Prof. Ravishankar Ramachandran, PhD - Central Drug Research Institute - Head, Molecular and Structural biology Division

Prof. Ravishankar Ramachandran

PhD

Central Drug Research Institute

Head, Molecular and Structural biology Division

Lucknow, Uttar Pradesh | India

Prof. Ravishankar Ramachandran, PhD - Central Drug Research Institute - Head, Molecular and Structural biology Division

Prof. Ravishankar Ramachandran

PhD

Introduction

Primary Affiliation: Central Drug Research Institute - Lucknow, Uttar Pradesh , India

Metrics

Number of Publications

50

Publications

Number of Profile Views

216

Profile Views

Number of Article Reads

357

Reads

Number of PubMed Central Citations

209

PubMed Central Citations

Publications

50Publications

357Reads

209PubMed Central Citations

Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy.

Mol Cell Endocrinol 2017 01 16;439:273-285. Epub 2016 Sep 16.

Division of Biochemistry, CSIR-Central Drug Research Institute, 10, Janakipuram Extn, Sitapur Road, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), CSIR- Central Drug Research Institute Campus, 10, Janakipuram Extn, Sitapur Road, Lucknow 226031, India. Electronic address:

View Article
January 2017
7 Reads
4.41 Impact Factor

Piscidin-1-analogs with double L- and D-lysine residues exhibited different conformations in lipopolysaccharide but comparable anti-endotoxin activities.

Sci Rep 2017 01 4;7:39925. Epub 2017 Jan 4.

Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow-226 031, India.

View Article
January 2017
18 Reads
4 PubMed Central Citations(source)
5.08 Impact Factor

The M. tuberculosis HAD phosphatase (Rv3042c) interacts with host proteins and is inhibited by Clofazimine.

Cell Mol Life Sci 2016 09 17;73(17):3401-17. Epub 2016 Mar 17.

Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, Uttar Pradesh, India.

View Article
September 2016
13 Reads
1 PubMed Central Citation(source)
5.81 Impact Factor

Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase.

Biochem Biophys Res Commun 2016 09 4;478(2):721-6. Epub 2016 Aug 4.

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address:

View Article
September 2016
3 Reads
2.30 Impact Factor

Crystal Structure of Mycobacterium tuberculosis H37Rv AldR (Rv2779c), a Regulator of the ald Gene: DNA BINDING AND IDENTIFICATION OF SMALL MOLECULE INHIBITORS.

J Biol Chem 2016 Jun 22;291(23):11967-80. Epub 2016 Mar 22.

From the Molecular and Structural Biology Division and

View Article
June 2016
9 Reads
2 PubMed Central Citations(source)
4.57 Impact Factor

Single Amino Acid Substitutions at Specific Positions of the Heptad Repeat Sequence of Piscidin-1 Yielded Novel Analogs That Show Low Cytotoxicity and In Vitro and In Vivo Antiendotoxin Activity.

Antimicrob Agents Chemother 2016 06 23;60(6):3687-99. Epub 2016 May 23.

Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, India Academy of Scientific and Innovative Research, Chennai, India

View Article
June 2016
15 Reads
3 PubMed Central Citations(source)
4.48 Impact Factor

Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors.

Org Biomol Chem 2016 Jan 11;14(4):1338-58. Epub 2015 Dec 11.

Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute (CSIR-CDRI), Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.

View Article
January 2016
6 Reads
3.56 Impact Factor

Characterization of M. tuberculosis SerB2, an essential HAD-family phosphatase, reveals novel properties.

PLoS One 2014 18;9(12):e115409. Epub 2014 Dec 18.

Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh, 226031, India.

View Article
December 2015
13 Reads
1 PubMed Central Citation(source)
3.23 Impact Factor

Mycobacterium tuberculosis class II apurinic/apyrimidinic-endonuclease/3'-5' exonuclease III exhibits DNA regulated modes of interaction with the sliding DNA β-clamp.

Mol Microbiol 2015 Oct 17;98(1):46-68. Epub 2015 Jul 17.

Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh, 226031, India.

View Article
October 2015
3 Reads
4.42 Impact Factor

Mutational analysis of Mycobacterium tuberculosis lysine ɛ-aminotransferase and inhibitor co-crystal structures, reveals distinct binding modes.

Biochem Biophys Res Commun 2015 Jul 17-24;463(1-2):154-60. Epub 2015 May 20.

