Przemyslaw Sapieha

Przemyslaw Sapieha

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Przemyslaw Sapieha

Przemyslaw Sapieha

Publications by authors named "Przemyslaw Sapieha"

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The protein tyrosine phosphatase PTPRJ/DEP-1 contributes to the regulation of the Notch-signaling pathway and sprouting angiogenesis.

Angiogenesis 2019 Oct 9. Epub 2019 Oct 9.

CRCHUM - Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.

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http://dx.doi.org/10.1007/s10456-019-09683-zDOI Listing
October 2019

In Vivo Laser-Mediated Retinal Ganglion Cell Optoporation Using K1.1 Conjugated Gold Nanoparticles.

Nano Lett 2018 11 12;18(11):6981-6988. Epub 2018 Oct 12.

Department of Engineering Physics , Polytechnique Montréal , Montreal , Quebec , Canada , H3C 3A7.

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http://dx.doi.org/10.1021/acs.nanolett.8b02896DOI Listing
November 2018

Nogo-A inhibits vascular regeneration in ischemic retinopathy.

Glia 2018 10 27;66(10):2079-2093. Epub 2018 Jul 27.

CUO-Recherche, Centre de recherche du CHU de Québec and Département d'ophtalmologie, Faculté de médecine, Université Laval, Quebec, Quebec, Canada.

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http://dx.doi.org/10.1002/glia.23462DOI Listing
October 2018

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest.

Trends Cell Biol 2018 08 25;28(8):595-607. Epub 2018 Apr 25.

Département de Biochimie et Médecine Moléculaire, C.P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7, Canada; Maisonneuve-Rosemont Hospital Research Centre, Montréal, QC, H1T 2M4, Canada; Département de Médecine, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, QC, H3C 3J7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2018.03.003DOI Listing
August 2018

On phagocytes and macular degeneration.

Prog Retin Eye Res 2017 Nov 7;61:98-128. Epub 2017 Jun 7.

Institut de la Vision, 17 rue Moreau, Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, 75012, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.preteyeres.2017.06.002DOI Listing
November 2017

miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD).

Clin Chem Lab Med 2017 May;55(5):763-775

Division of Clinical Biochemistry, Maisonneuve-Rosemont Hospital, University of Montreal, Department of Biochemistry and Molecular Medicine, Montreal, Quebec.

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http://dx.doi.org/10.1515/cclm-2016-0898DOI Listing
May 2017

Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization.

EMBO Mol Med 2016 12 1;8(12):1366-1379. Epub 2016 Dec 1.

Department of Biomedical Sciences, Maisonneuve-Rosemont Hospital Research Centre University of Montreal, Montreal, Quebec, Canada

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http://dx.doi.org/10.15252/emmm.201606531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5167134PMC
December 2016

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

Sci Transl Med 2016 10;8(362):362ra144

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, Université de Montréal, Montreal, Quebec H1T 2M4, Canada.

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http://dx.doi.org/10.1126/scitranslmed.aaf9440DOI Listing
October 2016

Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications.

Am J Physiol Heart Circ Physiol 2016 09 29;311(3):H738-49. Epub 2016 Jul 29.

Depatment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Harold Hamm Diabetes Center, Oklahoma City, Oklahoma;

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http://dx.doi.org/10.1152/ajpheart.00005.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142179PMC
September 2016

p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy.

J Neurosci 2016 08;36(34):8826-41

Lady Davis Institute-Jewish General Hospital, Center for Translational Research, McGill University, Montreal, Quebec H3T 1E2, Canada, Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada, McGill Cancer Center, McGill University, Montreal, Quebec H3A 1A3, Canada

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http://dx.doi.org/10.1523/JNEUROSCI.4278-15.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601903PMC
August 2016

Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration.

PLoS One 2015 7;10(5):e0125548. Epub 2015 May 7.

Analytic & Translational Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125548PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423995PMC
April 2016

MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD.

Oncotarget 2016 Apr;7(15):19171-84

Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.18632/oncotarget.8280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991373PMC
April 2016

Neuropilin-1-Expressing Microglia Are Associated With Nascent Retinal Vasculature Yet Dispensable for Developmental Angiogenesis.

