Publications by authors named "Qiang Zeng"

432 Publications

Associations of polycyclic aromatic hydrocarbons exposure and its interaction with XRCC1 genetic polymorphism with lung cancer: A case-control study.

Environ Pollut 2021 Sep 1;290:118077. Epub 2021 Sep 1.

State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address:

Humans are extensively exposed to polycyclic aromatic hydrocarbons (PAHs) daily via multiple pathways. Epidemiological studies have demonstrated that occupational exposure to PAHs increases the risk of lung cancer, but related studies in the general population are limited. Hence, we conducted a case-control study among the Chinese general population to investigate the associations between PAHs exposure and lung cancer risk and analyze the modifications of genetic polymorphisms in DNA repair genes. In this study, we enrolled 122 lung cancer cases and 244 healthy controls in Wuhan, China. Urinary PAHs metabolites were determined by gas chromatography-mass spectrometry, and rs25487 in X-ray repair cross-complementation 1 (XRCC1) gene was genotyped by the Agena Bioscience MassARRAY System. Then, multivariable logistic regression models were performed to estimate the potential associations. We found that urinary hydroxynaphthalene (OH-Nap), hydroxyphenanthrene (OH-Phe) and the sum of hydroxy PAHs (∑OH-PAHs) levels were significantly higher in lung cancer cases than those in controls. After adjusting for gender, age, BMI, smoking status, smoking pack-years, drinking status and family history, urinary ∑OH-Nap and ∑OH-Phe levels were positively associated with lung cancer risk, with dose-response relationships. Compared with those in the lowest tertiles, individuals in the highest tertiles of ∑OH-Nap and ∑OH-Phe had a 2.13-fold (95% CI: 1.10, 4.09) and 2.45-fold (95% CI: 1.23, 4.87) increased risk of lung cancer, respectively. Effects of gender, age, smoking status and smoking pack-years on the associations of PAHs exposure with lung cancer risk were shown in the subgroup analysis. Furthermore, associations of urinary ∑OH-Nap and ∑OH-PAHs levels with lung cancer risk were modified by XRCC1 rs25487 (P ≤ 0.025), and were more pronounced in wild-types of rs25487. These findings suggest that environmental exposure to naphthalene and phenanthrene is associated with increased lung cancer risk, and polymorphism of XRCC1 rs25487 might modify the naphthalene exposure-related lung cancer effect.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2021.118077DOI Listing
September 2021

Machine learning-assisted optimization of TBBPA-bis-(2,3-dibromopropyl ether) extraction process from ABS polymer.

Chemosphere 2021 Sep 2;287(Pt 2):132128. Epub 2021 Sep 2.

Energy Research Institute, Nangyang Technological University, 1 Cleantech Loop, 637141, Singapore; School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore. Electronic address:

The increasing amount of e-waste plastics needs to be disposed of properly, and removing the brominated flame retardants contained in them can effectively reduce their negative impact on the environment. In the present work, TBBPA-bis-(2,3-dibromopropyl ether) (TBBPA-DBP), a novel brominated flame retardant, was extracted by ultrasonic-assisted solvothermal extraction process. Response Surface Methodology (RSM) achieved by machine learning (support vector regression, SVR) was employed to estimate the optimum extraction conditions (extraction time, extraction temperature, liquid to solid ratio) in methanol or ethanol solvent. The predicted optimum conditions of TBBPA-DBP were 96 min, 131 mL g, 65 °C, in MeOH, and 120 min, 152 mL g, 67 °C in EtOH. And the validity of predicted conditions was verified.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2021.132128DOI Listing
September 2021

The sex-specific influence of genotype on exercise intervention for weight loss in adult with obesity.

Eur J Sport Sci 2021 Sep 3:1-17. Epub 2021 Sep 3.

Beijing University of Chinese Medicine, Beijing 100029, China.

The impact of exercise on weight loss varies significantly among individuals, and genes play a critical role. This study aims to explore whether the gene variant (rs8050136) affects the influence of exercise on weight. The study initially recruited 240 Han Chinese adults with obesity, and 178 of them (101 men, 77 women, aged from 21 to 60) completed a 12-week moderate aerobic exercise program. The participants were genotyped and obesity-related data were collected before and after the intervention. The intensity and the amount of exercise were precisely monitored. After the intervention, most obesity-related parameters of the participants showed a significant decrease. For muscle and lean body mass, significant change was only observed in males (P<0.001) but not females (P=0.205, P=0.200 respectively). Importantly, for weight and BMI loss, we observed a genotype-by-gender interaction (P=0.041, P=0.042 respectively, adjusted for age, exercise time and baseline value). In the further analysis, after stratified for gender, the exercise-induced weight loss (P=0.008), BMI loss (P=0.010), muscle mass loss (P=0.005) and lean body mass loss (P=0.004) showed greater decrease in male subjects carrying at least one A allele compared to non-carriers. In conclusion, our study suggests that in Han Chinese population with obesity, carrying "obese risk gene" (rs8050136) does not lead to the resistance to weight management intervention. More importantly, in male subjects, carrying risk allele would even lose more weight than non-carriers after exercise intervention.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/17461391.2021.1976843DOI Listing
September 2021

Urinary bisphenol A and its interaction with CYP17A1 rs743572 are associated with breast cancer risk.

Chemosphere 2021 Aug 12;286(Pt 3):131880. Epub 2021 Aug 12.

Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Objective: Bisphenol A (BPA), a common endocrine disrupter, can be activated by cytochrome P450 (CYP) metabolizing enzymes and might influence the development of breast cancer (BC). We hypothesized that BPA could interact with CYP genes, synergistically contributing to the BC risk.

Methods: Urinary BPA was measured in a total of 302 newly diagnosed BC patients and 302 healthy controls by ultra-high performance liquid chromatography-high resolution mass spectrometry. A set of seven CYP gene polymorphisms was genotyped by using the Sequenom MassARRAY system. A multivariate logistic regression model was used to assess the associations of BPA and BPA-SNP interaction with BC risk.