Molecular & Structural Biology Division, Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P., India. Electronic address:

View Article
August 2015
1 Read
2.30 Impact Factor

Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.

Org Biomol Chem 2015 May;13(19):5475-87

From Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Sector10, Jankipuram Extension, Sitapur Road, Uttar Pradesh, Lucknow-226031, India.

View Article
May 2015
15 Reads
1 PubMed Central Citation(source)
3.56 Impact Factor

Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3'-5' exonuclease III.

Biochim Biophys Acta 2015 May 5;1854(5):505-16. Epub 2015 Mar 5.

Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Lucknow, Uttar Pradesh 226031, India. Electronic address:

View Article
May 2015
10 Reads

Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents.

ACS Med Chem Lett 2014 Aug 2;5(8):878-83. Epub 2014 Jun 2.

Academy of Innovative Science and Research, Medicinal and Process Chemistry Division, Parasitology Division, Pharmacokinetics & Metabolism Division, and Molecular and Structural Biology Division, CSIR-Central Drug Research Institute (CSIR-CDRI) , Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.

View Article
August 2014
11 Reads
3.12 Impact Factor

Dynamics of physical interaction between HIV-1 Nef and ASK1: identifying the interacting motif(s).

PLoS One 2013 14;8(6):e67586. Epub 2013 Jun 14.

Division of Toxicology, Central Drug Research Institute (Council of Scientific & Industrial Research), BS-10/1, Sector-10 Jankipuram Extension, Uttar Pradesh, India.

View Article
January 2014
8 Reads
3 PubMed Central Citations(source)
3.23 Impact Factor

Cloning, overexpression, purification and preliminary X-ray analysis of a feast/famine regulatory protein (Rv2779c) from Mycobacterium tuberculosis H37Rv.

Acta Crystallogr F Struct Biol Commun 2014 Jan 24;70(Pt 1):97-100. Epub 2013 Dec 24.

Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, B.S/10/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226 031, India.

View Article
January 2014
4 Reads
3 PubMed Central Citations(source)

Identification of 1-[4-Benzyloxyphenyl)-but-3-enyl]-1H-azoles as New Class of Antitubercular and Antimicrobial Agents.

ACS Med Chem Lett 2013 Oct 26;4(10):958-63. Epub 2013 Aug 26.

Academy of Scientific and Innovative and Research, Division of Medicinal & Process Chemistry, Drug Target Discovery and Development, Microbiology, Molecular and Structural Biology, Pharmaceutics, Sophisticated Analytical Instrumentation Facility, Fermentation Technology, Pharmacokinetics & Metabolism, Central Drug Research Institute , CSIR, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226001, India.

View Article
October 2013
11 Reads
3.12 Impact Factor

Rv3868 (EccA1), an essential component of the Mycobacterium tuberculosis ESX-1 secretion system, is thermostable.

Biochim Biophys Acta 2013 Jun 13;1834(6):1181-6. Epub 2013 Feb 13.

CSIR-Central Drug Research Institute, Mahatma Gandhi Marg, Lucknow, India.

View Article
June 2013
6 Reads

Crystal structure of the hexachlorocyclohexane dehydrochlorinase (LinA-type2): mutational analysis, thermostability and enantioselectivity.

PLoS One 2012 27;7(11):e50373. Epub 2012 Nov 27.

Environmental Biotechnology Division, CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow, India.

View Article
June 2013
6 Reads
2 PubMed Central Citations(source)
3.23 Impact Factor

M. tuberculosis sliding β-clamp does not interact directly with the NAD+-dependent DNA ligase.

PLoS One 2012 24;7(4):e35702. Epub 2012 Apr 24.

Molecular and Structural Biology Division, Central Drug Research Institute (Council of Scientific and Industrial Research), Lucknow, Uttar Pradesh, India.

View Article
August 2012
2 Reads
4 PubMed Central Citations(source)
3.23 Impact Factor

Mechanism of inhibition of the ATPase domain of human topoisomerase IIα by 1,4-benzoquinone, 1,2-naphthoquinone, 1,4-naphthoquinone, and 9,10-phenanthroquinone.

Toxicol Sci 2012 Apr 4;126(2):372-90. Epub 2012 Jan 4.

Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Lucknow-226001, Uttar Pradesh, India.

View Article
April 2012
4 Reads
5 PubMed Central Citations(source)

A novel dimer-tetramer transition captured by the crystal structure of the HIV-1 Nef.