Invest Ophthalmol Vis Sci 2016 Apr;57(4):1530-6

Department of Biochemistry and Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada 2Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montrea.

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http://dx.doi.org/10.1167/iovs.15-18598DOI Listing
April 2016

Neurons and guidance cues in retinal vascular diseases.

Oncotarget 2016 Mar;7(9):9618-9

Department of Ophthalmology and Biochemistry and Molecular Medicine, MaisonneuveRosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.18632/oncotarget.7413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891070PMC
March 2016

Cell-specific optoporation with near-infrared ultrafast laser and functionalized gold nanoparticles.

Nanoscale 2015 Nov 13;7(42):17836-47. Epub 2015 Oct 13.

Laser Processing and Plasmonics Laboratory, Department of Engineering Physics, Polytechnique Montréal, C.P. 6079, Succursale Centre-ville, Montreal, QC H3C 3A7, Canada.

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http://dx.doi.org/10.1039/c5nr05650kDOI Listing
November 2015

ER Stress and Angiogenesis.

Cell Metab 2015 Oct 13;22(4):560-75. Epub 2015 Aug 13.

Departments of Ophthalmology, Biochemistry, & Molecular Medicine, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, QC H1T 2M4, Canada; Department of Neurology-Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.010DOI Listing
October 2015

Retinal neurons curb inflammation and enhance revascularization in ischemic retinopathies via proteinase-activated receptor-2.

Am J Pathol 2015 Feb 3;185(2):581-95. Epub 2014 Dec 3.

Department of Pharmacology, CHU Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, University of Montréal, Montréal, Québec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada; Department of Pediatrics, CHU Sainte-Justine Hospital, University of Montréal, Montréal, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.10.020DOI Listing
February 2015

Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration.

Am J Ophthalmol 2014 Nov 1;158(5):1071-78. Epub 2014 Aug 1.

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.ajo.2014.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389631PMC
November 2014

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis.

Nat Med 2014 Oct 14;20(10):1165-73. Epub 2014 Sep 14.

1] Department of Pediatrics, Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Université de Montréal, Montréal, Québec, Canada. [2] Department of Ophthalmology, Hôpital Maisonneuve-Rosemont Research Center, Université de Montreal, Montreal, Québec, Canada. [3] Department of Pharmacology, Université de Montréal, Montréal, Québec, Canada. [4] Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1038/nm.3669DOI Listing
October 2014

Assessment of vascular regeneration in the CNS using the mouse retina.

J Vis Exp 2014 Jun 23(88):e51351. Epub 2014 Jun 23.

Department of Neurology-Neurosurgery, McGill University; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montréal; Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montréal;

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http://dx.doi.org/10.3791/51351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204889PMC
June 2014

Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.

Arterioscler Thromb Vasc Biol 2014 Mar 23;34(3):581-6. Epub 2014 Jan 23.

From the Department of Ophthalmology, Boston Children's Hospital (Z.S., Z.F., J.-S.J., C. Hatton, A.J., C. Hurst, L.E., Z.C., D.P., Y.G., D.X., K.T., H.B., J.C., L.E.H.S.) and Department of Pathology, Beth Israel Deaconess Medical Center (D.P.), Harvard Medical School, Boston, MA; University Eye Hospital Freiburg, Freiburg, Germany (A.S.); Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, NC (M.L.E., F.L., D.C.Z.); Department of Ophthalmology, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada (P.S.); and Department of Ophthalmology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (A.H.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005334PMC
March 2014

Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function.

Invest Ophthalmol Vis Sci 2013 Dec 17;54(13):8125-39. Epub 2013 Dec 17.

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, Quebec, Canada.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.13-12496DOI Listing
December 2013

Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1.

Cell Metab 2013 Oct;18(4):505-18

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, QC H1T 2M4, Canada; Department of Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, QC H1T 2M4, Canada.

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http://dx.doi.org/10.1016/j.cmet.2013.09.003DOI Listing
October 2013

Eyeing central neurons in vascular growth and reparative angiogenesis.

Blood 2012 Sep 15;120(11):2182-94. Epub 2012 Jun 15.