Results: BC patients had a higher urinary BPA concentration than healthy individuals (P < 0.001). Each 1-unit increase in log-transformed urinary BPA was associated with a 54 % increased BC risk [95 % confidence interval (CI), 1.34-1.77, P < 0.001]. Individuals with the CYP19A1 rs1902580 GA + AA genotype showed a significantly higher BC risk than those with the GG genotype (OR = 1.45, 95 % CI, 1.01-2.09, P < 0.05). A significant BPA-CYP17A1 rs743572 interaction was found to be associated with a higher risk of BC (P = 0.020). Compared with low-BPA individuals carrying CYP17A1 rs743572 GG genotypes, high-BPA individuals with the GA + AA genotype had a higher BC risk, with an odds ratio of 2.49 (95 % CI, 1.52-4.13, P < 0.05).

Conclusions: The positive association of BPA exposure with BC risk might be modified by CYP17A1 rs743572, providing evidence for the interaction effect of environment-genes on the etiology of BC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2021.131880DOI Listing
August 2021

Early life exposure to air pollution and cell-mediated immune responses in preschoolers.

Chemosphere 2021 Aug 20;286(Pt 3):131963. Epub 2021 Aug 20.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address:

Background: Exposure to air pollution has been linked with altered immune function in adults, but little is known about its effects on early life. This study aimed to investigate the effects of exposure to air pollution during prenatal and postnatal windows on cell-mediated immune function in preschoolers.

Methods: Pre-school aged children (2.9 ± 0.5 y old, n = 391) were recruited from a mother-child cohort study in Wuhan, China. We used a spatial-temporal land use regression (LUR) model to estimate exposures of particulate matter with aerodynamic diameters ≤2.5 μm (PM) and ≤10 μm (PM), and nitrogen dioxide (NO) during the specific trimesters of pregnancy and the first two postnatal years. We measured peripheral blood T lymphocyte subsets and plasma cytokines as indicators of cellular immune function. We used multiple informant models to examine the associations of prenatal and postnatal exposures to air pollution with cell-mediated immune function.

Results: Prenatal exposures to PM, PM, and NO during early pregnancy were negatively associated with %CD3 and %CD3CD8 cells, and during late pregnancy were positively associated with %CD3 cells. Postnatal exposures to these air pollutants during 1-y or 2-y childhood were positively associated with IL-4, IL-5, IL-6, and TNF-α. We also observed that the associations of prenatal or postnatal air pollution exposures with cellular immune responses varied by child's sex.

Conclusions: Our results suggest that exposure to air pollution during different critical windows of early life may differentially alter cellular immune responses, and these effects appear to be sex-specific.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2021.131963DOI Listing
August 2021

Kinetics of low radioactive wastewater imbibition and radionuclides sorption in partially saturated ternary-binder mortar.

J Hazard Mater 2021 Aug 13;422:126897. Epub 2021 Aug 13.

Department of Civil Engineering, Tsinghua University, 100084 Beijing, PR China. Electronic address:

This study seeks to assess the imbibition kinetics of low radioactive wastewater (from the DayaBay nuclear power plant) into a partially saturated ternary-binder mortar, as well as the sorption kinetics of Co and Cs from the water. Mortar samples with the initial saturation degrees of 0, 0.4, 0.6, 0.8 and 1.0 were prepared for the wastewater treatment. Pore structure of the mortar was characterized using water vapor sorption isotherm and mercury intrusion porosimetry tests interpreted by the Guggenheim-Anderson-de Boer isothermal equilibrium, and volume- and energy-based fractal models. Results show that the mortar has consistent fractal pore structure between the models, and the liquid imbibitions follow the fractal imbibition kinetics, in which the parameters are non-linearly impacted by the initial saturation degrees. The sorption rate and retention capacity of Cs are much lower than those of Co, and both follow the Brouers-Sotolongo fractional kinetics. The findings uncover the complex liquid imbibition and radionuclides sorption kinetics in cement-based porous materials, and the in-situ data would contribute to the material designs and sorption controls for large scale in-situ treatments of wastewater from nuclear power plant.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2021.126897DOI Listing
August 2021

Online evaluation method of coal mine comprehensive level based on FCE.

PLoS One 2021 16;16(8):e0256026. Epub 2021 Aug 16.

School of Business Administration, Henan Polytechnic University, Henan Jiaozuo, China.

An online evaluation method of coal mine comprehensive level based on Fuzzy Comprehensive Evaluation method (FCE) is proposed. Firstly, following the principles of fairness, systematicness and hierarchy, taking research and development, production, sales, finance, safety and management as the first level indicators, a set of multi-level evaluation indicator system of coal mine comprehensive level combining objective and subjective evaluation indicators is established. Secondly, according to the characteristics of the indicator system, the specific process of FCE of coal mine comprehensive level is given. Then, taking SQL Server as the database management system and C#.NET as the development language, a set of B/S structure online evaluation system of coal mine comprehensive level based on FCE is designed and developed. Finally, the proposed method is applied to Coal group PM for test. The application shows that the method proposed can provide an efficient and convenient online evaluation platform to evaluate the comprehensive level of coal mines for the Coal group, and the horizontal and longitudinal comparison of the evaluation results can urge the coal mines to maintain their advantages and avoid their disadvantages, which is of some significance for improving the overall competitiveness of the Coal group.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0256026PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366963PMC
August 2021

Association between metabolic status and gut microbiome in obese populations.

Microb Genom 2021 Aug;7(8)

Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518000, PR China.

Despite that obesity is associated with many metabolic diseases, a significant proportion (10-30 %) of obese individuals is recognized as 'metabolically healthy obeses' (MHOs). The aim of the current study is to characterize the gut microbiome for MHOs as compared to 'metabolically unhealthy obeses' (MUOs). We compared the gut microbiome of 172 MHO and 138 MUO individuals from Chongqing (China) (inclined to eat red meat and food with a spicy taste), and performed validation with selected biomarkers in 40 MHOs and 33 MUOs from Quanzhou (China) (inclined to eat seafood and food with a light/bland taste). The genera , and had increased abundance in both Chongqing and Quanzhou MHOs. We also observed different microbial functions in MUOs compared to MHOs, including an increased abundance of genes associated with glycan biosynthesis and metabolism. In addition, the microbial gene markers identified from the Chongqing cohort bear a moderate accuracy [AUC (area under the operating characteristic curve)=0.69] for classifying MHOs distinct from MUOs in the Quanzhou cohort. These findings indicate that gut microbiome is significantly distinct between MHOs and MUOs, implicating the potential of the gut microbiome in stratification and refined management of obesity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1099/mgen.0.000639DOI Listing
August 2021

Efficient and selective removal of Ag as nano silver particles by the composite of SiO supported nano ferrous oxalate.