PLoS One 2011 2;6(11):e26629. Epub 2011 Nov 2.

Toxicology Division, Central Drug Research Institute, Council of Scientific & Industrial Research, Chattar Manzil, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, India.

View Article
March 2012
2 Reads
8 PubMed Central Citations(source)
3.23 Impact Factor

Structural biology of Mycobacterium tuberculosis proteins: the Indian efforts.

Tuberculosis (Edinb) 2011 Sep 22;91(5):456-68. Epub 2011 Apr 22.

Molecular and Structural Biology Division, Central Drug Research Institute, CSIR, Chattar Manzil Palace, MG Road, Lucknow 226001, India.

View Article
September 2011
6 Reads
2 PubMed Central Citations(source)
2.71 Impact Factor

Exploring the positional importance of aromatic residues and lysine in the interactions of peptides with the Plasmodium falciparum Hsp70-1.

Biochim Biophys Acta 2010 Nov 21;1804(11):2146-52. Epub 2010 Aug 21.

Central Drug Research Institute, CSIR, Lucknow, India.

View Article
November 2010
3 Reads
1 PubMed Central Citation(source)

Ligand-induced structural transitions, mutational analysis, and 'open' quaternary structure of the M. tuberculosis feast/famine regulatory protein (Rv3291c).

J Mol Biol 2009 Oct 3;392(4):1007-19. Epub 2009 Aug 3.

Molecular and Structural Biology Division, Central Drug Research Institute, P.O. Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226001, India.

View Article
October 2009
5 Reads
6 PubMed Central Citations(source)
4.33 Impact Factor

Hsp70-1 from Plasmodium falciparum: protein stability, domain analysis and chaperone activity.

Biophys Chem 2009 Jun 16;142(1-3):55-64. Epub 2009 Mar 16.

Molecular & Structural Biology Division, Central Drug Research Institute, P.O. Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow-226001, India.

View Article
June 2009
2 Reads
4 PubMed Central Citations(source)
1.99 Impact Factor

Interactions of the M. tuberculosis UsfX with the cognate sigma factor SigF and the anti-anti sigma factor RsfA.

Biochim Biophys Acta 2009 Mar 27;1794(3):541-53. Epub 2008 Nov 27.

Molecular and Structural Biology Division, Central Drug Research Institute, P.O. Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow-226001, India.

View Article
March 2009
2 Reads
2 PubMed Central Citations(source)

Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis.

J Biol Chem 2008 Dec 30;283(52):36532-41. Epub 2008 Oct 30.

Molecular and Structural Biology Division, Central Drug Research Institute, P.O. Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow-226001, India.

View Article
December 2008
2 Reads
9 PubMed Central Citations(source)
4.57 Impact Factor

Cloning, purification and comparative structural analysis of two hypothetical proteins from Mycobacterium tuberculosis found in the human granuloma during persistence and highly up-regulated under carbon-starvation conditions.

Protein Expr Purif 2008 Nov 2;62(1):64-74. Epub 2008 Jul 2.

Molecular & Structural Biology Division, Central Drug Research Institute, Chattar Manzil, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh 226001, India.

View Article
November 2008
1 Read
2 PubMed Central Citations(source)
1.70 Impact Factor

Mycobacterium tuberculosis UsfX (Rv3287c) exhibits novel nucleotide binding and hydrolysis properties.

Biochem Biophys Res Commun 2008 Oct 21;375(3):465-70. Epub 2008 Aug 21.

Molecular & Structural Biology Division, Central Drug Research Institute, P.O. Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh 226001, India.

View Article
October 2008
4 Reads
1 PubMed Central Citation(source)
2.30 Impact Factor

Crystal structures of the Mycobacterium tuberculosis secretory antigen alanine dehydrogenase (Rv2780) in apo and ternary complex forms captures "open" and "closed" enzyme conformations.

Proteins 2008 Aug;72(3):1089-95

Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow, India.

View Article
August 2008
2 Reads
9 PubMed Central Citations(source)
2.63 Impact Factor

NAD(+)-dependent DNA ligase: a novel target waiting for the right inhibitor.

Med Res Rev 2008 Jul;28(4):545-68

Medicinal & Process Chemistry Division, Central Drug Research Institute, Chattar Manzil, P.O. Box 173, Mahatma Gandhi Marg, Lucknow-226001, India.

