Publications by authors named "Ramla Muhammad Kamal"

3 Publications

  • Page 1 of 1

Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.

Biomed Pharmacother 2021 Aug 12;140:111732. Epub 2021 Jun 12.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Nerol, a monoterpene is evident to possess diverse biological activities, including antioxidant, anti-microbial, anti-spasmodic, anthelmintic, and anti-arrhythmias. This study aims to evaluate its hepatoprotective effect against paracetamol-induced liver toxicity in a rat model. Five groups of rats (n = 7) were orally treated (once daily) with 0.05% tween 80 dissolved in 0.9% NaCl solution (vehicle), paracetamol 640 mg/kg (negative control), 50 mg/kg silymarin (positive control), or nerol (50 and 100 mg/kg) for 14 days, followed by the hepatotoxicity induction using paracetamol (PCM). The blood samples and livers of the animals were collected and subjected to biochemical and microscopical analysis. The histological findings suggest that paracetamol caused lymphocyte infiltration and marked necrosis, whereas maintenance of the normal hepatic structural was observed in group pre-treated with silymarin and nerol. The rats pre-treated with nerol significantly and dose-dependently reduced the hepatotoxic markers in animals. Nerol at 100 mg/kg significantly reversed the paracetamol-induced altered situations, including the liver enzymes, plasma proteins, antioxidant enzymes and serum bilirubin, lipid peroxidation (LPO) and cholesterol [e.g., total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c)] levels in animals. Taken together, nerol exerted significant hepatoprotective activity in rats in a dose-dependent manner. PCM-induced toxicity and nerol induced hepatoprotective effects based on expression of inflammatory and apoptosis factors will be future line of work for establishing the precise mechanism of action of nerol in Wistar albino rats.
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http://dx.doi.org/10.1016/j.biopha.2021.111732DOI Listing
August 2021

Three Selected Edible Crops of the Genus as Potential Sources of Phytochemicals: Biochemical, Nutritional, and Medicinal Values.

Front Pharmacol 2021 13;12:625546. Epub 2021 May 13.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

species (Family Cucurbitaceae) are cultivated throughout the world for their edible fruits, leaves, shoots and seeds. Among the species of the genus there are three selected species that are used as vegetable, and for medicinal purposes, L (Bitter melon), Schumach (Bitter cucumber) and L (African pumpkin). The fruits and leaves of these species are rich in primary and secondary metabolites such as proteins, fibers, minerals (calcium, iron, magnesium, zinc), -carotene, foliate, ascorbic acid, among others. The extracts from species are used for the treatment of a variety of diseases and ailments in traditional medicine. species extracts are reputed to possess anti-diabetic, anti-microbial, anthelmintic bioactivity, abortifacient, anti-bacterial, anti-viral, and play chemo-preventive functions. In this review we summarize the biochemical, nutritional, and medicinal values of three species (, and ) as promising and innovative sources of natural bioactive compounds for future pharmaceutical usage.
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http://dx.doi.org/10.3389/fphar.2021.625546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155620PMC
May 2021

Nigella Plants - Traditional Uses, Bioactive Phytoconstituents, Preclinical and Clinical Studies.

Front Pharmacol 2021 26;12:625386. Epub 2021 Apr 26.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of and, in particular, . The pharmacological studies reported , and in humans have also been reviewed. One of the main strength of the use of is that the seeds are rich in the omega-6 fatty acid linoleic acid and provide an extra-source of dietary phytochemicals, including the bioactive thymoquinone, and characteristics saponins, alkaloids, and flavonoids. Among species, . L. is the most studied plant from the genus. Due to the phytochemical composition and pharmacological properties, the seed and seed oil from this plant can be considered as good candidates to formulate functional ingredients on the basis of folklore and scientific knowledge. Nonetheless, the main limations are that more studies, especially, clinical trials are required to standardize the results, e.g. to establish active molecules, dosage, chemical profile, long-term effects and impact of cooking/incorporation into foods.
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http://dx.doi.org/10.3389/fphar.2021.625386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107825PMC
April 2021
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