Environ Res 2021 Jul 29;202:111696. Epub 2021 Jul 29.

School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China; Faculty of Materials Metallurgy & Chemistry, Jiangxi University of Science & Technology, Ganzhou, Jiangxi, 341000, China. Electronic address:

Developing novel environmentally materials with high capacity and selectivity for Ag adsorption by transforming Ag to nano silver is important for the recovery of precious metals from Ag-containing solution. The present study systematically studied the Ag  adsorption process from solution by the composite of SiO supported nano ferrous oxalate (SNFO) synthesized from biotite-containing minerals. Batch experiments, dynamics and isothermal adsorption fitting results showed that Ag removal behaviours were in accordance with the pseudo-first-order kinetic model and Langmuir model, and the maximal Ag removal capacity was 223.68 mg/g. Thermodynamic fitting results suggested that Ag  removal by the composite was a spontaneous and endothermic reaction process. XRD and TEM revealed that the reaction products were consisted of SiO and nano silver particles, and FTIR and XPS results indicated that the Ag removal mechanisms were attributed to the synergistic reduction interaction between ferrous and the anions of oxalate. Meanwhile, the composite possesses high selectivity for Ag removal even at low Ag concentration. Moreover, the size of nano silver particles could be adjusted by different pH values. All above results demonstrated that the composite was an ideal material for selective recovery of Ag from Ag containing effluents in the form of nano silver.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2021.111696DOI Listing
July 2021

Urinary biomarkers of exposure to drinking water disinfection byproducts and ovarian reserve: A cross-sectional study in China.

J Hazard Mater 2021 Jul 21;421:126683. Epub 2021 Jul 21.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Experimental studies have demonstrated that disinfection byproducts (DBPs) can cause ovarian toxicity including inhibition of antral follicle growth and disruption of steroidogenesis, but there is a paucity of human evidence. We aimed to investigate whether urinary biomarkers of exposure to drinking water DBPs were associated with ovarian reserve. The present study included 956 women attending an infertility clinic in Wuhan, China from December 2018 to January 2020. Antral follicle count (AFC), ovarian volume (OV), anti-Mullerian hormone (AMH), and follicle-stimulating hormone (FSH) were measured as indicators of ovarian reserve. Urinary dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) were assessed as potential biomarkers of drinking water DBP exposures. Multivariate linear and Poisson regression models were applied to estimate the associations of urinary DCAA and TCAA concentrations with indicators of ovarian reserve. Elevated urinary DCAA and TCAA levels were monotonically associated with reduced total AFC (- 5.98%; 95% CI: - 10.30%, - 1.44% in DCAA and - 12.98%; 95% CI: - 17.00%, - 8.76% in TCAA comparing the extreme tertiles; both P for trends ≤ 0.01), and the former was only observed in right AFC but not in left AFC, whereas the latter was estimated for both right and left AFC. Moreover, elevated urinary TCAA levels were monotonically associated with decreased AMH (- 14.09%; 95% CI: - 24.79%, - 1.86% comparing the extreme tertiles; P for trend = 0.03). These negative associations were still observed for the exposure biomarkers modeled as continuous variables. Our findings suggest that exposure to drinking water DBPs may be associated with decreased ovarian reserve.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2021.126683DOI Listing
July 2021

Electrochemical Polymerization Induced Chirality Fixation of Crystalline Pillararene-Based Polymer and Its Application in Interfacial Chiral Sensing.

Anal Chem 2021 07 12;93(29):9965-9969. Epub 2021 Jul 12.

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510641, China.

A new strategy has been developed for the direct chirality fixation, which is induced by electrochemical polymerization, of macrocyclic hosts pillar[5]arene. Taking advantage of electrochemical polymerization, thiophene-modified pillar[5]arene monomers () have been regularly arranged under the action of an electric field to form chiral nanofiber-like crystalline pillar[5]arene-based polymers (), showing a significant circular dichroism (CD) signal. With the active photochemical properties, is first used as a photoelectrochemical (PEC) chiral sensor for the identification and determination of l- and d-ascorbic acid (l-AA, d-AA) without adding any extra photoactive probes. Importantly, the chiral recognition between and l-AA also triggers a polarity conversion for the photocurrent of the polymer, and it greatly results in a broad chiral detection range for l-AA, crossing 6 orders of magnitude. This work provides a promotional strategy for building a PEC chiral recognition platform based on pillararenes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.1c01941DOI Listing
July 2021

Methylenetetrahydrofolate Reductase Gene Polymorphism-Dietary Pattern Interaction on Hyperhomocysteinemia in a Chinese Population: A Cross-Sectional Study.

Front Cardiovasc Med 2021 24;8:638322. Epub 2021 Jun 24.

Health Management Institute, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, Beijing, China.

Hyperhomocysteinemia (Hhcy) has been recognized as a risk factor of several chronic diseases. There is accumulating evidence that both genetic and dietary factors had a notable impact on the risk of Hhcy. The present study aims to investigate the interaction effect on Hhcy between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and dietary intake. Data were collected in a cross-sectional survey conducted in China; 3,966 participants with complete information on sociodemographic characteristics, anthropometric measurements, and dietary intake were included in the analyses. Dietary patterns were identified by factor analysis combined with cluster analysis. Blood samples were collected and genotypes were tested. Both the multiplicative statistical model and the additive model were conducted to investigate the interactive effects. Proportions of genotypes among participants were 29.2% for , 47.4% for , and 23.4% for . Three dietary patterns were identified, namely, the balanced pattern, the snack pattern, and the high-meat pattern. Compared with the balanced pattern, the other two patterns were associated with an elevated risk of Hhcy [the snack pattern: odds ratio (OR) 1.2, 95% confidence interval (CI) 1.0-1.5; the high-meat pattern: OR 1.3, 95% CI 1.1-1.6] after adjustment for age group, gender, residential region, and genotypes. A multiplicative interaction between the high-meat pattern and genotype was observed, and synergistic effects between both the snack pattern and the high-meat pattern with were identified. Our results indicated that polymorphism and dietary patterns had interactive effects on Hhcy among the Chinese population. Subsequent targeted and appropriate dietary guidelines should be recommended for high-risk populations or patients of Hhcy carrying specific genotypes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcvm.2021.638322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263928PMC
June 2021

Effect of Size of Coarse Aggregate on Mechanical Properties of Metakaolin-Based Geopolymer Concrete and Ordinary Concrete.

