Publications by authors named "Raghav V Aachi"

2 Publications

  • Page 1 of 1

Laboratory characteristics of ischemic stroke patients with atrial fibrillation on or off therapeutic warfarin.

Clin Cardiol 2017 Dec 18;40(12):1347-1351. Epub 2017 Dec 18.

Department of Neurology, University of Texas Lozano Long School of Medicine, San Antonio.

Background: In patients with atrial fibrillation (AF), despite adequate anticoagulation, ischemic stroke (IS) is an uncommon yet concerning occurrence.

Hypothesis: Specific laboratory parameters may affect the efficacy of warfarin despite therapeutic international normalized ratio (INR) in patient with AF who present with IS.

Methods: We used the database from a multicenter clinical trial to identify AF patients who presented with IS. We trichotomized the cohort into patients with therapeutic INR on warfarin, subtherapeutic INR on warfarin, and on no anticoagulants. We then compared baseline laboratory characteristics and other baseline features among the groups.

Results: Patients with therapeutic INR presented with higher serum creatinine (P = 0.01) and blood urea nitrogen (P = 0.02) and lower glomerular filtration rates (P = 0.001) compared with other groups. Other laboratory parameters were not different among the 3 groups. Patients with therapeutic INR also presented with milder stroke symptoms (P = 0.01). Medical history of the 3 groups was not different, except for history of valvular heart disease, which was more prevalent in patients with therapeutic INR (P = 0.004). In-hospital mortality rates and 90-day disability were not different among the 3 groups.

Conclusions: AF patients who presented with IS on therapeutic warfarin had higher average serum creatinine and blood urea nitrogen, and lower glomerular filtration rates, compared with others. Impaired renal function may be a factor contributing to occurrence of IS in AF patients despite adequate anticoagulation. Larger, targeted studies are needed to confirm these findings.
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http://dx.doi.org/10.1002/clc.22838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490348PMC
December 2017

Letter by Behrouz and Aachi Regarding Article, "Cannabis, Tobacco, Alcohol Use, and the Risk of Early Stroke: A Population-Based Cohort Study of 45 000 Swedish Men".

Stroke 2017 05 7;48(5):e133. Epub 2017 Apr 7.

Department of Neurology, University of Texas School of Medicine, San Antonio.

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http://dx.doi.org/10.1161/STROKEAHA.117.016872DOI Listing
May 2017
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