Ralph Weissleder

Ralph Weissleder

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Ralph Weissleder

Publications by authors named "Ralph Weissleder"

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Imaging of Tie2 with a Fluorescently Labeled Small Molecule Affinity Ligand.

ACS Chem Biol 2020 Jan 13;15(1):151-157. Epub 2019 Dec 13.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acschembio.9b00724DOI Listing
January 2020

Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy.

Cell Chem Biol 2020 Jan 2;27(1):94-104.e5. Epub 2020 Jan 2.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.12.007DOI Listing
January 2020

Improving nanotherapy delivery and action through image-guided systems pharmacology.

Theranostics 2020 1;10(3):968-997. Epub 2020 Jan 1.

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.

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http://dx.doi.org/10.7150/thno.37215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956809PMC
January 2020

Bioassay for monitoring the anti-aging effect of cord blood treatment.

Theranostics 2019 1;9(1):1-10. Epub 2019 Jan 1.

Department of Biotechnology, College of Life Science, CHA University, Gyeonggi-do 13488, Republic of Korea.

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http://www.thno.org/v09p0001.htm
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http://dx.doi.org/10.7150/thno.30422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332798PMC
December 2019

Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs.

PLoS One 2019 2;14(12):e0225222. Epub 2019 Dec 2.

Center for Surgery, Innovation, and Bioengineering, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225222PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886851PMC
December 2019

Advances in clinical MRI technology.

Sci Transl Med 2019 Dec;11(523)

Department of Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.aba2591DOI Listing
December 2019

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.

Immunity 2019 11 12;51(5):899-914.e7. Epub 2019 Nov 12.

Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892583PMC
November 2019

Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy.

Theranostics 2019 26;9(26):8426-8436. Epub 2019 Nov 26.

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.7150/thno.35434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924259PMC
November 2019

Compact and Filter-Free Luminescence Biosensor for Mobile Diagnoses.

ACS Nano 2019 Oct 6;13(10):11698-11706. Epub 2019 Sep 6.

Center for Systems Biology , Massachusetts General Hospital, Harvard Medical School , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acsnano.9b05634DOI Listing
October 2019

Screening for new macrophage therapeutics.

Theranostics 2019 15;9(25):7714-7729. Epub 2019 Oct 15.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://dx.doi.org/10.7150/thno.34421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831478PMC
October 2019

Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.

Theranostics 2018 12;8(21):5842-5854. Epub 2018 Nov 12.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://www.thno.org/v08p5842.htm
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http://dx.doi.org/10.7150/thno.26888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299430PMC
September 2019

Single-Cell Intravital Microscopy of Trastuzumab Quantifies Heterogeneous in vivo Kinetics.

Cytometry A 2019 Aug 19. Epub 2019 Aug 19.

Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cyto.a.23872DOI Listing
August 2019

Glass Chemistry to Analyze Human Cells under Adverse Conditions.

ACS Omega 2019 Jul 3;4(7):11515-11521. Epub 2019 Jul 3.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsomega.9b01036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682085PMC
July 2019

A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor.

Proc Natl Acad Sci U S A 2019 Jun 17;116(23):11444-11453. Epub 2019 May 17.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1702372116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561274PMC
June 2019

Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity.

Cell Rep 2019 Jun;27(13):3972-3987.e6

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604862PMC
June 2019

Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy.

ACS Nano 2019 Apr 27;13(4):4028-4040. Epub 2019 Mar 27.

Experimental Therapeutics and Molecular Imaging Lab, Department of Neurology, Neuro-Oncology Division , Massachusetts General Hospital , Charlestown , Massachusetts 02129 , United States.

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http://dx.doi.org/10.1021/acsnano.8b08177DOI Listing
April 2019

Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.

Cell Rep 2019 04;27(1):255-268.e6

Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193031
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http://dx.doi.org/10.1016/j.celrep.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528836PMC
April 2019

A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart.

Bioconjug Chem 2019 03 18;30(3):733-740. Epub 2019 Jan 18.

Center for Systems Biology , Massachusetts General Hospital , 185 Cambridge St , CPZN 5206, Boston , Massachusetts 02114 , United States.