Materials (Basel) 2021 Jun 15;14(12). Epub 2021 Jun 15.

College of Civil Engineering and Architecture, Zhejiang University, Hangzhou 310058, China.

Geopolymer binders are a promising alternative to ordinary Portland cement (OPC) because they can significantly reduce CO emissions. However, to apply geopolymer in concrete, it is critical to understand the compatibility between the coarse aggregate and the geopolymer binder. Experimental studies were conducted to explore the effect of the size of the coarse aggregate on the mechanical properties and microstructure of a metakaolin-based geopolymer (MKGP) concrete and ordinary concrete. Three coarse aggregate size grades (5-10 mm, 10-16 mm, and 16-20 mm) were adopted to prepare the specimens. The microstructure of the concretes was investigated with scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS) and mercury intrusion porosimetry (MIP). Results showed an opposite coarse aggregate size effect between OPC and MKGP specimens in terms of compressive strength. SEM/EDS analysis indicated that the MKGP concrete has a weaker microstructure compared to OPC concrete induced by a higher porosity. The differences in mechanical properties and pore structure between the MKGP and OPC concrete are attributed to the greatly differing shrinkages triggered by the large surface area and penny-shaped particles of metakaolin. The findings in this work help tailor the mechanical properties and microstructure of MKGP concrete for future engineering applications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma14123316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232638PMC
June 2021

Bisphenol A exposure, interaction with genetic variants and colorectal cancer via mediating oxidative stress biomarkers.

Environ Pollut 2021 Oct 23;287:117630. Epub 2021 Jun 23.

Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Bisphenol A (BPA) may induce oxidative stress as well as the toxicity of colon cancer cells. We hypothesized that BPA exposure and interactions with genetic variants might be associated with colorectal cancer (CRC) risk, and the association might be partly mediated by oxidative stress. We measured urinary BPA and three oxidative stress markers [8-iso-prostaglandinF (8-isoPGF), 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)] in 275 new CRC cases and 538 healthy controls. A set of 25 genetic variations in 12 candidate DNA repair genes and 5 metabolic enzyme genes were genotyped by Sequenom MassARRAY approach. In multivariable logistic regression, significant positive associations of CRC risk with BPA, 8-OHdG and HNE-MA were observed. Additionally, 8-OHdG, HNE-MA and 8-isoPGF were significantly positively associated with BPA (P < 0.05). The mediation analysis showed BPA-associated HNE-MA significantly mediated 11.81% of the effect of BPA on CRC risk. Moreover, BPA was found to interact with ERCC5 rs17655 and rs2296147 (both P < 0.05) to increase CRC risk. In brief, our results suggested BPA was associated with CRC risk and the positive association of BPA with CRC risk might be partly mediated by the oxidative stress HNE-MA. BPA might interact with ERCC5 rs17655 and rs2296147 to increase CRC risk.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2021.117630DOI Listing
October 2021

Quantitative study of preoperative staging of gastric cancer using intravoxel incoherent motion diffusion-weighted imaging as a potential clinical index.

Eur J Radiol 2021 Aug 4;141:109627. Epub 2021 Mar 4.

Department of Gastrointestinal Surgery, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, 361004, China; Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, China; Xiamen Municipal Key Laboratory of Gastrointestinal Oncology, Xiamen, Fujian, 361004, China. Electronic address:

Purpose: To determine the utility of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in quantitative analysis of preoperative tumor (T) and node (N) stages of gastric cancer, and to quantify the diagnostic threshold of IVIM parameters for serosal invasion and lymphatic metastasis.

Materials And Methods: From October 2016 to February 2020, 98 patients with gastric cancer who were receiving treatment in Zhongshan Hospital, China, were subject to an IVIM sequence imaging analysis. The IVIM sequence data were imported into software for post-processing of tumor regions of interest, and the IVIM parameters (the microvascular volume fraction (f), the molecular diffusion coefficient (D) and perfusion-related incoherent microcirculation (D*) were calculated. The variation of these IVIM parameters with different tumor-node metastasis (TNM) stages were analyzed by one-way analysis of variance. The IVIM parameters of serosal invasion and lymphatic metastasis were examined by receiver operating characteristic curve analysis and t-tests.

Results: A total of 98 gastric cancer patients (65 males and 33 females) with an average age of 61.9 years were enrolled in this study. There were 14 patients in stage T1, 14 in stage T2, 10 in stage T3 and 60 in stage T4. There were 37 patients in stage N0, 19 in stage N1, 18 in stage N2 and 24 in stage N3. Statistically significant associations were found between the D values and T stages of gastric cancer. The D values of stage T4 cancers were significantly different from those of stage T2, T3 and T4 cancers. The D value decreased with increasing T stage. The mean D values of stages were 1.432 × 10 mm/s (T1), 1.225 × 10 mm/s (T2), 1.154 × 10 mm/s (T3) and 0.9468 × 10 mm/s (T4). The extent of the invasion of serosa was found to be significantly correlated with D value, with the diagnostic threshold for D being 1.107 × 10 mm/s. In addition, different pathological N stages of gastric cancer lesions showed statistically significantly variations in f values, but no correlation was found with different N stages. Finally, the extent of lymphatic metastasis was found to be correlated with D values, with the diagnostic threshold being 1.1739 × 10 mm/s. There was no statistically significant correlation between the IVIM MRI parameters and tumor size. The grade of tumor was found to be significantly correlated with D* value, with the diagnostic threshold for D* being 1.516 × 10 mm/s. There was no statistically significant correlation between the ADC value and tumor size. There was a significant difference in the ADC values among different T and N stage cancers. ADC value had statistically significant to distinguish gastric cancer with or without serosal invasion, its detection efficiency was not as high as that of D value, with an AUC of 0.628 and 0.830, respectively. The ADC value was not statistically significant in distinguishing gastric cancer with or without lymphatic metastasis (P ≥ 0.05). The ADC value had not statistically significant in distinguishing gastric cancer between low and medium-high grade (P ≥ 0.05).

