Publications by authors named "Ren-Ke Li"

232Publications

Understanding systemic factors in aging and rejuvenation.

Aging (Albany NY) 2020 11 13;12(21):20936-20937. Epub 2020 Nov 13.

Toronto General Hospital Research Institute, Division of Cardiovascular Surgery, University Health Network, Toronto, Ontario, Canada.

View Article and Find Full Text PDF
November 2020

Evidence for the existence of CD34 angiogenic stem cells in human first-trimester decidua and their therapeutic for ischaemic heart disease.

J Cell Mol Med 2020 Oct 8;24(20):11837-11848. Epub 2020 Sep 8.

Department of Cardiovascular Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

View Article and Find Full Text PDF
October 2020

Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction.

Cells 2020 08 13;9(8). Epub 2020 Aug 13.

Division of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5T 1P5, Canada.

View Article and Find Full Text PDF
August 2020

The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure.

Biomaterials 2020 Nov 3;258:120285. Epub 2020 Aug 3.

Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Cardiovascular Surgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Canada. Electronic address:

View Article and Find Full Text PDF
November 2020

Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors.

J Neuroinflammation 2020 Feb 7;17(1):51. Epub 2020 Feb 7.

Toronto General Hospital Research Institute, University Health Network, Toronto Medical Discovery Tower, Room 3-702, 101 College Street, Toronto, Ontario, M5G 1L7, Canada.

View Article and Find Full Text PDF
February 2020

Targeting aged bone marrow for systemic rejuvenation.

Aging (Albany NY) 2020 02 6;12(3):2024-2025. Epub 2020 Feb 6.

Toronto General Hospital Research Institute, Toronto General Hospital, Toronto, ON, Canada.

View Article and Find Full Text PDF
February 2020

A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair.

J Control Release 2020 04 17;320:73-82. Epub 2020 Jan 17.

Toronto General Hospital Research Institute, Division of Cardiovascular Surgery, University Health Network, Toronto, Canada; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Canada. Electronic address:

View Article and Find Full Text PDF
April 2020

A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function.

Biomaterials 2020 02 9;231:119672. Epub 2019 Dec 9.

Toronto General Hospital Research Institute, Division of Cardiovascular Surgery, University Health Network, Toronto, Canada; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Canada. Electronic address:

View Article and Find Full Text PDF
February 2020

Protective role of Nrf2 against ischemia reperfusion injury and cardiac allograft vasculopathy.

Am J Transplant 2020 05 3;20(5):1262-1271. Epub 2020 Jan 3.

Division of Cardiovascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

View Article and Find Full Text PDF
May 2020

Mesenchymal Stromal Cells from Patients with Cyanotic Congenital Heart Disease are Optimal Candidate for Cardiac Tissue Engineering.

Biomaterials 2020 02 6;230:119574. Epub 2019 Nov 6.

Department of Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China; The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Heilongjiang Province, China. Electronic address:

View Article and Find Full Text PDF
February 2020

CD34 Stem Cells: Promising Roles in Cardiac Repair and Regeneration.

Can J Cardiol 2019 10 11;35(10):1311-1321. Epub 2019 Jun 11.

Toronto General Hospital Research Institute, Division of Cardiovascular Surgery, University Health Network, Toronto, Ontario, Canada; Division of Cardiac Surgery, Department of Surgery, University of Toronto; Toronto, Ontario, Canada. Electronic address:

View Article and Find Full Text PDF
October 2019

Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation.

Aging Cell 2019 12 5;18(6):e13026. Epub 2019 Aug 5.

Division of Cardiovascular Surgery, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada.

View Article and Find Full Text PDF
December 2019

Effect of neuron-derived neurotrophic factor on rejuvenation of human adipose-derived stem cells for cardiac repair after myocardial infarction.

J Cell Mol Med 2019 09 9;23(9):5981-5993. Epub 2019 Jul 9.

Division of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.

View Article and Find Full Text PDF
September 2019

Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias.

Stem Cell Reports 2019 05 2;12(5):967-981. Epub 2019 May 2.

McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Peter Munk Cardiac Centre, University Health Network, Toronto, ON M5G 2N2, Canada; University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address:

View Article and Find Full Text PDF
May 2019

Knockout of Canopy 2 activates p16 pathway to impair cardiac repair.

J Mol Cell Cardiol 2019 07 29;132:36-48. Epub 2019 Apr 29.

Toronto General Hospital Research Institute, Division of Cardiovascular Surgery, University Health Network, Toronto, ON, Canada; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article and Find Full Text PDF
July 2019

Novel mediators of aneurysm progression in bicuspid aortic valve disease.

J Mol Cell Cardiol 2019 07 29;132:71-83. Epub 2019 Apr 29.

Division of Cardiovascular Surgery, Toronto General Hospital Research Institute and Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada; Department of Surgery, Division of Cardiac Surgery, University of Toronto, Toronto, ON, Canada. Electronic address:

View Article and Find Full Text PDF
July 2019

Commentary: Circulating factors released after myocardial infarction: Beneficial or detrimental?

J Thorac Cardiovasc Surg 2019 06 8;157(6):2270-2271. Epub 2018 Nov 8.

Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

View Article and Find Full Text PDF
June 2019