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http://pubs.acs.org/doi/10.1021/acs.bioconjchem.8b00882
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http://dx.doi.org/10.1021/acs.bioconjchem.8b00882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483069PMC
March 2019

Multichannel digital heteronuclear magnetic resonance biosensor.

Biosens Bioelectron 2019 Feb 27;126:240-248. Epub 2018 Oct 27.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for NanoMedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09565663183086
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http://dx.doi.org/10.1016/j.bios.2018.10.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483068PMC
February 2019

Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma.

PLoS One 2018 5;13(7):e0199414. Epub 2018 Jul 5.

HMS-MGH Center for Nervous System Repair, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199414PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033533PMC
December 2018

Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using Cu-Labeled Macrin.

ACS Nano 2018 12 11;12(12):12015-12029. Epub 2018 Dec 11.

Center for Systems Biology , Massachusetts General Hospital Research Institute , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acsnano.8b04338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482841PMC
December 2018

Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

ACS Nano 2018 12 14;12(12):12814-12826. Epub 2018 Dec 14.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acsnano.8b07954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307086PMC
December 2018

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Immunity 2018 12 11;49(6):1148-1161.e7. Epub 2018 Dec 11.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301092PMC
December 2018

Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells.

JCI Insight 2018 11 2;3(21). Epub 2018 Nov 2.

Center for Systems Biology, Massachusetts General Hospital (MGH), Boston, Massachusetts, USA.

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https://insight.jci.org/articles/view/122961
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http://dx.doi.org/10.1172/jci.insight.122961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238736PMC
November 2018

Site occupancy calibration of taxane pharmacology in live cells and tissues.

Proc Natl Acad Sci U S A 2018 11 14;115(48):E11406-E11414. Epub 2018 Nov 14.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1800047115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275538PMC
November 2018

A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse.

Circ Res 2018 11;123(11):1208-1219

From the Department of Radiology, Center for Systems Biology (M.H., A.D.A., S.C., Y.I., K.R.K., F.K.S., R.W., M.N.), Massachusetts General Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309285PMC
November 2018

High dynamic range fluorescence imaging.

IEEE J Sel Top Quantum Electron 2019 Jan-Feb;25(1). Epub 2018 Nov 19.

Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston 02114, USA.

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http://dx.doi.org/10.1109/JSTQE.2018.2881608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785194PMC
November 2018

Developing a Roadmap for Interventional Oncology.

Oncologist 2018 10 29;23(10):1162-1170. Epub 2018 Jun 29.

Division of Interventional Radiology, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2017-0654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263130PMC
October 2018

Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings.

ACS Nano 2018 09 20;12(9):9081-9090. Epub 2018 Aug 20.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.

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http://pubs.acs.org/doi/10.1021/acsnano.8b03029
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http://dx.doi.org/10.1021/acsnano.8b03029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519708PMC
September 2018

Recording the wild lives of immune cells.

Sci Immunol 2018 09;3(27)

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.

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http://immunology.sciencemag.org/lookup/doi/10.1126/sciimmun
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http://dx.doi.org/10.1126/sciimmunol.aaq0491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771424PMC
September 2018

Unsupervised Medical Image Segmentation Based on the Local Center of Mass.

Sci Rep 2018 08 29;8(1):13012. Epub 2018 Aug 29.

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41598-018-31333-5
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http://dx.doi.org/10.1038/s41598-018-31333-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115387PMC
August 2018

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Nat Biomed Eng 2018 08 21;2(8):578-588. Epub 2018 May 21.

Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41551-018-0236-8DOI Listing
August 2018

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Nat Biomed Eng 2018 21;2:578-588. Epub 2018 May 21.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192054PMC
May 2018

Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis.

ACS Nano 2018 04 20;12(4):3378-3384. Epub 2018 Mar 20.

Department of Systems Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsnano.7b08965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019292PMC
April 2018

Unraveling Tetrazine-Triggered Bioorthogonal Elimination Enables Chemical Tools for Ultrafast Release and Universal Cleavage.