Conclusion: We found that significant differences existed between whole-volume IVIM parameters of different T or N stages in gastric cancers, and were able to quantify different T or N stages of gastric cancer by the values of these parameters. The results of this quantitative study provide new tools for evaluating the prognosis of gastric cancer and will be valuable for the development of an new imaging method for determining the morphological stages of gastric cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejrad.2021.109627DOI Listing
August 2021

Prevention of dementia using mobile phone applications (PRODEMOS): protocol for an international randomised controlled trial.

BMJ Open 2021 06 9;11(6):e049762. Epub 2021 Jun 9.

Beijing Key Laboratory of Clinical Epidemiology, Capital Medical University School of Public Health, Beijing, China.

Introduction: Profiles of high risk for future dementia are well understood and are likely to concern mostly those in low-income and middle-income countries and people at greater disadvantage in high-income countries. Approximately 30%-40% of dementia cases have been estimated to be attributed to modifiable risk factors, including hypertension, smoking and sedentary lifestyle. Tailored interventions targeting these risk factors can potentially prevent or delay the onset of dementia. Mobile health (mHealth) improves accessibility of such prevention strategies in hard-to-reach populations while at the same time tailoring such approaches. In the current study, we will investigate the effectiveness and implementation of a coach-supported mHealth intervention, targeting dementia risk factors, to reduce dementia risk.

Methods And Analysis: The prevention of dementia using mobile phone applications (PRODEMOS) randomised controlled trial will follow an effectiveness-implementation hybrid design, taking place in the UK and China. People are eligible if they are 55-75 years old, of low socioeconomic status (UK) or from the general population (China); have ≥2 dementia risk factors; and own a smartphone. 2400 participants will be randomised to either a coach-supported, interactive mHealth platform, facilitating self-management of dementia risk factors, or a static control platform. The intervention and follow-up period will be 18 months. The primary effectiveness outcome is change in the previously validated Cardiovascular Risk Factors, Ageing and Incidence of Dementia dementia risk score. The main secondary outcomes include improvement of individual risk factors and cost-effectiveness. Implementation outcomes include acceptability, adoption, feasibility and sustainability of the intervention.

Ethics And Dissemination: The PRODEMOS trial is sponsored in the UK by the University of Cambridge and is granted ethical approval by the London-Brighton and Sussex Research Ethics Committee (reference: 20/LO/01440). In China, the trial is approved by the medical ethics committees of Capital Medical University, Beijing Tiantan Hospital, Beijing Geriatric Hospital, Chinese People's Liberation Army General Hospital, Taishan Medical University and Xuanwu Hospital. Results will be published in a peer-reviewed journal.

Trial Registration Number: ISRCTN15986016.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2021-049762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8191602PMC
June 2021

Fluoride exposure and children's intelligence: Gene-environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study.

Environ Int 2021 10 4;155:106681. Epub 2021 Jun 4.

Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Excessive fluoride exposure has been associated with intelligence loss, but little is known about gene-fluoride interactions on intelligence at SNP-set, gene and pathway level.

Objectives: Here we conducted a population-based study in Chinese school-aged children to estimate the associations of fluoride from internal and external exposures with intelligence as well as to explore the gene-fluoride interactions on intelligence at SNP-set, gene and neurodevelopmental pathway level.

Methods: A total of 952 resident children aged 7 to 13 were included in the current study. The fluoride contents in drinking water, urine, hair and nail were measured using the ion-selective electrode method. LASSO Binomial regression was conducted to screen the intelligence-related SNP-set. The gene-fluoride interactions at gene and pathway levels were detected by the Adaptive Rank Truncated Product method.

Results: The probability of high intelligence was inversely correlated with fluoride contents in water, urine, hair and nail (all P < 0.001). The SNP-set based on rs3788319, rs1879417, rs57377675, rs11556505 and rs7187776 was related to high intelligence (P = 0.001) alone and by interaction with water, urinary and hair fluoride (P = 0.030, 0.040, 0.010), separately. In gene level, CLU and TOMM40 interacted with hair fluoride (both P = 0.017) on intelligence. In pathway level, Alzheimer disease pathway, metabolic pathway, signal transduction pathway, sphingolipid signaling pathway and PI3K-AKT signaling pathway interacted with fluoride on intelligence in men.

Conclusions: Our study suggests that fluoride is inversely associated with intelligence. Moreover, the interactions of fluoride with mitochondrial function-related SNP-set, genes and pathways may also be involved in high intelligence loss.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envint.2021.106681DOI Listing
October 2021

Circ_0000615 promotes high glucose-induced human retinal pigment epithelium cell apoptosis, inflammation and oxidative stress via miR-646/YAP1 axis in diabetic retinopathy.

Eur J Ophthalmol 2021 Jun 7:11206721211020200. Epub 2021 Jun 7.

Department of Ophthalmology, Chang'an Hospital, Xi'an, Shaanxi, China.

Background: Diabetic retinopathy (DR), a common complication of diabetes mellitus, is the major cause of visual impairment and blindness. Circ_0000615 was found to be elevated in retina samples of diabetic patients. Hence, the detailed effects and molecular mechanisms of circ_0000615 in DN progression were explored.