View Article
July 2008
2 Reads
8 PubMed Central Citations(source)
8.43 Impact Factor

Overexpression, purification, crystallization and preliminary X-ray analysis of Rv2780 from Mycobacterium tuberculosis H37Rv.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 May 5;64(Pt 5):367-70. Epub 2008 Apr 5.

Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226001, India.

View Article
May 2008
4 Reads
1 PubMed Central Citation(source)
0.57 Impact Factor

Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv.

Nucleic Acids Res 2007 25;35(21):7324-35. Epub 2007 Oct 25.

Molecular & Structural Biology Division, Central Drug Research Institute, P.O. Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow-226001, India.

View Article
January 2008
3 Reads
12 PubMed Central Citations(source)
9.11 Impact Factor

Purification, crystallization and preliminary structural analysis of nucleoside diphosphate kinase from Bacillus anthracis.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Dec 30;63(Pt 12):1084-6. Epub 2007 Nov 30.

Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226 001, India.

View Article
December 2007
6 Reads
0.57 Impact Factor

NAD+-dependent DNA ligase (Rv3014c) from Mycobacterium tuberculosis: novel structure-function relationship and identification of a specific inhibitor.

Proteins 2007 Oct;69(1):97-111

Molecular and Structural Biology Division, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India.

View Article
October 2007
17 Reads
11 PubMed Central Citations(source)
2.63 Impact Factor

Direct evidence for a glutamate switch necessary for substrate recognition: crystal structures of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv.

J Mol Biol 2006 Oct 11;362(5):877-86. Epub 2006 Aug 11.

Molecular and Structural Biology Division, Central Drug Research Institute, Chattar Manzil, Mahatma Gandhi Marg, Lucknow-226001, India.

View Article
October 2006
1 Read
6 PubMed Central Citations(source)
4.33 Impact Factor

Overexpression, purification and crystallization of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Jun 31;62(Pt 6):572-5. Epub 2006 May 31.

Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226001, India.

View Article
June 2006
2 Reads
3 PubMed Central Citations(source)
0.57 Impact Factor

Mycobacterium tuberculosis NAD+-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I.

Nucleic Acids Res 2005 15;33(22):7090-101. Epub 2005 Dec 15.

Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil, Mahatma Gandhi Marg, Lucknow 226001, India.

View Article
January 2006
8 Reads
10 PubMed Central Citations(source)
9.11 Impact Factor

NAD+-dependent DNA Ligase (Rv3014c) from Mycobacterium tuberculosis. Crystal structure of the adenylation domain and identification of novel inhibitors.

J Biol Chem 2005 Aug 17;280(34):30273-81. Epub 2005 May 17.

Division Molecular and Structural Biology, Central Drug Research Institute, Chattar Manzil, Mahatma Gandhi Marg, Lucknow-226001, India.

View Article
August 2005
17 Reads
19 PubMed Central Citations(source)
4.57 Impact Factor

Characterization of the HslU chaperone affinity for HslV protease.

Protein Sci 2005 May 31;14(5):1357-62. Epub 2005 Mar 31.

Max-Planck-Institut für Biochemie, Martinsried, Germany.

View Article
May 2005
17 Reads
6 PubMed Central Citations(source)
2.85 Impact Factor

Cloning, expression, purification and crystallization of a transcriptional regulatory protein (Rv3291c) from Mycobacterium tuberculosis H37Rv.

Acta Crystallogr D Biol Crystallogr 2004 Oct 23;60(Pt 10):1874-6. Epub 2004 Sep 23.

Molecular and Structural Biology Division, Central Drug Research Institute, PO Box 173, Chattar Manzil Palace, Mahatma Gandhi Marg, Lucknow 226001 (U.P.), India.

View Article
October 2004
4 Reads
2 PubMed Central Citations(source)
7.23 Impact Factor

Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV.

Biophys Chem 2003 ;100(1-3):437-52

Abteilung Strukturforschung, Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, D-82152 Planegg-Martinsried, Germany.

View Article
December 2003
3 Reads
8 PubMed Central Citations(source)
1.99 Impact Factor

Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY).

Proc Natl Acad Sci U S A 2002 May;99(11):7396-401

Abteilung Strukturforschung, Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, D-82152 Planegg-Martinsried, Germany.

View Article
May 2002
4 Reads
21 PubMed Central Citations(source)
9.81 Impact Factor