J Am Chem Soc 2018 03 14;140(10):3603-3612. Epub 2018 Feb 14.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/jacs.7b11217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857921PMC
March 2018

New Technologies for Analysis of Extracellular Vesicles.

Chem Rev 2018 02 31;118(4):1917-1950. Epub 2018 Jan 31.

Center for Systems Biology, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acs.chemrev.7b00534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029891PMC
February 2018

Fluorescence anisotropy imaging in drug discovery.

Adv Drug Deliv Rev 2019 Nov - Dec;151-152:262-288. Epub 2018 Feb 2.

Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.addr.2018.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072632PMC
February 2018

Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System.

ACS Photonics 2018 Feb 3;5(2):487-494. Epub 2017 Nov 3.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://pubs.acs.org/doi/10.1021/acsphotonics.7b00992
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http://dx.doi.org/10.1021/acsphotonics.7b00992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966285PMC
February 2018

Design and Development of Fluorescent Vemurafenib Analogs for Imaging.

Theranostics 2017 6;7(5):1257-1265. Epub 2017 Mar 6.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA, 02114, USA.

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http://dx.doi.org/10.7150/thno.18238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399591PMC
January 2018

Multiplexed Profiling of Single Extracellular Vesicles.

ACS Nano 2018 01 4;12(1):494-503. Epub 2018 Jan 4.

Center for Systems Biology, Massachusetts General Hospital , 185 Cambridge St, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.7b07060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898240PMC
January 2018

Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection.

ACS Nano 2017 11 25;11(11):11041-11046. Epub 2017 Oct 25.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsnano.7b05083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237084PMC
November 2017

Nanomagnetic System for Rapid Diagnosis of Acute Infection.

ACS Nano 2017 11 14;11(11):11425-11432. Epub 2017 Nov 14.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.7b06074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296367PMC
November 2017

Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications.

Theranostics 2016 18;6(10):1603-10. Epub 2016 Jun 18.

1. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;; 5. Massachusetts General Hospital Cancer Center, Boston, MA 02114;; 6. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.7150/thno.15534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955059PMC
October 2017

Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.

Am J Physiol Renal Physiol 2017 Oct 12;313(4):F1026-F1037. Epub 2017 Jul 12.

Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts;

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http://dx.doi.org/10.1152/ajprenal.00038.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668581PMC
October 2017

Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.

ACS Nano 2017 10 25;11(10):10062-10069. Epub 2017 Aug 25.

Department of Systems Biology, Harvard Medical School , Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.7b04318DOI Listing
October 2017

Imaging the emergence and natural progression of spontaneous autoimmune diabetes.

Proc Natl Acad Sci U S A 2017 09 24;114(37):E7776-E7785. Epub 2017 Aug 24.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1707381114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604023PMC
September 2017

Novel nanosensing technologies for exosome detection and profiling.

Lab Chip 2017 08;17(17):2892-2898

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c7lc00247eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572557PMC
August 2017

Evolution of macromolecular complexity in drug delivery systems.

Nat Rev Chem 2017 Aug 9;1(8). Epub 2017 Aug 9.

Harvard-MIT Division of Health Sciences, Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/s41570-017-0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613785PMC
August 2017

Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.

Nat Protoc 2017 Jul 29;12(7):1472-1497. Epub 2017 Jun 29.

Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2017.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928516PMC
July 2017

Nano-palladium is a cellular catalyst for in vivo chemistry.

Nat Commun 2017 07 12;8:15906. Epub 2017 Jul 12.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncomms15906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510178PMC
July 2017

Prediction of Anti-cancer Nanotherapy Efficacy by Imaging.

Nanotheranostics 2017 6;1(3):296-312. Epub 2017 Jul 6.

Center for Systems Biology, Massachusetts General Hospital, USA.

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http://dx.doi.org/10.7150/ntno.20564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646731PMC
July 2017

MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.

Stem Cell Reports 2017 06 18;8(6):1497-1505. Epub 2017 May 18.

Department of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470095PMC
June 2017

Imaging of anticancer drug action in single cells.

Nat Rev Cancer 2017 06;17(7):399-414

Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nrc.2017.41DOI Listing
June 2017

Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.