Methods: The levels of circ_0000615, microRNA (miR)-646 and YAP1 (yes-associated protein 1) were detected using quantitative real-time polymerase chain reaction and Western blot assays. Cell viability, apoptosis, inflammation and reactive oxygen species (ROS) generation were determined using cell counting kit-8 assay, flow cytometry, caspase3 activity analysis, Western blot, enzyme-linked immunosorbent assay (ELISA) and Dichlorofluorescein diacetate (DCFH-DA) assay, respectively. The binding interaction between miR-646 and circ_0000615 or YAP1 was determined using dual-luciferase reporter, RNA immunoprecipitation (RIP), and RNA pull-down assays.

Results: Circ_0000615 was elevated in high glucose (HG)-induced human retinal pigment epithelium (HRPE) cells. Knockdown of circ_0000615 attenuated HG-triggered HRPE cell apoptosis, inflammation, and ROS generation. Mechanistically, miR-646 was confirmed to be a target of circ_0000615, inhibition of miR-646 reversed the protective effects of circ_0000615 knockdown on HG-evoked HRPE cell dysfunction. MiR-646 was verified to target YAP1, overexpression of YAP1 abolished the impairment induced by miR-646 on HG-induced HRPE cell damage. Besides that, we confirmed that circ_0000615 could regulate YAP1 expression via miR-646.

Conclusion: Circ_0000615 contributed to HG-induced HRPE cell dysfunction via miR-646/YAP1 axis, suggesting a novel insight into the pathogenesis of DR and a potential candidate for DR treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1177/11206721211020200DOI Listing
June 2021

Serum concentrations of organochlorine pesticides, biomarkers of oxidative stress, and risk of breast cancer.

Environ Pollut 2021 Oct 25;286:117386. Epub 2021 May 25.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Studies have documented that exposure to organochlorine pesticides (OCPs) is linked with breast cancer, but the underlying biological mechanisms are still unknown. This study included 313 women diagnosed with breast cancer and 313 controls in Wuhan, China, and measured 18 OCPs in serum and 3 oxidative stress biomarkers in urine. Multivariable adjusted regression models were used to evaluate the associations among OCPs, oxidative stress biomarkers, and breast cancer. The mediating effect of oxidative stress was assessed by mediation analysis. We observed that most OCPs were positively associated with risk of breast cancer (all FDR-P values < 0.05 or 0.10). Moreover, we found that p,p'-DDT, p,p'-DDD, dieldrin, heptachlor, and heptachlor epoxide were positively associated with 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA) and 8-iso-prostaglandin F (8-isoPGF), which in turn were positively associated with risk of breast cancer. Mediation analysis indicated that HNE-MA and 8-isoPGF mediated the positive associations between these OCPs and risk of breast cancer, with mediating proportion ranging from 6.23% to 19.9%. Our results suggest that lipid peroxidation may mediate the positive associations between OCP exposures and risk of breast cancer.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2021.117386DOI Listing
October 2021

Prenatal and postnatal exposure to vanadium and the immune function of children.

J Trace Elem Med Biol 2021 Sep 15;67:126787. Epub 2021 May 15.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: The immunotoxicity induced by vanadium exposure have been reported in some toxicology researches. However, evidence from population-based epidemiological studies was lacking.

Methods: This study was conducted to assess the associations between prenatal and postnatal exposure to vanadium and immune function of children. A total of 407 pre-school aged children were followed, whose peripheral blood was collected for T lymphocyte subsets and inflammatory cytokines analysis, as well as vanadium concentration measurement. Maternal urine samples were also collected to measure vanadium concentration. We used generalized linear models to evaluate the associations of maternal and children vanadium concentration with children's immune function. Stratification analysis was further conducted to explore the potential gender-specific effects.

Results: The geometric means of vanadium concentration in maternal urine and children plasma were 0.85 and 1.12 μg/L, respectively. Maternal urinary vanadium was inversely associated with the percentage of CD3CD4 cells [-5.53 % (-10.38 %, -0.41 %)] and absolute counts of CD3 cells [-2.43 % (-5.05 %, 0.25 %)], and we only observed significant negative associations in males when stratifying by fetal gender. Children plasma vanadium was also associated with reduced absolute counts of CD3 cells [-5.25 % (-9.57 %, -0.73 %)], but gender-specific effects were not observed. No significant associations of vanadium exposure with cytokines were found.

Conclusions: Prenatal and postnatal exposure to vanadium had suppressive impacts on childhood cellular immune. Further studies are needed to confirm our findings.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2021.126787DOI Listing
September 2021

The Dynamic Counterbalance of RAC1-YAP/OB-Cadherin Coordinates Tissue Spreading with Stem Cell Fate Patterning.

Adv Sci (Weinh) 2021 05 8;8(10):2004000. Epub 2021 Mar 8.

Beijing Laboratory of Biomedical Materials, Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. China.

Tissue spreading represents a key morphogenetic feature of embryonic development and regenerative medicine. However, how molecular signaling orchestrates the spreading dynamics and cell fate commitment of multicellular tissue remains poorly understood. Here, it is demonstrated that the dynamic counterbalance between RAC1-YAP and OB-cadherin plays a key role in coordinating heterogeneous spreading dynamics with distinct cell fate patterning during collective spreading. The spatiotemporal evolution of individual stem cells in spheroids during collective spreading is mapped. Time-lapse cell migratory trajectory analysis combined with in situ cellular biomechanics detection reveal heterogeneous patterns of collective spreading characteristics, where the cells at the periphery are faster, stiffer, and directional compared to those in the center of the spheroid. Single-cell sequencing shows that the divergent spreading result in distinct cell fate patterning, where differentiation, proliferation, and metabolism are enhanced in peripheral cells. Molecular analysis demonstrates that the increased expression of RAC1-YAP rather than OB-cadherin facilitated cell spreading and induced differentiation, and vice versa. The in vivo wound healing experiment confirms the functional role of RAC1-YAP signaling in tissue spreading. These findings shed light on the mechanism of tissue morphogenesis in the progression of development and provide a practical strategy for desirable regenerative therapies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/advs.202004000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132063PMC
May 2021

Clinical management and treatment of obesity in China.

