany.

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http://dx.doi.org/10.1053/j.seminhematol.2017.04.007DOI Listing
April 2017

Finding the unexpected--how we identified a second class of introns and the U12-dependent spliceosome.

RNA 2015 Apr;21(4):544-5

Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA

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http://dx.doi.org/10.1261/rna.050245.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371272PMC
April 2015

Biochemical defects in minor spliceosome function in the developmental disorder MOPD I.

RNA 2014 Jul 27;20(7):1078-89. Epub 2014 May 27.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1261/rna.045187.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114687PMC
July 2014

Defects in spliceosomal machinery: a new pathway of leukaemogenesis.

Br J Haematol 2012 Jul 18;158(2):165-173. Epub 2012 May 18.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2012.09158.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507475PMC
July 2012

New connections between splicing and human disease.

Trends Genet 2012 Apr 5;28(4):147-54. Epub 2012 Mar 5.

Department of Molecular Genetics, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1016/j.tig.2012.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319163PMC
April 2012

Rates of in situ transcription and splicing in large human genes.

Nat Struct Mol Biol 2009 Nov 11;16(11):1128-33. Epub 2009 Oct 11.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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http://www.nature.com/articles/nsmb.1666
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http://dx.doi.org/10.1038/nsmb.1666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783620PMC
November 2009

Biased chromatin signatures around polyadenylation sites and exons.

Mol Cell 2009 Oct;36(2):245-54

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10972765090074
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http://dx.doi.org/10.1016/j.molcel.2009.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786773PMC
October 2009

The conserved 3' end domain of U6atac snRNA can direct U6 snRNA to the minor spliceosome.

RNA 2009 Jun 16;15(6):1198-207. Epub 2009 Apr 16.

1Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1261/rna.1505709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685526PMC
June 2009

Mutational analysis of the U12-dependent branch site consensus sequence.

RNA 2008 Nov 29;14(11):2430-9. Epub 2008 Sep 29.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://www.rnajournal.org/cgi/doi/10.1261/rna.1189008
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http://dx.doi.org/10.1261/rna.1189008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578861PMC
November 2008

A glimpse into the active site of a group II intron and maybe the spliceosome, too.

RNA 2008 Sep 24;14(9):1697-703. Epub 2008 Jul 24.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1261/rna.1154408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2525965PMC
September 2008

Where in the cell is the minor spliceosome?

Proc Natl Acad Sci U S A 2008 Jun 17;105(25):8485-6. Epub 2008 Jun 17.

Yale University and Howard Hughes Medical Institute, New Haven, CT 06536, USA.

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http://dx.doi.org/10.1073/pnas.0804024105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438384PMC
June 2008

Fluorescence and solution NMR study of the active site of a 160-kDa group II intron ribozyme.

RNA 2006 Sep 7;12(9):1693-707. Epub 2006 Aug 7.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1261/rna.137006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557703PMC
September 2006

Structure of a self-splicing group II intron catalytic effector domain 5: parallels with spliceosomal U6 RNA.

RNA 2006 Feb;12(2):235-47

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1261/rna.2237806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370903PMC
February 2006

A mutational analysis of U12-dependent splice site dinucleotides.

RNA 2005 Sep 25;11(9):1430-40. Epub 2005 Jul 25.

Department of Molecular Genetics, NE-20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1261/rna.7206305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370826PMC
September 2005

U4 small nuclear RNA can function in both the major and minor spliceosomes.

Proc Natl Acad Sci U S A 2004 Jan 22;101(1):93-8. Epub 2003 Dec 22.

Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1073/pnas.0304919101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC314144PMC
January 2004

Domains of human U4atac snRNA required for U12-dependent splicing in vivo.

Nucleic Acids Res 2002 Nov;30(21):4650-7

Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135832PMC
http://dx.doi.org/10.1093/nar/gkf609DOI Listing
November 2002

A catalytically active group II intron domain 5 can function in the U12-dependent spliceosome.

Mol Cell 2002 May;9(5):1145-50

Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00505-1DOI Listing
May 2002