Adv Drug Deliv Rev 2017 04 4;113:61-86. Epub 2016 Jun 4.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2016.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136524PMC
April 2017

Transparent Electrophysiology Microelectrodes and Interconnects from Metal Nanomesh.

ACS Nano 2017 04 11;11(4):4365-4372. Epub 2017 Apr 11.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 02114, United States.

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http://pubs.acs.org/doi/10.1021/acsnano.7b01995
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http://dx.doi.org/10.1021/acsnano.7b01995DOI Listing
April 2017

Motion characterization scheme to minimize motion artifacts in intravital microscopy.

J Biomed Opt 2017 03;22(3):36005

Richard B. Simches Research Center, Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1117/1.JBO.22.3.036005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333764PMC
March 2017

Quantitating drug-target engagement in single cells in vitro and in vivo.

Nat Chem Biol 2017 02 5;13(2):168-173. Epub 2016 Dec 5.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.2248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630128PMC
February 2017

Facile silicification of plastic surface for bioassays.

Chem Commun (Camb) 2017 Feb;53(13):2134-2137

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA. and Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c6cc09359kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327824PMC
February 2017

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging.

Nat Commun 2017 02 8;8:14293. Epub 2017 Feb 8.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncomms14293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309815PMC
February 2017

Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing.

Bioconjug Chem 2017 01 7;28(1):33-37. Epub 2016 Nov 7.

Department of Systems Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474933PMC
January 2017

PF4 Promotes Platelet Production and Lung Cancer Growth.

Cell Rep 2016 11;17(7):1764-1772

Center for Systems Biology, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, MA 02114, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108525PMC
November 2016

Supramolecular Metallo-Bioadhesive for Minimally Invasive Use.

Adv Mater 2016 Oct 12;28(39):8675-8680. Epub 2016 Aug 12.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St., CPZN 5206, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adma.201602606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144581PMC
October 2016

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Circ Res 2016 Sep 21;119(7):853-64. Epub 2016 Jul 21.

From the Center for Systems Biology, Department of Imaging (H.B.S., M.H., T.H., G.C., Y.S., Y.I., B.T., R.W., F.K.S., M.N.) and Cardiovascular Research Center (M.N.), Massachusetts General Hospital and Harvard Medical School, Boston; Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MS (K.J.L.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA (M.B.M., P.L.); Department of Cardiology and Angiology I, Heart Center Freiburg University, Germany (T.H.); Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA (O.F.K., J.E.D., D.G.A.); David H. Koch Institute for Integrative Cancer Research (O.F.K., J.E.D., D.G.A.) and Department of Chemical Engineering (D.G.A.), Massachusetts Institute of Technology, Cambridge; Alnylam Pharmaceuticals, Cambridge, MA (A.B., K.F.); and Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378496PMC
September 2016

E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction.

Arterioscler Thromb Vasc Biol 2016 09 28;36(9):1802-8. Epub 2016 Jul 28.

From the Center for Systems Biology, Department of Imaging, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, Boston (P.D., F.F.H., Y.S., Y.I., B.T., R.W., F.K.S., M.N.); Department of Systems Biology, Harvard Medical School, Boston, MA (R.W.); and GlycoMimetics Inc, Rockville, MD (J.L.M.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001901PMC
September 2016

Imaging approaches to optimize molecular therapies.

Sci Transl Med 2016 09;8(355):355ps16

Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaf3936DOI Listing
September 2016

Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response.

Sci Rep 2016 09 9;6:32985. Epub 2016 Sep 9.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge St., CPZN 5206, Boston, MA 02114, USA.

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http://www.nature.com/articles/srep32985
Publisher Site
http://dx.doi.org/10.1038/srep32985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017129PMC
September 2016

Fluorescent vinblastine probes for live cell imaging.

Chem Commun (Camb) 2016 Aug;52(64):9953-6

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA. and Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1039/c6cc04129aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970878PMC
August 2016

Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement.

IEEE J Sel Top Quantum Electron 2016 May-Jun;22(3). Epub 2016 Mar 10.

Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston 02114, USA.

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http://dx.doi.org/10.1109/JSTQE.2015.2501384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946648PMC
March 2016