Lancet Diabetes Endocrinol 2021 06;9(6):393-405

Department of Epidemiology and Biostatistics and Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

China has one of the largest populations with obesity in the world, and obesity has become a major challenge for the country's health-care system. Current guidelines for obesity management are not adequately supported by evidence from clinical studies in Chinese populations. Effective lifestyle interventions suitable for Chinese populations are scarce, insufficient weight-loss medications have been approved by regulatory bodies, and there is low acceptance of non-lifestyle interventions (ie, medications and surgery) among both health-care providers and the general public. Large, well designed, and well implemented clinical trials are needed to strengthen the evidence base for the clinical management of obesity in China. Obesity management can be improved through use of a tiered system involving health management centres, integrated lifestyle interventions and medical treatments, strengthened obesity education and training, and use of advanced electronic health technologies. Resource mobilisation, support from major stakeholders for people with overweight or obesity, and education and changes to social norms among the wider public are also needed. National health policies should prioritise both obesity prevention and improvement of the treatment and management of obesity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-8587(21)00047-4DOI Listing
June 2021

Applying a Bayesian multivariate spatio-temporal interaction model based approach to rank sites with promise using severity-weighted decision parameters.

Accid Anal Prev 2021 Jul 19;157:106190. Epub 2021 May 19.

School of Traffic and Transportation, Changsha University of Science and Technology, Changsha, 410114, PR China. Electronic address:

Ranking sites with promise is an essential step for cost-effective engineering improvement on roadway traffic safety. This study proposes a Bayesian multivariate spatio-temporal interaction model based approach for ranking sites. The severity-weighted crash frequency and crash rate are used as the decision parameters. The posterior expected rank and posterior mean of the decision parameters are adopted as the statistical criteria. The proposed approach is applied to rank road segments on Kaiyang Freeway in China, which is conducted via programming in the freeware WinBUGS. The results of Bayesian estimation and assessment indicate that incorporating spatio-temporal correlations and interactions into the crash frequency model significantly improves the overall goodness-of-fit performance and affects the identified crash-contributing factors and the estimated safety effects for each severity level. With respect to the ranking results, significant differences are found between those generated from the proposed approach and those generated from the naïve ranking approach and a Bayesian approach based on the multivariate Poisson-lognormal model. Besides, the ranks under the posterior mean criterion are found generally consistent with those under the posterior expected rank criterion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aap.2021.106190DOI Listing
July 2021

Automated Nanoparticle Analysis in Surface Plasmon Resonance Microscopy.

Anal Chem 2021 05 11;93(20):7399-7404. Epub 2021 May 11.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.

The unique capability of surface plasmon resonance microscopy (SPRM) in single nanoparticle analysis has found use in various chemical and biological applications. While SPRM offers exceptional sensitivity, the statistical analysis of numerous nanoparticles has been extremely laborious and time-consuming. Herein, we presented an image processing software package for nanoparticle analysis in SPRM, which is empowered by a deep learning algorithm. This package enabled fully automated nanoparticle identification, digital counting, three-dimensional tracking of particle locations, and quantification of dwell time and Brownian motion properties. With a built-in image filtering process to improve the contrast, robust identification and analysis have been achieved from SPRM images of low refractive index nanoparticles. This software tool would largely promote the translation of SPRM technology into the digital sensing platform for high throughput sample screening.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.1c01493DOI Listing
May 2021

Efficient removal of arsenite by a composite of amino modified silica supported MnO/Fe-Al hydroxide (SNMFA) prepared from biotite.

J Environ Manage 2021 Aug 6;291:112678. Epub 2021 May 6.

School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, China.

Developing materials from natural minerals to efficiently remove arsenite (As(Ⅲ)) from solution is vital important for resources comprehensive utilization and environment protection. In this study, biotite containing minerals was used to prepare a novel composite of amino modified silica supported MnO/Fe-Al hydroxide (SNMFA composite), which was then applied to remove arsenite. Scanning electron microscope (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) results indicated that many amorphous MnO and Fe-Al hydroxide nano sheets were loaded on the surface of layered silica structure. Batch experiments showed that this composite could efficiently remove As(Ⅲ) from aqueous solution, and the maximal removal capacity was identified as 46.11 mg/g. As(Ⅲ) adsorption behaviours of SNMFA composite were confirmed by the pseudo-second-order kinetic model and Langmuir model, indicating that As(Ⅲ) adsorption on its surface was monolayer adsorption. The adsorption process was a pH and temperature dependent process, and increasing pH and temperature have facilitated the removal of As(Ⅲ). Thermodynamic analysis showed that As(Ⅲ) adsorption process was a spontaneous endothermic reaction. The As(Ⅲ) removal was mainly relied on the stable inner-sphere coordination model, and the corresponding mechanisms were involved in chelation, precipitation, oxidation-adsorption and electrostatic interaction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2021.112678DOI Listing
August 2021

Bortezomib-based regimens improve the prognosis of newly diagnosed MM patients with chromosomal aberrations except for del(17q13): A retrospective study from a single center.

Medicine (Baltimore) 2021 May;100(18):e25834

Department of Hematology, West China Hospital, Sichuan University, Chengdu, China.

Abstract: Chromosomal aberrations are generally considered to have a remarkable impact on the outcome of multiple myeloma. Bortezomib helps to achieve complete responses and leads to longer life expectancy in many multiple myeloma patients. This study was designed to clarify whether bortezomib can improve the poor prognosis resulting from del(17q13), del(13q14), amp(1q21), t(4,14), t(14,16) in patients with multiple myeloma. A total of 255 MM patients treated with bortezomib-based regimens were included in this study. All chromosomal aberrations were detected by interphase fluorescence in situ hybridization. Kaplan-Meier survival and Multivariable Cox regression analysis were employed to assess the prognostic situation in progression-free survival and overall survival. The result showed that the progression-free survival and overall survival of patients with del(17q13) were shorter than those without del(17q13) in multivariate analysis and patients with del(13q14), amp(1q21), t(4,14), t(14,16) were similar to patients without these chromosomal aberrations in progression-free survival and overall survival after receiving bortezomib-based regimens.In conclusion Bortezomib-based regimens can overcome the poor prognosis derived from del(13q14), amp(1q21), t(4,14), t(14,16) but not del(17q13).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000025834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104214PMC
May 2021

Impact of Ambient Air Quality Standards revision on the exposure-response of air pollution in Tianjin, China.