Department of Ophthalmology & Biochemistry, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Montreal, QC, Canada.

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http://dx.doi.org/10.1182/blood-2012-04-396846DOI Listing
September 2012

Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A.

Acta Paediatr 2012 Aug 5;101(8):819-26. Epub 2012 May 5.

Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montréal, QC, Canada.

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http://dx.doi.org/10.1111/j.1651-2227.2012.02692.xDOI Listing
August 2012

Understanding retinopathy of prematurity: update on pathogenesis.

Neonatology 2011 3;100(4):343-53. Epub 2011 Oct 3.

Department of Pediatrics, Ophthalmology and Pharmacology, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, Qué., Canada.

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http://dx.doi.org/10.1159/000330174DOI Listing
March 2012

Lipid metabolites in the pathogenesis and treatment of neovascular eye disease.

Br J Ophthalmol 2011 Nov 18;95(11):1496-501. Epub 2011 Mar 18.

Department of Ophthalmology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1136/bjo.2010.194241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711020PMC
November 2011

Choroidal involution is a key component of oxygen-induced retinopathy.

Invest Ophthalmol Vis Sci 2011 Aug 5;52(9):6238-48. Epub 2011 Aug 5.

Department of Ophthalmology and Pharmacology, Hôpital Sainte-Justine Research Center, Montreal, Canada.

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http://dx.doi.org/10.1167/iovs.10-6742DOI Listing
August 2011

Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice.

Invest Ophthalmol Vis Sci 2011 Apr 25;52(5):2809-16. Epub 2011 Apr 25.

Department of Ophthalmology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA

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http://dx.doi.org/10.1167/iovs.10-6496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088563PMC
April 2011

Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migration.

Am J Physiol Regul Integr Comp Physiol 2011 Mar 15;300(3):R577-85. Epub 2010 Dec 15.

Department of Pediatrics, Maisonneuve-Rosemont Hospital Research Centre, University of Montreal, Quebec, Canada.

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http://dx.doi.org/10.1152/ajpregu.00137.2010DOI Listing
March 2011

Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life.

J Clin Invest 2010 Sep 1;120(9):3022-32. Epub 2010 Sep 1.

Department of Ophthalmology, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI42142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929716PMC
September 2010

The mouse retina as an angiogenesis model.

Invest Ophthalmol Vis Sci 2010 Jun;51(6):2813-26

Department of Ophthalmology, Harvard Medical School, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1167/iovs.10-5176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891451PMC
June 2010

Proliferative retinopathies: angiogenesis that blinds.

Int J Biochem Cell Biol 2010 Jan 15;42(1):5-12. Epub 2009 Oct 15.

Department of Ophthalmology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.biocel.2009.10.006DOI Listing
January 2010

Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.

J Neurosci 2009 Apr;29(17):5536-45

Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montreal, Quebec H3T 1J4, Canada.

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http://dx.doi.org/10.1523/JNEUROSCI.0831-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665839PMC
April 2009

Extracellular signal-regulated kinases 1/2 are required for adult retinal ganglion cell axon regeneration induced by fibroblast growth factor-2.

J Neurosci Res 2006 May;83(6):985-95

Department of Pathology and Cell Biology, Université de Montréal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/jnr.20803DOI Listing
May 2006

Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS.

Mol Cell Neurosci 2005 Apr;28(4):625-35

Department of Pathology and Cell Biology, Université de Montréal, 2900, Boulevard Edouard-Montpetit, Pavillon Principal, Room N-535, Montreal, Quebec, Canada H3T 1J4.

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http://dx.doi.org/10.1016/j.mcn.2004.10.011DOI Listing
April 2005

Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury.

Mol Cell Neurosci 2003 Nov;24(3):656-72

Department of Pathology and Cell Biology, Université de Montréal, Montreal, Quebec H3T 1J4, Canada.

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November 2003

TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo.

J Neurosci 2002 May;22(10):3977-86

Department of Pathology and Cell Biology, Université de Montréal, Montreal, Quebec H3T 1J4, Canada.

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http://dx.doi.org/20026382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757661PMC
May 2002