Environ Res 2021 07 1;198:111269. Epub 2021 May 1.

School of Public Health, Tianjin Medical University, Tianjin, 300070, China; Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China. Electronic address:

To improve air quality, China issued a new version of Ambient Air Quality Standards in 2012, and Tianjin officially implemented these new standards in 2013. In order to observe whether the atmospheric quality and health had been improved after the release of the new standards, this study compared the exposure-response relationships between pollutant concentrations and daily deaths (and years of life lost, YLL) in the six central districts of Tianjin in 2007-2010 and 2014-2017, which were the two periods around the release of the new standards. The exposure-response coefficients were calculated by using the generalized additive model with the time series data. The results showed that the effects of PM and NO during 2014-2017 were lower than those during 2007-2010 (PM: 0.10<0.30, 2.07<4.52; NO2: 0.24<0.87, 6.39<11.98), while the results of SO were opposite (SO: 0.61>0.31, 10.31>1.64). And the excess deaths and YLL caused by the portion of the pollutants that exceeded the new standards also declined (PM: 156<206 persons, 3493<3913 person-years; NO: 64<136 persons, 1844<2895 person-years; SO did not exceed the new standards). The results proved that the new standards had a certain protective effect on the health of the population in the central districts of Tianjin. These findings may provide evidence for the formulation of public health policies and further improvement and development of the Ambient Air Quality Standards.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2021.111269DOI Listing
July 2021

Urinary bisphenol A and its alternatives among pregnant women: Predictors and risk assessment.

Sci Total Environ 2021 Aug 18;784:147184. Epub 2021 Apr 18.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Exposure to bisphenol A (BPA) has been associated with various adverse health outcomes. Recently, an increasing concern on its alternatives such as bisphenol S (BPS) and bisphenol F (BPF) has been aroused due to the restriction use of BPA. Few studies have identified predictors of exposure to BPA alternatives and assessed their health risks.

Objective: The aim of this study was to identify predictors of BPA and its alternatives and to assess their health risks among pregnant women.

Methods: We detected first morning urinary concentrations of BPA and its alternatives (BPS and BPF) among 1097 pregnant women from an established Chinese cohort. A questionnaire was conducted to obtain demographic characteristics, dietary habits, and lifestyles. We examined the predictors of creatinine-adjusted urinary BPA and its alternatives concentrations using multivariable linear regression. Risk assessment of exposure to BPA and its alternatives was calculated based on the estimated of daily intake (EDI).

Results: Geometric means of creatinine-adjusted urinary BPA, BPF, and BPS were 0.92, 0.12, and 0.08 μg/g creatinine, respectively. Pregnant women from Wuhan had lower concentrations of BPA, BPF, and ∑BPs (sum of BPA, BPF, and BPS) than those from Xiaogan. Intake of fried food was related to higher concentrations of BPA, and intake of pickled food was associated with higher concentrations of BPF and ∑BPs. The maximum EDI values for exposure to BPA, BPF, BPS, and ∑BPs ranged from 5.6428 to 13.3356 nmol/kg body weight/day, which were below the tolerable daily intake (TDI) for BPA defined by the European Food Safety Authority (EFSA) (18 nmol/kg body weight/day). The maximum hazard index (HI) value was 0.7409.

Conclusion: Several predictors identified in this study may inform public recommendations to reduce exposure to BPA and its alternatives.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.147184DOI Listing
August 2021

Molecular Determination of Organic Adsorption Sites on Smectite during Fe Redox Processes Using ToF-SIMS Analysis.

Environ Sci Technol 2021 05 26;55(10):7123-7134. Epub 2021 Apr 26.

Environmental Molecular Science Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.

Turnover of soil organic carbon (SOC) is strongly affected by a balance between mineral protection and microbial degradation. However, the mechanisms controlling the heterogeneous and preferential adsorption of different types of SOC remain elusive. In this work, the heterogeneous adsorption of humic substances (HSs) and microbial carbon (MC) on a clay mineral (nontronite NAu-2) during microbial-mediated Fe redox cycling was determined using time-of-flight secondary ion mass spectrometry (ToF-SIMS). The results revealed that HSs pre-adsorbed on NAu-2 would partially inhibit structural modification of NAu-2 by microbial Fe(III) reduction, thus retarding the subsequent adsorption of MC. In contrast, NAu-2 without precoated HSs adsorbed a significant amount of MC from microbial polysaccharides as a result of Fe(III) reduction. This was attributed to the deposition of a thin Al-rich layer on the clay surface, which provided active sites for MC adsorption. This study provides direct and detailed molecular evidence for the first time to explain the preferential adsorption of MC over HSs on the surface of clay minerals in iron redox processes, which could be critical for the preservation of MC in soil. The results also indicate that ToF-SIMS is a unique tool for understanding complex organic-mineral-microbe interactions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.est.0c08407DOI Listing
May 2021

Gut Microbiome Alterations in Patients With Thyroid Nodules.

Front Cell Infect Microbiol 2021 12;11:643968. Epub 2021 Mar 12.

Health Management Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Thyroid nodules are found in nearly half of the adult population. Accumulating evidence suggests that the gut microbiota plays an important role in thyroid metabolism, yet the association between gut microbiota capacity, thyroid nodules, and thyroid function has not been studied comprehensively. We performed a gut microbiome genome-wide association study in 196 patients with thyroid nodules and 283 controls by using whole-genome shotgun sequencing. We found that participants with high-grade thyroid nodules have decreased number of gut microbial species and gene families compared with those with lower grade nodules and controls. There are also significant alterations in the overall microbial composition in participants with high-grade thyroid nodules. The gut microbiome in participants with high-grade thyroid nodules is characterized by greater amino acid degradation and lower butyrate production. The relative abundances of multiple butyrate producing microbes are reduced in patients with high-grade thyroid nodules and the relative abundances of L-histidine metabolism pathways are associated with thyrotropin-releasing hormone. Our study describes the gut microbiome characteristics in thyroid nodules and a gut-thyroid link and highlight specific gut microbiota as a potential therapeutic target to regulate thyroid metabolism.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2021.643968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005713PMC
July 2021
-->